ライフサイエンスコーパス: PAS

1 PAS accounted for 18% of strokes in women younger than 3

2 PAS field deployments confirm the ability to record diff

3 PAS was diagnosed in 126 of 155 women (81%) (placental p

4 PAS(C) has to transmit the signal to the C-terminal kina

5 onger-lasting alternative, PASylated IL-1Ra (PAS-IL-1Ra) has been generated by in-frame fusion of a l

6 mice suggests a function for the HIF-2alpha PAS-B domain beyond heterodimerization with HIF-1beta.

7 Mice carrying a HIF-2alpha PAS-B S305M mutation that disrupts PT2385 binding, but n

8 -1Ra and PAS800-IL-1Ra (carrying 600 and 800 PAS residues, respectively), with that of anakinra in mi

9 romophore-binding domain (CBD, composed of a PAS and a GAF domain).

10 ocation and surrounding sequence motifs of a PAS appear to differentiate its regulation by the PAPs.

11 Together, our results reveal a PAS-guided and PAP-mediated paradigm for gene expression

12 Strikingly, the AAUAAA PAS assumes an unusual conformation that allows this sho

13 ansferrable deep learning model for accurate PAS recognition, which requires no prior knowledge or hu

14 g static-dynamic model in which oxidized Aer-PAS interacts directly with HAMP AS-2, enforcing a stati

15 significant facilitation 10-30 minutes after PAS (P < 0.05).

16 ith the global higher flexibility of the AHR PAS-A and its loosely packed structural elements, sugges

17 alpha6) domain across the membrane to alpha1(PAS(C)).

18 lymers gives water-soluble altrose PASs (alt-PASs) in high yields without degradation of the polymer

19 Circular dichroism analysis shows the alt-PASs adopt a right-handed helical conformation in aqueou

20 Cytotoxicity studies reveal that the alt-PASs are nontoxic to HEK, HeLa, and NIH3T3 cells.

21 Although PAS domains were described as intracellular sensors, rec

22 zylated polymers gives water-soluble altrose PASs (alt-PASs) in high yields without degradation of th

23 and we examine heme binding to the PAS-A and PAS-B domains.

24 mains bind HIF-2alpha and that both bHLH and PAS domains of HIF-2alpha interacted with ORF34.

25 ed HIF-2alpha ubiquitination at the bHLH and PAS domains.

26 pport a model whereby the disulfide bond and PAS domain of SrrB sense and respond to the cellular red

27 In addition, we expressed the Cap and PAS domain of hERG3 in Escherichia coli and, using spect

28 like for the hERG channel in which N-Cap and PAS domain truncations mainly affected channel deactivat

29 el of voltage gating, but that the N-Cap and PAS domains have different roles in these channels.

30 nti-tubercular action of DHPS inhibitors and PAS by up to 1000 fold.

31 sumably cutaneous afferents, whereas LAI and PAS require activity in (higher threshold) afferents act

32 ry polysynaptic circuits involved in LAI and PAS.

33 rotation of the heme-binding beta H-NOX and PAS domains.

34 ophils, neutrophils), pathological score and PAS positive cells observed between both genotypes.

35 PE analyses to date (microarray, RNA-Seq and PAS-Seq) are NRIP1 (RIP140), a transcriptional co-regula

36 hundreds of previously unidentified TSS and PAS which revealed two interesting phenomena: first, gen

37 curately annotate cell type-specific TSS and PAS.

38 oposed for PAS recognition, most of them are PAS motif- and human-specific, which leads to high risks

39 esent homology models of the murine AhR:ARNT PAS domain dimer developed using recently available X-ra

40 favored the HIF2alpha:ARNT heterodimer-based PAS-B model, most mutants derived from the CLOCK:BMAL1-b

41 nalyses revealed significant binding between PAS-IL-1Ra and IL-1R1, although with a slightly lower af

42 ry confirmed reciprocal interactions between PAS and known PRC2 subunits, and sequence similarity sea

43 xcitation, the basic-helix-loop-helix (bHLH)-PAS family transcription factor ARNT2 recruits the NCoR2

44 helix-loop-helix transcription factor (bHLH)/PAS proteins in Drosophila melanogaster known as germ ce

45 The basic helix-loop-helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (brain and muscle

46 Thus, the interplay of bHLH-PAS complexes at activity-dependent regulatory elements

47 tly available X-ray structures of other bHLH-PAS protein dimers.

