ライフサイエンスコーパス: PLP

1 PLP concentrations were inversely associated with glucos

2 PLP has also been reported to bind tightly at a secondar

3 PLP is restricted proximally by limiting its mRNA and pr

4 PLP ratings were obtained throughout the week after stim

5 PLP relief associated with reduced activity in the S1/M1

6 PLP synthase (PLPS) is a remarkable single-enzyme biosyn

7 PLP was used as direct biomarker for vitamin B-6 status,

8 PLP, a highly reactive aldehyde, poses a problem for cel

9 PLP, pyridoxal, pyridoxic acid (PA), 3-hydroxykynurenine

10 PLP-1 orthologs localized on RNA granules may similarly

11 PLP-150Q mice show progressive neurological symptoms and

12 PLP-dependent enzymes optimize specific chemical reactio

13 PLP-derived RNA was detected in the cytoplasm of the Hep

14 PLP-SYN and age-matched wild-type mice were treated for

15 homolog (bacterial), PROSC, which encodes a PLP-binding protein of hitherto unknown function.

16 Another disrupts a gene encoding a PLP phosphatase, thus preserving PLP levels.

17 ents of glutamic acid decarboxylase (GAD), a PLP-dependent enzyme synthesizing the neurotransmitter g

18 t this cysteine-thiol lyase (C-T lyase) is a PLP-dependent enzyme that moved horizontally into a uniq

19 o an aminoacrylate intermediate as part of a PLP-catalyzed beta-replacement reaction.

20 say is based on fast imine metathesis with a PLP aryl imine probe to capture the target compound for

21 the inactive SHMT2 dimer-and not the active PLP-bound tetramer-binds and inhibits BRISC.

22 ind, and sham-controlled design to alleviate PLP via task-concurrent NIBS over the primary sensorimot

23 aled an array of different preferences among PLPs.

24 TBSs, retinyl esters, some carotenoids, and PLP differed by village site.

25 complexation between the capped beta-CD and PLP/Py.

26 ctrochemical and fluorescence detection, and PLP is analyzed by HPLC with fluorescence detection.

27 in formation of the second intermediate and PLP.

28 stably decrease the levels of Plp1 mRNA and PLP protein throughout the neuraxis in vivo.

29 0-10) pain scores for residual limb pain and PLP at 1 year.

30 e of the vitamin B6 pathway at both PDXK and PLP levels recapitulated PDXK disruption effects.

31 ical performance for the detection of Py and PLP by a square wave stripping voltammetric technique (S

32 crog L(-1) and 0.043 microg L(-1) for Py and PLP, respectively, at signal to noise ratio of 3.

33 synthesize specific MIP cavities for Py and PLP.

34 the WDR1 KD phenotype of megakaryocytes and PLPs.

35 als with germlines variants of CDH1 that are PLP had histopathologic evidence for DGC on endoscopy an

36 Vitamin B-6 deficiency was defined as PLP <20 nmol/L, and insufficiency as PLP 20-30 nmol/L.

37 ined as PLP <20 nmol/L, and insufficiency as PLP 20-30 nmol/L.

38 Notably, the association was strongest at PLP concentrations < ~20 nmol/L, a recognized threshold

39 ures of the Eb/O-PLP-AFPA complex and Asp-AT-PLP-AFPA complex revealed that GabR is incapable of faci

40 methasone was co-delivered with autoantigen (PLP) in vivo to create effective ASIT for the treatment

41 The observed correlation between PLP relief and decreased S1/M1 activity confirms our pre

42 re that the external aldimine formed between PLP and GABA is apparently responsible for triggering th

43 We evaluated the vitamin B-6 biomarkers PLP, pyridoxal, and pyridoxic acid (PA) and the pyridoxi

44 While plants can biosynthesize PLP de novo, they also have salvage pathways that serve

45 Insight into the mechanisms underlying both PLP and NIBS-induced PLP relief is needed for future imp

46 g at the active site is heavily hampered but PLP binding is preserved.

