1 PABA 22 alone minimally increased p21 (waf1) and acetyla
2 PABA is observed to remain on the surface at all potenti
3 PABA pools were severely depleted in engineered fruit th
4 PABA/NO is a diazeniumdiolate of structure Me(2)NN(O)=NO
5 [
11C]
PABA and [18F]FDS were assessed for their ability to dis
6 [
11C]
PABA was the most promising tracer investigated and warr
7 In the rat S aureus VDO model, [
11C]
PABA could detect as few as 103 bacteria and exhibited t
8 oli was possible using a combination of [
11C]
PABA and [18F]FDS.
9 , a further increase of the pK(a) from 4.
67 (
PABA) to 5.32 (anisidine) resulted in a 2.5-fold decreas
10 n the pK(a) range from -1.7 (H(2)O) to 4.
67 (
PABA), with a slope of beta(nuc) = 0.80 +/- 0.1.
11 The initiation of
a PABA-deficient diet after P. yoelii infection is establi
12 ABA-deficient maternal milk, mice fed with
a PABA-deficient diet after the weaning continued to contr
13 hoprim-sulfamethoxazole, rapidly
accumulated PABA.
14 Protonation of p-aminobenzoic
acid (
PABA) and p-aminobenzoic acid methyl ester (PABAOMe) occ
15 e zwitterionic molecule p-aminobenzoic
acid (
PABA) at a Ag(111) electrode surface.
16 at exogenously supplied p-aminobenzoic
acid (
PABA) can antagonize the action of antifolates that inte
17 ike humans, can utilize p-aminobenzoic
acid (
PABA) for the de novo generation of folate.
18 mino acids (AroAAs) and p-aminobenzoic
acid (
PABA) was demonstrated in M. maripaludis.
19 mpetitive antagonist to p-aminobenzoic
acid (
PABA), which is a precursor of folates.
20 milk is deficient in para-aminobenzoic
acid (
PABA), which is required for de novo folate synthesis by
21 ve bacterial uptake: para-aminobenzoic
acid (
PABA), with uptake in all representative bacteria includ
22 class of broad-spectrum p-aminobenzoic
acid (
PABA)-based antibiotics.
23 which in turn cleaves a p-aminobenzoic
acid (
PABA)-peptide adduct to release free PABA and thus allow
24 Tapcin is a mixed p-aminobenzoic
acid (
PABA)-thiazole with a rare tri-thiazole substructure and
25 for a potent activator, 4-aminobenzoic
acid (
PABA): PABA-bound Best1 and Best2 structures are solved
26 containing multiple rho-aminobenzoic
acids (
PABAs) led us to search soil metagenomes for BGCs that p
27 was predicted to encode a unique N-
acylated PABA and thiazole containing structure.
28 lex structures with a p-aminobenzyl
alcohol (
PABA) self-eliminating spacer showed better growth inhib
29 st step in the synthesis of p-
aminobenzoate (
PABA) moiety of folate remains to be elucidated.
30 n how plants synthesize the p-
aminobenzoate (
PABA) moiety of folates.
31 size folate from pteridine, p-
aminobenzoate (
PABA), and glutamate moieties.
32 synthesized from pteridine, p-
aminobenzoate (
PABA), and glutamate precursors.
33 by mimicking the substrate p-
aminobenzoate (
PABA).
34 tep in the DKFP pathway, required AroAAs
and PABA for growth.
35 Pteridine
and PABA levels in transgenic fruit were >20-fold higher tha
36 PAHAs
and PABAs exhibit strikingly different cellular effects from
37 olymer poly(3-amino-benzylamine-co-
aniline) (
PABA) does not only provide the suitable electrostatic c
38 te 5 and cathepsin K cleavage of the Leu-
Arg-
PABA element will liberate alendronic acid.
39 inyl-para-aminophenylmeth ylalcohol (Leu-
Arg-
PABA).
40 c acid (PAS), we hypothesized that
bacterial PABA biosynthesis contributes to intrinsic antifolate re
41 he same binding site as in GABA-bound
Best2;
PABA treatment rescues the functional deficiency of pati
42 to produce bioactive nitric oxide (NO),
but PABA/NO was the most reactive.
