ライフサイエンスコーパス: PDGFR-alpha

1 PDGFR alpha hyperphosphorylation and enhanced proliferat

2 PDGFR alpha-positive cells in optic nerve and spinal cor

3 PDGFR-alpha activation led to BBB impairment and this wa

4 PDGFR-alpha and -beta immunoreactivity was observed in r

5 PDGFR-alpha and -beta proteins are expressed in native a

6 PDGFR-alpha and -beta were expressed on all melanoma cel

7 PDGFR-alpha signaling may contribute to BBB impairment v

8 PDGFR-alpha suppression prevented neurological deficits,

9 PDGFR-alpha(+)Sca-1(+) (PalphaS) MSCs have augmented gro

10 ial growth factor receptor (VEGFR)-2 and -3, PDGFR-alpha and-beta, and c-Kit, was tested for efficacy

11 Ab-PDGFR-alpha decreased significantly the overall smooth m

12 eived a blocking antibody to PDGFR-alpha (Ab-PDGFR-alpha; 10 mg/kg; n=5) or PDGFR-beta (Ab-PDGFR-beta

13 PDGFR-beta (1.2+/-0.2, P<0.01) but not in Ab-PDGFR-alpha (2.2+/-0.4).

14 Serum Ab-PDGFR-alpha concentrations fell rapidly after day 7 to 0

15 In addition, PDGFR-alpha and -beta protein expression was observed in

16 These data demonstrate that all PDGFR alpha-positive cells in the embryonic rat spinal c

17 lial cells that express PDGF receptor alpha (PDGFR alpha) [1] and divide in response to PDGF [2-5], s

18 atelet-derived growth factor receptor alpha (PDGFR alpha) as one target of mutant Cbl-induced deregul

19 atelet-derived growth factor receptor alpha (PDGFR alpha)-positive.

20 atelet-derived growth factor receptor-alpha (PDGFR alpha) expression in vivo and in isolated mammary

21 atelet-derived growth factor receptor-alpha (PDGFR alpha), suggesting that negative selection using c

22 atelet-derived growth factor receptor alpha (PDGFR-alpha) and stem cell antigen 1 (Sca-1) have recent

23 atelet-derived growth factor receptor alpha (PDGFR-alpha) signaling, resulting in increased apoptosis

24 atelet-derived growth factor receptor alpha (PDGFR-alpha), a tyrosine kinase receptor, was found in p

25 atelet-derived growth factor receptor-alpha (PDGFR-alpha) activation caused an increase of IKDR in NG

26 atelet-derived growth factor receptor-alpha (PDGFR-alpha)(+)Sca-1(+)CD45(-)Ter119(-) (PalphaS) cells.

27 growth factor receptor beta (PDGFR beta) and PDGFR alpha, but not insulin-like growth factor-1R and e

28 from fusion of the Fip1-like 1 (FIP1L1) and PDGFR alpha (PDGFRA) genes has been identified as a ther

29 Both PDGFR-beta- and PDGFR-alpha-mediated pathways promote collagen depositio

30 Because KIT and PDGFR-alpha remain drivers of GIST after resistance to i

31 and indicate an oncogenic role for c-Kit and PDGFR-alpha tyrosine kinases in the context of Int3 sign

32 ing anti-PDGFR-beta antibody (APB5), an anti-PDGFR-alpha antibody (APA5), or control immunoglobulin G

33 The PDGF-B, PDGFR-alpha, and PDGFR-beta mRNA expression was induced

34 ived growth factor receptor-alpha and -beta (PDGFR-alpha and -beta), we designed this study to test t

35 nstrated that imatinib mesylate blocked both PDGFR-alpha and PDGFR-beta in vivo.

36 antibodies: allophycocyanin (APC)-conjugated PDGFR-alpha, FITC-conjugated Sca-1, phycoerythrin (PE)-c

37 By contrast, PDGFR-alpha+ cells exhibiting the morphology of ICC gut

38 In contrast, PDGFR-alpha inhibition did not affect vascular maturatio

39 oligodendrocytes develops from a different, PDGFR alpha-negative lineage(s).

40 o test the hypothesis that inhibiting either PDGFR-alpha or PDGFR-beta with a specific mouse/human ch

41 Viral entry in cells harbouring endogenous PDGFR-alpha was competitively inhibited by pretreatment

42 R-1, -3, c-Kit and RET, most cells expressed PDGFR-alpha and -beta.

43 PDGF-A null mice had many fewer PDGFR alpha-progenitors than either wild-type or PDGF-B

44 Consistent with this finding, PDGFR-alpha immunoreactivity was confined to NG2+ cells

45 mouse, a deletion that includes the gene for PDGFR alpha, is a recessive lethal that exhibits a domin

46 ed function for PDGFR-beta in CDR formation, PDGFR-alpha is also clearly capable of eliciting CDRs.

47 like Nanog(low)Sox2(low)Lin28(high)CD24(high)PDGFR-alpha(high) population.

48 Targeted human PDGFR-alpha activation in mouse beta-cells stimulated Er

49 ockade of receptor function with a humanized PDGFR-alpha blocking antibody (IMC-3G3) or targeted inhi

50 otype in Pdgfr-alpha(-/-) embryos identified PDGFR-alpha as a critical mediator of signaling in the e

51 a activation and exogenous PDGF-AA increased PDGFR-alpha activation, regardless of thrombin inhibitio

52 neutralizing antibodies inhibit HCMV-induced PDGFR-alpha phosphorylation.

