ライフサイエンスコーパス: PGC

1 PGC-1alpha is enhanced in NAc D1-MSNs, specifically afte

2 PGC-1alpha ribosome-associated messenger RNA in MSN subt

3 PGC-1alpha supports neurulation by stimulating autophagy

4 PGC-1alpha was expressed in a subset of established glio

5 PGC-1alphash cells also had impaired proliferation and m

6 PGCs undergo rapid mitotic proliferation, then enter pro

7 PGCs utilize a G protein coupled receptor (GPCR), Tre1,

8 al coactivator PPARgamma coactivator 1alpha (PGC-1alpha) reduced hepatic and plasma FGF21 and white a

9 activated receptor gamma coactivator 1alpha (PGC-1alpha), and fewer mitochondria than controls from u

10 activated receptor-gamma coactivator-1alpha (PGC-1alpha), a master regulator of mitochondrial biogene

11 activated receptor gamma coactivator-1alpha (PGC-1alpha).

12 -activated receptor gamma coactivator 1beta (PGC-1beta) and PGC-1alpha-related coactivator (PRC).

13 nos-1nos-2 PGCs fail to silence hundreds of transcripts normally ex

14 Cs lacking PRC2 resembles that of nos-1nos-2 PGCs.

15 Overall, these data implicate TFEB as a PGC-1alpha-dependent regulator of adipocyte browning and

16 ted glucagon-dependent glucose production, a PGC-1alpha-regulated metabolic pathway.

17 substitute during Akt3 depletion for absent PGC-1alpha activity to restore mitochondrial homeostasis

18 tochondrial activity, possibly by activating PGC-1alpha and SIRT1, to improve physical endurance, str

19 me of the post-implantation epiblast and all PGC stages in rat to reveal enrichment of distinct gene

20 ctivated receptor gamma coactivator-1 alpha (PGC-1alpha) plays a critical role in mitochondrial bioge

21 ctivated receptor gamma coactivator 1-alpha (PGC-1alpha) and its downstream proteins nuclear respirat

22 ctivated receptor gamma coactivator 1-alpha (PGC-1alpha) is a transcriptional coactivator that contro

23 ctivated receptor-gamma coactivator-1-alpha (PGC-1alpha) pathway.

24 ctivated receptor gamma coactivator 1-alpha (PGC-1alpha), a critical transcriptional co-activator of

25 ctivated receptor gamma coactivator 1-alpha (PGC-1alpha), induced physiologically by fasting and path

26 or-activated receptor-y coactivator 1-alpha (PGC-1alpha), peroxisome proliferator-activated receptor-

27 ctivated receptor gamma coactivator 1-alpha (PGC-1alpha).

28 ctivated receptor gamma coactivator 1-alpha (PGC-1alpha).

29 Although PGCs are nonmitotic, we find that lobe formation is driv

30 We first amplified PGC numbers in culture before cryopreservation and subse

31 as regioirregularity was found for analogous PGCs with ether side-chain substituents.

32 Selective expression of NT-PGC-1alpha and PGC-1alpha in PGC-1alpha(-/-) brown adipocytes similarly

33 ptor gamma coactivator 1beta (PGC-1beta) and PGC-1alpha-related coactivator (PRC).

34 lacenta, the levels of H3K27 acetylation and PGC-1alpha promoter methylation correlated significantly

35 erexpression reduced palmitate oxidation and PGC-1alpha mRNA.

36 highlight the combined effects of Parkin and PGC-1alpha in the maintenance of mitochondrial homeostas

37 ators of mitochondrial biogenesis, SIRT1 and PGC-1alpha.

38 linked genes in pre-implantation embryos and PGCs.

39 RT1 toward select peptide-substrates such as PGC-1alpha.

40 Data on clinical ASD (PGC-ASD: 5305 cases, 5305 pseudo-controls; iPSYCH-ASD: 7

41 This is because avian PGCs have a unique migration route through the vascular

42 r the transplantation of cryopreserved avian PGCs from rare heritage breeds of chicken.