43 possible role for the protection afforded
by PABA-deficient maternal milk, mice fed with a PABA-defic
44 ined immunodeficiency were also protected
by PABA-deficient diet.
45 Finally, dynamic (11)
C-
PABA PET in a 33-year-old woman with cystic fibrosis and
46 Dynamic (11)
C-
PABA PET in a mouse model of M. abscessus pulmonary infe
47 Conclusions: (11)
C-
PABA PET is an innovative, clinically translatable, noni
48 Dynamic (11)
C-
PABA positron emission tomography (PET) was performed in
49 Measurements and Main Results: (11)
C-
PABA was intracellularly metabolized by M. abscessus to
50 valuated (11)C-para-aminobenzoic acid ((11)
C-
PABA), a chemically identical radioanalog of PABA, to de
51 hese bipartite proteins are commonly
called "
PABA synthases," although it is unclear whether they pro
52 In Escherichia
coli,
PABA is made from chorismate in two steps.
53 malaria species, requires exogenous
dietary PABA for survival.
54 pport further studies to investigate
dietary PABA restriction in the management of severe malaria in
55 N,N-dimethylamino)diazen-1-ium-1,2-
diolate (
PABA/NO) were synthesized and studied.
56 N,N-dimethylamino) diazen-1-ium-1,2-
diolate (
PABA/NO) resulted in a dose-dependent increase in intrac
57 N,N-dimethylami no)diazen-1-ium-1,2-
diolate (
PABA/NO), liberates NO and elicits toxicity in vitro and
58 -N,N-dimethylamino)diazen-1-ium-1,2-
diolate (
PABA/NO), which is efficiently metabolized to potentiall
59 We sought to
explain PABA/NO's physicochemical uniqueness among these four co
60 s study highlights the potential of 2-[18F]
F-
PABA PET imaging for direct visualization of IE.
61 In vivo, 2-[18F]
F-
PABA PET/MRI successfully visualized IE in mice.
62 2-[18F]
F-
PABA uptake by S aureus was confirmed in vitro, with acc
63 In vitro assays measured 2-[18F]
F-
PABA uptake by S aureus, distinguishing living bacteria
64 uates 2-[18F]F-p-aminobenzoic acid (2-[18F]
F-
PABA), a bacteria-specific PET tracer, for detecting IE.
65 Finally,
PABA/NO produced antitumor effects in a human ovarian ca
66 Our search
for PABA-specific adenylation domain sequences in soil metag
67 f MAC-purified PGH revealed a K(m) value
for PABA-GLU of 60 +/- 0.08 microM and a specific activity o
68 c acid (PABA)-peptide adduct to release
free PABA and thus allows the growth of an auxotrophic strain
69 for phenylalanine and arylamine derived
from PABA were observed.
70 nation of pyruvate and aromatization to
give PABA.
71 breakdown product, p-aminobenzoyl-
glutamate (
PABA-GLU).
72 Within 4
h,
PABA/NO activated the UPR and led to translational atten
73 far, the only known plant enzyme involved
in PABA synthesis is ADC synthase, which has fused domains
74 onsistent with the presence of
intracellular PABA/NO or metabolites, because cells overexpressing MRP
75 Analysis of the pH-k(cat)/
K(
PABA) profile revealed a pK(a) of 5.52 +/- 0.14 and a so
76 e effect (SKIE) of 2.01 +/- 0.04 on k(cat)/
K(
PABA).
77 Mice fed
low-
PABA diets do not die from lethal doses of P. yoelii.
78 g fruit contained an average of 19-fold
more PABA than controls.
79 Moreover,
PABA was shown to be derived from an early intermediate
80 studies showed that in the absence of
MRP1,
PABA/NO activated the extracellular-regulated and stress
81 No PABA accumulation was noted by heat-inactivated bacteria
82 was added, indicating that it forms ADC,
not PABA.
83 d to test the metabolism and accumulation
of PABA into M. abscessus reference and clinical isolates.
