ライフサイエンスコーパス: PCP

1 PCP establishment involves the subcellular polarization

2 PCP is associated with significant allograft loss.

3 PCP is crucial during many biological patterning process

4 PCP occurred beyond 12 months after transplantation in 4

5 PCP proteins form intercellular complexes, linked by Cel

6 PCP signaling is mediated by multiple core components wi

7 PCP signaling is partially active in Nodal-deficient emb

8 PCP significantly reduced rodent duration MMN (p<0.001)

9 PCP was mostly a late-onset disease occurring after comp

10 PCP was still established.

11 PCPs frequently harbour somatic BRAF(V600E) mutations an

12 We identified 10 PCPs of relevance and demonstrated that their use within

13 A subset of 10 PCPs that were used within 6 h of urine collection contr

14 f SPAs was evaluated in 15 categories of 214 PCPs collected in Toronto, Canada.

15 When the 214 PCPs were separated into products labeled as containing

16 ic organo-copper cluster [Cu(4)(PCP)(3)](+) (PCP = 2,6-(PPh(2))(2)C(6)H(3)) that features suppressed

17 he 3PC and 222 233 members attributed to 312 PCPs and 14 physician organizations that continued in a

18 port a cationic organo-copper cluster [Cu(4)(PCP)(3)](+) (PCP = 2,6-(PPh(2))(2)C(6)H(3)) that feature

19 Of 4230 PCPs, 1 had a readmission rate that was significantly hi

20 ccuracy: 0.66 DLS, 0.63 dermatologists, 0.44 PCPs and 0.40 NPs).

21 ne teledermatology consults were placed by 6 PCPs from an outpatient clinic between May and December

22 lene bisphosphonate (PCP) analog of InsP(8); PCP analogs of other PP-InsP signaling molecules were in

23 r treatment that are normally delivered by a PCP.

24 Follow-up visits with a PCP within 7 days of discharge were also measured.

25 In addition, PCP-treated animals showed a significant reduction of st

26 g/day, median: 88 g/day) via greywater after PCP use were calculated, which represents a nonignorable

27 (30% and 17% respectively, three years after PCP).

28 clinically-significant PCP infections among PCP PCR-positive oncology patients.

29 Variation in readmission rates among PCPs is very low.

30 ) in complex with MEK and the ATP analog AMP-PCP, revealing interactions between BRAF and ATP that in

31 polarized actin-rich protrusive activity and PCP.

32 ution from 2012 to 2015, using serum BDG and PCP PCR.

33 answered questions about infant feeding and PCP use on their baby.

34 ling directs mitotic spindle orientation and PCP signaling, processes that are crucial for the mainte

35 s, and studies have shown these polarity and PCP proteins modulate spermatid polarity and adhesion vi

36 s MCRA and PACEM for exposures from food and PCPs, respectively).

37 ted with better adherence, few survivors and PCPs have one.

38 Wnt pathway mutants are often classified as PCP mutants due to similarities between their phenotypes

39 noid character of quaternized pyridine-based PCP-Ru complexes.

40 structure, and reactivity of pyridine-based PCP-Ru complexes.

41 We examined the association between PCP use and urinary concentrations of phthalate metaboli

42 y (2009-10) explored the association between PCP use during pregnancy and the postpartum period among

43 Associations between PCP use and concentrations of the other phthalate metabo

44 al disorders and strengthen the link between PCP and NTD.

45 cords and audio-recorded discussions between PCPs and patients.

46 olically resistant methylene bisphosphonate (PCP) analog of InsP(8); PCP analogs of other PP-InsP sig

47 point to the cognitive impairments caused by PCP arising from neural discoordination.

48 to-hippocampal hyper-connectivity induced by PCP, enhanced PCP-modulated functional connectivity loca

49 at exploration of the possibility of MLC by PCP-type pincer complexes, we report herein the synthesi

50 in a stable cohort of patients cared for by PCPs during a 7-year period showed that comprehensive UM

51 even better than the most-highly chlorinated PCP, and much better than its two other TeCP isomers.

52 atients with a positive PCR and a compatible PCP clinical syndrome, BDG had a sensitivity of 70%, spe

53 ANG-1/Van Gogh and PRKL-1/Prickle containing PCP pathway and a Slit-independent SAX-3/Robo pathway co

54 t of core PCP proteins, thereby coordinating PCP and iPCP.

