ライフサイエンスコーパス: PCPA

1 ostnatal day 26 using parachlorophylalanine (PCPA).

2 tisense oligonucleotide (U1 AMO), triggering PCPA.

3 pA, suggesting that the enzyme is encoded by pcpA.

4 ody response to the proteins PiaA, PsaA, and PcpA.

5 ocessing factors, including those regulating PCPA.

6 , lacking a p-hydroxyl group, do not bind to PcpA.

7 Fs), that binds intronic PASs and suppresses PCPA.

8 structure of LSD1-CoREST in the presence of PCPA.

9 AD as the site of covalent modification by 2-PCPA.

10 rain areas, but to a much lesser extent than PCPA.

11 tase gene, pcpE, were identified upstream of pcpA.

12 pCPA (10 mg/kg in 3 microliters) was administered into t

13 roup of mice pretreated with AMPT 100 mg/kg, PCPA 100 mg/kg or PRAZ 1 mg/kg, the effect of D1 was att

14 stnatal day 26 with parachlorophenylalanine (PCPA 100 mg/kg, every other day); controls received sali

15 droxylase inhibitor parachlorophenylalanine (PCPA; 100 mg/kg, s.c.).

16 PcpA (2,6-dichloro-p-hydroquinone 1,2-dioxygenase) from

17 ically with saline or p-chlorophenylalanine (pCPA, 350 mg/kg) to block 5-HT synthesis.

18 systemically with para-chlorophenylalanine (pCPA; 350 mg/kg single i.p. injection) which reduced for

19 ls treated with the 5-HT synthesis inhibitor pCPA (4-chloro-dl-phenylalanine methyl ester hydrochlori

20 of 5-HT stores using p-chlorophenylalanine (PCPA), a 5-HT-synthesis inhibitor, abolished luminal fac

21 e in the presence of p-chloro-phenylalanine (PCPA), a tryptophan hydroxylase inhibitor, the serotonin

22 This peptide matched a part of PcpA, a protein of unknown function that is induced in S

23 rnal prenatal stress and 5-HT depletion with pCPA, a tryptophan hydroxylase inhibitor, reduced the le

24 also reveals that the phenyl ring of the FAD-PCPA adduct in LSD1 does not form extensive interactions

25 th FAD in LSD1 that is distinct from the FAD-PCPA adduct of MAO B.

26 pCPA administration increased NPY levels in several regi

27 Chronic exposure to PCPA alone significantly decreased locomotor activity an

28 PCPA alone significantly increased nose poke latency com

29 he treatment with 4-Chloro-DL-phenylalanine (pcpa, an inhibitor of 5-HT synthesis) abolished the anti

30 overed from the lungs of mice immunized with PcpA and alum versus mice immunized with alum only.

31 etic parameters of the inhibition of LSD1 by PCPA and determined the crystal structure of LSD1-CoREST

32 eversible inactivation product formed with 1-PCPA and mammalian mitochondrial monoamine oxidase B.

33 f the pcp genes, a 24-kb fragment containing pcpA and pcpC was completely sequenced.

34 Both PCPA and TP+PCPA significantly and substantially deplete

35 PCPA and TP+PCPA significantly decreased locomotor activ

36 Following provocation, PCPA and TP+PCPA significantly increased aggression towa

37 cing premature cleavage and polyadenylation (PCPA) and loss of expression of long (>45 kb) genes, a s

38 Human anti-PhtD, -PcpA, and -Ply antibodies were purified and Fab fragment

39 Anti-PhtD, -PcpA, and -Ply human antibodies were assessed for their

40 The abilities of DeltapsaR, pcpA, and DeltapsaR DeltapcpA mutant strains to colonize

41 The four gene products PcpB, PcpC, PcpA, and PcpE were responsible for the metabolism of PC

42 cpR was essential for the induction of pcpB, pcpA, and pcpE.

43 pneumoniae protein vaccine candidates PhtD, PcpA, and Ply in preventing adherence to lung HECs in vi

44 Our results support the potential of PhtD, PcpA, and Ply protein vaccine candidates as alternatives

45 , while PsaR-dependent repression of psaBCA, pcpA, and rlrA transcription is direct.

46 Anti-PhtD but not anti-PcpA antibodies showed a protective role against mouse N

47 d between the flavin cofactor of MAO N and 1-PCPA are similar to those reported for the irreversible

48 files of LSD1 activity and inactivation by 2-PCPA as a function of pH are consistent with a mechanism

49 -HT levels were depleted greater than 95% by pCPA as compared to saline controls.

50 termination by cleavage and polyadenylation (PCPA) at cryptic polyadenylation signals (PASs) in intro

51 Human antibodies generated against PhtD and PcpA caused a decrease in adherence to A549 cells (P < 0

52 y pretreatment with parachlorophenylalanine (PCPA), completely prevented the anticonvulsant action of

53 tional experiments suggest cotranscriptional PCPA counteracted by U1 association with nascent transcr

54 This PcpA-dependent effect on bacterial burden appeared earli

55 a bacteremic pneumonia model, we observed a PcpA-dependent increase in bacterial burden in the lungs

56 on models to investigate the kinetics of the PcpA-dependent pneumococcal disease in mice.

57 P significantly increased aggression whereas PCPA did not, suggesting that in a high-threat context,

58 two other choline-binding proteins (PspC and PcpA) did not affect killing by ALF.

59 -targeted metabolic profiling and a targeted pCPA dose-response study identified 21 biomarkers in the

60 o inhibit splicing, dose-dependently shifted PCPA downstream and elicited mRNA 3' UTR shortening and

61 In this study, we have demonstrated that PcpA elicits statistically significant protection in mur

62 A carrier isolate lacking PcpA exhibited decreased virulence in mice, and there wa

63 PcpA exhibits a high degree of substrate specificity for

64 rvival times of mice infected with wild-type PcpA-expressing pneumococci.

