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1 ORR in PD-L1-positive patients was 60% (n = 9) v 19% (n
2 ORR in the intention-to-treat (ITT) population was 17% (
3 ORR increased with higher TMB, plateauing at 10 or more
4 ORR was 28.6% (95% CI, 24.1% to 33.5%); 33 patients (8.9
5 ORR was 30% overall and 41% and 15% in patients with 1%
6 ORR was 30.6% (95% CI, 20.0% to 47.5%) for all patients
7 ORR was 32% for the first 25 enrolled patients (8 PR [7
8 ORR was 36% (15 of 42 patients).
9 ORR was 37.5% with a complete response rate of 12.5%, me
10 ORR was 42% with nivolumab and 14% with dacarbazine; amo
11 ORR was 57% (95% CI, 39.4% to 73.7%) for cisplatin plus
12 ORR(W15) for the entire population was 42%; it was signi
13 ORR(week24) was as follows: RCC, 63% (19/30; 95% CI, 43.
14 ORR-IC was higher in the tucatinib arm (47.3%; 95% CI, 3
15 ORRs were similar for patients with a germline or somati
25 ponse rate (ORR); the null hypothesis (<= 5% ORR) would be rejected within each cohort if there were
28 ) nanoparticles with an exceptional activity-ORR and OER current densities of 7.21 and 6.85 mA cm(-2)
30 % (95% CI, 70.0-97.8) with BID dosing and an ORR of 79.2% (95% CI, 57.9-92.9) and an estimated PFS ra
32 ier-positive DLBCL patients (de novo) had an ORR of 44%, median progression-free survival (mPFS) of 6
34 urvival (mPFS) of 6 months, and 16% CR vs an ORR of 19%, mPFS of 1.5 months, and 5% CR in classifier-
35 his study met its primary end point, with an ORR of 38% (P < .0001) in this mixed histology, pretreat
37 and pembrolizumab with chemotherapy, with an ORR, DCR and median duration of response of 32%, 77% and
38 he ORR ratio (1.09; 90% CI, 0.974-1.211) and ORR difference (5.53; 95% CI, -3.08 to 14.04) were withi
39 ction of some fundamentals of fuel cells and ORR catalysts with performance metrics is provided, foll
40 omplete remission rate per investigator, and ORR of 70% (51% to 85%), with a 43% complete metabolic r
41 ntify the kinetics of the HER, HOR, OER, and ORR in acidic and basic solutions are provided, and exam
46 roving the catalytic performance of Pt-based ORR catalysts, including the development of various Pt n
54 or the mechanism of iron porphyrin-catalyzed ORR and provides an unusually complete mechanistic study
62 been applied to understanding and designing ORR catalysts, it has also been recognized that these un
63 In patients with lymph node-only disease, ORR was 49.0% (95% CI, 34.8% to 63.4%), and median OS wa
64 inib to trastuzumab and capecitabine doubled ORR-IC, reduced risk of intracranial progression or deat
66 vation affirms that FePc demetalation during ORR proceeds via a direct loss of Fe(2+) and that carbon
67 on relation of Pt-alloy nanocatalysts during ORR demands concerted efforts in precision synthesis, ad
72 anotubes exhibits excellent electrocatalytic ORR activity (E(1/2) =0.83 V vs. RHE, n=3.93, and j(L) =
73 2)O(2)/H(2)O selectivity in electrocatalytic ORR by iron(tetramesitylporphyrin) (Fe(TMP)) in DMF.
74 duce 90-100 % H(2) O(2) from electrochemical ORR catalysis in neutral pH water, whereas the Co-TPP mo
75 roton exchange membrane (PEM) electrolyzers, ORR-related PEM fuel cells, NRR-driven ammonia electrosy
77 lectrocatalytic activity toward two-electron ORR to H(2)O(2), a future green "dream" process for chem
80 erimental ORR was compared with an estimated ORR of 60% based on historical data, verified by a rando
81 al and mechanistic basis for the exceptional ORR activity of M-N-C electrocatalysts impedes rational
82 PGM-free Fe-N-C electrocatalysts now exhibit ORR activities approaching that of PGM electrocatalysts
85 nce-Tafel slopes of 35 and 38 mV dec(-1) for ORR and OER, respectively-resulting in the lowest ORR ov
86 bits promising electrocatalytic activity for ORR with a half-wave potential of 0.89 V in 0.1 M NaOH,
