ライフサイエンスコーパス: P2X(4) receptor

1 mall-molecule antagonist 5-BDBD at the human P2X4 receptor.

2 aining valuable PET tracers for studying the P2X4 receptor.

3 lar dynamics study of the closed form of the P2X4 receptor.

4 ding of these antagonists are present in the P2X4 receptor.

5 toma cells stably transfected with the human P2X4 receptor.

6 EK293 cells transfected to express the human P2X4 receptor.

7 g that the 58-kDa protein was a glycosylated P2X(4) receptor.

8 LB fusion with the PM, but not activation of P2X(4) receptors.

9 profile characteristic of the involvement of P2X(4) receptors.

10 revealed a novel physiologic function of the P2X(4) receptor and suggested the importance of N-linked

11 ated current in WT cells, implying that both P2X4 receptor and another yet-to-be-identified P2X recep

12 s by which CCs are activated by pH sensitive P2X4 receptor and ectonucleotidases, providing a feedbac

13 ion results in the translocation of P2X1 and P2X4 receptors and pannexin-1 hemichannels to the immune

14 tivity of CCs via the purinergic ADORA2B and P2X4 receptors, and that luminal adenosine content is it

15 This study advances the understanding of P2X4 receptor antagonism and underscores the challenges

16 ons led to a series of compounds with potent P2X4 receptor antagonism, promising in vitro inhibition

17 Finally, treatment with the P2X4 receptor antagonist 5-BDBD reduced the severity of

18 velopment of 1,4-naphthodiazepinedione-based P2X4 receptor antagonists aimed at both therapeutic appl

19 P2X4 receptor antagonists have potential as drugs for th

20 aracterizing the biochemical property of the P2X(4) receptor, antibody against cP2X(4)R detected a 44

21 Here, we demonstrate that P2X(4) receptors are expressed in neurons of the spinal

22 P2X4 receptors are ATP-gated cation channels that are wi

23 Thus, our data indicate that P2X4 receptors are dynamically regulated mobile ATP sens

24 These studies provide evidence that P2X4 receptors are functionally important in hepatocyte

25 P2X4 receptors are likely involved because the calcium r

26 However, the nature of how plasma membrane P2X4 receptors are regulated in microglia is not fully u

27 ATP-gated ionotropic P2X4 receptors are up-regulated in activated microglia a

28 r at other sites in the nervous system where P2x4 receptors are widely expressed.

29 This perspective focuses on P2X(4) receptors as a new cardioprotective target in hea

30 cetate (PMA), results in a cation influx via P2X(4) receptors at the site of LB fusion with the plasm

31 mpletely abolished the pH sensitivity of the P2X4 receptor at all agonist concentrations.

32 and localized ATP production that stimulated P2X4 receptors, Ca(2+) influx, and pseudopod protrusion

33 ic lactone that stabilizes the open state of P2X(4) receptor channels.

34 purification and pulldown assays reveal that P2X4 receptors complex with aminobutyric acid, type A (G

35 The chick P2X4 receptor (cP2X(4)R) mRNA was expressed in the heart

36 CXCL12 directly triggers a purinergic P2x4 receptor-dependent proinflammatory response of TEMR

37 2X receptors, ion currents through homomeric P2X4 receptors exhibit intermediate desensitization when

38 To identify P2X4 receptor-expressing cells, we generated BAC transge

39 well-characterized tool with which to study P2X4 receptor-expressing cells.

40 Iba1 protein, a microglial marker, and P2X(4) receptor expression were significantly increased

41 and potential use as PET tracers for imaging P2X4 receptor expression in cancer.

42 P2X4 receptor expression in the liver, liver histology,

43 Furthermore, increased surface P2X4 receptor expression significantly decreases the fre

44 de that pannexin-1 hemichannels and P2X1 and P2X4 receptors facilitate ATP release and autocrine feed

45 ever, it was not clear whether the lysosomal P2X4 receptors function as channels and how they are act

46 expressing tdTomato under the control of the P2X4 receptor gene (P2rx4).

47 In contrast, inhibition of P2X4 receptor had no effect on Th1 cells and on the prod

48 tations of equivalent residues in P2X(2) and P2X(4) receptors have similar effects and if these mutan

49 Cells expressing ATP-gated P2X4 receptors have proven problematic to identify and s

50 313)-Ile(333) ectodomain sequence of the rat P2X(4) receptor in ATP binding and transduction of signa

51 present crystal structures of the zebrafish P2X(4) receptor in its closed, resting state.

52 study a potential physiological role of the P2X(4) receptor in mediating the positive inotropic effe

53 py structures of full-length wild-type human P2X4 receptor in apo closed, antagonist-bound inhibited,

54 eport the crystal structure of the zebrafish P2X4 receptor in complex with ATP and a new structure of

55 aracterize the electrophysiologic actions of P2X4 receptors in cardiac myocytes and to determine whet

56 cells, consistent with an important role of P2X4 receptors in mediating the ATP current not only in

57 also requires the activation of postsynaptic P2X4 receptors in OHCs.