65 PcpA expression is repressed under high manganese concen

66 In the model of sepsis using strain TIGR4, PcpA expression resulted in shorter times to become mori

67 abels into the inactivator, [2,3-(13)C(2)]-1-PCPA, followed by analysis using on-line liquid chromato

68 ss spectrometry analyses are consistent with PCPA forming a covalent adduct with FAD in LSD1 that is

69 emature 3' end cleavage and polyadenylation (PCPA) from cryptic polyadenylation signals (PASs) in int

70 Freezing in the PCPA group was significantly elevated compared to TP and

71 significantly elevated compared to TP and TP+PCPA groups, but not compared to controls.

72 PcpA has low but significant sequence similarity to an u

73 idence supports covalent attachment of the 1-PCPA inactivator to the cofactor as N(5)-3-oxo-3-phenylp

74 Potent inhibitors of PcpA include ortho-disubstituted phenols and 3-bromocate

75 moribund and subcutaneous immunization with PcpA increased survival times of mice infected with wild

76 e level of the globus pallidus) by 48 h post-pCPA injection.

77 Here we show that 2-PCPA is a time-dependent, mechanism-based irreversible i

78 PcpA is an aromatic ring-cleaving dioxygenase that is ho

79 We suggest that the hyperphagia induced by pCPA is mediated by increased NPY levels and secretion i

80 PcpA is under the control of a manganese-dependent regul

81 that pneumococcal choline binding protein A (PcpA) is important for the full virulence of Streptococc

82 1-Phenylcyclopropylamine (1-PCPA) is shown to be an inactivator of the fungal flavoe

83 TP+PCPA males were also significantly more aggressive in th

84 those of the wild type, confirming that both PcpA-mediated gene regulation and PsaR-mediated gene reg

85 epleting 5-HT with para-chlorophenylalanine (PCPA) mimicked seizure-induced hypoventilation, partiall

86 Following withdrawal from TP+PCPA, most behavioral and neurochemical measures returne

87 The ability of pneumococci to make PcpA negatively modulated both the infiltration and apop

88 Neither PcpA nor PsaR was found to be required for colonization

89 model we further investigated the effects of PcpA on recruitment of innate immune regulatory cells.

90 droxylase (Tph) using p-chlorophenylalanine (pCPA) or genetic knockout of the neuronal specific Tph2

91 otonin depleting drug p-chlorophenylalanine (PCPA) or with the serotonin reuptake inhibitor fluoxetin

92 characterized, and the corresponding genes, pcpA, pcpB, and pcpC, have been individually cloned and

93 nusual because the four PCP-degrading genes, pcpA, pcpB, pcpC, and pcpE, were found to be located at

94 to pneumococcal protein antigens PhtD, LytB, PcpA, PhtE, and Ply were compared between otitis-prone a

95 PcpA, PiaA, and PsaA were the most immunogenic proteins.

96 d at 6 h post-intrastriatal injection in the pCPA/QA group as compared to saline/QA animals (P < 0.05

97 In the pCPA/QA group, striatal PPE and PPT mRNA levels were fur

98 in the striatal lesion site of saline/QA and pCPA/QA groups with respect to their contralateral uninj

99 pcpA, rrgA, rrgB, and rrgC encode several outer surface

100 gatively affect the transcription of psaBCA, pcpA, rrgA, rrgB, rrgC, srtBCD, and rlrA in the presence

101 ngest competitive inhibitor, consistent with PcpA's substrate specificity.

102 2-PCPA shows limited selectivity for human MAOs versus LSD

103 Both PCPA and TP+PCPA significantly and substantially depleted 5-HT and 5

104 PCPA significantly and substantially depleted 5-HT and 5

105 PCPA and TP+PCPA significantly decreased locomotor activity.

106 Following provocation, PCPA and TP+PCPA significantly increased aggression toward smaller n

107 pCPA significantly increased food intake compared with c

108 ally expressed transcripts (HIDE-seq) mapped PCPA sites genome wide in divergent organisms.

109 es could also be mapped onto the sequence of PcpA, suggesting that the enzyme is encoded by pcpA.

110 in Saccharomyces cerevisiae and S. pombe and PcpA, the anchor for gamma-TuSCs at the SPB inner plaque

111 contain substitutions on the phenyl ring of PCPA to fully engage neighboring residues.

112 ating that trans-2-phenylcyclopropylamine (2-PCPA, tranylcypromine, Parnate) was the most potent with

113 tidepressant trans-2-phenylcyclopropylamine (PCPA; tranylcypromine; Parnate), are also capable of inh

114 sponse study identified 21 biomarkers in the pCPA-treated mice while 17 metabolites in the Tph2-/- mi

115 At puberty (P40), half the PCPA-treated rats and half the saline-treated rats began

116 kers while minimizing nonspecific effects of pCPA treatment or Tph2 knockout (Tph2-/-).

117 The most striking effect of combining T+PCPA was a significant increase in attack frequency as w

118 The presence of PcpA was associated with increased IL-6 levels, suppress

119 show that the ability of pneumococci to make PcpA was associated with unresolved inflammation in both

120 Taken together, the ability to make PcpA was strongly associated with increased bacterial bu

121 T synthesis inhibitor p-chlorophenylalanine (pCPA), which increases feeding, increased hypothalamic N

122 Here we report the 2.6 A structure of PcpA, which consists of four betaalphabetabetabeta motif