47 rtoire of reactions that can be catalyzed by PLP-dependent enzymes.

48 We identified 20 carriers of germline CDH1 PLP variants; they underwent endoscopic examinations and

49 rticular, PLP(178-191)-specific CD8 T cells (PLP-CD8) robustly suppress the MS mouse model experiment

50 compared vitamin B-6 intake and circulating PLP concentrations of RTRs with those of healthy control

51 ontributed to the explanation of circulating PLP in multivariable-adjusted regression models.

52 In contrast, PLP(ECD) induced EAE not only in WT mice, but in B cell-

53 y (IQR: 4.8-6.1 y) and 297 healthy controls, PLP, plasma 3-hydroxykynurenine (3-HK), and xanthurenic

54 dies is the first insight into a coronavirus PLP's interface with ISG15 via SARS-CoV PLpro in complex

55 the distinct specificities among coronavirus PLPs observed and addresses a critical gap of how PLPs c

56 isease virus leader protease and coronavirus PLPs, which act as deubiquitinating and deISGylating (in

57 e to the recognition of ISG15 by coronavirus PLPs at a structural and biochemical level are poorly un

58 Critically, PLP relief and reduced S1/M1 activity correlated with pr

59 inhibition reduced fibrinogen binding of d12 PLPs.

60 Further, we found that IFN-gammaR-deficient PLP-CD8 exhibited altered granzyme/IFN-gamma profiles, a

61 -gammaR-deficient mice, IFN-gammaR-deficient PLP-CD8 exhibited suboptimal suppression in WT mice.

62 d with WT counterparts, IFN-gammaR-deficient PLP-CD8 were defective in suppressing disease in IFN-gam

63 inding experiments, which revealed different PLP-binding stoichiometries with WT and mutant PNPOx for

64 lem for cells, which is how to supply enough PLP for apoenzymes while maintaining free PLP concentrat

65 dominant myelin proteolipid protein epitope (PLP(178-191)) elicited identical EAE in WT and muMT mice

66 wever, cultured fibroblasts showed excessive PLP accumulation.

67 Finally, PLP and HKr demonstrated highly sex-specific and corrobo

68 The padlock probe-lateral flow (PLP-LF) test is the first of its kind and can ideally be

69 Plasma folate, PLP, and vitamin B-12 concentrations were categorized di

70 to a new subfamily of alanine racemase-fold PLP-dependent decarboxylases that are not involved in po

71 talytic activity and/or reduced affinity for PLP precursors which justify this behavior.

72 ird compared with the first quartile and for PLP sufficiency compared with deficiency [OR: 0.60 (95%

73 lated relative and absolute risks of CRC for PLP and the ratios 3-hydroxykynurenine:XA (HK:XA), an in

74 PDXK kinase activity is required for PLP production and AML cell proliferation, and pharmacol

75 el analysis, difference in change scores for PLP was significantly greater in the TMR group compared

76 ens new avenues for developing treatment for PLP and related pain conditions.

77 reacts with the second intermediate to form PLP.

78 gh PLP for apoenzymes while maintaining free PLP concentrations low enough to avoid unwanted reaction

79 to undergo product inhibition resulting from PLP binding at the active site.

80 Individuals from 13 families with germline PLP variants of CDH1 were evaluated at the Michigan Medi

81 mperature neutron structure of a homodimeric PLP-dependent enzyme, aspartate aminotransferase, which

82 observed and addresses a critical gap of how PLPs can interact with ISG15s from a wide variety of spe

83 on pain in major limb amputees, TMR improved PLP and trended toward improved residual limb pain compa

84 In intention-to-treat analysis, changes in PLP scores at 1 year were 3.2 versus -0.2 (difference 3.

85 1.7- to 2.9-fold more specific to changes in PLP than a previously proposed marker, HK:xanthurenic ac

86 VX-765 prevented motor deficits in PLP-SYN mice compared with placebo controls.

87 ly, plasma levels of metabolites involved in PLP-dependent reactions, such as the kynurenine pathway,

