ライフサイエンスコーパス: PHD finger

1 e C terminus of RAG2 contains a noncanonical PHD finger.

2 The ASH1 protein contains a SET domain and a PHD finger.

3 o RAG-1 are separable functions of the RAG-2 PHD finger.

4 that is dependent on histone binding by the PHD finger.

5 ylase activity, a property that requires the PHD fingers.

6 l role in determining the selectivity of the PHD fingers.

7 ne H3K4 and contain a set of uncharacterized PHD fingers.

8 of the histone and non-histone targeting by PHD fingers.

9 one 3 (H3K4me3) through a plant homeodomain (PHD) finger.

10 istones, by one of Aire's plant homeodomain (PHD) fingers.

11 BRPF1 (bromodomain PHD finger 1) is a core subunit of the MOZ histone acety

12 Here, we identify a role of double PHD fingers 2 (DPF2) in modulating inflammation.

13 -specific effect on expression of the double PHD fingers 3 (DPF3) of the BAF SWI/SNF complex as asses

14 ithin an intron of DPF3, encoding for Double PHD Fingers 3, a member of chromatin remodeling complexe

15 ING2 contains a plant homeodomain (PHD) finger, a motif common to many chromatin-regulatory

16 mimic disease-causing mutations in the hATRX PHD finger, abolish repression.

17 a conserved tryptophan residue in the RAG-2 PHD finger abolished binding to H3K4me3 and greatly impa

18 in the non-core region and suggests that the PHD finger adopts two distinct states.

19 The removal of PHD fingers affected neither binding nor mutual Jade-1-H

20 ough mutations in either the first or second PHD finger allow for Rpd3S complex formation, the assemb

21 dition of the PHD finger domain or the third PHD finger alone into MLL-ENL blocks the hematopoietic s

22 milar preferences to those displayed by each PHD finger alone.

23 ld increase in affinity compared with either PHD finger alone.

24 e, the first report that deregulation of the PHD finger, an 'effector' of specific histone modificati

25 s including a C-terminal SET domain, central PHD fingers, an N-terminal DNA-binding homology, and two

26 InsP-binding region of ING2 (consisting of a PHD finger and a polybasic region) revealed a number of

27 We demonstrate that the tandem PHD finger and bromodomain of KAP-1, an arrangement ofte

28 nteraction of KAP1 with HP1 and on an intact PHD finger and bromodomain of KAP1, suggesting that thes

29 on in the linker region between MLL1's third PHD finger and bromodomain.

30 Here, we show that the [BPTF PHD finger and bromodomain: histone PTM] interaction is

31 ontaining the HMG box and hath region plus 4 PHD fingers and a SET domain.

32 stic three-pronged pocket of histone-binding PHD fingers and binds to methylated histone H3 tails.

33 ocalization signal (NLS), a SAND domain, two PHD fingers and four nuclear receptor targeting motifs.

34 ent domain that includes the CXXC domain and PHD fingers and is controlled by direct interactions wit

35 MLL1 fusion proteins lack the PHD fingers and require prebinding of a wild-type MLL1 c

36 hy MLL translocation breakpoints exclude the PHD fingers and suggest a possible role for these domain

37 s consistently delete the plant homeodomain (PHD) fingers and more carboxyl terminal MLL sequences.

38 ative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors invo

39 region with an acidic stretch, a WAKZ motif, PHD fingers, and bromodomain.

40 ractions, highlight therapeutic potential of PHD fingers, and compare inhibition strategies.

41 main (ASH1L(BD)), a plant homeodomain (ASH1L(PHD)) finger, and a bromo-adjacent homology (ASH1L(BAH))

42 Hence, the PHD finger appears to negatively regulate self-acetylati

43 n of the aromatic H3K4me-binding site of the PHD fingers appears to have no effect.

44 PHD fingers are modular domains in chromatin-associated

45 noprecipitation experiments reveal that both PHD fingers are required for binding to H3K14ac in vivo

46 Plant homeodomain (PHD) fingers are critical effectors of histone post-tran

47 Plant homeodomain (PHD) fingers are structurally conserved zinc fingers tha

48 Together, these data identify the PHD finger as a novel and functionally important domain

49 Together, our data identify the PHD finger as a phosphoinositide binding module and a nu

50 Our findings call attention to the PHD finger as a previously uncharacterized chromatin-bin

51 itate the functional characterization of new PHD fingers, as well as other protein families, solely b

