ライフサイエンスコーパス: PGF

1 PGF accounted for 23.4% (n=364) of all deaths (n=1555) i

2 PGF is a secreted factor that supports hypertrophy and c

3 PGF is induced in the heart after pressure-overload stim

4 PGF promoted metastasis of BCCs and also facilitated hom

5 PGF transgenic mice showed a more adaptive type of cardi

6 PGF was studied from the perspective of "hard outcomes"

7 PGF(2alpha) and 17,20beta-P thereby seemed to act throug

8 PGF(2alpha) and latanoprost acid induce coordinated alte

9 PGF(2alpha) at 8% WT levels was sufficient to induce coo

10 PGF(2alpha) has been implicated in wound healing and car

11 PGF(2alpha) increased the secretion of MMP-2 in a dose-d

12 PGF(2alpha) induces phosphorylation of JunD bound to the

13 PGF(2alpha) was also found to induce the expression of E

14 PGF(2alpha)-induced ERK1/2 phosphorylation was prevented

15 PGF-CTERM occurs in 29 archaeal species, some of which h

16 PGF-CTERM proteins include the major cell surface protei

17 Our results revealed that: (1) PGF varied depending on the pollinator species, and was

18 eroxide reductase activity and 9alpha,11beta-PGF(2) (PGF(2)(alphabeta)) from PGD(2) by the PGD(2) 11-

19 d correlated against severity; 9alpha,11beta-PGF(2) and PGI(2) metabolites were measured for control

20 easured as PGD(2) reduction to 9alpha,11beta-PGF(2) by ELISA) were impaired by small interfering RNA

21 changes in leukotriene E(4) or 9alpha,11beta-PGF(2) levels after AD.

22 re diminished only weakly, and 9alpha,11beta-PGF(2) levels conversely increased.

23 sed urinary tetranor PGDM > 2,3-dinor-11beta-PGF(2alpha) > 11beta-PGF(2alpha) in mice.

24 increased tetranor PGDM and 2,3-dinor-11beta-PGF(2alpha) in humans coincident with facial flushing.

25 elevated tetranor PGDM and 2,3-dinor-11beta-PGF(2alpha) in volunteers, coincident with a pyrexial an

26 respondingly, both PGDM and 2,3-dinor-11beta-PGF(2alpha) were suppressed by inhibition of COX-1 and C

27 tes, 11beta-PGF(2alpha) and 2,3-dinor-11beta-PGF(2alpha), in human urine and was the only endogenous

28 PGDM > 2,3-dinor-11beta-PGF(2alpha) > 11beta-PGF(2alpha) in mice.

29 abundant than the PGD(2) metabolites, 11beta-PGF(2alpha) and 2,3-dinor-11beta-PGF(2alpha), in human u

30 estion of higher urinary excretion of 11beta-PGF(2alpha) and a lower excretion of a PGE(2) metabolite

31 The same strong inter-15-PGF correlations were observed in plasma from healthy yo

32 All plasma 15-PGF isomers increased over time with in vitro cigarette

33 acidified, and total (free + esterified) 15-PGFs and AA were extracted with organic solvents.

34 itation of several 15-series PGF isomers (15-PGFs) and AA by high-performance liquid chromatography-t

35 ng HPLC-tandem MS applied to plasma total 15-PGFs.

36 0.83%) and lowest with P. rapae (2.71%); (2) PGF with B. ignitus depended on the distance between GM

37 reductase activity and 9alpha,11beta-PGF(2) (PGF(2)(alphabeta)) from PGD(2) by the PGD(2) 11-ketoredu

38 in levels of prostaglandin (PG)E(2), PGD(2), PGF(2alpha), and thromboxane B(2), as well as the expres

39 perfusion with 5 micromol/L PGE(2), PGD(2), PGF(2alpha), or carboprostacyclin.

