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1                                              PNEC cell lines should be generally useful for genetic a
2                                              PNEC-enriched cultures were generated from human induced
3                                              PNECs are an extraordinarily rich and diverse signaling
4                                              PNECs can be colabeled with alveolar cells during lung d
5                                              PNECs express mAsh1, a basic helix-loop-helix (bHLH) tra
6                        This revealed over 40 PNEC neuropeptide and peptide hormone genes, most cells
7                     Associated with aberrant PNEC innervation, the authors discovered that GABA hyper
8                             The lowest acute PNEC were observed for algae and invertebrates and corre
9                                 In addition, PNECs expressed NT4 as a target-derived mechanism underl
10 s concentration to 5% of species (HC(5)) and PNEC values for each group.
11 tion: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregatio
12                    Nearly half of calculated PNEC were below current PVs in practice in Brazil, Unite
13 te NE tumors and derived prostate NE cancer (PNEC) cell lines from a transgenic mouse model using a c
14 survival, we established prostate NE cancer (PNEC) cell lines from CR2-TAg prostate tumors and metast
15 xposure elevated the level of NT4 and caused PNEC hyperinnervation and nodose neuron hyperactivity.
16 triggers apical succinate receptors, causing PNECs to release ATP.
17 s function in pulmonary neuroendocrine cell (PNEC) differentiation has not been fully addressed.
18 l for primary pulmonary neuroendocrine cell (PNEC) hyperplasia/neoplasia using v-Ha-ras driven by the
19              Pulmonary neuroendocrine cells (PNEC) are rare airway epithelial cells that have recentl
20 ophages, and pulmonary neuroendocrine cells (PNEC).
21  of solitary pulmonary neuroendocrine cells (PNECs) and neuroepithelial bodies (NEBs) along the main
22              Pulmonary neuroendocrine cells (PNECs) are proposed to be the first specialized cell typ
23              Pulmonary neuroendocrine cells (PNECs) are rare airway cells with potential sensory capa
24              Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells that also unique
25              Pulmonary neuroendocrine cells (PNECs) are sensory epithelial cells that transmit airway
26              Pulmonary neuroendocrine cells (PNECs) are the only innervated airway epithelial cells.
27 ated to form pulmonary neuroendocrine cells (PNECs), a putative cell of origin for neuroendocrine-pos
28 expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population.
29 th increased pulmonary neuroendocrine cells (PNECs), excess PNEC-derived neuropeptides are responsibl
30 ells to form pulmonary neuroendocrine cells (PNECs), putative precursors to small cell lung cancers (
31 cells, and 'pulmonary neuroendocrine cells' (PNECs) - are obscure.
32                                Characterized PNEC cultures were exposed to HDM extract, a volatile ch
33  proposed Predicted No-Effect Concentration (PNEC) and the Environmental Quality Standard (EQS) for M
34 on of the Predicted No Effect concentration (PNEC).
35            Treatment of nude mice containing PNEC tumor xenografts with (i) amiloride, a diuretic tha
36 ioavailability into consideration to correct PNEC for local conditions.
37 argeted inactivation of Ctnnb by Nkx2.1-cre, PNEC differentiation was not interrupted.
38 ms (algae, invertebrates and fish) to derive PNEC values for the 14 metals most commonly observed in
39 wed that nitrosamine treated rodents develop PNEC hyperplasia but non-NE lung tumors, with variable o
40  that SCLC can originate from differentiated PNECs.
41 rcinomas, with rascal mRNA in differentiated PNECs and tumor cells.
42                                We discovered PNECs located within pig and human submucosal glands, a
43 ons of sensors we show are expressed by each PNEC.
44 lmonary neuroendocrine cells (PNECs), excess PNEC-derived neuropeptides are responsible for pulmonary
45  KRAS or EGFR genes did not induce or expand PNECs, but tumors resembling early-stage SCLC grew in im
46 area covered by NEBs composed of 20 or fewer PNECs was significantly enlarged after naphthalene treat
47                                     Finally, PNEC values obtained in this study may be used for ecolo
48 ormation, Wnt signaling is not essential for PNEC differentiation; however, its over-activation promo
49                                          How PNECs sense and respond to external stimuli remains poor
50 stablish the foundation of investigating how PNECs contribute to lung homeostasis, injury/repair, and
51 ion methods, and little is known about human PNEC function in response to asthma-relevant stimuli.