43 In conclusion, PCMF-based PGC-LC-MS/MS dramatically improves the glycomics sensiti

44 the expression of mitochondrial biogenesis (PGC-1alpha [peroxisome proliferator-activated receptor-g

45 trate that Hh signaling is required for both PGC specification and general endomesodermal patterning.

46 s SCD1 deficiency-mediated induction of both PGC-1alpha and ER stress.

47 d from the donor rare heritage breed broiler PGCs, and using cryopreserved semen, we were able to pro

48 se B, and alpha-1 acid glycoprotein (AGP) by PGC-LC-MS.

49 identify structures, which are resolved by (PGC)LC and/or IM, validating the combination of the two

50 onstrate that the as-synthesized Nano-Fe(3)C@PGC exhibits an outstanding electrocatalytic activity to

51 ed in porous graphitized carbon (Nano-Fe(3)C@PGC), which is synthesized by facile approach involving

52 Equipped with Nano-Fe(3)C@PGC, the microbial fuel cells based on a mixed bacterium

53 lf-packed capillary porous graphitic carbon (PGC) columns for nanoflow LC-MS/MS analyses of native gl

54 opeptide isomers on porous graphitic carbon (PGC)-LC was significantly improved by elevating the sepa

55 ectrometer with a porous graphitized carbon (PGC) column, while the N-glycans and glycolipids isolate

56 port the use of a porous graphitized carbon (PGC) LC-MS method with effective separation and sensitiv

57 ric separation on porous graphitized carbon (PGC) packed in long capillaries.

58 ionary phase (e.g., porous graphitic carbon [PGC]), to manipulate analyte retention.

59 tream effectors during primordial germ cell (PGC) development.

60 ocess is essential for primordial germ cell (PGC) maturation during embryonic development.

61 istinct mechanisms for primordial germ cell (PGC) specification are observed within Bilatera: early d

62 rect responsiveness to primordial germ cell (PGC) specification, a unique functional feature of forma

63 correlates with higher primordial germ cell (PGC) survival probability.

64 fication whereby human primordial germ cell (PGC)-like cells differentiated from human induced plurip

65 and characterized its primordial germ cells (PGCs) and compared them with chicken.

66 Diploid primordial germ cells (PGCs) are a potential means to freeze down the entire ge

67 ic gonad coalescence, primordial germ cells (PGCs) follow a carefully choreographed migratory route c

68 In animals, primordial germ cells (PGCs) give rise to the germ lines, the cell lineages tha

69 ted niche wrapping of primordial germ cells (PGCs) in the C. elegans embryonic gonad primordium.

70 mal cells to form the primordial germ cells (PGCs) is restricted to the second through the fourth abd

71 aenorhabditis elegans primordial germ cells (PGCs) jettison mitochondria and cytoplasm by forming a l

72 the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs nos-1 and nos-2 in C. e

73 ications occur in the primordial germ cells (PGCs) of emergent starved L1 larvae that correlate with

74 ional activity in the primordial germ cells (PGCs) of the sea urchin embryo (Strongylocentrotus purpu

75 ises from pluripotent primordial germ cells (PGCs) that enter the fetal testis around embryonic day (

76 These primordial germ cells (PGCs) undergo rapid proliferation, yet the germline is h

77 nal role of piwil2 in primordial germ cells (PGCs) was investigated in Nile tilapia using CRISPR/Cas9

78 d for the survival of primordial germ cells (PGCs), as well as the suppression of germ cell tumours i

79 lation and culture of primordial germ cells (PGCs), modification of the genome of PGCs in vitro, and

80 Primordial germ cells (PGCs), the founder cells of the germline, are specified

81 program of Drosophila primordial germ cells (PGCs), we show that cluster dispersal is accomplished by

82 the specification of primordial germ cells (PGCs).

83 productive cells, the primordial germ cells (PGCs).

84 strikingly, to early primordial germ cells (PGCs).