55 Core PCP is adopted as a model pathway, in term of which we i

56 Core PCP protein Vangl2 emerged in the cell boundaries since

57 reduced levels of Dishevelled (Dsh), a core PCP factor.

58 lized Celsr1 carries with it additional core PCP proteins, including the posteriorly enriched Fz6 and

59 The existing model explains how core PCP proteins, including Van Gogh (Vang) and Dishevelled

60 We propose that the upregulation of core PCP components, together with the loss of the key negati

61 nvolves the subcellular polarization of core PCP components.

62 asymmetric localizations of a subset of core PCP proteins, thereby coordinating PCP and iPCP.

63 la sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apica

64 The core PCP gene Van Gogh (Vang), Vangl1/2 in mammals, is the mo

65 ains the asymmetric localization of the core PCP protein Vangl2.

66 The core PCP proteins are also required for auditory circuit asse

67 al tissue architecture, rather than cortical PCP cues, regulates the decision between symmetric and s

68 gioma (ACP) and papillary craniopharyngioma (PCP), differ in genesis and age distribution.

69 d/Vang signaling couples to the Fat/Dachsous PCP directional signal in opposite directions depending

70 No patient developed PCP prophylaxis breakthrough.

71 ited data on whether these mutations disrupt PCP signaling in vivo.

72 evailing model, PKD mutations do not disrupt PCP signaling but instead act independently and in paral

73 ir follicle angling, a hallmark of disrupted PCP.

74 Disrupting PCP signaling results in inaccurate control of tubule di

75 iometric requirement and localization during PCP establishment.

76 ral years, the number of contacts with Dutch PCP cooperatives has increased to 245 contacts per 1000

77 e and NEP, ACE2, PEP (prolyl-endopeptidase), PCP (prolyl-carboxypeptidase) in kidney biopsy homogenat

78 hyper-connectivity induced by PCP, enhanced PCP-modulated functional connectivity locally within the

79 opmental events associated with establishing PCP in the utricle.

80 Female PCPs generated less visit revenue than male colleagues i

81 In 2017, female PCPs generated 10.9% less revenue from office visits tha

82 , patient, and visit characteristics, female PCPs generated equal revenue but spent 15.7% more time w

83 y of 100%, PPV of 100%, and NPV of 52.0% for PCP.

84 of 81.2%, PPV of 34.6%, and NPV of 95.2% for PCP.

85 Per visit, after adjustment for PCP, patient, and visit characteristics, female PCPs gen

86 ive analysis of adult patients evaluated for PCP at our institution from 2012 to 2015, using serum BD

87 nt/heterotrimeric G protein/PI3K pathway for PCP regulation.

88 Polymerase chain reaction (PCR) for PCP detection is highly sensitive, but cannot differenti

89 d PDGFRalpha+ cells reveal a requirement for PCP in their oriented cell migration guided by WNT5A.

90 angl1/2 in mammals, is the most specific for PCP.

91 BDG lacks specificity for PCP, and its clinical performance in high-risk cancer pa

92 ents with a compatible clinical syndrome for PCP, higher BDG values (>200 pg/mL) were consistently as

93 ed treatment and preventive dental care from PCPs.

94 entive dental care prior to age 2 years from PCPs or dentists vs no preventive dental care.

95 over, Suzanne's impact on ongoing and future PCP studies is fundamental, long-lasting and transformat

96 d grain yield by 47.1-55.0%, decreased grain PCP content by 83.6-86.2% and increased the soil PCP rem

97 ve by both BDG and PCR were unlikely to have PCP.

98 Programs holding PCPs accountable for readmissions may prove ineffective.

99 P) is unknown, although federal policy holds PCPs accountable for reducing readmissions.

100 How PCP and iPCP are coordinated during development and the

101 ncentric pattern is not caused by defects in PCP but is due to misaligned support cells.

102 fects are not solely explained by defects in PCP signaling, and some hair cell phenotypes warrant re-

103 (2)R without changes in A(2A)R expression in PCP-treated animals.

104 Finally, in PCP-treated animals, sub-chronic administration of halop

105 of NTD patients found to harbor mutations in PCP genes, but there is limited data on whether these mu

106 in conjunction with clinical presentation in PCP PCR-positive patients.