40 at vasodilatory prostaglandins (PGs) PGE(2), PGF(2alpha), and PGE(3) accompany the erythema in the fi

41 and COX-2 as well as their products PGE(2), PGF(2alpha), and thromboxane B(2) and their receptors fo

42 PGD(2), PGE(2), PGF(2alpha), carbaprostacyclin (cPGI(2); a stable prosta

43 IV-1, while 9,10-dihydro-15d-PGJ(2), PGE(2), PGF(2alpha), or PGD(2) that lack the reactive alpha,beta

44 nfluent OCCM cells were treated with PGE(2), PGF(2alpha), specific activators/inhibitors of the EP pr

45 both isoforms with prostaglandin F(2alpha) (PGF(2alpha)) activates the small G-protein Rho, leading

46 ormonal pheromones, prostaglandin F(2alpha) (PGF(2alpha)) and 17alpha,20beta-dihydroxy-4-pregnen-3-on

47 and regioisomers of prostaglandin F(2alpha) (PGF(2alpha)) and are used as biomarkers for lipid peroxi

48 mechanisms by which prostaglandin F(2alpha) (PGF(2alpha)) increases intracellular Ca2+ concentration

49 y demonstrated that prostaglandin F(2alpha) (PGF(2alpha)) induces a rapid and transient expression of

50 Prostaglandin F(2alpha) (PGF(2alpha)) is a potent antiadipogenic factor in cultur

51 e of the major PGs, prostaglandin F(2alpha) (PGF(2alpha)) is present in human urine in significant co

52 of prostaglandins E(2) (PGE(2)), F(2alpha) (PGF(2alpha)), lipoxin A(4) (LXA(4)) and its receptor FPR

53 ogical activator is prostaglandin-F(2alpha) (PGF(2alpha)).

54 re stereoisomers of prostaglandin F(2alpha) (PGF(2alpha)).

55 hly effective ocular hypotensive agent, is a PGF(2)(alpha) analogue that inhibits both the PGD(2) 11-

56 Travoprost acid, PGF(2alpha,) unoprostone, and S-1033 were tested in addi

57 approximately 30% enhancement by activating PGF(2alpha) receptor or thromboxane receptor, or approxi

58 ured in expression of PAPPA, FLT1, ENG, AFP, PGF, and LGALS14, but not LGALS13 or the lineage marker

59 how the regulation of EGR-1 expression after PGF(2alpha) activation of FP receptors and suggests that

60 luteolytic mediator prostaglandin F2-alpha (PGF) significantly increased TNF in the ovaries when com

61 Although PGF transgenic mice did not have a baseline phenotype or

62 Furthermore, although PGF(2alpha) increases intracellular cyclic AMP via Galph

63 t cryptococcal production of both PGE(2) and PGF(2 alpha) can be chemically inhibited by caffeic acid

64 red colonic motility index, lower TxA(2) and PGF(2) and higher PGE(2) levels than controls.

65 on of 9 alpha,11 beta-PGF(2) from PGD(2) and PGF(2)(alpha) from PGH(2) in the presence of NADPH.

66 31 and increased the synthesis of PGE(2) and PGF(2)alpha.

67 f PGE(2) and PGF(2alpha) and that PGE(2) and PGF(2alpha) act as paracrine factors that stimulate mela

68 PGE(2) and PGF(2alpha) alter cell function by binding and activatin

69 ocyte PAR-2 stimulates release of PGE(2) and PGF(2alpha) and that PGE(2) and PGF(2alpha) act as parac

70 The prostaglandins (PG) E(2) and PGF(2alpha) are important cytokines in periodontal physi

71 In this study, we examined the PGE(2) and PGF(2alpha) effects on the immortalized cementoblastic O

72 We conclude that PGE(2) and PGF(2alpha) exert an anabolic effect on OCCM mineralizat

73 endricity observed in response to PGE(2) and PGF(2alpha) is cAMP-independent.

74 PGE(2) and PGF(2alpha) significantly increased mineralization of OC

75 nocytes, as well as by release of PGE(2) and PGF(2alpha) that stimulate melanocyte dendricity through

76 dins involved in inflammation are PGE(2) and PGF(2alpha).