48 2 basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) domain proteins-CLOCK and BMAL1.

49 he basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) superfamily.

50 y, ARNT2 recruits the neuronal-specific bHLH-PAS factor NPAS4 to activity-dependent regulatory elemen

51 racterizing a Phaeodactylum tricornutum bHLH-PAS nuclear protein, hereby named RITMO1, we shed light

52 ere we show that SIM2s, a member of the bHLH/PAS family of transcription factors, regulates DNA damag

53 In addition, we demonstrate that the bHLH/PAS transcription factor Single-minded (Sim) acts as a d

54 ting distance between the two flavin-binding PAS (Per-Arnt-Sim) domains implies that they tightly san

55 udied 191 patients with severe bioprosthetic PAS (63+/-16 years, 58% men) who underwent redo AVR betw

56 mptomatic patients with severe bioprosthetic PAS undergoing redo AVR, baseline LV-GLS provides increm

57 esis analogous to the functions performed by PAS-domain-containing regulatory proteins found in compl

58 ating defects identified by PL with those by PAS and DLTS methods.

59 Categoric PAS and Alvarado scores were equivocal for 59.5% (53 of

60 es among APA isoforms than did S. cerevisiae PASs in different locations of gene are surrounded with

61 susceptibility in a previously characterized PAS resistant strain of M. tuberculosis.

62 gulation on the BMAL1 C terminus and the CLK PAS-B domain and demonstrate the importance of a BMAL1 T

63 ambiguously position a key loop of the CLOCK PAS-B domain in the secondary pocket of CRY1, analogous

64 iven primarily by interaction with the CLOCK PAS-B domain.

65 te capillary plexus with an empty, collapsed PAS-positive lens capsule in the pupillary region.

66 averaging times as compared to conventional PAS and QEPAS techniques and determines the electrical Q

67 nstrated that PAS is not unique to N. crassa PAS homologs likely influence the distribution of H3K27

68 oly(A) tracts, a common problem with current PAS annotation methods.

69 r any sample and enable the deployment of CV-PAS SECM as an analytical tool for traditionally challen

70 stripping charge extracted from a shared CV-PAS give three distinct probe approach curves (CV-PACs),

71 clic voltammetry probe approach surfaces (CV-PASs), consisting of CVs performed between incremental m

72 S-like domains do not match sequence-derived PAS domain models, and thus their distribution across th

73 Importantly, different PASs of a gene are distinctly regulated by different PAP

74 rs (PAS) with polyurethane foam (PUF) discs (PAS-PUF).

75 nd others using both the proximal and distal PAS to differing degrees.

76 roximal PAS is conserved, whereas the distal PAS is disrupted within certain alleles by sequence vari

77 on use of either the proximal or the distal PAS, which differ in length by 100 bp.

78 d in the usage of the proximal versus distal PAS, with some alleles using only the proximal PAS, and

79 n S. pombe, strong motifs surrounding distal PASs lead to higher abundances of long 3' UTR isoforms t

80 r Eag1 also has three intracellular domains: PAS, C-linker, and CNBHD.