107 l improvements in quality and a reduction in PCP visits but no significant difference in the total co

108 affold protein with multifunctional roles in PCP, tight junction and Hippo signaling.

109 human transmission in all colonized/infected PCP cases.

110 These data indicate that intact PCP complexes formed between cochlear-supporting cells a

111 ic focus on strategies that aim to integrate PCPs into the care of cancer survivors across different

112 At the tissue level, intercellular PCP signaling regulates the asymmetric localization of P

113 morphogenesis, and provides new insight into PCP-related disorders in humans.

114 es both tissue-level and hair cell-intrinsic PCP signaling.

115 Herein, we investigated PCP of the mouse vestibular organs.

116 r trans-endocytosis, and adhesive junctional PCP complexes appear to be destined for degradation upon

117 beled as not containing BHT, the BHT-labeled PCPs (mean: 369 253 ng//g, median: 382 560 ng/g) contain

118 however, Nodal induces C and E in a largely PCP-dependent manner, arguing that Nodal acts both upstr

119 gation on the RCM depolymerization of linear PCP reveals a more random chain degradation process.

120 provide a global cue that coordinates local PCP with tissue axes.

121 nical WNT signaling establishes or maintains PCP signaling in this context.

122 ed seven Wnt paralogues, including the major PCP regulator Wnt5a, which was, surprisingly, dispensabl

123 Therefore, mesenchymal PCP induced by Hh signaling drives cell clustering and s

124 cultivation in contaminated soil with 100 mg PCP per kg soil but without nZVI, the addition of 100 mg

125 PCPs less often, and nearly one half had no PCP visits in a given year by 2016.

126 ears, while the proportion of adults with no PCP visits in a given year rose from 38.1% to 46.4%.

127 Consistent with this, in the absence of PCP signaling, peripheral axons turn randomly and often

128 Analyses of PCP-mutant mice and genetic interaction studies show tha

129 integrated with the detailed cell biology of PCP phenomena, completely changed how the field studies

130 Blocking of PCP-dependent elongation disrupts the shaping of opposin

131 from the open neural tube characteristic of PCP mutants.

132 litated rhizosphere microbial degradation of PCP.

133 is likely to be an important determinant of PCP outcomes in diverse contexts.

134 d identical performance for the diagnosis of PCP, compared to qPCR assays.

135 een protrusion dynamics and establishment of PCP and directed migration.

136 he cytoskeleton and represent a new facet of PCP function.

137 that can be rescued by an activated form of PCP effector Daam1.

138 ous mechanism that requires the formation of PCP protein complexes between cochlear-supporting cells

139 ulating tubule diameter is a key function of PCP signaling but that loss of this control does not ind

140 ls and shortened cochlea - both hallmarks of PCP defects.

141 To assess the incidence of PCP in patients with autoimmune blistering diseases rece

142 ects are germline autonomous, independent of PCP genes, and can be rescued by wild-type Cmb, but not

143 ]) significantly increased the likelihood of PCP.

144 l switch that underlies the central logic of PCP signaling during morphogenesis, and provides new ins

145 These results extend our current model of PCP signaling from polarizing a field of epithelial cell

146 The occurrence of PCP was significantly associated with atovaquone prophyl

147 The 99th percentile of PCP readmission rates was 14.0%, 1.1 percentage points h

148 The 10th and 90th percentiles of PCP readmission rates were 12.4% and 13.4%, respectively

149 secretion, specifically during the period of PCP establishment.

150 d that Nrdp1 acts as a negative regulator of PCP signaling by inhibiting Dvl through a novel polyubiq

151 Thus, the mitotic reorganization of PCP proteins must alter not only proteins intrinsic to t

152 tion or CMV infection may reduce the risk of PCP.

153 ings, an established system for the study of PCP.

154 PCP through polarizing a specific subset of PCP proteins.

155 The type, frequency, and timing of PCP and food packaging use 24 h before and during the ur

156 regulates polarized endosomal trafficking of PCP components to compartmentalized membrane domains.

157 Only 22% of PCPs and 42% of cardiologists (p = 0.0477) felt extremel

158 was rated as the top concern by only 39% of PCPs, after weight and breast health.

159 study PCP, but her vision of, and impact on, PCP studies in flies translates to all animal models.