88 BS can alleviate neuropathic pain (including PLP), both disease and treatment mechanisms remain tenuo

89 hanisms underlying both PLP and NIBS-induced PLP relief is needed for future implementation of such t

90 LM-PLP infection preferentially induced PLP-specific CD8 T-cell responses.

91 sinins with the substrate pyridoxal inhibits PLP biosynthesis as demonstrated by kinetic measurements

92 The key enzyme CndF is PLP-dependent and catalyzes the synthesis of (S)-2-amino

93 phosphorylation disrupts Pfn1 binding to its PLP-containing ligands with little effect on actin bindi

94 f 5-ethynyluridine (EU) and added EU-labeled PLPs to HepG2 cells.

95 ivity confirms our previous findings linking PLP with increased S1/M1 activity.

96 t carcinogenic and non-tumour primary liver (PLP) cells.

97 LM-PLP infection preferentially induced PLP-specific CD8 T-

98 rotein peptide (PLP) amino acids 178-191 (LM-PLP).

99 he induction of PLP-specific CD8 T-cells, LM-PLP infection did not result in disease.

100 In fact, LM-PLP infection resulted in significant amelioration of PL

101 Importantly, infection with LM-PLP ameliorated established disease.

102 We hypothesized that a longer PLP antigen may better engage B cells and designed a pep

103 via reduced PDXK enzymatic activity and low PLP.

104 tment cerebrospinal fluid samples showed low PLP concentrations and evidence of reduced activity of P

105 izures and lethality are associated with low PLP levels and can be rescued by ubiquitous expression o

106 g worse functional vitamin B-6 status.Median PLP, 3-HK, and XA concentrations were 41 nmol/L (IQR: 29

107 d a catalytic site characteristic of minimal PLP catalytic domains.

108 sterior insula, as well as S2, in modulating PLP.

109 Lastly, our novel PLP intervention using task-concurrent NIBS opens new av

110 omparison between the structures of the Eb/O-PLP-AFPA complex and Asp-AT-PLP-AFPA complex revealed th

111 urotransmitter stimulation in the absence of PLP and GluR2 or when alphav integrin levels were reduce

112 trations and evidence of reduced activity of PLP-dependent enzymes.

113 tion: in this protocol, only the analysis of PLP requires mixing with trichloroacetic acid to release

114 acellular homeostasis and bioavailability of PLP.

115 identified increasing numbers of carriers of PLP variants in CDH1 who lack a family history of DGC.

116 s of endoscopic surveillance for carriers of PLP variants of CDH1 with and without family history of

117 Low concentrations of PLP are associated with rheumatic, cardiovascular, and n

118 r variation in circulating concentrations of PLP influences long-term outcome.We compared vitamin B-6

119 em cells to restore myelin in the context of PLP overexpression.

120 A deficiency of PLP can present, therefore, as seizures and other sympto

121 Deficiency of PLP in the brain can be caused by inborn errors affectin

122 this data indicated that the co-delivery of PLP and dexamethasone with a water-in-oil emulsion is ef

123 Furthermore, disruption of PLP-dependent enzymes ODC1 or GOT2 selectively inhibited

124 ompassing the extracellular domains (ECD) of PLP.

125 structural waters, is located at the edge of PLP opposite the reactive Schiff base.

126 Here, we report the identification of PLP-1, a Caenorhabditis elegans protein related to the h

127 amine biosynthesis, indicating impairment of PLP-dependent enzymatic activities.

128 B6 vitamer metabolism or by inactivation of PLP, which can occur when compounds accumulate as a resu

129 Despite the induction of PLP-specific CD8 T-cells, LM-PLP infection did not resul

130 reated with a single injection (10 mg/kg) of PLP-LCL or empty LCL as a control.

131 Intracellular levels of PLP regulate the interaction between BRISC and SHMT2, as

132 -positive neurons in the substantia nigra of PLP-SYN mice.

133 rotonation state of the pyridine nitrogen of PLP, which affects the rates of catalysis.