81 HIF1A (encoding HIF-1alpha) and endothelial PAS domain protein 1 (EPAS1 encoding HIF-2alpha), inhibi

82 factor 1 subunit alpha (HIF1A), endothelial PAS domain 1 protein (EPAS1, also called HIF2A), CA9, so

83 investigation of the role of the endothelial PAS domain-containing protein 1 (EPAS1), a regulatory al

84 EU PAS registration number: EUPAS5269.

85 The highly evolvable PAS scaffold can bind a broad range of ligands, includin

86 show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which

87 er, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domai

88 Putting the extracytoplasmic PAS domain into context of the membrane-embedded CitA co

89 h reliably discerns bona fide PAS from false PAS that arise due to internal poly(A) tracts, a common

90 species in solution in the oxidized (ferric) PAS-A protein, and by mutagenesis we identify His144 as

91 Our approach reliably discerns bona fide PAS from false PAS that arise due to internal poly(A) tr

92 ates their pursuit/capture by XRN2 following PAS processing.

93 tio was 2.4 (95% CI: 1.6, 3.4; P < .001) for PAS and 10 (95% CI: 1.5, 70.4; P < .001) for placental p

94 between $37.6 million and $90.2 million for PAS testing.

95 Although many methods have been proposed for PAS recognition, most of them are PAS motif- and human-s

96 verts the signal on the cytoplasmic side for PAS(C) and kinase regulation.

97 pecially well-suited and straightforward for PASs as the helical conformations formed result from con

98 global gene expression patterns of CTBs from PAS cases to gestational age-matched control cells that

99 These data suggest that CTBs from PAS cases up-regulate a cancer-like proinvasion mechanis

100 how distinct differences in the glc- and gal-PAS systems that correlate well with observed difference

101 served differences in solubility between gal-PASs and glc-PASs.

102 ences in solubility between gal-PASs and glc-PASs.

103 s glycogen in hepatocytes in the diet group (PAS stain score 1.61 vs 2.46, P < 0.0001).

104 cellular Cache domain and a cytoplasmic HAMP-PAS-DHp-CA region.

105 r 2019, 160 gravid women suspected of having PAS underwent placental MRI as part of a prospective tri

106 The basic helix-loop-helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (

107 ide an elegant molecular explanation for how PAS sequences are recognized for mRNA 3'-end formation.

108 that our single model trained over all human PAS motifs not only outperforms the state-of-the-art met

109 rns from the training species and identifies PAS in target species without re-training.

110 e widely used in computationally identifying PAS, the need for tremendous amounts of annotation data

111 is opposite in S. cerevisiae Differences in PAS placement between convergent genes lead to starkly d

112 was the most highly up-regulated molecule in PAS samples.

113 onical (Star-PAP) PAPs play diverse roles in PAS selection and gene expression.

114 monstrate HLA-A allele-specific variation in PAS usage, which modulates their cell surface expression

115 Inaccessible PAS-HAMP surfaces overlapped with a cluster of PAS kinas

116 that requires integration of sensory input (PAS) and not when plasticity was induced purely by corti

117 Removing an intronic PAS results in ectopic expression of the neuronal ankyri

118 ssion levels by increasing usage of intronic PAS.

119 ously reported that the use of this intronic PAS depends on the nuclear polyadenylation factor SYDN-1

120 CPA factors (U1-CPAFs), that binds intronic PASs and suppresses PCPA.

121 ipsychotic medication, binds to the isolated PAS domain of EAG channels and inhibits currents from th

122 It learns PAS patterns from the training species and identifies PA

123 between 2000 and 2012 (excluding mechanical PAS, severe other valve disease transcatheter AVR, and L

124 d light on the function of CPSF in mediating PAS-dependent RNA cleavage and polyadenylation.

125 esting phenomena: first, genes with multiple PASs tend to harbor a motif near the most proximal PAS,

126 Neuronal PAS domain protein 4 (Npas4), a recently discovered IEG,

127 ew loci, nucleobindin 1 (NUCB1) and neuronal PAS domain protein 4 (NPAS4) (p <6x 10(-6)).

128 The circadian transcription factor neuronal PAS domain 2 (NPAS2) is linked to psychiatric disorders

129 The circadian transcription factor neuronal PAS domain protein 2 (NPAS2) is enriched in reward-relat

130 he transcription factor (TF) NPAS4 (neuronal PAS domain protein 4) has been found to provide activity

131 In mice, loss of neuronal PAS domain protein 3 (NPAS3) impairs postnatal hippocamp

132 d sequencing (NFL-PAS), we generated 733 NFL-PAS amplicons from eight children.