160 ne (PCP, 15 mg/kg/d by osmotic minipump), or PCP+glycine (16% by weight diet) interventions.

161 ishevelled 1/2 and frizzled 3/6, while other PCP proteins (Vangl1/2, Celsr1 and dishevelled 3) remain

162 timulus responsive nature of this particular PCP is due to the flexibility of the ligands employed.

163 as remarkably enhanced by pentachlorophenol (PCP), by forming ion-pairing complexes via a passive dif

164 dy soil contaminated with pentachlorophenol (PCP).

165 would require more than 3500 admissions per PCP per year.

166 T examination, including pre-contrast phase (PCP), arterial phase (AP), and portal venous phase (PVP)

167 the NMDA-receptor antagonists phencyclidine (PCP) and ketamine.

168 in rats treated with saline, phencyclidine (PCP, 15 mg/kg/d by osmotic minipump), or PCP+glycine (16

169 ia endophenotypes, namely the phencyclidine (PCP) mouse model and the A(2A)R knockout mice, were used

170 t by a UPMC-employed primary care physician (PCP) in 2014.

171 ission rates vary by primary care physician (PCP) is unknown, although federal policy holds PCPs acco

172 9 primary care physicians (PCPs) and 100 generally healthy patients recruited at ag

173 i attributed to 107 primary care physicians (PCPs) and 4 physician organizations participating in the

174 and superior to six primary care physicians (PCPs) and six nurse practitioners (NPs) (top-1 accuracy:

175 was introduced for primary care physicians (PCPs) to offer advice about LARC methods to a specified

176 racteristics of the primary care physicians (PCPs), patients, and types of visit and for practice fix

177 monitoring by their primary care physicians (PCPs).

178 agnosis of Pneumocystis jirovecii pneumonia (PCP).

179 Pneumocystis pneumonia (PCP) is a potentially lethal opportunistic infection tha

180 Pneumocystis pneumonia (PCP) is associated with morbidity and mortality in solid

181 agement of suspected Pneumocystis pneumonia (PCP).

182 proteins that regulate planar cell polarity (PCP) and cell adhesion in bilaterians.

183 Planar cell polarity (PCP) and neural tube defects (NTDs) are linked, with a s

184 Defects in planar cell polarity (PCP) can disrupt spindle positioning during tissue morph

185 eviously implicated as planar cell polarity (PCP) effectors and in developmentally regulated cilium f

186 ryos defective for the planar cell polarity (PCP) gene, Vangl2, exhibit increased perpendicular divis

187 atypical cadherin and planar cell polarity (PCP) genes.

188 Planar cell polarity (PCP) organizes the orientation of cellular protrusions a

189 mammalian cochlea, the planar cell polarity (PCP) pathway aligns hair cell orientation along the plan

190 We found that the planar cell polarity (PCP) pathway is required in alveolar epithelial cells an

191 putative ligand of the planar cell polarity (PCP) pathway, causes the SpM-SHF to expand isotropically

192 ant elongation via the planar cell polarity (PCP) pathway.

193 Planar cell polarity (PCP) plays crucial roles in developmental processes such

194 s function of the core planar cell polarity (PCP) protein VANGL2.

195 The core planar cell polarity (PCP) proteins coordinate the orientations of hair cells

196 Planar cell polarity (PCP) proteins localize asymmetrically to instruct cell p

197 r of cell polarity and planar cell polarity (PCP) proteins, and studies have shown these polarity and

198 Whether planar cell polarity (PCP) proteins, which regulate cytoskeleton dynamics and

199 Planar cell polarity (PCP) reflects cellular orientation within the plane of a

200 e-level, intercellular planar cell polarity (PCP) signaling and a hair cell-intrinsic, microtubule-me

201 SIGNIFICANCE STATEMENT Planar cell polarity (PCP) signaling has emerged as a complementary mechanism

202 y link between Shh and planar cell polarity (PCP) signaling may also occur in other developmental pro

203 Planar cell polarity (PCP) signaling orients developmental events in vertebrat

204 mmetry directed by the planar cell polarity (PCP) signaling pathway orients numerous morphogenetic ev

205 g of the AP axis while planar cell polarity (PCP) signaling polarizes cells with respect to this axis

206 fied as an effector of planar cell polarity (PCP) under control of Rho kinase, is essential for sperm

207 Planar cell polarity (PCP), the long-range in-plane polarization of epithelial

208 cked as they engage in planar cell polarity (PCP)-dependent movement.