52 We show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains fro

53 Pygopus contains a PHD finger at its C terminus, a motif often found in chr

54 of immunodeficiencies are located within the PHD finger, at either zinc-coordinating residues or resi

55 It has been proposed that VEL PHD fingers bind to methylated histone H3 tails to facil

56 ectroscopic approaches to show that the Set3 PHD finger binds di- and trimethylated states of H3K4 wi

57 The ING2 PHD finger binds H3K4me3, a histone mark that is associa

58 A typical PHD finger binds to the unmodified or methylated amino-t

59 The MtING2 PHD finger bound H3K4me2/3 peptides weakly in vitro, but

60 solution crystal structure of the mouse RAG2 PHD finger bound to H3K4me3 reveals the molecular basis

61 nsferase domain and the adjacent bromodomain/PHD finger (bromo/PHD) region of the transcriptional coa

62 a/TRIM33/Ectodermin and demonstrate that its PHD finger-bromodomain constitutes a multivalent histone

63 biquitinate its substrate Smad4 requires its PHD finger-bromodomain, as does its transcriptional repr

64 ribe a dual inhibitor of the bromodomain and PHD finger (BRPF) family member BRPF2 and the TATA box b

65 to increased H3K4me3 engagement by the BPTF PHD finger, but it is unknown if this mechanism has a br

66 MLL5 includes a SET domain and a single PHD finger, but lacks A-T hooks and methyltransferase ho

67 Deletion of the PHD finger, but not the bromodomain, impaired the abilit

68 allel alpha-helices and a plant homeodomain (PHD) finger, but their genetic role has not been previou

69 Here, we demonstrate that the triple PHD finger cassette of MLL4, harboring its fourth, fifth

70 The three PHD finger cassette, one of the highly conserved domains

71 igenome reader domain families (Bromodomain, PHD finger, Chromodomain, MBT, PWWP and Tudor).

72 Deletion of the two PHD fingers completely abolished Jade-1 transcriptional

73 Plant homeodomain (PHD) fingers comprise a large and well-established famil

74 CHD4 contains tandem plant homeodomain (PHD) fingers connected by a short linker, the biological

75 e provide evidence on the genomic scale that PHD fingers constitute a general class of effector modul

76 ining protein 24) and BRPF1 (bromodomain and PHD finger containing protein 1) are involved in the epi

77 URF was disabled by silencing of bromodomain PHD-finger containing transcription factor (BPTF), the l

78 ial readout for selective recruitment of the PHD finger-containing components of chromatin remodeling

79 he histone deacetylase HDAC1, Mrg15, and the PHD finger-containing Pf1 and show that this complex pla

80 Bromodomain and PHD finger-containing protein 1 (BRPF1) is a multivalent

81 Bromodomain- and PHD finger-containing protein 1 (BRPF1) is a multivalent

82 BRPF1 (bromodomain- and PHD finger-containing protein 1) is a unique chromatin r

83 Cti6 is a PHD finger-containing protein that has been shown to par

84 ve analysis of one such poorly characterized PHD finger-containing protein, PHRF1.

85 ific functions of many of the over 100 human PHD finger-containing proteins are poorly understood.

86 volutionary conserved genes encoding nuclear PHD finger-containing proteins implicated in a variety o

87 The BRPF (bromodomain and PHD finger-containing) family are scaffolding proteins i

88 Here we show that a plant homeodomain (PHD) finger-containing protein, VIN3-LIKE 1 (VIL1), part

89 (also known as PHF21A), a plant homeodomain (PHD) finger-containing protein.

90 Plant homeodomain (PHD) finger-containing proteins are implicated in fundam

91 e integrity and provide new insight into how PHD fingers contribute to chromatin biology.

92 s essential for viability and that the first PHD finger contributes to the preferred binding of PHD1-

93 Structural modeling of PHD fingers demonstrates a conserved mechanism for recog

94 rom PHF23, KDM5A and BPTF, suggests a common PHD finger-dependent mechanism that promotes leukemogene

95 ilarity to one another within the C-terminal PHD finger domain and also contain an additional N-termi

96 the transcription repression activity to the PHD finger domain of the chick Pcl2 protein.

97 Finally, the addition of the PHD finger domain or the third PHD finger alone into MLL

98 C (FLC), is critical for vernalization and a PHD finger domain protein, VERNALIZATION INSENSITIVE 3 (

99 cells is critically dependent on a conserved PHD finger domain, suggesting that Pcl2 might function t

100 and the H3K4me3/2-binding plant homeodomain (PHD) finger domain of PHF23.