52 ate a previously unrecognized role for human PNEC in mediating a direct neuroendocrine response to ae
53 eveloped and characterized an in vitro human PNEC model and investigated the neuroendocrine response
54 profile hundreds of the rare mouse and human PNECs.
55                                 Importantly, PNECs have long been speculated to constitute the cells
56 as enabled us to manipulate gene activity in PNECs.
57 (CGRP) locus that encodes a major peptide in PNECs.
58 used to ablate multiple tumor suppressors in PNECs that were simultaneously labeled for following the
59 ll lung cancers (SCLCs), and we can increase PNECs by reducing levels of retinoblastoma (RB) proteins
60 essor genes TP53 and RB1 allowed the induced PNECs to form subcutaneous growths in immune-deficient m
61 ested that early deletion of Nkx2.1 inhibits PNEC differentiation, while late repression does not.
62 lung development, and following lung injury, PNECs can contribute to Clara cells and ciliated cells.
63 r, these studies provide unique insight into PNEC lineage and function and establish the foundation o
64 al crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm.
65                          Targeting the nerve-PNEC axis may be a valid treatment strategy for mucus ov
66 s overproduction and changes along the nerve-PNEC axis without any defects in inflammation.
67 y-state immune cells and innervating nerves, PNECs, as prototype tissue-resident neuroendocrine cells
68 y of local cell targets, and we show the new PNEC signal angiotensin directly activates one subtype o
69 ber, targets, functions, and conservation of PNEC signals are largely unknown.
70 tem that permits tracing the early events of PNEC transformation has not been available.
71 ficient mice after subcutaneous injection of PNEC-containing cultures in which expression of both RB
72       We have characterized a novel model of PNEC-enriched human airway epithelium and utilized this
73 fectively attenuated by either prevention of PNEC formation, inactivation of CGRP gene, endothelium-s
74 dence for NT4-dependent neural regulation of PNEC secretion of GABA in a neonatal disease model.
75 so may have endocrine activity like those of PNEC-derived carcinoid tumors.
76 rrent model, we observed that elimination of PNECs has no apparent consequence on Clara cell recovery
77 ion in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers inc
78 o identify the location, size, and number of PNECs and NEBs in the airways.
79 g using this tool revealed the plasticity of PNECs.
80                  Single-cell RNA profiles of PNECs are heterogeneous; when RB levels are reduced, the
81                          Although studies of PNECs have suggested their involvement in a number of lu
82                                         Once PNEC were derived, a framework was proposed to calculate
83 arly life allergen exposure by orchestrating PNEC innervation and secretion of GABA.
84  In particular, we prove that summing up PEC/PNEC ratios might serve as a justifiable CA-approximatio
85 ation; however, its over-activation promotes PNEC features.
86 dings identify a local circuit in which rare PNECs within submucosal glands sense an environmental cu
87  To what extent neural innervation regulates PNEC secretion and function is unknown.
88                            However, studying PNEC function in humans has been challenging due to a la
89 a corroborate this role and demonstrate that PNECs are important for lung response to signals, such a
90                                We found that PNECs were the only cellular source of GABA in airways.
91 s, and as xenografted tumors, indicated that PNECs express consistent features ex vivo and in vivo an
92                  We demonstrate in vivo that PNECs act as precise airway sensors that elicit immune r
93                                          The PNEC number per square millimeter was also increased mor
94              These findings suggest that the PNEC and neuropeptide abnormalities documented in a wide
95                                        These PNECs sense succinate, an inflammatory molecule in liqui
96                                   Similar to PNEC in normal lung, Uchl1(positive) cells were innervat
97               NECs have also been likened to PNECs, which differentiate in situ within lung airway ep
98 NT4 as a target-derived mechanism underlying PNEC innervation during development.
99                                           WD-PNECs and WD-PBECs were generated from nasal and bronchi
100                                           WD-PNECs may provide an authentic surrogate model with whic
101 ogenesis and proinflammatory responses in WD-PNECs compared with WD-PBECs that reproduce many hallmar
102 l-differentiated primary pediatric nasal (WD-PNECs) and bronchial epithelial cells (WD-PBECs).

 
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