85 asmids in circulating Primordial Germ Cells (PGCs).

86 d by injecting fluorescently labeled chicken PGCs.

87 In DDX4 knockout chickens, PGCs are initially formed but are lost during meiosis in

88 The coactivator PGC-1alpha1 is activated by exercise training in skeleta

89 deficient cells. Transcriptional coactivator PGC-1alpha, mitochondrial superoxide dismutase (SOD2), a

90 erator-activated receptor gamma coactivator (PGC)-1alpha as well as attenuated forskolin-stimulated u

91 erator-activated receptor gamma coactivator (PGC)-1alpha is a master regulator of mitochondrial bioge

92 erator activated receptor gamma coactivator (PGC)-1alpha, has been proposed as a master regulator of

93 Unlike other coactivators, PGC-1alpha contains protein domains involved in RNA regu

94 pase (ATGL/bmm) and transcriptional cofactor PGC-1.

95 SCD1 deficiency is governed by the cofactor, PGC-1alpha.

96 overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk

97 through the Psychiatric Genomics Consortium (PGC) or the Danish iPSYCH project.

98 cs from the Psychiatric Genomics Consortium (PGC) study of schizophrenia yielded seven newly genome-w

99 s) from the Psychiatric Genomics Consortium (PGC) were used for PGS weighting.

100 ease of the Psychiatric Genomics Consortium (PGC), the PGC2-MDD (Major Depression Dataset).

101 cted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analys

102 roup of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 1

103 inch and advance the first stage of creating PGC-mediated germ-line transgenics of a vocal learning s

104 metabolic reprograming through the AMPK/CREB/PGC-1alpha pathway in female mice.

105 regenerate avian species using cryopreserved PGCs.

106 control mechanism detects and drives damaged PGCs into apoptosis.

107 th increased H3K27 acetylation and decreased PGC-1alpha promoter methylation.

108 This modification decreases PGC-1alpha's activity required for NRF1- and NRF2-depend

109 ch are aberrantly elevated in DND1-deficient PGCs.

110 To prevent somatic differentiation, PGCs must transiently silence their genome, an early dev

111 ted as XPSCs) that are permissive for direct PGC-like cell induction in vitro and are capable of cont

112 ed phospho-Smad159 levels also distinguishes PGCs from their somatic neighbours so that emerging PGCs

113 d gonads contained fluorescent labeled donor PGCs.

114 However, the early PGC-LC elution of smaller glycans (tri-, tetra-, and pen

115 enes results in supernumerary and/or ectopic PGCs, either individually or in segment-specific combina

116 om their somatic neighbours so that emerging PGCs become refractory to Bmp signalling that otherwise

117 One such gene encoded PGC-1alpha, an established target of TFEB that promotes

118 t the early embryonic stages when endogenous PGCs migrate through circulation to the genital ridge.

119 MUFAs enhance PGC-1alpha/PPARalpha signaling and promote oxidative met

120 (M) of oxygen for its activity, and enhances PGC-1alpha K224 monomethylation.

121 erforms a second, crucial function to ensure PGC survival.

122 ing Prdm14, a unique marker and an essential PGC transcriptional regulator.

123 nced respiration in NT-PGC-1alpha-expressing PGC-1alpha(-/-) brown adipocytes.

124 PGC-1alpha(-/-) brown adipocytes expressing PGC-1alpha, suggesting a direct effect of NT-PGC-1alpha

125 having comparable levels of TFAM expression, PGC-1alpha(-/-) brown adipocytes expressing NT-PGC-1alph

126 ce) while neither compromising the favorable PGC-LC properties including the high peak capacity and g

127 pients for male PGCs and possibly for female PGCs although with lower efficiency.

128 IR of female PGCs caused uncoupling of germ cell differentiation and

129 Finally, PGC-1alpha was expressed in NAc D1-MSNs versus D2-MSNs u

130 ions for isolating and culturing zebra finch PGCs in vitro and were able to transfect them with gene-

131 en the 2 species, including that zebra finch PGCs were more numerous, more widely distributed in earl

132 valuated against our existing capillary-flow PGC-LC-MS/MS platform (Jensen et al., Nat.