87 PD-L1+ and PD-L1- patients, was assessed for ORR, disease control rate, and safety, but not survival.
89 undaries were 0.81 to 1.24 with a 90% CI for ORR ratio (proposed biosimilar/trastuzumab) and -15% to
91 arbon-based, metal-free electrocatalysts for ORR and various defects in metal oxides/selenides for OE
92 lations, we present a microkinetic model for ORR on Fe-N-C SACs, disclosing a self-adjusting mechanis
93 lectrochemical, and catalytic properties for ORR to a typical Fe-N-C material and prototypical pyrrol
94 he electrocatalytic activity/selectivity for ORR (H(2)O(2) and H(2)O products) and H(2)O(2) reduction
96 sitive versus PRESSING-negative subgroup for ORR (59.2% v 75.3%; P = .030), PFS (7.7 v 12.1 months; P
97 erved in right- versus left-sided tumors for ORR (55.2% v 74.1%; P = .037), PFS (8.4 v 11.5 months; P
100 g the main causes of instability of PGM-free ORR catalysts in acidic environments, focusing on transi
101 freedom for each marker effect obtained from ORR and use it to deshrink both the estimated effect and
103 y end points were similar in the two groups: ORR 16% (complete response [CR]/partial responses[PRs],
104 of the five above-mentioned reactions (HER, ORR, CO(2) RR, NRR, and OER), the current challenges fac
105 g H(2)O(2) productivity considering its high ORR activity, highest H(2)O(2) selectivity, and lowest H
106 the surface gives rise to the observed high ORR and OER electrocatalytic activity and small discharg
108 trocatalysts exhibit an unprecedentedly high ORR activity with a half-wave potential (E(1/2) ) of 0.9
109 num-based nanocrystals that enable very high ORR activities in acidic media; however, improving the a
110 .74; 95% CI, 0.67 to 0.82; P < .001), higher ORR (64.5% v 53.6%; P < .001), higher R0 resection rate
111 ients with high BCL2 expression had a higher ORR (94% [17/18]) than patients with low BCL2 expression
112 d Ir-SAC exhibits orders of magnitude higher ORR activity than iridium nanoparticles with a record-hi
117 Fe/Al-contaminated acidic environments like ORR or acid mine drainage sites has the potential to imp
118 ng unsolvated (in case of PF(6) (-)) lowered ORR activation barriers with a 200-mV lower overpotentia
119 nd OER, respectively-resulting in the lowest ORR overpotential of 4.0 mV and OER overpotential of 5.1
123 rasmall and ordered L1(0) -PtCo nanoparticle ORR catalysts further doped with a few percent of metals
125 first section, we start with the activity of ORR on the nanoscale surface and then focus on the appro
127 Density functional theory calculations of ORR and OER on Mo(3) P (110) reveal that an oxide overla
128 enables the rapid and reliable evaluation of ORR activity using standard rotating disk electrode (RDE
129 ion process can be correlated with a loss of ORR activity suggesting that Fe-containing sites are ess
131 vity toward H(2)O(2) and a positive shift of ORR onset potential by ~320 mV compared with the OCNT su
132 the standard error so that the Wald test of ORR is brought back to the same level as that of EMMA.
134 sults indicate that the achieved outstanding ORR performance results from the synergetic enhancement
135 h-SA electrocatalyst exhibits an outstanding ORR activity, outperforming SA electrocatalysts with onl
137 + bevacizumab and provides advantage in PFS, ORR, and R0 resection rate at the price of a moderate in
140 portant in the performance of iron porphyrin ORR catalysts, we suggest that electrostatic stabilizers
141 that have been developed for iron porphyrin ORR electrocatalysts to improve the performance of the c
142 .5 %) Ni PF) was obtained, showing prominent ORR activity with an onset potential of 0.92 V (vs.
146 imary end point was objective response rate (ORR) at 24 weeks (ORR(Wk24)); secondary efficacy end poi
147 primary end point was overall response rate (ORR) at day 28; the key secondary end point was duration
149 point was overall hematologic response rate (ORR) by the end of 6 continuous 28-day cycles for the fi
152 imary end point was objective response rate (ORR) in patients with 1% or more and less than 1% tumor
153 rametinib led to an objective response rate (ORR) of 78%, including 44% complete responses (CRs).