53 observed after other types of liver injury, PDGFR-alpha loss in HSCs led to a significant albeit tra

54 At least one target of imatinib (KIT, PDGFR-alpha, or PDGFR-beta) was expressed in all tumors,

55 pathway with lithium treatment rescued NG2(+)PDGFR-alpha(+) progenitor cell proliferation in BBS muta

56 so known as neuron-glial antigen 2 or NG2)(+)PDGFR-alpha(+) neural progenitors.

57 responds to activation of PDGFR-beta but not PDGFR-alpha, was not phosphorylated on tyrosine in mutan

58 after E16, coinciding with the appearance of PDGFR alpha-immunoreactive cells in the starting populat

59 Our findings highlight a novel aspect of PDGFR alpha signaling in tumorigenesis.

60 spinal cord cells that had been depleted of PDGFR alpha-expressing cells by antibody-mediated comple

61 lso failed to induce hyperphosphorylation of PDGFR alpha.

62 othesis that TGF-beta mediates the levels of PDGFR alpha protein via regulation of c-Cbl was tested.

63 e were profound reductions in the numbers of PDGFR alpha-progenitors and oligodendrocytes in the spin

64 > G mutation in exon 12 (amino acid 567) of PDGFR-alpha.

65 e Pdgf-c gene or pharmacological blockade of PDGFR-alpha impair the WAT-beige transition.

66 IFN-gamma treatment led to downregulation of PDGFR-alpha (platelet-derived growth factor receptor-alp

67 Both RA and D3 decreased the expression of PDGFR-alpha and PDGFR-beta throughout differentiation.

68 are downregulated by increased expression of PDGFR-alpha or PDGFR-beta in NSCLC cells.

69 king a functional Shp-2, while the levels of PDGFR-alpha EGFR and IGFIR were not changed.

70 tial of the melanoma cells: higher levels of PDGFR-alpha were expressed on cells with higher metastat

71 in expression, activity, and localization of PDGFR-alpha and -beta were analyzed by Western blot and

72 so correlated with the expression pattern of PDGFR-alpha.

73 Subsequent experiments confirmed the role of PDGFR-alpha and PDGFR-beta as receptors for AAV-5.

74 e present study, we investigated the role of PDGFR-alpha following ICH-induced brain injury in mice,

75 r our findings support a profibrotic role of PDGFR-alpha in HSCs during chronic liver injury in vivo

76 To examine the role of PDGFR-alpha in HSCs, Lrat-Cre recombinase and Pdgfra-flo

77 ker profile of infected cells, NG2+, olig2+, PDGFR-alpha+, nestin+, GFAP-, and CC1-, indicated a clos

78 We found that FAP was robustly expressed on PDGFR-alpha(+), Sca-1(+) multipotent bone marrow stromal

79 Only siRNA constructs for c-Kit and/or PDGFR-alpha were able to inhibit HC11-Int3 colony format

80 d demonstrated that disrupting the paracrine PDGFR alpha signaling between tumor cells and stromal fi

81 stimulation by HCMV, tyrosine-phosphorylated PDGFR-alpha associated with the p85 regulatory subunit o

82 vimentin+), and oligodendrocyte progenitors (PDGFR-alpha+) were proliferating.

83 atelet-derived growth factor-alpha receptor (PDGFR-alpha) is specifically phosphorylated by both labo

84 the platelet-derived growth factor receptor (PDGFR-alpha-polypeptide) and AAV-5 transduction.

85 telet-derived growth factor alpha-receptors (PDGFR alpha) are expressed by a subset of neuroepithelia

86 through activation of PDGF-alpha receptors (PDGFR-alpha) on perivascular astrocytes, and treatment o

87 We conclude that TGF-beta regulates PDGFR alpha in the mammary stroma via a c-Cbl-independen

88 Furthermore, RGC-5 cells showed PDGFR-alpha/beta tyrosine phosphorylation that induced t

89 mor cells and stromal fibroblasts by soluble PDGFR alpha-IgG significantly reduced tumor growth.

90 Thrombin inhibition suppressed PDGFR-alpha activation and exogenous PDGF-AA increased P

91 Together, these data indicate that PDGFR-alpha and tyrosine kinase activity act via a commo

92 Taken together, these data indicate that PDGFR-alpha is a critical receptor required for HCMV inf

93 ectable levels in O4+ cells, suggesting that PDGFR-alpha signaling is absent in pre-OLs in situ.

94 The therapeutic interventions targeting the PDGFR-alpha signaling may be a novel strategy to prevent

95 r astrocytes, and treatment of mice with the PDGFR-alpha antagonist imatinib after ischemic stroke re

96 dation for the future testing of therapeutic PDGFR-alpha inhibition in hepatic fibrosis, especially i

97 Thus, PDGFR alpha signaling is required for the recruitment of

98 In vitro, Cbl-N directly bound to PDGFR alpha derived from PDGF-AA-stimulated cells but no

99 ental groups received a blocking antibody to PDGFR-alpha (Ab-PDGFR-alpha; 10 mg/kg; n=5) or PDGFR-bet

100 -mediated induction was primarily limited to PDGFR-alpha.

101 In mutant Cbl transfectants, PDGFR alpha was hyperphosphorylated and constitutively c

102 +) progenitor cells, as well as in human WAT-PDGFR-alpha(+) adipocytes, supporting the physiological

103 beige phenotype in differentiated mouse WAT-PDGFR-alpha(+) progenitor cells, as well as in human WAT

104 When PDGFR alpha-positive cells were purified from embryonic

105 Cells in which PDGFR-alpha was genetically deleted or functionally bloc

106 association of transfected Cbl proteins with PDGFR alpha.

107 HCMV glycoprotein B directly interacts with PDGFR-alpha, resulting in receptor tyrosine phosphorylat