134 Ectopic positioning of PLP to more distal portions of the centriole is sufficie

135 molecular probe to examine the reactivity of PLP in both GabR and a homologous aspartate aminotransfe

136 d in intracellular homeostatic regulation of PLP, supplying this cofactor to apoenzymes while minimiz

137 indicates a previously unrecognized role of PLP binding in Pfn1 antitumor effects.

138 tions by modulating the electronic states of PLP through distinct active site environments.

139 tions by modulating the electronic states of PLP through weak interactions in the active site.

140 tion by reducing its load in the striatum of PLP-SYN mice.

141 partly due to an incomplete understanding of PLP-related disease mechanisms.

142 walk independently during the first year of PLP normalization.

143 Therefore, the activity of PLPs from SARS-CoV, MERS-CoV, and mouse hepatitis virus

144 ct on megakaryopoiesis and the generation of PLPs.

145 We have recently shown that this depends on PLP-CD8 elaborating IFN-gamma and perforin in a coordina

146 he protonation states of ionizable groups on PLP and the reacting substrates and underscore the essen

147 ind that a deprotonated pyridine nitrogen on PLP precludes formation of a true quinonoid species and

148 ion of the efficacy of this trigger in other PLP-enzyme active sites.

149 er of functional vitamin B-6 status, and PA:(PLP + pyridoxal) (PAr), a marker of inflammation and oxi

150 Phantom limb pain (PLP) is notoriously difficult to treat, partly due to an

151 -related residual limb or phantom limb pain (PLP).

152 that platelets and platelet-like particles (PLPs) derived from the megakaryoblastic cell line MEG-01

153 ved a population of platelet-like particles (PLPs) in the infusate, which include platelets released

154 Platelet-like particles (PLPs) produced by WDR1 KD cells were fewer in number but

155 n expression of d12 platelet-like particles (PLPs), whereas p38 inhibition reduced fibrinogen binding

156 s coassembled into procapsid-like particles (PLPs).

157 es assembly of P22 procapsid-like particles (PLPs).

158 reatment to produce platelet-like-particles (PLPs).

159 In particular, PLP(178-191)-specific CD8 T cells (PLP-CD8) robustly sup

160 carriers of pathogenic or likely pathogenic (PLP) germline variants of CDH1.

161 s (LM) encoding proteolipid protein peptide (PLP) amino acids 178-191 (LM-PLP).

162 ctivates a number of pyridoxal 5'-phosephate(PLP)-dependent enzymes, some of which have been linked t

163 ting concentrations of pyridoxal-5-phospate (PLP) in renal transplant recipients (RTRs).

164 on interactions with pyridoxal-5'-phosphate (PLP) and GABA, and thereby promotes the biosynthesis of

165 B(6) cofactors like pyridoxal 5'-phosphate (PLP) and pyridoxal (Py) by forming host-guest inclusion

166 ma concentrations of pyridoxal 5'-phosphate (PLP) are common in renal transplant recipients (RTRs) an

167 metabolism, and uses pyridoxal-5'-phosphate (PLP) as a cofactor.

168 ntified by measuring pyridoxal 5'-phosphate (PLP) concentrations in a DBS before and after a 30 min i

169 DXK activity and low pyridoxal 5'-phosphate (PLP) concentrations.

170 athway that produces pyridoxal 5'-phosphate (PLP) from glutamine, ribose 5-phosphate, and glyceraldeh

171 Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung cancer risk.

172 e vitamin B-6 marker pyridoxal 5'-phosphate (PLP) have been associated with reduced colorectal cancer

173 e essential cofactor pyridoxal 5'-phosphate (PLP) in Escherichia coli Surprisingly, incubation of the

174 outinely measured as pyridoxal 5'-phosphate (PLP) in plasma.