58 t previously unanticipated roles for ATP and P2X4 receptors in the neural circuitry controlling feedi

59 The crystal structure of a P2X4 receptor, in combination with mutagenesis studies,

60 l and functional data regarding the P2X2 and P2X4 receptors indicate that the central trihelical TM2

61 These results indicate that P2X(4) receptors influence inflammasome signaling involv

62 hibition, mutation, or silencing of P2X1 and P2X4 receptors inhibits Ca(2+) entry, nuclear factors of

63 The data suggest that the native P2X(4) receptor is involved in mediating the P2 agonist-

64 Biochemical evidence showed that the P2X(4) receptor is the major subtype shared by these air

65 ranes and that transfer of the TM regions of P2X(4) receptors is sufficient to convey sensitivity to

66 The P2X4 receptor is a ligand-gated ion channel activated by

67 The P2X4 receptor is a ligand-gated ion channel that is expr

68 The P2X4 receptor is a newly identified receptor expressed i

69 Activity of P2X4 receptor is associated with neuropathic pain, infla

70 The P2X4 receptor is implicated in various pathological cond

71 The P2X4 receptor is involved in immunological and inflammat

72 e and have shown further that ATP-responsive P2X4 receptor is required for Tbeta4-induced HUVEC migra

73 The P2X4 receptor is unique among family members in its sens

74 Ca(2+) entry through P2X4 receptors is known to trigger downstream signaling

75 We find that plasma membrane P2X4 receptor lateral mobility in resting microglial pro

76 ted morphine-induced migration, suggesting a P2X(4) receptor-mediated effect.

77 in, indicating that these responses were not P2X(4) receptor-mediated.

78 GABA(A) receptors in recombinant system and P2X4 receptor-mediated GABAergic depression in SF-1 GFP-

79 nd clear evidence for functional presynaptic P2X4 receptor-mediated responses in terminals of AgRP-NP

80 ATP decreased cellular glycogen content; and P2X4 receptor messenger RNA increased in glycogen-rich l

81 uantum dot-labeled P2X4 receptors to explore P2X4 receptor mobility in the processes of resting and a

82 1 microM), while at recombinant rat P2X2 and P2X4 receptors no enhancing or antagonistic properties w

83 Genetic deletion of the PSD-95 or P2X4 receptors obliterated ATP-mediated down-regulation

84 ogical evidence for functional expression of P2X4 receptors on AgRP-NPY neuron somata, but instead, w

85 Accordingly, inhibition of the P2X4 receptor or direct mTOR blockade prevents induction

86 ned in myocytes from both wild-type (WT) and P2X4 receptor-overexpressing transgenic (TG) mice.

87 The P2X4 receptor (P2X4R) is a member of a family of puriner

88 P2X4 receptors (P2X4R) have emerged as potentially impor

89 Of the seven P2X subtypes, P2X4 receptors (P2X4Rs) are richly expressed in the brai

90 Activation of a cardiac myocyte P2X4 receptor protects against heart failure.

91 nd involves increased expression of Iba1 and P2X(4) receptor protein, which imparts a promigratory ph

92 tures of the detergent-solubilized zebrafish P2X4 receptor provide a blueprint for receptor mechanism

93 The recent crystal structure of a P2X4 receptor provides a 3D view of their topology and a

94 Furthermore, inhibition of P2X4 receptor reduced the production of IL-17 but not of

95 es activate NLRP1 inflammasomes, but whether P2X(4) receptors regulate inflammasome signaling is esse

96 tion with zinc, which potentiates P2X(2) and P2X(4) receptor responses, or lowering the pH to 6.8, wh

97 on feeding-related regulation of presynaptic P2X4 receptor responses, and the rationale to explore ex

98 ing ion channel structure with the ATP-gated P2X(4) receptor reveals similarity in pore architecture

99 In the presence of the P2X4 receptor-selective allosteric enhancer ivermectin (

100 conclusion, these data show that epithelial P2X(4) receptors serve as ATP-gated calcium entry channe

101 We analyzed the P2X4 receptor structure-activity relationship of a known

102 The P2X(4) receptor subunit (P2X(4)R) is likely to be import

103 In intact heart study, the P2X4 receptor TG mouse exhibited significantly elevated

104 on with no associated heart pathology in the P2X4 receptor TG mouse suggests a novel physiologic role

105 use suggests a novel physiologic role of the P2X4 receptor, that of stimulating the cardiac contracti

106 Furthermore, in P2X4 receptors, this ability to alter ion selectivity ca

107 ncreased responsiveness of the overexpressed P2X4 receptor to endogenous ATP is responsible for the e

108 olecule imaging to track quantum dot-labeled P2X4 receptors to explore P2X4 receptor mobility in the

109 4)R showed that only the glycosylated 58-kDa P2X(4) receptor was expressed on the cell surface, indic

110 The nonglycosylated 44-kDa P2X(4) receptor was resistant to various detergent/aqueo

111 P2X4 receptors were expressed in hepatocytes and Kupffer

112 ia a novel interaction between mu-opioid and P2X(4) receptors, which is dependent upon PI3K/Akt pathw

113 -2,4-disulfonate, with residues from the rat P2X4 receptor, which is insensitive to these antagonists

114 nsistent with overexpression of a functional P2X4 receptor with consequent increase in the receptor-m

115 Inhibition of P2X4 receptor with the specific antagonist 5-BDBD and sm