ライフサイエンスコーパス: O. formigenes

1 O. formigenes interacts with colonic epithelium and indu

2 O. formigenes prevalence was 50%.

3 Transplanting mice with human feces and O. formigenes introduced new microbial populations resem

4 showed even greater sensitivity in detecting O. formigenes and provided support for further division

5 sequences of oxc or frc were able to divide O. formigenes strains into at least two groups, consiste

6 ly aged healthy volunteers were examined for O. formigenes by culture and DNA analysis.

7 Serial fecal samples were examined for O. formigenes presence and microbiota characteristics.

8 the multivariable model, the odds ratio for O. formigenes remained 0.3 (95% confidence interval 0.1

9 he obligate anaerobe Oxalobacter formigenes, O. formigenes formyl coenzyme A transferase (FRC).

10 on of oxalate-degrading enzymes derived from O. formigenes to determine any subsequent increased resi

11 nized human donors supplemented with a human O. formigenes strain into recipient mice.

12 Intestinal O. formigenes colonization has been associated with a lo

13 develop murine models to allow investigating O. formigenes in the context of its native human microbi

14 Compared with control medium, O. formigenes CM significantly stimulated oxalate uptake

15 We investigated whether the absence of O. formigenes and the presence of hyperoxaluria are corr

16 d not differ with the presence or absence of O. formigenes colonization.

17 It was hypothesized that the absence of O. formigenes could lead to increased colonic absorption

18 Absence of O. formigenes from the intestinal tract of CF patients a

19 peroxaluria type 1, rectal administration of O. formigenes CM significantly reduced (>32.5%) urinary

20 both detection as well as classification of O. formigenes strains.

21 Detection of O. formigenes in six of these seven patients required DN

22 Detection of O. formigenes in the gastrointestinal tract has attracte

23 We therefore evaluated the effects of O. formigenes culture conditioned medium (CM) on apical

24 end our understanding of the epidemiology of O. formigenes carriage, and are consistent with the hypo

25 To confirm the importance of O. formigenes in regulating hyperoxaluria, laboratory ra

26 urrent kidney stone episodes and the lack of O. formigenes colonization.

27 As expected, the lack of O. formigenes revealed a clear association with prophyla

28 s is associated with the progressive loss of O. formigenes colonization in populations that have been

29 s, and the CF patient with normal numbers of O. formigenes was the only one of the 43 patients who ha

30 The prevalence of O. formigenes, determined by stool culture, was 17% amon

31 s, consistent with the current separation of O. formigenes strains into groups I and II on the basis

32 ssess the effects of an antibiotic course on O. formigenes colonization, urine electrolytes, and the

33 identified significant antibiotic effects on O. formigenes colonization and urinary electrolytes and

34 colonization; such models can define optimal O. formigenes strains to facilitate clinical trials.

35 e importance of the microbiome, particularly O. formigenes in host oxalate homeostasis.

36 resembling the human microbiome, with stable O. formigenes colonization; such models can define optim

37 The difficulties in sustaining O. formigenes colonization underscore the need to identi

38 oups in Venezuela and the Hadza in Tanzania, O. formigenes was detected in 60-80% of the adult subjec

39 ns, taken together, support the concept that O. formigenes is important in maintaining oxalate homeos

40 We conclude that O. formigenes-derived bioactive factors stimulate oxalat

41 cal and epidemiological studies suggest that O. formigenes colonization reduces the risk for kidney s

42 In subjects not on antibiotics, the O. formigenes-positive samples had higher alpha-diversit

43 ficantly differed in Beta-diversity from the O. formigenes-negative samples.

44 ultrafiltration of the CM revealed that the O. formigenes-derived factors have molecular masses of 1

45 Treating the O. formigenes CM with heat or pepsin completely abolishe

46 structure differed in subjects according to O. formigenes presence.

47 Now using O. formigenes-specific PCR, we have compared the prevale

48 All seven CF patients colonised with O. formigenes had normal urinary oxalate levels, but 19

49 t 19 (53%) of 36 patients not colonised with O. formigenes were hyperoxaluric, with the most severe h

50 (16%) of 43 CF patients were colonised with O. formigenes.

51 these results suggest that colonization with O. formigenes is associated with a 70% reduction in the

52 ll humanized mice were stably colonized with O. formigenes through 8 weeks after gavage, whereas mice

53 amples from an individual not colonized with O. formigenes, indicating unique specificity.

54 maintained in the gnotobiotic facility with O. formigenes, using either a laboratory isolate or an i

55 excretion in hyperoxaluric mice treated with O. formigenes CM reflects the in vivo retention of biolo