77 rachidonate metabolites (PGD(2), PGE(2), and PGF(2)) by the action of three groups of enzymes.

78 rachidonate metabolites (PGD(2), PGE(2), and PGF(2)) by the action of three groups of enzymes.

79 ers and ethanolamides of PGE(2), PGD(2), and PGF(2alpha) were major products of the endocannabinoid-d

80 GH(2) mimetic (U-51605), PGD(2,) PGJ(2), and PGF(2alpha).

81 lpha,11beta-prostaglandin (PG) F(2alpha) and PGF(2alpha) prostanoids that sustain the growth of myelo

82 cortex expression of VEGFB, FLT4, FLT1, and PGF was associated with worse cognitive trajectories (p

83 g on PGHS-1 pathways involving PGD, PGE, and PGF.

84 t levels of PGE(2), PGD(2), thromboxane, and PGF(2alpha), but not PGI(2).

85 d catalyzes the formation of 9 alpha,11 beta-PGF(2) from PGD(2) and PGF(2)(alpha) from PGH(2) in the

86 dogenic-associated gene (VEGF, VEGFR2, BFGF, PGF, HGF, Ang-1, VWF, PECAM-1 and ENOS) expression analy

87 Bound PGF(2alpha) isomers are derivatized by 1-pyrenyldiazomet

88 ong the 414 heart transplants complicated by PGF, 354 (85.5%) recipients died and 60 (14.5%) were ret

89 Thus, induction of EGR-1 expression by PGF(2alpha) was blocked using dominant-negative construc

90 blocked the induction of EGR-1 expression by PGF(2alpha).

91 PGE(2) treatment or, to a lesser extent, by PGF(2alpha), but not by other prostaglandins, such as PG

92 ased uveoscleral outflow of aqueous humor by PGF(2alpha).

93 bit contractions and inflammation induced by PGF(2alpha).

94 vation of ERK1/2 mediates nur77 induction by PGF(2alpha).

95 t-negative JunD abolished nur77 induction by PGF(2alpha).

96 that activation of the human FP receptor by PGF(2alpha) could induce the expression of EGR-1 and fou

97 ents contraction of rat uterus stimulated by PGF(2alpha) and induces relaxation of aorta previously c

98 sites, but its binding is not stimulated by PGF(2alpha).

99 FP receptor stimulation by PGF(2alpha) induced the phosphorylation of C-Raf, MEK1/2

100 iadipogenic properties possibly supported by PGF(2alpha) synthase activity.

101 Cloprostenol (PGF(2alpha) agonist) administration to Akr1b7(-/-) mice

102 ure, two model structures of PGFS containing PGF(2)(alpha) and PGH(2) were built.

103 In contrast, PGF(2alpha) levels remained unchanged and were three-fol

104 e Trp53 induces preterm birth through a COX2/PGF synthase/PGF(2alpha) pathway.

105 CRP significantly decreased PGF-1alpha release from HAECs under basal (48% decrease,

106 Akr1b7 loss was associated with decreased PGF(2alpha) WAT contents.

107 An important difference between COX-derived PGF(2alpha) and the IsoPs is that the former is an optic

108 le resolution in the separation of different PGF(2alpha) isomers and can be used not only for sample

109 PKC inhibitor bisindolylmaleimide I enhanced PGF(2alpha)-stimulated IP accumulation in transfected ce

110 pects to PGF(2alpha) and its enantiomer, ent-PGF(2alpha), are formed in equal amounts esterified in t

111 pared by centrifugation and esterified 8-epi PGF(2alpha) measured at the start and finish of each tre

112 resulted in a significant decrease in 8-epi PGF(2alpha) production, from 38.8 (95% CI 24.9 to 52.7)

113 tion on 8-epi prostaglandin F(2alpha) (8-epi PGF(2alpha)) content and the effect of concurrent oral a

114 in an increase in platelet-esterified 8-epi PGF(2alpha), a free radical and cyclooxygenase-dependent

115 ficant increase in platelet-esterified 8-epi PGF(2alpha), from 32.9 (95% confidence interval [CI] 11.