175 Pyridoxal 5'-phosphate (PLP) is a fundamental, multifunctional enzyme cofactor u

176 ate aminotransferase.Pyridoxal 5'-phosphate (PLP) is a ubiquitous co factor for diverse enzymes, amon

177 Pyridoxal-5'-phosphate (PLP) is introduced to a biomimetic indicator displacemen

178 d among these plasma pyridoxal 5'-phosphate (PLP) is most commonly used.

179 in uses the cofactor pyridoxal 5'-phosphate (PLP) to abstract sulfur from free cysteine, resulting in

180 pyridoxine (Py) and pyridoxal-5'-phosphate (PLP) using the same MIP format.

181 n B-6 in the form of pyridoxal 5'-phosphate (PLP), and total B-12 with serum TC, LDL-C, HDL-C, and TG

182 s a dimer that binds pyridoxal-5'-phosphate (PLP), apparently without a solvent-exposed Schiff base.

183 tatus marker, plasma pyridoxal 5'-phosphate (PLP), decreases during inflammation; therefore, causal r

184 e pathway to produce pyridoxal 5'-phosphate (PLP), the active form of the vitamin, which is implicate

185 Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, functions as a cofa

186 vitamin B6 (VB6) to pyridoxal 5'-phosphate (PLP), the biologically active form of VB6 and involved i

187 li, the synthesis of pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B(6), tak

188 ficiency of cellular pyridoxal 5'-phosphate (PLP), which is the coenzyme form of vitamin B-6, may imp

189 y includes conserved pyridoxal 5'-phosphate (PLP)-binding proteins that play a critical role in the h

190 nhibition of BioA, a pyridoxal 5'-phosphate (PLP)-dependent aminotransferase.

191 me biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent and reversible reaction between glycine a

192 diation of the plant pyridoxal 5'-phosphate (PLP)-dependent aromatic l-amino acid decarboxylase (AAAD

193 ex is a low-activity pyridoxal 5'-phosphate (PLP)-dependent cysteine desulfurase enzyme that consists

194 catalytic cascade, a pyridoxal 5'-phosphate (PLP)-dependent enzyme (Fub7), and a flavin mononucleotid

195 erase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, the principal

196 , a highly conserved pyridoxal 5'-phosphate (PLP)-dependent enzyme, present in different isoforms in

197 o acids performed by pyridoxal-5'-phosphate (PLP)-dependent enzymes.

198 rated that AbmH is a pyridoxal 5'-phosphate (PLP)-dependent transaldolase that catalyzes a threo-sele

199 The pyridoxal 5'-phosphate (PLP)-dependent transaminase BioA catalyzes the second st

200 hich is the cofactor pyridoxal 5'-phosphate (PLP).

201 Enzymes dependent on pyridoxal 5'-phosphate (PLP, the active form of vitamin B6) perform a myriad of

202 tween plasma folate, pyridoxal 5'-phosphate (PLP; the biologically active form of vitamin B-6), and v

203 This pyridoxal 5-phosphate (PLP)-dependent reaction is mediated by the enzyme serine

204 mes (LCL) containing prednisolone phosphate (PLP-LCL) in a mouse model of arthritis.

205 an enzyme that produces pyridoxal phosphate (PLP) from vitamin B6-as an acute myeloid leukemia (AML)-

206 pterins and vitamin B6 (pyridoxal phosphate (PLP))) in human cerebrospinal fluid (CSF) can be used as

207 eline serum riboflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flavin mononucleotide (FM

208 Pyridoxal phosphate (PLP)-dependent enzymes can catalyze transformations of l

209 ited diseases involving pyridoxal phosphate (PLP)-dependent enzymes, including primary hyperoxaluria

210 namine produced by some pyridoxal phosphate (PLP)-dependent enzymes.

211 ation and production of pyridoxal phosphate (PLP).

212 in B6 (also known as pyridoxal 5'-phosphate [PLP]), in complex with artesunate at 2.4- angstrom resol

213 Plasma PLP (AMI patients only) and PA predicted all-cause morta

214 Plasma PLP and vitamin B-12 concentrations were not associated

215 baseline vitamin B-6 was measured as plasma PLP by high-performance liquid chromatography (HPLC).