101 se screens identified the plant homeodomain (PHD)-finger domain protein PHF5A as differentially requi

102 lt shows that the binding specificity of the PHD-finger domain of VIN3 plays a role in mediating a pr

103 alteration in the binding specificity of the PHD-finger domain of VIN3 results in a hypervernalizatio

104 VIN3 encodes a PHD-finger domain that binds to modified histones in vit

105 subunit that contains the chromatin binding PHD finger domains attenuates enhancer functions, but un

106 To date, about 15 PHD finger domains have been structurally characterized,

107 PHD finger domains in viral proteins and in the cellular

108 auxin responses through the action of their PHD finger domains.

109 (NLS) sequences, and four plant homeodomain (PHD) finger domains.

110 Msc1 and RBP2 each possess three PHD fingers, domains commonly found in proteins that inf

111 H3 tail structure in complex with the double PHD finger (DPF) of the lysine acetyltransferase MOZ/MYS

112 ontaining C terminus of BRM binds to the CBP PHD finger, enhances PHD binding to histone H3, and enha

113 Binding studies establish that the BPTF PHD finger exhibits a modest preference for K4me3- over

114 ventional PHD finger followed by an extended PHD finger exists in the mammalian AF10 protein, among a

115 A specific module containing a conventional PHD finger followed by an extended PHD finger exists in

116 timulated 500-fold by Slx4, and requires the PHD finger for activity in vitro and in vivo.

117 on differences in binding affinities of the PHD fingers for H3K4me and the methylation state of the

118 y X-ray crystallography to show that the VEL PHD finger forms the central module of a larger compact

119 d protein that is homologous to the multiple PHD fingers found in the N-terminal regions of mammalian

120 The protein contains a SET domain, a PHD finger, four AT hooks, and a region with homology to

121 3 ligases, reporting for the first time that PHD fingers from a nuclear protein exhibit E3 ubiquitin

122 analysis of the H3K4me3-binding sites of the PHD fingers from PHF23, KDM5A and BPTF, suggests a commo

123 l-characterized CBDs: the plant homeodomain (PHD) finger from ING2 and the chromodomain from heteroch

124 The PHD finger functions as an epigenetic reader that binds

125 A line of evidence suggests that the PHD finger functions in chromatin remodeling and protein

126 t correlation between the abilities of NUP98-PHD finger fusion chimeras to associate with H3K4me3-enr

127 rations to sites that differed from both the PHD finger fusion-directed and LEDGF-directed integratio

128 Similar PHD finger-H3 tail-binding properties were recently repo

129 Furthermore, our data suggest that the PHD finger has a role in the recruitment of p300 to chro

130 The dysregulation of PHD fingers has been implicated in several human disease

131 Insertion of only the first and second PHD fingers has no such effect.

132 However, a set of PHD fingers has recently been shown to bind non-histone

133 A few PHD fingers have recently been found to also associate w

134 Several PHD fingers have recently been shown to recognize other

135 that contain one or more plant homeodomain (PHD) fingers have been implicated in the regulation of c

136 Plant homeodomain (PHD) fingers have emerged as one of the largest families

137 on as to how BCL9 co-factors binding to Pygo PHD fingers impact indirectly on their histone binding a

138 2.0 A resolution structure of the mouse ING2 PHD finger in complex with a histone H3 peptide trimethy

139 To evaluate the role of Aire's PHD finger in MECs on a global scale in vivo, we complem

140 methylated at lysine 4 (H3K4me3) by the ING4 PHD finger in mediating ING4 gene expression and tumor s

141 Here we show that inclusion of the PHD fingers in the MLL fusion protein MLL-AF9 blocked im

142 The roles of Plant Homeodomain (PHD) fingers in catalysis of histone modifications are u

143 talizing MLL fusion protein, the loss of the PHD fingers, in combination with the gain of the activat

144 d substitutions in either the bromodomain or PHD finger, including ones that mimic disease-causing mu

145 s to investigate the interaction of the ING3 PHD finger (ING3PHD) with the active transcription mark

146 e, expression of the fusion protein with the PHD finger insertion mediates the down-regulation of the

147 highlight the molecular mechanisms by which PHD fingers interact with ligands other than the amino t

148 Further, we demonstrate that the ING2 PHD finger interacts with PtdIns(5)P in vivo and provide

149 Here, we classify PHD fingers into different groups based on the analysis

150 a chimeric RAG-2 protein in which the mouse PHD finger is replaced by the corresponding domain from

151 The function of the PHD fingers is obscure and their specific role in transf

152 t recognition of the histone H3 tails by the PHD fingers is required for repressive activity of the C

153 ur study suggests that a common function for PHD fingers is to transduce methyl-lysine events and she

154 ne 3 (H3)-tails by Aire's plant homeodomain (PHD) finger is essential for Aire function in cultured c

155 The plant homeodomain (PHD) finger is found in many chromatin-associated protei

156 oblem is to predict structural features of a PHD finger knowing only its sequence.