116 the levels of the isoprostane product, 8-epi-PGF(2alpha).

117 e, and 2 microg PGF(2alpha)-isopropyl ester (PGF(2alpha)-IE) was applied to the other eye of cynomolg

118 andin E2 (PGE(2)) and prostaglandin F2alpha (PGF(2alpha)), are enzymatically degraded by 15-hydroxypr

119 and MSCs expressed placental growth factor (PGF) and its cognate receptor VEGFR1, respectively, in a

120 VEGF family member placental growth factor (PGF) as an aldosterone-regulated vascular MR target gene

121 , VEGFD (FIGF), and placental growth factor (PGF); VEGF receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VE

122 Primary graft failure (PGF) is the most common cause of short-term mortality af

123 sculopathy (CAV), and primary graft failure (PGF).

124 iments to measure pollen-mediated gene flow (PGF) in the absence and presence of pollinators (Bombus

125 a a transporter, which has high affinity for PGF(2alpha) and PGE(2), but not prostacyclin (PGI(2)).

126 the g-HCM cells than in the n-HCM cells (for PGF(2alpha), 60% vs. 151%).

127 at the necessary and sufficient elements for PGF(2alpha) induction of Nur77 promoter activity are loc

128 as the likely protein-processing enzyme for PGF-CTERM.

129 pathway indicates that a single pathway from PGF(2alpha) receptor to CREB is responsible for inducing

130 In recipients with prompt graft function (PGF), the mean cold storage time was 22+/-9 hr versus 29

131 All four PG-Gs (PGE(2)-G, PGD(2)-G, PGF(2alpha)-G, and 6-keto-PGF(1alpha)-G) and the prostag

132 on were in the following order: CCh > ET-1 > PGF(2alpha).

133 7 nM) > bimatoprost acid (EC(50) = 112 nM) > PGF(2alpha) (EC(50) = 120 nM) >> unoprostone (UF-021; EC

134 In summary, we have identified PGF as what we believe to be a novel downstream target o

135 There was no significant difference in PGF at 90 days or recipient mortality after up to 5 year

136 Secondary outcomes included PGF and other postoperative events, such as renal failur

137 the anti-substituted isoprostanes, including PGF(2)(alpha), were, however, observed in the product mi

138 mulated Pgf gene transcription and increased PGF protein expression and secretion in the mouse vascul

139 nerated cardiac-specific and adult inducible PGF-overexpressing transgenic mice and analyzed Pgf(-/-)

140 otic human vessels, MR antagonists inhibited PGF expression.

141 th OTR-As, atosiban and nolasiban, inhibited PGF(2alpha)-induced contractions in a dose-dependent man

142 Urinary F(2)-iPs, PGF(2alpha) isomers derived from arachidonic acid (AA) a

143 -1); P < 0.05) at day 14 and the renal 8-iso PGF(2alpha) excretion (3.53 +/- 0.71 pg. d(-1); P < 0.05

144 Renal excretion of 8-iso PGF(2alpha) was increased in AngII400 group at day 12 (2

145 (PG) E(1) and 8-iso-PGE(2), but not by 8-iso-PGF(1alpha), 8-iso-PGF(2alpha), and 8-iso-PGF(3)alpha.

146 of cells with TP antagonists, whereas 8-iso-PGF(2 alpha) was without effect.

147 rostane using an antibody specific for 8-Iso-PGF(2) (15-F(2t)-IsoP).

148 GE(2) , 8-iso-PGE(2) , tetranor-PGE-M, 8-iso-PGF(2) alpha, and leukotriene C(4) , D(4) , and E(4) , w

149 However, 8-iso-PGF(2alpha) also originates from enzymatic sources linke

150 flammation or oxidative stress derived 8-iso-PGF(2alpha) and estimate their associations with phthala

151 For example, a 22.4% higher 8-iso-PGF(2alpha) concentration (95% confidence interval = 14.

152 e, associations between phthalates and 8-iso-PGF(2alpha) could have been misinterpreted.