216 Vitamin B-6 deficiency as measured by plasma PLP is associated with a clear increase in CRC risk.

217 nowledge, it is not known whether low plasma PLP concentrations have functional (i.e., intracellular)

218 In these groups, the median plasma PLP concentrations were 29 nmol/L (17-50 nmol/L) and 41

219 tality.We assessed the association of plasma PLP with functional vitamin B-6 status and explored the

220 onal and longitudinal associations of plasma PLP with Kyns were estimated using linear and nonlinear

221 lementation increased the mean +/- SD plasma PLP concentration from 25.8 +/- 3.6 to 143 +/- 58 nmol/L

222 inverse marker of vitamin B-6 status.Plasma PLP concentrations were associated with a reduced CRC ri

223 termed HK ratio (HKr), was related to plasma PLP with standardized regression coefficients (95% CIs)

224 A ratio was inversely associated with plasma PLP (beta = -0.21, P < 0.001).

225 estigated using pulsed-laser polymerization (PLP) and high-resolution mass spectrometry.

226 here a previously unknown class of potential PLP enzyme inactivators; namely, a family of quaternary,

227 encoding a PLP phosphatase, thus preserving PLP levels.

228 irst H5N1 target hybrids with padlock probe (PLP) and then PLP is circularized upon the action of T4

229 ffective combination of a (1) padlock probe (PLP)-mediated rolling circle amplification (RCA) bioassa

230 sphorylation site within the poly-l-proline (PLP) binding pocket.

231 ity to torovirus (ToV) papain-like protease (PLP) (ToV-PLP).

232 ron (IFN) antagonists, papain-like protease (PLP) and N protein.

233 uctural studies of the papain-like protease (PLP) domains of coronaviruses (CoVs) revealed an adjacen

234 ncode multifunctional papain-like proteases (PLPs) that have the ability to process the viral polypro

235 the restriction of pericentrin-like protein (PLP) and the pericentriolar material (PCM) to the proxim

236 ecedented role for Pericentrin-like protein (PLP), which localizes to the tips of extended Cnn flares

237 proteins include myelin proteolipid protein (PLP) and axon-enriched proteins involved in mitochondria

238 on of protein levels of proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG), the

239 ell compartments of the proteolipid protein (PLP) expressed in COS-7 cells.

240 , the gene that encodes proteolipid protein (PLP), result in failure of myelination and neurological

241 yelin-specific protein, proteolipid protein (PLP), was unaltered.

242 ely, Tsc1 deletion from proteolipid protein (PLP)-positive oligodendrocytes slowed remyelination.

243 d as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during in

244 cid (PA) and the pyridoxic acid:(pyridoxal + PLP) ratio (PAr), a proposed marker of vitamin B-6 catab

245 a general acid to advance the Cys-quinonoid PLP intermediate, as a nucleophile to form an NFS1 persu

246 of unknown etiology characterized by reduced PLP levels.

247 reased polyploidy, and significantly reduced PLP counts.

248 of intervention NIBS significantly relieved PLP, with effects lasting at least 1 week.

249 ether from promiscuous enzymes that restores PLP synthesis in strain JK1.

250 iency, which was confirmed by very low serum PLP concentrations.

251 or significantly affecting protein stability/PLP-binding.

252 ease in lysosome exocytosis and cell surface PLP levels.

253 protection in proteolipid protein alpha-syn (PLP-SYN) mice, a transgenic mouse model of MSA.

254 D cells were fewer in number but larger than PLPs produced from unmodified MEG-01 cells, and had sign

255 We demonstrate here that PLP(ECD)-immunized B cell-deficient mice failed to exhib

256 onstrate, through kinetic measurements, that PLP inhibition is actually of a mixed-type nature and re

257 t with both RNA and protein, we propose that PLP-1 couples certain RNAs with their protein partners i

258 Our results reveal that PLP-1 functions downstream of small RNA biogenesis durin

259 of germ granules in C. elegans We show that PLP-1 is essential for silencing different types of tran

260 sulted in visible turbidity, suggesting that PLP is being produced by some alternative pathway.