157 However, that of VEL PHD fingers lacks this architecture and exhibits unusual

158 nal regulators, including plant homeodomain (PHD)-finger-like domains, and defines a plant-specific p

159 K4me2 recruits the Set3 complex via the Set3 PHD finger, localizing the Hos2 and Hst1 subunits to dea

160 The PHD finger may promote both gene expression and repressi

161 MLL4, harboring its fourth, fifth and sixth PHD fingers (MLL4(PHD456)) forms an integrated module, m

162 y insertion" (L3MBTL1) and "surface groove" (PHD finger) modes of methyllysine recognition, a carboxy

163 The PHD finger motif is a signature chromatin-associated mot

164 rotein sequence shows strong homology to the PHD-finger motif found in known transcription factors fr

165 tational domain search revealed a C-terminal PHD-finger motif.

166 rmination of the MS1 protein and loss of the PHD-finger motif.

167 Msc1 contains 3 plant homeodomain (PHD) finger motifs, characteristically defined by a C4HC

168 introduction of wild-type BHC80 but not by a PHD-finger mutant that cannot bind H3.

169 ), which bind methylated H3K4 (H3K4me3), the PHD finger of BHC80 binds unmethylated H3K4 (H3K4me0), a

170 The crystal structure of the PHD finger of BHC80 bound to an unmodified H3 peptide ha

171 d NMR structures of the bromodomain-proximal PHD finger of BPTF in free and H3(1-15)K4me3-bound state

172 We show that the second PHD finger of CHD4 initiates recruitment to the nucleoso

173 The second PHD finger of human BPTF is known to specifically recogn

174 Insertion of the third PHD finger of MLL into MLL-ENL allows the recruitment of

175 This activity is conserved in the second PHD finger of MLL4, the closest homolog to MLL1 but not

176 cluding disulfiram that directly targets the PHD finger of PHF23 (PHF23PHD).

177 ing PHD finger, such as the carboxy-terminal PHD finger of PHF23 or JARID1A (also known as KDM5A or R

178 one-binding activity is not conserved in the PHD finger of Set4 suggests different functions for the

179 ted screen for PI interactors identified the PHD finger of TAF3, a TATA box binding protein-associate

180 The PHD finger of the RAG2 polypeptide of the RAG1/RAG2 comp

181 We demonstrated that the PHD finger of Ubiquitin Protein Ligase E3 Component N-Re

182 0 fusion protein, which lacks the N-terminal PHD fingers of AF10.

183 of acetylated histone binding by the double PHD fingers of DPF3b.

184 We find that the PHD fingers of ING2 and other diverse nuclear proteins b

185 We show that each of the three PHD fingers of Msc1 can act as ubiquitin E3 ligases, rep

186 The function of the PHD fingers of Msc1 is needed to rescue the DNA damage s

187 Our data support a critical role for the PHD fingers of NUP98-PHF23, and related NUP98-KDM5A and

188 RPD3 binds directly to PCL via the conserved PHD fingers of PCL and the N terminus of RPD3.

189 The Zn-coordinated PHD fingers of Pygopus (Pygo) proteins are critical for

190 Here, we show that the dual PHD fingers of Rco1, a member of the Rpd3S histone deace

191 erminants of methyllysine recognition by the PHD fingers of Set3 and its orthologs.

192 Here we report that, in contrast to the PHD fingers of the bromodomain PHD finger transcription

193 the full-length protein reveals that the two PHD fingers of the dimer are chemically equivalent and i

194 (MBD5 and MBD6) that bind to the C-terminal PHD fingers of the large scaffold subunits ASXL1-3 and s

195 A pair of readers, the PHD fingers of the protein CHD4, has been shown to bival

196 that mono-methylates histone H3K4 and seven PHD fingers of unclear function.