84 Exogenous application
of PABA or compounds downstream in the folate biosynthesis
85 ons of a new pathway for the biosynthesis
of PABA in methanococci.
86 k inhibited by physiologic concentrations
of PABA, its glucose ester, or folates.
87 inhibited by physiological concentrations
of PABA, its glucose ester, or folates.
88 Cytotoxicity
of PABA/NO was also examined in a mouse skin fibroblast (NI
89 Disruption
of PABA biosynthesis is also demonstrated to lead to loss o
90 Herein, we demonstrate that disruption
of PABA biosynthesis potentiates the anti-tubercular action
91 a single pharmacologically relevant dose
of PABA/NO, S-glutathionylation occurs rapidly (<5 min) and
92 38 were critical to the cytotoxic effects
of PABA/NO.
93 ally, we demonstrate selective inhibition
of PABA biosynthesis in M. tuberculosis using the small mol
94 nfirmed that a GSTpi-activated metabolite
of PABA/NO was effluxed by MRP1 in a GSH-dependent manner.
95 tential on the adsorption and orientation
of PABA.
96 ay be linked with the cytotoxic potential
of PABA/NO.
97 PABA), a chemically identical radioanalog
of PABA, to detect and localize infections due to M. absces
98 synthase, which catalyzes the first step
of PABA synthesis.
99 Plasmodial enzymes for the synthesis
of PABA via the shikimate pathway are being investigated as
100 the DKFP pathway, did not require AroAAs
or PABA for growth.
101 otent activator, 4-aminobenzoic acid (
PABA):
PABA-bound Best1 and Best2 structures are solved and ill
102 xamic acids (PAHAs) and
polyaminobenzamides (
PABAs) were synthesized and evaluated as isoform-selecti
103 ch soil metagenomes for BGCs that
polymerize PABA.
104 cid and cell wall biosynthesis,
prioritizing PABA over D-Ala/D-Glu biosynthesis.
105 ombinant Arabidopsis protein did not
produce PABA unless the E. coli PabC enzyme was added, indicatin
106 although it is unclear whether they
produce PABA or ADC.
107 tutes a revision of the previously
published PABA/NO structure.
108 mycetes, and Plasmodium spp. also
synthesize PABA but have proteins comprising fused domains homologo
109 ence of biosynthetic machinery to
synthesize PABA, Plasmodium yoelii, a rodent malaria species, requi
110 This is consistent with the fact
that PABA/NO induces S-glutathionylation and inactivation of
111 Changes in the SFG signal indicate
that PABA changes orientation in response to the charge on th
112 peared only in chloroplasts, indicating
that PABA synthesis is plastidial.
113 Studies revealed
that PABA/NO's N-methyl-p-aminobenzoic acid substituent is bo
114 We now show
that PABA/NO induces nitrosative stress, resulting in undetec
115 content in food plants and that boosting
the PABA supply can produce further gains.
116 Our studies suggest that
the PABA content in the diet will affect the host clearance
117 purified recombinant proteins convert ADC
to PABA.
118 ion product of the PabA and PabB enzymes--
to PABA and pyruvate.
119 GSTpi results in a decreased sensitivity
to PABA/NO.
120 ing advanced, but there was no fall in
total PABA content, which stayed between 0.7 and 2.3 nmol.g(-1
121 When
transgenic PABA- and pteridine-overproduction traits were combined
122 This study reveals that the M.
tuberculosis PABA biosynthetic pathway is responsible for intrinsic r
123 AHAs inhibited HDAC >50% (1 microM), and
two PABAs inhibited HDAC >50% (5 microM).
124 that whereas nitrosylation was
undetectable,
PABA/NO treatment caused S-glutathionylation of PDI.
125 Here, we
use PABA-specific adenylation-domain sequences to guide the
126 ate levels 2-fold, but engineered fruit
were PABA-depleted.
127 tion of cellular proteins in comparison
with PABA/NO.
128 Consistent
with PABA/NO's potent suppression of A2780 human ovarian canc
129 igh in folate, and supplying such fruit
with PABA by means of the fruit stalk increased their folate
130 E. coli pabA pabB double mutant and a
yeast PABA-synthase deletant.