154 erated and yielded an overall response rate (ORR) of partial response or better of 95.8% (95% confide
157 primary end point was overall response rate (ORR) using the revised International Working Group crite
158 th de novo R/R DLBCL, overall response rate (ORR) was 29%, including 11% complete response (CR).
159 -assessed confirmed objective response rate (ORR) was 43%, and duration of response was 7.4 months.
160 aluable patients, the overall response rate (ORR) was 44% (complete response [CR], 28%); among them,
161 uable population, the overall response rate (ORR) was 56% (29/52) and was similar between the 10 mg/k
163 ree survival (PFS), objective response rate (ORR), and disease control rate (DCR), as well as related
165 verall survival (OS), overall response rate (ORR), duration of response (DOR), clinical-benefit rate,
166 ical outcomes were: objective response rate (ORR), immune-related adverse events (irAEs), progression
167 ints included tumor objective response rate (ORR), overall survival (OS), and change in plasma 25(OH)
169 were correlated with overall response rate (ORR), progression-free survival (PFS), and overall survi
170 objectives included objective response rate (ORR), progression-free survival (PFS), duration of respo
171 ree survival (PFS), objective response rate (ORR), R0 resection rate, grade 3/4 adverse events, and s
172 Purpose To evaluate objective response rate (ORR), safety, and survival after TACE by using idarubici
178 centrally assessed objective response rate (ORR); secondary end points included progression-free sur
179 rimary endpoint was objective response rate (ORR); the null hypothesis (<= 5% ORR) would be rejected
180 firmed intracranial objective response rate (ORR-IC) was evaluated in patients with measurable intrac
182 acy end points were objective response rate (ORR; per RECIST/Prostate Cancer Clinical Trials Working
183 cohort 3B) had CNS objective response rates (ORR), the drug combination would be deemed promising.
185 xhibits excellent oxygen reduction reaction (ORR) activity (with a half-wave potential of 0.89 V), ou
186 and a comparable oxygen reduction reaction (ORR) activity to that of Pt/C as well as a better stabil
187 with exceptional oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) activities are
188 catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in fuel cells o
189 urability for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is crucial towa
190 h kinetics of the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER)(1-4) has lo
191 and establish the oxygen reduction reaction (ORR) as the major surface reaction in ambient conditions
193 ver, the sluggish oxygen reduction reaction (ORR) at the cathode has remained a longstanding challeng
194 yrin (Co-TPP), an oxygen reduction reaction (ORR) catalyst with highly variable product selectivity,
195 l-free (PGM-free) oxygen reduction reaction (ORR) catalysts for proton exchange membrane (PEM) fuel c
196 ing highly active oxygen reduction reaction (ORR) catalysts is crucial to boost the fuel cell economy
197 irst study of the oxygen reduction reaction (ORR) catalyzed by a cofacial porphyrin scaffold accessed
198 ical study of the oxygen reduction reaction (ORR) catalyzed by iron tetraphenylporphyrin (Fe(TPP)) in
199 catalysts for the oxygen reduction reaction (ORR) cathode in proton-exchange-membrane fuel cells rema
201 he development of oxygen reduction reaction (ORR) electrocatalysts based on earth-abundant nonpreciou
202 eplace Pt for the oxygen reduction reaction (ORR) has been a key challenge for advancing fuel cell te
203 catalysts for the oxygen reduction reaction (ORR) has been a key challenge for advancing fuel cell te
205 catalysts for the oxygen reduction reaction (ORR) in acid, and are the most promising candidates for
206 catalysts for the oxygen reduction reaction (ORR) in acid, but how Fe, N, and C precursors transform
207 catalysts for the oxygen reduction reaction (ORR) in challenging acidic media are crucial for proton-
208 materials for the oxygen reduction reaction (ORR) in fuel cells has been the objective worldwide for
209 catalysts for the oxygen reduction reaction (ORR) in fuel cells; however, their active site structure
210 urability for the oxygen-reduction reaction (ORR) in proton-exchange membrane fuel cells (PEMFCs).