153 (P<0.01) and diastolic BP (P<0.01) and 8-iso-PGF(2alpha) decreased (P<0.05), whereas urinary NO(X) in

154 atterns, chromatographic separation of 8-iso-PGF(2alpha) from its isomers is necessary for its quanti

155 was optimized for rapid measurement of 8-iso-PGF(2alpha) in urine, and it is ideally suited for clini

156 menadione and alphaEE showed increased 8-iso-PGF(2alpha) levels compared with untreated controls, whe

157 assay had a linear range of 1-40 pg of 8-iso-PGF(2alpha) on column and can quantify as little as 40 p

158 eated controls, whereas no increase in 8-iso-PGF(2alpha) was detected in kidneys of alphaEE-treated g

159 urinary 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) as the oxidative stress biomarker.

160 jor urinary metabolite of 15-F2t-IsoP (8-iso-PGF(2alpha)) is 2,3-dinor-5,6-dihydro-15-F2t-IsoP (15-F2

161 ease in 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)) levels compared with untreated controls.

162 urinary 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)), a biomarker of lipid peroxidation.

163 insulin, 8-isoprostaglandin F(2alpha) (8-iso-PGF(2alpha)), and glucose measurements.

164 -PGE(2), but not by 8-iso-PGF(1alpha), 8-iso-PGF(2alpha), and 8-iso-PGF(3)alpha.

165 of prostaglandin F(2alpha), including 8-iso-PGF(2alpha), following derivatization with 1-pyrenyldiaz

166 r prostaglandins (e.g. PGE(1), PGE(2), 8-iso-PGF(2alpha), prostacyclin), leukotrienes (e.g. LTB(4), L

167 ) were associated with both sources of 8-iso-PGF(2alpha).

168 ociated with a significant increase in 8-iso-PGF(2alpha).

169 sociated with oxidative stress derived 8-iso-PGF(2alpha).

170 d solely with oxidative stress derived 8-iso-PGF(2alpha).

171 biomarkers than the commonly measured 8-iso-PGF(2alpha).

172 To clarify this, the 8-iso-PGF(2alpha)/prostaglandin F(2alpha) ratio approach was u

173 so-PGF(1alpha), 8-iso-PGF(2alpha), and 8-iso-PGF(3)alpha.

174 ostane E(2) (8-iso-PGE) and F(2alpha) (8-iso-PGF) sensitize nociceptors and capsaicin-sensitive DRG n

175 8-Isoprostane PGF(2alpha) and malonyldialdehyde were measured in group

176 and 6-keto prostaglandin F(1alpha) (6-kepto PGF(1alpha)).

177 fold) and the prostacyclin metabolite 6-keto PGF(1alpha) (5.7-fold).

178 inor TxB2 (Tx-M), and PGI2, 2,3-dinor 6-keto PGF(1alpha) (PGI-M), only PGI-M was depressed by the COX

179 g/ml for control and 10(-6) M NOC/oFQ 6-Keto PGF(1alpha) and TXB(2), respectively).

180 y increased cerebrospinal fluid (CSF) 6-Keto PGF(1alpha) and TXB(2), the stable breakdown products of

181 ex vivo, depressed urinary 2,3 dinor 6-keto PGF(1alpha) by approximately 60% but had no effect on th

182 depressed, whereas urinary 2,3-dinor 6-keto PGF(1alpha), but not 2,3-dinor-TxB(2), was increased in

183 immunoassay of its stable metabolite, 6-keto PGF(1alpha), that was abolished by diclofenac.

184 rothromboxane B2 (Tx-M) and 2'3-donor-6-keto-PGF(1alpha) (PGI-M).

185 significantly increased secretion of 6-keto-PGF(1alpha) and PGE(2).

186 e cardiac prostaglandin (PG) E(2) and 6-keto-PGF(1alpha) levels were significantly decreased in heart

187 Levels of 6-keto-PGF(1alpha), a stable metabolite of prostacyclin, were r

188 sgenics exhibited only an increase in 6-keto-PGF(1alpha), not a decrease in PGE(2).