133 nd accuracy, we present a new capillary-flow PGC-LC-MS/MS-based configuration comprising a post-colum

134 Here we investigate the molecular basis for PGC specification in Nematostella, a representative pre-

135 C-1 family member PRC and can compensate for PGC-1alpha activity during mitochondrial stress by an Ak

136 ctions of SGP wrapping that are critical for PGC quiescence and survival.

137 1, but not centralspindlin, is essential for PGC lobe formation.

138 We demonstrate a novel role for PGC-1alpha in NAc in cocaine action.

139 gene conservation to be a universal host for PGCs of different avian species.

140 However, forced PGC-1alpha over-expression rescued the deficits in oxida

141 ression of the mitochondrial biogenesis gene PGC-1alpha.

142 issecting the molecular mechanisms governing PGC specification.

143 ectly or partially by modulating the hepatic PGC-1alpha-FGF21 axis.

144 Furthermore, a higher PGC-1alpha expression was associated with an adverse out

145 However, how PGC-1alpha is regulated in response to oxygen availabili

146 y, our work uncovers novel insights into how PGCs exposed to DNA damage can become developmentally de

147 However, PGC-1alpha knockout did not prevent fasting-induced supp

148 narily divergent regulatory network of human PGCs (hPGCs) remains unclear.

149 enous DNA damage has the potential to impact PGCs, there is little known about how these cells respon

150 xpression of NT-PGC-1alpha and PGC-1alpha in PGC-1alpha(-/-) brown adipocytes similarly induced expre

151 ntenance of naive pluripotency as well as in PGC differentiation, likely through preserving a particu

152 -1 expression (1.94+/-0.38) and decreases in PGC-1alpha expression (0.61+/-0.07) and COX IV activity

153 metabolism, glioblastoma cells deficient in PGC-1alpha displayed ROS accumulation, had reduced RNA l

154 of a role for this ancient group of genes in PGC development.

155 aining resulted in a significant increase in PGC-1alpha expression in both groups, with no further ch

156 Complementary effects were observed in PGC-1alpha-low LNT-229 cells engineered to overexpress P

157 e uncover that the crucial role of Prdm14 in PGC specification is conserved between rat and mice, by

158 en compared to HC, coupled to a reduction in PGC-1alpha, NRF-1, Nrf2, TFam, mfn2 and SOD1/2 gene expr

159 ate activation of the GLP-1 target sygl-1 in PGCs.

160 tational time points and assessed the DDR in PGCs.

161 gests the functional importance of piwil2 in PGCs survival.

162 and identified small molecules that increase PGC-1alpha acetylation, suppress gluconeogenic gene expr

163 ression, deceased NAD+, and SIRT1, increased PGC-1alpha acetylation (inactive form), lower AMPK activ

164 These results were associated with increased PGC-1alpha, UCP2 and UCP3 mRNA and decreased reactive ox

165 mechanism by which SCD1 deficiency increases PGC-1alpha and subsequently induces ER stress still rema

166 ross age, as observed within two independent PGC-SCZ2 subsamples, and showed an increase in magnitude

167 support the existence of zygotically-induced PGCs in the eumetazoan common ancestor.

168 m PEMF treatment was sufficient to instigate PGC-1alpha-associated transcriptional cascades governing

169 Here, we investigated PGC development in rats, by genetically modifying Prdm14

170 ial biogenesis through a mechanism involving PGC-1alpha activation.

171 Compatible with the known PGC-1alpha functions in reactive oxygen species (ROS) me

172 The integration rate of labeled PGCs was measured in 7.5-day, 14.5-day and 18.5-day old

173 that the role of these Hox genes is to limit PGC development with respect to their number, segmental

174 tic dysfunction in skeletal muscle, with low PGC-1alpha/ERRalpha signalling, and downregulation of ox

175 more aggressive behavior and therefore makes PGC-1alpha a potential target for anti-glioblastoma ther

176 d DNA damage differs between female and male PGCs post-sex determination.