133 h proviral amplification and sequencing (NFL-PAS) were performed at one time point after 6 to 9 years

134 h proviral amplification and sequencing (NFL-PAS), we generated 733 NFL-PAS amplicons from eight chil

135 (range, 2.0 to 11.1 months), 733 single NFL-PAS amplicons were generated.

136 ally foamy macrophages with typical numerous PAS-positive, non-acid fast particles.

137 S-HAMP surfaces overlapped with a cluster of PAS kinase-on lesions and with cysteine substitutions th

138 sociation of IFVs with presence and depth of PAS invasiveness.

139 s of 100-200 ms, nor was there any effect of PAS.

140 he cytoplasmic side into the alpha1-helix of PAS(C).

141 reviously a rare condition, the incidence of PAS has increased to 1:731 pregnancies, likely due to th

142 -burst rapid rate TMS was applied instead of PAS.

143 his strategy restores the wild type level of PAS susceptibility in a previously characterized PAS res

144 Loss of PAS resulted in losses of H3K27 methylation concentrated

145 s underpinning its assembly and mechanism of PAS recognition are not understood.

146 s that from other combined MRI predictors of PAS (eg, myometrial thinning, intraplacental T2-hypointe

147 d facilitates further functional research of PAS.

148 eural network for multiclass segmentation of PAS-stained nephrectomy samples and transplant biopsies.

149 hods in species without experimental data on PAS.

150 between the molecular structure of the PER2 PAS core and the pace of SCN circadian timekeeping.

151 This study provides new insights into pig PAS and facilitates further functional research of PAS.

152 -PAS, January 2010 to October 29, 2014; post-PAS, October 30, 2014, to June 2, 2017) were identified

153 ssess T2DM SPK listings in the pre- and post-PAS eras.

154 rsus kidney transplant listing pre- and post-PAS.

155 arities declined slightly but persisted post-PAS (era by region interaction P < 0.001).

156 to SPK declined slightly but persisted post-PAS.

157 ysis showed reduced percentages for SPK post-PAS (22.1%-20.8%; P = 0.003).

158 SPK listings for T2DM increased in the post-PAS era (3.4%-3.9%; univariate P = 0.038), while those f

159 ood of transplantation increased in the post-PAS era (both P < 0.001).

160 Among 41 205 listings (27 393 pre-PAS; 24 439 T2DM), univariate analysis showed reduced pe

161 listings for SPK and kidney transplant (pre-PAS, January 2010 to October 29, 2014; post-PAS, October

162 the ability of IFV diameter to help predict PAS, placenta percreta, and peripartum complications and

163 improved the ability of MRI to help predict PAS.

164 ptors improved the ability of MRI to predict PAS (AUC, 0.94 vs 0.89; P = .009).

165 on, which enables the possibility to predict PAS from untrained species, naturally becomes a promisin

166 More objective means for predicting PAS and clinical outcome may be provided by MRI descript

167 end to harbor a motif near the most proximal PAS, which likely represents a new cleavage and polyaden

168 The proximal PAS is conserved, whereas the distal PAS is disrupted wi

169 S, with some alleles using only the proximal PAS, and others using both the proximal and distal PAS t

170 osomal) small nuclear RNA, silences proximal PASs and its inhibition with antisense morpholino oligon

171 polyurethane foam passive air samplers (PUF-PAS) from January 2012 to November 2015.

172 polyurethane foam passive air samplers (PUF-PAS).