189 GE(2)-G, PGD(2)-G, PGF(2alpha)-G, and 6-keto-PGF(1alpha)-G) and the prostaglandins (PGs) that are for

190 crease in tissue levels of PGE(2) and 6-keto-PGF(1alpha).

191 In this report we show, using mice lacking PGF(2)alpha receptor and pregnant rats, that PGF(2)alpha

192 o commands for the vector graphics languages PGF/TikZ that can be compiled into scalable vector graph

193 [9,11-dideoxy-9 alpha,11 alpha-methanoepoxy PGF(2 alpha) (U46619)] in CHO cells transfected with the

194 s topically applied to one eye, and 2 microg PGF(2alpha)-isopropyl ester (PGF(2alpha)-IE) was applied

195 crease in the Fura PE-3 signal to 0.1 microM PGF(2alpha) was abolished, whereas 10 microM PGF(2alpha)

196 au rise in [Ca2+]i in response to 0.1 microM PGF(2alpha) was insensitive to diltiazem, and was abolis

197 The [Ca2+]i response to 0.1 microM PGF(2alpha) was mimicked by the FP receptor agonist flup

198 han that seen for the response to 0.1 microM PGF(2alpha), and were also much less sensitive to U-7312

199 Both responses became maximal at 0.1 microM PGF(2alpha).

200 he rises in [Ca2+]i in response to 10 microM PGF(2alpha) and 0.01 microM U-46619 were partially inhib

201 PGF(2alpha) was abolished, whereas 10 microM PGF(2alpha) and 0.05 microM U-46619 still caused substan

202 fluprostenol, whilst the effect of 10 microM PGF(2alpha) was mimicked by the TP receptor agonist U-46

203 U-46619 and 10-100 microM PGF(2alpha) cause a TP receptor-mediated Ca2+ influx inv

204 ls: PGE2 (3.7+/-0.7 versus 1.1+/-0.2 pg/mL), PGF(1alpha) (16.2+/-2.8 versus 7.2+/-1.2 pg/mL), and bra

205 ng that links a specific pheromone molecule (PGF(2alpha)) to neurogenesis in a vertebrate animal.

206 upport targeting the vascular aldosterone/MR/PGF/Flt1 pathway as a therapeutic strategy for ischemic

207 The addition of 1 muM PGF(2alpha) also increased MMP-2 secretion in a time-dep

208 the expression of EGR-1 and found that 1 muM PGF(2alpha) produced a time-dependent induction of both

209 Neither PGF(2alpha) or PGE(2) elevated cAMP in human melanocytes

210 s showed that 24 hours of exposure to 100 nM PGF(2alpha) significantly increased mRNA for MMP-1 and -

211 cleral tissues were exposed to 100 to 500 nM PGF(2alpha), 17-phenyltrinor PGF(2alpha), or PhXA85 (the

212 The secretory action of PGF(2alpha) was inhibited by pretreatment with a protein

213 The addition of PGF(2alpha) and latanoprost acid increased ERK1/2 activi

214 Interestingly, addition of PGF(2alpha), which was not known to affect lymphocytes,

215 (2alpha)-G but is observed after addition of PGF(2alpha).

216 donate independent of COX and is composed of PGF(2alpha) and its enantiomer, although the latter comp

217 e results suggest that low concentrations of PGF(2alpha) act via FP receptors to cause IP3-dependent

218 At higher concentrations of PGF(2alpha), a further slower rise in [Ca2+]i was superi

219 e mixture (10:1), fluorescent derivatives of PGF(2alpha) remain bound to cellulose while a significan

220 1- or 5-year mortality or the development of PGF (odds ratio, 1.11; 95% CI, 0.88-1.39; P = .37).

221 .14; P =.18) mortality or the development of PGF (odds ratio, 1.11; 95% CI, 0.88-1.39; P =.37).