209 idial rotation (OR), a planar cell polarity (PCP)-mediated cell motility process.

210 coordinate epithelial planar cell polarity (PCP).

211 less-deficient cochleae lacked the polarized PCP components dishevelled 1/2 and frizzled 3/6, while o

212 rs with varying lengths of polycyclopentene (PCP) backbone and polystyrene (PS) grafts is investigate

213 enzene within a porous coordination polymer (PCP).

214 bes the use of porous coordination polymers (PCP) with integrated metal bis(dithiolene) units to achi

215 orks (MOFs) or porous coordination polymers (PCPs) are open, crystalline supramolecular coordination

216 mined the association between posttransplant PCP and 3 variables: cytomegalovirus (CMV) infection, al

217 of a familiar space to cease resembling pre-PCP representations despite preserved place fields.

218 ens as well as other personal care products (PCP) and consumer products.

219 PA) are used in some personal care products (PCPs) and containers for food processing and packaging.

220 dely used in various personal care products (PCPs), little is known about their levels, composition p

221 exposures from food, personal care products (PCPs), thermal paper, and dust (using the tools MCRA and

222 Protein-correlation-profiling (PCP), in combination with quantitative proteomics, has e

223 the Brassicaceae, the pollen coat proteins (PCPs), are emerging as important signalling molecules th

224 Forty-nine patients with proven PCP and 126 patients without PCP were included.

225 -directed care versus primary care provider (PCP)-directed care-were assessed by using multivariable

226 9-5.76]; P=0.03), and primary care provider (PCP; OR, 2.00 [CI, 1.08-3.75]; P=0.03).

227 ibed, which focus on primary care providers (PCPs) as receiving cancer survivors who are transferred

228 rvivors and 20.0% of primary care providers (PCPs) had a survivorship care plan (SCP).

229 Geneticists rated PCP management of 8 MDR results (73% [CI, 39% to 99%]) a

230 ariable PCP defects; thus, how Wnts regulate PCP remains unresolved.

231 l system to show that secreted Wnts regulate PCP through polarizing a specific subset of PCP proteins

232 ently associated with clinically-significant PCP infections among PCP PCR-positive oncology patients.

233 content by 83.6-86.2% and increased the soil PCP removal rate from 49.9 to 83.9-89.0%.

234 wer of Drosophila as a model system to study PCP, but her vision of, and impact on, PCP studies in fl

235 ll migration and invasiveness by suppressing PCP signaling.

236 For high-risk survivors, PCP possession of a SCP was associated only with increas

237 We found that PCP was normal in quintuple mutant wings that rely solel

238 Given that PCPs tend to undergo frequent formulation changes, which

239 Arabidopsis thaliana pollen-borne CRPs, the PCP-Bs (for pollen coat protein B-class) that are relate

240 ockout mice, similar to that observed in the PCP animal model of sensory gating impairment of schizop

241 ed for an annual health habits screen in the PCP general medicine clinics were studied.

242 While mutations in the PCP genes vangl2 and scrib cause random orientations of

243 onformation of the photoactive ligand in the PCP, and thereby the positions at which cycloaddition oc

244 Upon Arl3 loss, the PCP signaling molecules Celsr1 and Vangl2 failed to main

245 e zebrafish lateral line, disruptions of the PCP and Wnt pathways have differential effects on hair c

246 ing metathesis (RCM) depolymerization of the PCP BB backbone appears to occur through an end-to-end d

247 rine sample collection for almost all of the PCP categories.

248 rosophila allowing intricate analysis of the PCP pathway.

249 ally, constitutively active Rac1 rescued the PCP defects in Par3-deficient cochleae.

250 efect is unknown but we demonstrate that the PCP and Wnt pathways work in parallel to establish prope

251 We conclude that the PCP pathway contributes significantly to the motility an

252 tric information to become accessible to the PCP components.