197 trimethylated at K4) by a plant homeodomain (PHD) finger of human BPTF (bromodomain and PHD domain tr

198 leoporin 98 and the third plant homeodomain (PHD) finger of JARID1A drives an oncogenic transcription

199 We found that the plant homeodomain (PHD) finger of Jhd2 is important for its chromatin assoc

200 The plant homeodomain (PHD) finger of Set3 binds methylated lysine 4 of histone

201 We recently found that plant homeodomain (PHD) finger of tumour suppressor ING2 (inhibitor of grow

202 a prime example of histone tail binding by a PHD finger (of Pygo) being modulated by a cofactor (BCL9

203 a unique chromatin regulator possessing two PHD fingers, one bromodomain and a PWWP domain for recog

204 Acf1 is a novel protein that contains two PHD fingers, one bromodomain, and two new conserved regi

205 Purified PHD finger or full-length UBR7 monoubiquitinated H2BK120

206 romatin remodeling activities cluster in the PHD finger or the helicase domain respectively.

207 Substitution of highly related PHD fingers or bromodomains failed to restore repression

208 at a cancer-associated mutation in the PHRF1 PHD finger (P221L) abolishes its histone interaction and

209 Here we identify the UHRF1 PHD finger (PHD(UHRF1)), an important regulator of DNA C

210 Recently, a tandem plant homeodomain (PHD) finger (PHD1-PHD2, or PHD12) of human DPF3b, which

211 Here we show that the second PHD finger (PHD2) of MLL1 is an E3 ubiquitin ligase in t

212 y express ATRX protein with mutations in the PHD finger (PHDmut) or helicase domains (K1584R), we exa

213 0, PFK, PHT1;4, PTR3, KUP2, GRAS, TCP, bHLH, PHD finger, PLATZ and genes involved in developmental, s

214 s from binding studies of H3(1-15)K4me3 with PHD finger point mutants.

215 d long protein containing a SET domain, five PHD fingers, potential zinc fingers, and a very long run

216 istone methyl-lysine binding activity of the PHD fingers present within the Saccharomyces cerevisiae

217 Bromodomain-PHD finger protein 1 (BRPF1) belongs to the BRPF family

218 as a quaternary complex with the bromodomain-PHD finger protein 1 (BRPF1), inhibitor of growth 5 (ING

219 We here report a PRC2-associated cofactor, PHD finger protein 19 (PHF19; also known as polycomb-lik

220 Here we show that PHD finger protein 20-like 1 (PHF20L1) regulates DNMT1 t

221 utative human homologs of Bye1, the proteins PHD finger protein 3 and death-inducer obliterator, whic

222 nds splicing factor 3B subunit 1 (SF3B1) and PHD finger protein 5A (PHF5A), the components of the hum

223 Here we identify PHD Finger Protein 7 (PHF7) as an important factor for m

224 ls, forced expression of the testis-specific PHD finger protein 7 (PHF7) disrupts oogenesis, leading

225 logical processes and diseases revealed that PHD finger protein 8 (PHF8, KDM7B) was significantly ass

226 The Arabidopsis thaliana (Arabidopsis) PHD finger protein EDM2 and RRM domain proteins EDM3 and

227 osophila identified pygopus, which encodes a PHD finger protein, as an additional nuclear component o

228 Here we report a cortex-specific PHD finger protein, Phf21b, which is highly expressed in

229 Plant homeodomain (PHD) finger protein 7 (PHF7) is a RING-type E3 ubiquitin

230 t of the BDP1/BDP2 complex and identified an PhD-finger protein (PHD 1, PF3D7_1008100) that could med

231 tified the co-chaperone SGT1b (EDM1) and the PHD-finger protein EDM2 as critical regulators of RPP7.

232 re we reveal that the ubiquitously expressed PHD-finger protein OBE3 forms a central module with the

233 one H3T3/T6 phosphorylation and retention of PHD finger proteins in chromatin during mitosis.

234 transferase complexes, both of which contain PHD finger proteins that bind methylated H3K4.

235 ongs to a family of evolutionarily conserved PHD finger proteins thought to act as co-activators of W

236 Recently, PHD finger proteins, like Yng1 in the NuA3 HAT complex,

237 ecent papers describe how plant homeodomain (PHD) finger proteins read part of this code.

238 mechanisms underlying this novel function of PHD fingers provides a basis for deciphering the role of

239 region consisting of a PHD finger-Zn knuckle-PHD finger (PZP) folds into a single module that recogni

240 While most PHD fingers recognize unmodified and methylated states o

241 The ING1 PHD finger recognizes methylated H3K4 but not other hist

242 Inclusion of 2 or more PHD fingers reduced association with the Hoxa9 locus and

243 itution within the aromatic cage of the BPTF PHD finger, resulting in a reversal of binding preferenc

244 ation of a novel transcript containing SNF2, PHD-finger, RING-finger, helicase, and linker histone do

245 3 and Thr 6 of the peptide, account for the PHD finger's high specificity and affinity.