222 sted predictive model for the development of PGF was formulated in a similar fashion.

223 ion has been well studied, but the effect of PGF(2alpha) on mucin production remains poorly understoo

224 This resorption is preceded by elevation of PGF(2~) but is not preceded by a decrease in circulating

225 The 1-pyrenylmethyl esters of PGF(2alpha) can be quantitatively extracted from cellulo

226 quantification of 1-pyrenylmethyl esters of PGF(2alpha) isomers at picogram level are complicated by

227 The purified 1-pyrenylmethyl esters of PGF(2alpha) were quantitatively analyzed by reverse-phas

228 clerosis, aldosterone enhanced expression of PGF and its receptor, FMS-like tyrosine kinase 1 (Flt1).

229 has dual catalytic activities: formation of PGF(2)(alpha) from PGH(2) by the PGH(2) 9,11-endoperoxid

230 Formation of PGF(2)(alpha) from PGH(2) most likely involves a direct

231 idate the effect and underlying mechanism of PGF(2alpha) on MUC5AC production, we investigated the si

232 Low concentrations (0.01-1 microM) of PGF(2alpha) caused a transient followed by a plateau ris

233 roxyprostaglandin dehydrogenase oxidation of PGF(2 alpha)-G was observed.

234 The low prevalence of PGF has limited efforts at identifying risk factors for

235 of follow-up, nor any difference in rates of PGF at 90 days and CAV at 5 years between recipients of

236 own to coordinate the specific regulation of PGF in human trophoblast cell lines.

237 The regulation of PGF(2alpha)-induced MUC5AC expression by CREB was furthe

238 The release of PGF-1alpha, a stable product of PGI2, was also assayed i

239 Following the removal of PGF(2alpha), however, FP(A)-expressing cells show rapid

240 edure of derivatization includes sorption of PGF(2alpha) isomers from solution in a hexane:ethyl acet

241 hibitory effects involved the suppression of PGF(2alpha)-mediated increase in intracellular calcium l

242 , we investigated the signal transduction of PGF(2alpha) associated with this effect using normal hum

243 d CXCL10 expression by MSCs was dependent on PGF expression by BCCs.

244 tors independently have a positive effect on PGF gene expression, when combined, DLX3 acts as an anta

245 ned the effects of atosiban and nolasiban on PGF(2alpha)-induced contractions and pro-inflammatory re

246 simultaneous effect of multiple variables on PGF.

247 cinoma cell line, with HGF, IL-6, PGE(2), or PGF(2)alpha resulted in significantly increased cell gro

248 hout increasing recipient mortality, CAV, or PGF.

249 erved after addition of PGE(2), PGD(2)-G, or PGF(2alpha)-G but is observed after addition of PGF(2alp

250 erefore, controlling tissue levels of HRG or PGF might be a promising strategy in chronic inflammator

251 PGE(2) release were in the following order: PGF(2alpha) > CCh > ET-1; and their effects on inositol

252 and g-HCM cells were in the following order: PGF(2alpha) > ET-1 > CCh; their effects on PGE(2) releas

253 O2, VO2, HCO3, K+, phosphate, lactate, PGE2, PGF(1alpha), and bradykinin) potentially involved in erg

254 receptor agonists fluprostenol and 17-phenyl PGF(2alpha).

255 o 100 to 500 nM PGF(2alpha), 17-phenyltrinor PGF(2alpha), or PhXA85 (the active form of latanoprost)

256 n), exposure to PGF(2alpha), 17-phenyltrinor PGF(2alpha), or PhXA85 each increased scleral permeabili

257 h exposure to PGF(2alpha) or 17-phenyltrinor-PGF(2alpha).

258 n matrix adhesion, we demonstrate a profound PGF(2alpha)-induced alteration in cytoskeletal remodelli

259 spectrometry, the vast majority of putative PGF(2alpha) in human urine is derived from the free radi

260 determined, however, that levels of putative PGF(2alpha) in urine cannot be suppressed by nonsteroida

261 of their functional antagonism in regulating PGF promoter activity.