177 id males may be suitable recipients for male PGCs and possibly for female PGCs although with lower ef

178 entiation and meiotic initiation, while male PGCs exhibited repression of piRNA metabolism and transp

179 Similar to Mdr49, PGC migration defects in the Npc1a embryos are ameliorat

180 T1 (sirtuin-1) and its downstream mediators: PGC-1alpha (proliferator-activated receptor gamma coacti

181 zation is required for the survival of mouse PGCs and spermatogonial stem cells by suppressing apopto

182 In exercised muscle, PGC-1alpha1 enhances the expression of kynurenine aminot

183 C-1alpha(-/-) brown adipocytes expressing NT-PGC-1alpha had higher expression of mtDNA-encoded ETC ge

184 s associated with enhanced respiration in NT-PGC-1alpha-expressing PGC-1alpha(-/-) brown adipocytes.

185 Selective expression of NT-PGC-1alpha and PGC-1alpha in PGC-1alpha(-/-) brown adipo

186 Here we sought to investigate the role of NT-PGC-1alpha in brown adipocyte mitochondria.

187 PGC-1alpha, suggesting a direct effect of NT-PGC-1alpha on mtDNA transcription.

188 we found that, in brown adipocytes, some NT-PGC-1alpha localizes to mitochondria, whereas PGC-1alpha

189 nd similar mRNA expression (all P < 0.05) of PGC-1alpha, p53 and CPT1 mRNA in HCHO, LCHF and LCAL.

190 emethylates monomethylated lysine (K) 224 of PGC-1alpha under normoxic conditions.

191 antly increased mouse placental abundance of PGC-1alpha expression and downstream mitochondrial trans

192 Pharmacologic activation of PGC-1alpha restores barrier integrity in cells treated w

193 Accordingly, depletion of PGC-1alpha in chemoAML cells abolished such induction of

194 Sildenafil also induces the expression of PGC-1 family member PRC and can compensate for PGC-1alph

195 eurons and MEFs show increased expression of PGC-1alpha (peroxisome proliferator-activated receptor-g

196 ibroblasts also show increased expression of PGC-1alpha (peroxisome proliferator-activated receptor-g

197 Expression of PGC-1alpha K224R mutant significantly increases mitochon

198 Ectopic expression of PGC-1alpha restores mitochondrial oxidative phosphorylat

199 n complex 1 (mTORC1) along with induction of PGC-1alpha and ER stress.

200 endothelial cells through the inhibition of PGC-1alpha nuclear localization and is also required for

201 sising the divergent molecular mechanisms of PGC specification.

202 Overexpression of PGC-1alpha attenuates the inhibition in cellular respira

203 terfere with PRC2-dependent reprogramming of PGC chromatin.

204 To dissect the role of PGC-1alpha in mediating the downstream effects of TFEB o

205 However, the role of PGC-1alpha in NAc in cocaine action is unknown.

206 Suppression of PGC-1alpha expression by shRNA in the PGC-1alpha-positiv

207 Suppression of PGC-1beta and PRC with siRNA reverses the effects of IGF

208 However, the RNA targets of PGC-1alpha and how they pertain to metabolism are unknow

209 ing a calcium-mitochondrial axis upstream of PGC-1alpha transcriptional upregulation, recapitulating

210 s of human AGP revealed the potential use of PGC-LC-MS for extensive glycoprotein analysis for biomar

211 cells (PGCs), modification of the genome of PGCs in vitro, and injection of the PGCs into the extrae

212 igration and directs subsequent migration of PGCs through the midgut primordium.

213 d4 controls the maintenance and migration of PGCs.

214 ral endoderm results in increased numbers of PGCs due to an expansion of the PGC niche.

215 Measurement of the mutation rate of PGCs in culture revealed that 2.7 x 10(-10) de novo sing

216 g an essential role of piwil2 in survival of PGCs.