261 e, and all 4 products formed directly by the PLP-dependent enzymes kynurenine transaminase and kynure

262 amino acid configuration is catalyzed by the PLP-dependent epimerase AbmD.

263 ion induces electronic delocalization in the PLP, which correlates with the enhancement in catalytic

264 In one monomer, the PLP remained as an internal aldimine with a deprotonated

265 ism concluding with covalent labeling of the PLP cofactor.

266 The solid-state NMR chemical shifts of the PLP pyridine ring nitrogen and additional sites, coupled

267 is coupled to the pyridinyl nitrogen of the PLP, influencing the electrophilicity of the cofactor.

268 es focused primarily on the formation of the PLP-alphav integrin-AMPA receptor complex in vivo and wh

269 he rate-limiting step of inactivation of the PLP-dependent enzyme BioA by dihydro-(1,4)-pyridone 1.

270 onine beta-synthase (CBS) are members of the PLP-II family, and involved in L-cysteine production.

271 previously identified as a new member of the PLP-II family, which are predominantly seen in bacteria.

272 logue in the beta-subunit active site of the PLP-requiring enzyme tryptophan synthase.

273 et hybrids with padlock probe (PLP) and then PLP is circularized upon the action of T4 ligase enzyme.

274 ogress, the stepwise mechanism by which this PLP-dependent enzyme operates remains unclear.

275 Thus, PLP activation is controlled by the proximity of the pyr

276 s pyridoxine 5'-phosphate (PNP) oxidation to PLP, catalyzed by the FMN-dependent enzyme PNP oxidase (

277 Using reverse genetics, we generated a ToV-PLP knockout recombinant virus.

278 ntly, we demonstrated that the exogenous ToV-PLP gene that was inserted into the EVG genome encodes a

279 gain fitness through the acquisition of ToV-PLP from a recombination event.IMPORTANCE Enteroviruses

280 ovirus (ToV) papain-like protease (PLP) (ToV-PLP).

281 Importantly, the recombinant ToV-PLP protein derived from this novel enterovirus also sho

282 These results suggest that ToV-PLP functions as an innate immune antagonist; enteroviru

283 Compared to the wild-type virus, the ToV-PLP knockout mutant virus showed impaired growth and ind

284 hway utilizes Thi5, a novel enzyme that uses PLP as a substrate.

285 in maintenance, because their ablation using PLP-CreERT resulted in hindlimb paralysis with immobilit

286 a, SER, and MTs in rodent optic nerves where PLP is replaced by the peripheral nerve myelin protein,

287 s as a dimer with unknown functions, whereas PLP binding stabilizes the active tetrameric state.

288 ased intracellular Ca(2+) signaling, whereas PLP null OPCs did not reduce GluR2 at the cell surface o

289 ain metabolic contexts and diseases in which PLP levels are reduced, the presence of these PDXK varia

290 n via formation of an external aldimine with PLP.

291 Treatment of CIA with PLP-LCL significantly suppressed joint swelling.

292 NP disrupts the GCV system by competing with PLP in GcvP protein.

293 ed the clinical and biochemical profile with PLP supplementation in 1 family, improvement in power, p

294 the biochemical profile can be rescued with PLP supplementation associated with clinical improvement

295 s and other symptoms that are treatable with PLP and/or pyridoxine.

296 in which the only IFN-gamma available to WT PLP-CD8 is that which they produce themselves.

297 study, we show that although wild-type (WT) PLP-CD8 were robustly suppressive in IFN-gammaR-deficien

298 the fluorescence response of the probes ZnO@PLP and ZnO@Py showed good linearity to histidine concen

299 The cofactors decorated QDs (ZnO@PLP and ZnO@Py) were applied for the sensing of BAs.

300 Addition of histamine to the ZnO@PLP and ZnO@Py solution resulted selective fluorescence