262 method for quantitation of several 15-series PGF isomers (15-PGFs) and AA by high-performance liquid

263 ddition, the OTR-As significantly suppressed PGF(2alpha)-induced activation of pro-inflammatory pathw

264 es preterm birth through a COX2/PGF synthase/PGF(2alpha) pathway.

265 shed, using luteinized granulosa cells, that PGF(2alpha) stimulates in vitro nur77 expression in a ti

266 Our research confirmed that PGF depended on pollinator species, distance between pla

267 Our results demonstrated that PGF(2alpha) induces MUC5AC overproduction via a signalin

268 PGF(2)alpha receptor and pregnant rats, that PGF(2)alpha is responsible for the rapid and massive exp

269 Mechanistically, we show that PGF does not have a direct effect on cardiomyocytes but

270 The PGF(2alpha)- and latanoprost-acid-induced ERK1/2 activat

271 ty was less intense in the sections from the PGF(2alpha)-IE-treated eyes compared with the vehicle-tr

272 Pressure reductions of 5 mm Hg in the PGF(2alpha)-IE-treated eyes were confirmed.

273 , a TNF-neutralizing antibody, inhibited the PGF-induced decrease in P4 and delayed luteal regression

274 role in ovarian physiology by mediating the PGF(2alpha) induction of 20alpha-HSD, a steroidogenic en

275 Proteomics suggests that the PGF-CTERM region is removed.

276 era to prostaglandin (PG)F(2alpha) or to the PGF(2alpha) analogue latanoprost acid alters mRNA for ma

277 treatment with PGF and were resistant to the PGF-induced decrease in P4.

278 Therefore, PGF(2alpha) seemed to modulate male brain plasticity tha

279 Moreover, we show that these PGF(2alpha)-induced alterations in adhesion and morpholo

280 osure to PhXA85 and similar with exposure to PGF(2alpha) or 17-phenyltrinor-PGF(2alpha).

281 (-6) cm/sec for 70 kDa dextran), exposure to PGF(2alpha), 17-phenyltrinor PGF(2alpha), or PhXA85 each

282 ts of compounds identical in all respects to PGF(2alpha) and its enantiomer, ent-PGF(2alpha), are for

283 Moreover, IOP-lowering topical PGF(2alpha)-IE treatment decreases the amount of TIGR pr

284 nce between GM and non-GM cottons; (3) total PGF to Shiyuan321 (8.61%) was higher than to Hai7124 (4.

285 ator of WAT development through at least two PGF(2alpha)-dependent mechanisms: inhibition of adipogen

286 d in understanding the mechanisms underlying PGF and in matching recipients with donors in efforts to

287 the nonsupplemented group; P<0.001); urinary PGF(2-alpha) excretion was also highest in the JO group

288 the renal-cell membrane and elevated urinary PGF(2-alpha) excretion, and the precipitous fall in inul

289 Thus, quantification of urinary PGF(2alpha) actually reflects oxidative stress status as

290 The elucidation that urinary PGF(2alpha) in humans is derived from the IsoP pathway h

291 Exposure to waterborne PGF(2alpha) induced a multitude of changes in male goldf

292 was to evaluate risk factors associated with PGF after heart transplantation.

293 s of pretransplant variables associated with PGF included: ischemic time, donor gender, donor age, mu

294 nd donor characteristics are associated with PGF.

295 ute treatment of FP(B)-expressing cells with PGF(2alpha) leads to a subcellular reorganization of bet

296 ansporter (hPGT), stimulation of the FP with PGF(2alpha) (1 nM-1 microM), or the less potent FP agoni

297 were significantly better in recipients with PGF (90% and 74%) versus DGF (79% and 54%) (P<0.002).

298 d for 24 hours with medium supplemented with PGF(2a), latanoprost acid, or vehicle.

299 Treatment with PGF also reduced serum progesterone (P4) concentrations

300 luteal regression 24 h after treatment with PGF and were resistant to the PGF-induced decrease in P4