217 ng in the germline, and the transcriptome of PGCs lacking PRC2 resembles that of nos-1nos-2 PGCs.

218 aining self-renewal and expansion in vivo of PGCs and controlling follicle activation will be essenti

219 -low LNT-229 cells engineered to overexpress PGC-1alpha.

220 Here we show that porcine PGCs originate from the posterior pre-primitive-streak c

221 LWM-PP/PGC (HR 1.42, P < 0.001) and LWM-PP/PG (HR 2.05, P < 0.0

222 esh with absorbable poliglecaprone-25(LWM-PP/PGC), or polyglactin-910(LWM-PP/PG).

223 ey drivers of adipogenesis (i.e., PPARgamma, PGC-1alpha), presumably by negatively modulating the glu

224 We find that laminin also preserves PGC quiescence during embryogenesis.

225 SGPs are known to promote PGC survival during embryogenesis and exit from quiescen

226 We show that CRL3(GCL) promotes PGC fate by mediating degradation of Torso, a receptor t

227 jected mutant larvae had no or less putative PGCs compared to control fish, suggesting an essential r

228 We first present evidence that the putative PGCs delaminate from the endomesoderm upon feeding, migr

229 oughput chemical screen platform to quantify PGC-1alpha acetylation in cells and identified small mol

230 an accurate transcriptional timeline for rat PGC development.

231 Meanwhile, no replicative PGCs or prophase I meiocytes could be found.

232 Therapies that rescue PGC-1alpha function may provide a complementary approach

233 ts, suggesting that these genes may restrict PGC formation to specific abdominal segments in G. bimac

234 ally derived poly(4,6-d-glucose carbonate)s (PGCs) containing carbonate side chain substituents in th

235 3 cases, 11 359 controls) and schizophrenia (PGC-SCZ2: 34 241 cases, 45 604 controls, 1235 trios) wer

236 SGLT2 inhibitors may also upregulate SIRT1, PGC-1alpha, and FGF21 by a direct effect on the heart.

237 upregulated angiogenic pathways via a SIRT1-PGC-1alpha pathway.

238 ) receptor-mediated recruitment of the SIRT1-PGC-1alpha axis, which is relevant to the neuroprotectiv

239 genesis and oxidative metabolism via a SIRT1/PGC-1alpha/PPARalpha-dependent pathway through an unknow

240 ailure), but SGLT2 inhibitors activate SIRT1/PGC-1alpha/FGF21 signaling and promote autophagy.

241 lf15, Pln4, Cluh, Trpc5, Gfra1, and Slc25a25 PGC-1alpha depletion decreased a fraction of these gluca

242 n, we generated mice with adipocyte-specific PGC-1alpha deficiency and TFEB overexpression.

243 uid chromatography tandem mass spectrometry (PGC-LC-MS/MS) enables the quantitative elucidation of gl

244 d chromatography coupled mass spectrometry ((PGC)LC-MS) is arguably the gold-standard for the structu

245 ds and that hPGCLCs resemble the early-stage PGCs randomly migrating in the midline region of human e

246 cental explant activated AMPK and stimulated PGC-1alpha expression, concomitant with increased H3K27

247 In summary, PGC-1alpha modifies the neoplastic phenotype of glioblas

248 f one of the largest schizophrenia GWAS (SWG PGC, 2014).

249 The targeted PGCs were germline competent and were used to produce DD

250 We hypothesized that targeting PGC-1alpha acetylation in the liver, a chemical modifica

251 r expression of mtDNA-encoded ETC genes than PGC-1alpha(-/-) brown adipocytes expressing PGC-1alpha,

252 is of secreted proteins, we demonstrate that PGC-1alpha modulates the secretome of mouse embryonic fi

253 This study revealed that PGC-1alpha monomethylation, which is dependent on oxygen

254 These studies show that PGC-1alpha binds to intronic RNA sequences, some of them

255 Our findings show that PGC-1alpha1 activates the MAS in skeletal muscle, suppor

256 Here, we show that PGC-1alpha1 elevates aspartate and glutamate levels and

257 Our results show that PGCs prior to sex determination lack a G1 cell cycle che

258 bly, loss of Prdm14 completely abrogates the PGC program, as demonstrated by failure of the maintenan

259 d pharmacologic strategies that activate the PGC-1alpha pathway enhance host epithelial cell mitochon

260 Having successfully activated the PGC transcriptional program, a potent quality control me

261 21x by changing the applied potential at the PGC stationary phase.