253 ducts (TPs) of BHT were also detected in the PCPs at low concentrations (ETPs: < MQL to 19 014 ng/g,

254 Nine SPAs were detected in the PCPs, of which only 2,6-di-tert-butyl-4-methylphenol (BH

255 pplying positive potential (+2.0 V) to these PCPs promotes ethylene capture, and subsequent dose of n

256 out and high encounters probably caused this PCP cluster, which was controlled after systematic trime

257 even though Wnt ligands could contribute to PCP, they are not essential, and another global cue must

258 n instructive link from Wnt5a/b gradients to PCP-factor-regulated polarized cilia positioning that is

259 ake of [Ru(bpy)2(dppz)]2+ is only limited to PCP, or it is a general phenomenon for other highly chlo

260 Visits to PCPs declined by 24.2%, from 169.5 to 134.3 visits per 1

261 place cell firing fields are preserved under PCP, but the drug discoordinates the subsecond temporal

262 wing margin mechanosensory bristles undergo PCP-directed apical rotation, inducing twisting that res

263 concentrations of BHT than the BHT-unlabeled PCPs (mean: 4960 ng/g, median: 199 ng/g) did (p < 0.01).

264 and patient outcomes in trained vs untrained PCPs are needed before screening is widely implemented i

265 at different thresholds were evaluated using PCP PCR alone or in conjunction with clinical presentati

266 We show that the Frizzled/Vang PCP signaling module coordinates polarity among and betw

267 hs1 axis acts in parallel to the core-Vangl2 PCP axis to control mesenchymal cell clustering.

268 arity cues, yet Wnt mutants display variable PCP defects; thus, how Wnts regulate PCP remains unresol

269 of preferring oncology-directed care-versus PCP-directed care-for their general preventive care (bla

270 alculations found that dermal absorption via PCP use may be an important exposure pathway for BHT (me

271 s of the SILAC-labeled peptidisc library via PCP allows generation of over 4900 possible binary inter

272 human exposure to and discharge of SPAs via PCP use.

273 mmercially insured adults have been visiting PCPs less often, and nearly one half had no PCP visits i

274 idence (5-15 years and 45-60 years), whereas PCPs are restricted to adults mainly in the fifth and si

275 evelopment, and provide a mechanism by which PCP proteins may regulate axon outgrowth and guidance in

276 While PCP has been successfully applied to soluble proteomes,

277 With PCP PCR alone as the reference method, BDG (>=80 pg/mL)

278 The near-person emissions associated with PCP may contribute to exposures that would not be proper

279 ge in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions.

280 performance of serum BDG in conjunction with PCP PCR on respiratory samples in patients with cancer a

281 nction, such as its ability to interact with PCP effectors.

282 ion of blebs is sufficient to interfere with PCP and directed migration.

283 l acts both upstream of and in parallel with PCP during gastrulation to regulate embryonic axis exten

284 stead act independently and in parallel with PCP signaling to affect OCD.

285 lex PJA reliably discriminated patients with PCP from patients with P. jirovecii colonization.

286 For each case (SOT recipient with PCP), 3-5 controls (SOT recipients without PCP) were inc

287 nts with proven PCP and 126 patients without PCP were included.

288 h PCP), 3-5 controls (SOT recipients without PCP) were included.

289 Wnt/PCP (planar cell polarity) signaling, one of the noncano

290 Wnt/PCP signaling components are frequently dysregulated in

291 jections of spiral ganglion neurons in a Wnt/PCP pathway mutant, Prickle1, suggest the Wnt/PCP pathwa

292 We emphasize Wnt/PCP component localization within migrating cells and di

293 Gsc in Xenopus animal cap assays and key Wnt/PCP factors (RhoA, Vangl2, Prickle, Wnt11) rescued Gsc-m

294 re analyzed by qRT-PCR for expression of WNT/PCP genes.

295 y the interactions between Par proteins, Wnt/PCP signaling pathway, and cell-cell adhesion.

296 tenophore genomes lack components of the Wnt/PCP pathway and cell-cell adhesion complexes raising the

297 CP pathway mutant, Prickle1, suggest the Wnt/PCP pathway plays a role in guiding cochlear afferents t

298 yndrome results from perturbation of the Wnt/PCP pathway, suggest specific relevant domains of the pr

299 ies that address the mechanisms by which Wnt/PCP signaling mediate collective cell migration in devel

300 pulmonary mesenchyme, suggesting that Wnt5a/PCP is a molecular circuit recruited by the recently ide