173 We applied the model to PUF-PAS samples collected in Chicago and show that previous

174 s from TFEB-treated mice we observed reduced PAS staining and improved ultrastructure, with reduced n

175 How poly(A) polymerases may regulate PAS usage and hence gene expression is poorly understood

176 sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several

177 In this work, we propose a robust, PAS motif agnostic, and highly interpretable and transfe

178 right-handed helical poly amido-saccharides (PASs) with beta-N-(1-->2)-d-amide linkages are synthesiz

179 al mercury (GEM) with a passive air sampler (PAS) that uses a sulfur-impregnated carbon sorbent and a

180 rk (KNP), Uganda using passive air samplers (PAS) with polyurethane foam (PUF) discs (PAS-PUF).

181 associated with Panic and Agoraphobia scale (PAS) scores (beta=0.005, SE=0.002, p=0.021, n=131) among

182 s were evaluated using periodic acid Schiff (PAS) stains.

183 rgical excision showed Periodic acid Schiff (PAS)-positive eosinophilic structures inside macrophages

184 KOH) stain followed by periodic acid-Schiff (PAS) evaluation if KOH testing is negative, and (3) pret

185 a samples stained with Periodic Acid-Schiff (PAS) highlighted the presence of starch and cellulose.

186 ith hematoxylin-eosin, periodic acid-Schiff (PAS) reaction, and Masson trichrome method.

187 ens were reexamined by periodic acid-Schiff (PAS) staining and PCR to identify undiagnosed amoebic ap

188 sections stained with periodic acid-Schiff (PAS).

189 The study assessments (HAM-D-6, MADRS, SDQ, PAS, CGI-S, and CGI-I) were performed at days 0, 1, 3 (e

190 -helical structure reaching from the sensory PAS(P) (alpha6) domain across the membrane to alpha1(PAS

191 ere we used polyadenylation site sequencing (PAS-Seq) of RNA from normal and PE human placentae to in

192 hnology and polyadenylation site sequencing (PAS-seq) to re-annotate the bamboo genome, and identify

193 ong, defined-length, N-terminal Pro/Ala/Ser (PAS) random-coil polypeptide with IL-1Ra.

194 Severe PAS was defined as aortic valve area <0.8 cm(2), mean ao

195 c/minimally symptomatic patients with severe PAS undergoing redo AVR, we sought to determine whether

196 ying the cis-determinants of poly(A) signal (PAS) on the DNA sequence is the key to understand the me

197 of the downstream product of poly(A) signal (PAS) processing is important.

198 (A) tails, modest changes in poly(A) signal (PAS) usage, and evidence of mitochondrial damage in thes

199 y divergence in core polyadenylation signal (PAS) and downstream sequence element (DSE) motifs drive

200 nition of the AAUAAA polyadenylation signal (PAS), and the molecular mechanism of this recognition ha

201 ylated from cryptic polyadenylation signals (PAS) located in intron 1 or 2 of approximately 1% of cel

202 the presence of two polyadenylation signals (PAS).

203 human mRNAs by juxtaposing poly(A) signals (PASs) and cleavage sites that are otherwise too far apar

204 urate and robust method for poly(A) signals (PASs) identification is not only desired for the purpose

205 ge of more proximal polyadenylation signals (PASs) in introns and last exons.

206 (PCPA) from cryptic polyadenylation signals (PASs) in introns.

207 ydrocarbon receptor (AHR), a PER, ARNT, SIM (PAS) family transcription factor that responds to divers

208 he eag domain, consisting of a Per-ARNT-Sim (PAS) domain capped by a short sequence containing an amp

209 nvironmental ligand-dependent, per ARNT-sim (PAS) domain containing bHLH transcription factor that me

210 ion, early doors (Edo), in the PER-ARNT-SIM (PAS) domain dimerization region of period 2 (PER2) (I324

211 EAG channels contain a Per-Arnt-Sim (PAS) domain in their intracellular N-terminal region.

212 racytoplasmic, citrate-sensing Per-Arnt-Sim (PAS) domain of HK CitA are identical for the isolated do

213 basic helix-loop-helix (bHLH), Per-Arnt-Sim (PAS) domain protein, a novel type of hormone receptor.