262 tochondrial homeostasis as controlled by the PGC family of transcriptional activators is required for

263 e ring formation is locally inhibited by the PGC nucleus, which migrates to one side of the cell befo

264 n inappropriately engulf and cannibalize the PGC cell body.

265 he mRNA decay factor KSRP to destabilize the PGC-1alpha mRNA.

266 nt state of developmental competence for the PGC fate.

267 ion of PGC-1alpha expression by shRNA in the PGC-1alpha-positive U343MG glioblastoma line suppressed

268 om 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership betwe

269 Interestingly, the PGC-1alpha knockdown conferred protection against hypoxi

270 e early instructions during formation of the PGC lineage.

271 d numbers of PGCs due to an expansion of the PGC niche.

272 To promote the PGC-LC-MS/MS-based method for glycome-wide applications,

273 We then show that the PGC clusters arise at the interface between hedgehog1 an

274 lary EMLC columns are configured so that the PGC stationary phase serves as the working electrode in

275 tabolizing CYP24A1 in the kidney through the PGC-1alpha-ERRalpha pathway.

276 gulf and degrade large lobes extended by the PGCs [4].

277 (Hh), which serves as a guidance cue for the PGCs, is potentiated by mesodermally restricted HMGCoA-r

278 ngs demonstrate important differences in the PGCs of the zebra finch and advance the first stage of c

279 ntly restores translation selectively in the PGCs.

280 addition to eEF1A, the cytoplasmic pH of the PGCs appears to repress translation and simply increasin

281 enome of PGCs in vitro, and injection of the PGCs into the extraembryonic blood vessel at the early e

282 e that together they ensure selection of the PGCs with highest germ plasm quantity and least cellular

283 We conclude that the PGCs of this sea urchin institute parallel pathways to q

284 -containing lineages (denoted herein as the "PGC-specification hypothesis").

285 nnectivities and structural details of these PGCs were examined through a combination of comprehensiv

286 This PGC-1alpha1-dependent mechanism allows trained muscle to

287 that lysine demethylase 3A (KDM3A) binds to PGC-1alpha and demethylates monomethylated lysine (K) 22

288 Among the top-scoring RNA sequences bound to PGC-1alpha were Foxo1, Camk1delta, Per1, Klf15, Pln4, Cl

289 A large fraction of RNAs bound to PGC-1alpha were intronic sequences of genes involved in

290 Next, in exploring functional links to PGC-1alpha, the master regulator of mitochondrial biogen

291 to genetic instability that is restricted to PGCs within the genital ridge during a narrow temporal w

292 We trace PGC development in rats, for the first time, from specif

293 ere not the canonical direct transcriptional PGC-1alpha targets such as OXPHOS or gluconeogenic genes

294 The gonad primordium contains two PGCs that are wrapped individually by two somatic gonad

295 enograft experiment, tumors formed by U343MG PGC-1alphash glioblastoma cells grew much slower than co

296 a representative pre-bilaterian animal where PGCs arise as paired endomesodermal cell clusters during

297 GC-1alpha localizes to mitochondria, whereas PGC-1alpha resides in the nucleus.

298 Here, we interrogated whether PGC-1alpha is involved in tumor growth and the metabolic

299 ther showed that treating APN(-/-) mice with PGC-1alpha activator pyrroloquinoline quinone enhances m

300 Without PGC-1alpha, the ability of TFEB overexpression to brown

301 Zebrafish PGC migration depends on the formation of cellular protr