246 The PHD fingers seemed to be necessary for the formation of

247 r families, providing informative labels for PHD finger sequences.

248 A PHD finger signature is found in plant vernalization (VE

249 ne H3 (H3K4me1) and seven plant homeodomain (PHD) fingers, six of which have not been structurally an

250 ing an H3K4-trimethylation (H3K4me3)-binding PHD finger, such as the carboxy-terminal PHD finger of P

251 Strong binding of other ING and YNG PHD fingers suggests that the recognition of H3K4me3 his

252 s that the binding of Cyp33 to the MLL third PHD finger switches the MLL function from transactivatio

253 ionarily conserved nuclear protein bearing a PHD finger that is essential for its activity.

254 A point mutation in the p300 PHD finger that is related to the Rubinstein-Taybi syndr

255 In these processes, a PHD finger that specifically recognizes H3K4me3/2 marks

256 Mutations in PHD fingers that abrogated H3K4me3 binding also abolishe

257 gene assembly--contains a plant homeodomain (PHD) finger that specifically recognizes histone H3 trim

258 LL protein contains three plant homeodomain (PHD) fingers that are well conserved between species but

259 nserved modules including plant homeodomain (PHD) fingers that recognize varied H3K4me states.

260 putative double zinc-finger domain, called a PHD finger, that is present not only in the products of

261 BS69 contains regions of similarity to the PHD finger, the bromodomain, and the MYND domain, all of

262 KAP-1 contains a RING finger, B boxes, and a PHD finger; the RING-B1-B2 structure is required for KRA

263 Along with the SET domain and the PHD fingers, this new element is a signature feature for

264 Binding of the RAG-2 PHD finger to chromatin across the IgH D-J(H)-C locus sh

265 olecules that disrupt binding of the JARID1A PHD finger to histone peptides.

266 erstand the path of allostery from the RAG-2 PHD finger to RAG-1, here we employed phylogenetic subst

267 crocyclic calixarenes can disrupt binding of PHD fingers to methylated lysine 4 of histone H3 in vitr

268 ochemical evidence for the utility of tandem PHD fingers to recruit protein complexes at targeted gen

269 The close structural relationship of PHD fingers to RING fingers suggests that other PHD doma

270 tudy, we demonstrate the ability of the CHD5 PHD fingers to specifically recognize the unmodified N-t

271 stone H3, reduce the binding affinity of the PHD finger toward the histone substrate.

272 ULE (MINU) catalytic subunits and the TRIPLE PHD FINGERS (TPF) signature subunits.

273 ntrast to the PHD fingers of the bromodomain PHD finger transcription factor (BPTF) and inhibitor of

274 Bromodomain PHD finger transcription factor (BPTF) is the largest su

275 ons with its largest subunit,the bromodomain PHD finger transcription factor BPTF.

276 Here, we show that loss of BPTF (Bromodomain PHD Finger Transcription Factor), a core component of th

277 Depletion of Bptf (bromodomain PHD finger transcription factor), the largest NURF subun

278 A fusion protein in which the ING2 PHD finger was linked to the LEDGF IBD directed integrat

279 ging the polybasic regions between different PHD fingers we show that this region is a strong determi

280 the molecular basis of the integrated tandem PHD finger, which acts as one functional unit in the seq

281 antly, BP1 can directly bind DNA through its PHD finger, which might increase nucleosome residence an

282 Among these folds are PHD fingers, which are present in most chromatin modific

283 ins four highly conserved plant homeodomain (PHD) fingers, which are invariably deleted in oncogenic

284 s preceded by a tandem of plant homeodomain (PHD) fingers whose biological roles and requirements for

285 rated a direct interaction of the chick Pcl2 PHD finger with EZH2, a component of the ESC/E(Z) repres

286 mechanism of multivalent association of the PHD fingers with chromatin and reveal their critical rol

287 raction of the C-terminal plant homeodomain (PHD) finger with histone H3 trimethylated at Lys4 (H3K4m

288 l beta-sheet formation on the surface of the PHD finger, with the long side chains of arginine 2 (R2)

289 An AF10 region consisting of a PHD finger-Zn knuckle-PHD finger (PZP) folds into a sing