214 runcation of the N-Cap domain, Per-Arnt-Sim (PAS) domain, or both in K(V)10.2 abolished the current a

215 the presence of an N-terminal Per-Arnt-Sim (PAS) domain.

216 RmcA contains four Per-Arnt-Sim (PAS) domains and domains with the potential to catalyze

217 basic helix-loop-helix (bHLH)-Per-ARNT-SIM (PAS) protein, the repressor of AhR function (AhRR).

218 putative c-di-GMP turnover and Per-Arnt-Sim (PAS) sensory domains.

219 t upstream of an N-terminal Period/Arnt/Sim (PAS) domain, which upon removal dramatically accelerates

220 rocessing by blocking the Fip1-poly(A) site (PAS) interaction.

221 -gCs to bind to the peripheral anionic site (PAS) of Electrophorus electricus AChE (EeAChE) and compe

222 y role for an intronic polyadenylation site (PAS) in temporal- and tissue-specific regulation of UNC-

223 inhibition of proximal polyadenylation site (PAS) usage.

224 (TSS) or cleavage and polyadenylation sites (PAS).

225 ctivating enhancer-containing poly(A) sites (PASs).

226 compared cleavage and polyadenylation sites (PASs) in two yeast species, S. cerevisiae and S. pombe A

227 genes harbor multiple polyadenylation sites (PASs), leading to expression of alternative polyadenylat

228 f distal cleavage and polyadenylation sites (PASs), leading to long 3' UTR isoform expression.

229 Therefore, cross-species PAS identification, which enables the possibility to pre

230 ng method named Poly(A)-DG for cross-species PAS identification.

231 We show Star-PAP-specific PAS usage regulates the expression of the eukaryotic tra

232 ata from positron annihilation spectroscopy (PAS), secondary ion mass spectrometry (SIMS), and deep l

233 onance broadband photoacoustic spectroscopy (PAS) technique with a supercontinuum laser (SCL) in the

234 identification of placenta accreta spectrum (PAS) disorder is essential for treatment planning.

235 , the hallmark of placenta accreta spectrum (PAS), increases the risk of preterm delivery, hemorrhage

236 tive periodic acid-schiff reaction staining (PAS staining), disgnosing Whipple's disease.

237 o relieve severe prosthetic aortic stenosis (PAS) is increasing.

238 ty following paired associative stimulation (PAS) in the depressor anguli oris muscle (DAO).

239 first study, paired associative stimulation (PAS) was delivered by pairing motor point stimulation of

240 creased risk of pregnancy-associated stroke (PAS).

241 ATG16L1 to the pre-autophagosomal structure (PAS) and showed that it requires sequences within its co

242 ocalized at the preautophagosomal structure (PAS).

243 encoding an unknown PRC2 accessory subunit (PAS).

244 The 2014 pancreas allocation system (PAS) intended to decrease geographic variability in list

245 quence similarity searches demonstrated that PAS is not unique to N. crassa PAS homologs likely influ

246 The PAS and Cap domains are both vital for the normal functi

247 The PAS domain is structurally similar to the PAS domains in

248 The PAS sensor system has been calibrated with known concent

249 The PAS-Cys, GAF-Cys and double-Cys attachment each entails

250 lizes an N-terminal latch region against the PAS core.

251 onto the transcription factor alongside the PAS domains, extending above the DNA-binding bHLH domain

252 :ARNT dimer models of both the PAS-A and the PAS-B dramatically decreased the levels of DNA binding,

253 is critical for phagophore nucleation at the PAS.

254 an important hinge-bbeta region between the PAS beta-sheet and the N-terminal cap helix that in turn

255 identified specific interactions between the PAS, CNBHD, and VS that modulate voltage-dependent gatin

256 target the HIF-2 isoform through binding the PAS-B domain of HIF-2alpha.

257 We show that upon citrate binding, the PAS domain contracts, resulting in a shortening of the C

258 MAL1-based AhR:ARNT dimer models of both the PAS-A and the PAS-B dramatically decreased the levels of

259 n (MDF, delta(202)Hg) of GEM taken up by the PAS was lower than that of actively pumped samples by 1.