211 nhancement of the oxygen reduction reaction (ORR) in the presence of L1(0)-CoMPt NPs (M = Mn, Fe, Ni,
213 -electron (2e(-)) oxygen reduction reaction (ORR) is an attractive alternative to the industrial anth
216 splay outstanding oxygen reduction reaction (ORR) mass activity of 47 mA mg(cat.) (-1) represents 1.3
217 esulting from the oxygen reduction reaction (ORR) or hydrogen peroxide reduction on platinum, has bee
218 ing the catalytic oxygen reduction reaction (ORR) through the interaction between -OH groups in HAP a
219 ard four-electron oxygen reduction reaction (ORR) to H(2)O is a mainstream line of research for repla
220 catalysts for the oxygen reduction reaction (ORR) to overcome sluggish kinetics and catalyst instabil
221 SACs catalyze the oxygen reduction reaction (ORR) via a 2 e(-) pathway with a high H(2) O(2) selectiv
222 to facilitate the oxygen reduction reaction (ORR), and the key factor enabling their success is to re
223 catalysts for the oxygen reduction reaction (ORR), due to the controllable architectures, excellent e
224 in the context of oxygen reduction reaction (ORR), electrochemical CO(2) reduction reaction (CO(2) RR
225 action (HER), the oxygen reduction reaction (ORR), the CO(2) reduction reaction (CO(2) RR), the nitro
226 for the cathodic oxygen reduction reaction (ORR), which demands a comprehensive understanding of the
227 s of the cathodic oxygen reduction reaction (ORR), which requires a significant amount of Pt-based ca
228 tivity toward the oxygen reduction reaction (ORR), while the inner Ni-N(4) clusters are responsible f
238 eaction, OER, and oxygen reduction reaction, ORR) and nitrogen (i.e., nitrogen reduction reaction, NR
239 th oxygen reduction and evolution reactions (ORR and OER) at high rates at thermodynamic potentials.
240 l electrocatalysts for the oxygen reduction (ORR) are highly desirable for several electrochemical de
242 statistics of the ordinary ridge regression (ORR) have the same patterns across the genome as those o
245 R activity) and Pt/C (92 % vs. 78 % retained ORR activity after 10 h running) in alkaline electrolyte
246 bringing new opportunities to revolutionize ORR catalysis in terms of cost, activity and durability.
249 l (PFS), duration of response (DOR), safety, ORR according to PD-L1 status and health-related quality
252 chanisms which enable enhanced and sustained ORR activity and the practical methods to achieve them i
263 e, to reduce H(2) O(2) generation during the ORR on the Co catalysts, potential strategies are outlin
264 recruited to power the study to evaluate the ORR(W15) difference between PD-L1+ and PD-L1- patients,
265 ncept of utilizing dual active sites for the ORR and demonstrate its effectiveness by synthesizing a
266 ed as the most promising composition for the ORR and employed as a target for nanoparticle synthesis.
268 efficient and stable electrocatalyst for the ORR and the OER in alkaline electrolytes, and shows prom
270 electrocatalysts have been designed for the ORR or the OER; however, the origin of the advanced acti
272 rin catalysts have long been studied for the ORR, but the origins of their selectivity are not well u
278 WT metastatic colorectal cancer improved the ORR and rate of secondary resection of metastases and re
279 of these prisms, which in turn modulates the ORR reactivity with respect to selectivity and kinetics.
281 demands a comprehensive understanding of the ORR processes on these catalysts under reaction conditio
283 echanism shows the potential to overcome the ORR energy barrier bottleneck to develop highly active c
284 s of 5 nm L1(0)-CoMPt NPs, we could push the ORR catalytic activity of these NPs toward the optimum r
287 omplete response [CR], 28%); among them, the ORR was 65% (CR, 41%) in non-GCB and 69% and 56% in rela
288 on, resulting in a mass activity towards the ORR of 16.37 amperes per milligram of palladium at 0.9 v
289 at disease progression and compared with the ORR by using the Wilcoxon rank sum test and with PFS by
290 coefficient [Formula: see text] and with the ORR rate constant [Formula: see text] in nonaqueous Li-,
292 ravel the evolution pathway of precursors to ORR-active catalyst comprised exclusively of single-atom
294 -dose and standard-dose vitamin D3 for tumor ORR (58% vs 63%, respectively; difference, -5% [95% CI,
297 s objective response rate (ORR) at 24 weeks (ORR(Wk24)); secondary efficacy end points included durat
298 se three time points was not associated with ORR (P = .63, .29, and .27, respectively) or PFS (P = .2
299 gh tumor viral status did not correlate with ORR, PFS, or OS, there was a trend toward improved PFS a
300 esponse [32%]; 95% CI, 41.3% to 70.0%), with ORRs of 59% in virus-positive and 53% in virus-negative