260 ts conducted at 5, 20, and 30 degrees C, the PAS can be used for reliable isotopic characterization o

261 cysteine substitutions that crosslinked the PAS beta-scaffold to the HAMP AS-2 helix.

262 We present a crystal structure for the PAS-A domain of hCLOCK, and we examine heme binding to t

263 hich is homologous to, but distinct from the PAS superfamily.

264 ng spectroscopy and kinetics, identified the PAS domain as the location for heme binding.

265 In contrast, mutants with Cys in the PAS only or no Cys residues at all exhibit red-shifted e

266 Mutant EAG channels that lack the PAS domain show significantly lower inhibition by CH, su

267 We demonstrate that this contraction of the PAS domain, which is well characterized for the isolated

268 obtained results show the suitability of the PAS sensor to be employed in a fully operational large s

269 ted ERG and ELK K(+) channels and places the PAS domain as a new target for drug discovery in EAG and

270 Here, we show that the PAS domain regulates both kinase and phosphatase enzyme

271 yl hydrocarbon receptor (AHR) belongs to the PAS (PER-ARNT-SIM) family transcription factors and medi

272 abrogated the localisation of ATG16L1 to the PAS and inhibited LC3 lipidation.

273 annel function through ligand binding to the PAS domain can be attained.

274 Here we show that CRY1 binds directly to the PAS domain core of CLOCK:BMAL1, driven primarily by inte

275 could be activated by ligand binding to the PAS domain.

276 channels directly through the binding to the PAS domain.

277 he PAS domain is structurally similar to the PAS domains in non-ion channel proteins, where these dom

278 S1P specifically binds to the PAS domains of HIF-1alpha.

279 that regulated recruitment of ATG16L1 to the PAS is required for its autophagic activity.

280 both to the catalytic active site and to the PAS of human AChE and BChE.

281 f hCLOCK, and we examine heme binding to the PAS-A and PAS-B domains.

282 e Che2 chemosensory system by binding to the PAS-heme domain of the Aer2 receptor.

283 Women in the NPAS group vs the PAS group had more vascular risk factors, including chro

284 ural similarity, it is not known whether the PAS domain can regulate EAG channel function via ligand

285 reased CTB invasiveness, consistent with the PAS phenotype.

286 ) zonation and glycogen accumulation through PAS staining.

287 variables related to palatal contour (PP to PAS, SN to PAS, palatal surface angle) and occlusal plan

288 related to palatal contour (PP to PAS, SN to PAS, palatal surface angle) and occlusal planes (UOP/POP

289 The TlpC dCACHE LBD has two PAS-like subdomains, as predicted.

290 Here, we compared the efficacy of two PAS-IL-1Ra molecules, PAS600-IL-1Ra and PAS800-IL-1Ra (c

291 ) of the dCACHE family, a structure with two PAS-like subdomains, one membrane-proximal and the other

292 Retrospective analyses using PAS staining and PCR identified 3 and 3 more cases, resp

293 These results validate PAS-IL-1Ra as an active IL-1 antagonist with marked in v

294 IFVs of 2 mm or greater were associated with PAS (AUC, 0.81; 95% CI: 0.67, 0.95; P = .04).

295 ntal fetal vessel (IFV) diameter at MRI with PAS and peripartum complications.

296 negative, and (3) pretreatment testing with PAS.

297 the women was 31 (25-35) years in those with PAS and 48 (41-52) years in those with NPAS.

298 on the cytoplasmic side connecting TM2 with PAS(C) contains an LxxxLxxxL sequence.

299 ere detected at MRI in 109 of 126 women with PAS (86%) and in 67 of 68 women with placental percreta

300 in these extended 3'-end regions than within PAS-upstream regions and indeed are substantially more f

301 recruitment of Atg17 complexes to the yeast PAS, and their unusual shape.