ライフサイエンスコーパス: PPAR-gamma

1 PPAR gamma is required for fat cell development and is t

2 PPAR-gamma agonists modulate NF-kappaB-dependent inflamm

3 PPAR-gamma agonists reduce inflammation, in part, throug

4 PPAR-gamma agonists, like pioglitazone, appear antiprote

5 PPAR-gamma agonists, such as rosiglitazone, may therefor

6 PPAR-gamma agonists, the thiazolidinediones, are clinica

7 PPAR-gamma and RXR-alpha form a non-symmetric complex, a

8 PPAR-gamma coactivator (PGC)-1alpha, a known regulator o

9 PPAR-gamma expression in AM was critical for the suppres

10 PPAR-gamma has been shown to act on both fronts, reducin

11 PPAR-gamma is the target of the thiazolidinedione (TZD)

12 PPAR-gamma ligands abrogated these effects.

13 in macrophages and T cells in vivo through a PPAR gamma-dependent mechanism.

14 rostaglandin E(2) and MCP-1 production via a PPAR gamma-dependent mechanism possibly involving activa

15 ic epithelium with 5-amino salicylic acid, a PPAR-gamma (peroxisome proliferator-activated receptor g

16 Ciglitazone, a PPAR-gamma agonist with anti-inflammatory properties, wa

17 Here we show that rosiglitazone, a PPAR-gamma agonist, rescued the dendrites and dendritic

18 Rosiglitazone (RSG), a PPAR-gamma agonist, has been shown to reduce inflammatio

19 tazone, in a manner inhibited by T0070907, a PPAR-gamma antagonist that also inhibited the ACEA effec

20 PPAR-alpha-dependent metabolism and abnormal PPAR-gamma pathway in beating embryoid bodies (EBs) with

21 IL-10R blockage abolished PPAR-gamma-mediated inhibition of MyD88 expression.

22 n factor known to interact with and activate PPAR-gamma and NF-kappaB, is suppressed in the glomerula

23 cyte differentiation and partially activated PPAR gamma target genes involved in adipogenesis and, at

24 Therefore, microbiota-activated PPAR-gamma signaling is a homeostatic pathway that preve

25 mediated by the transcriptional co-activator PPAR-gamma co-activator-1 alpha (PGC1-alpha).

26 ike HL-60 cells with a constitutively active PPAR-gamma construct.

27 ipocyte differentiation in part by affecting PPAR gamma activity.

28 ferator-activated receptor-gamma and -alpha (PPAR-gamma/-alpha) in the NTS and NG in HFD rats were ma

29 FAS, PPAR-alpha, PPAR-gamma, and CB1-R were markedly altered in WT-FF.

30 Treatments that activate PPAR-alpha, PPAR-gamma, and PPAR-delta alone or in combination have

31 tor-activated receptors (PPARs), PPAR-alpha, PPAR-gamma, and PPAR-delta.

32 duced TauNuF-alpha release, it did not alter PPAR-gamma expression.

33 -6, and FIV RNA detection in brain, although PPAR-gamma in glia was increased compared with PBS-treat

34 ctivities were enhanced by n-3 LDL, DHA, and PPAR gamma agonist, whereas activity of a luciferase gen

35 tor-activated receptor delta (PPARdelta) and PPAR gamma coactivator 1 alpha (PGC1alpha), key transcri

36 d safety profile, of the dual PPAR-alpha and PPAR-gamma agonist aleglitazar.

37 mice showed higher levels of PPAR-alpha and PPAR-gamma gene expression, elevated abundance of mitoch

38 on of TGF-beta signaling by cPLA(2)alpha and PPAR-gamma may represent an important mechanism for cont

39 ferator-activated receptor (PPAR)-alpha, and PPAR-gamma.

40 ptor gamma in luciferase reporter assay, and PPAR-gamma selective antagonist completely inhibited MDS

41 eceptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that

42 e expression of hepatocyte growth factor and PPAR-gamma, have been demonstrated in blacks with SSc, a

43 mers with the retinoid X receptor (RXR), and PPAR-gamma has been intensively studied as a drug target

44 tiation through direct regulation of ST2 and PPAR-gamma expression.

45 vascular endothelium, with decreased TJ and PPAR-gamma expression, and increased pulmonary macrophag

46 As PPAR-gamma is also expressed in neurons, we generated mi

47 the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein

48 ylation of histone H3 at Lys27 (H3K27me3) at PPAR-gamma chromatin.

49 ly, and 4) associated with reduction of both PPAR-gamma and catalase activity, which are reversed by

50 agonistic regulation of TGF-beta activity by PPAR-gamma ligands involves cellular PPAR-gamma, since 1

51 nt transcriptional responses were blocked by PPAR-gamma without preventing Smad2/3 activation.

52 Inhibition of chemotaxis by PPAR-gamma ligands correlated with decreases in extracel

53 n at the COL1A2 locus, were all prevented by PPAR-gamma.

54 paB promoter activity, which was reversed by PPAR-gamma agonist.

55 ying the abrogation of TGF-beta signaling by PPAR-gamma in normal human fibroblasts in culture.

56 ceptor-gamma (PPAR-gamma) ligand that causes PPAR-gamma dissociation from Smad2/3, allowing Smad2/3 a

57 In vascular endothelial cells, PPAR-gamma activation inhibits endothelial inflammation

58 In vascular smooth muscle cells, PPAR-gamma activation inhibits proliferation and migrati

59 vity by PPAR-gamma ligands involves cellular PPAR-gamma, since 15-deoxy-Delta12,14-prostaglandin J(2)

60 the concomitant down-regulation of cellular PPAR-gamma mRNA expression.

61 Blocking the endogenous activation of CNS PPAR-gamma with pharmacological antagonists or reducing

62 hat both acute and chronic activation of CNS PPAR-gamma, by either TZDs or hypothalamic overexpressio

63 nknown role for central nervous system (CNS) PPAR-gamma in the regulation of energy balance.

64 LPS treatment significantly decreased PPAR-gamma expression in vivo and in vitro and was assoc

65 activated receptor (PPAR)-alpha, PPAR-delta, PPAR-gamma, cd36/Fat, and Ucp2, which coincided with red

66 nents that control adipose cell development: PPAR-gamma, PGC1-alpha, and PRDM16.

67 atives were designed and synthesized as dual PPAR gamma agonist/angiotensin II antagonists for the po

68 part from reduced amounts of the endogenous PPAR-gamma ligand 15-keto-prostaglandin E(2) (15-keto-PG

69 ity, bind to PPAR-gamma and markedly enhance PPAR-gamma transcriptional activity.

70 y isolated human PMNs constitutively express PPAR-gamma, which is up-regulated by the sepsis-induced

71 ), a coactivator of the transcription factor PPAR-gamma that controls mitochondrial biogenesis and fu

72 We found that the transcription factor PPAR-gamma was downregulated following IAV infection in

73 elopment depends on the transcription factor PPAR-gamma; however, the environmental cues required for

74 and AMG131) as a potent selective ligand for PPAR gamma that is structurally and pharmacologically di

75 s important novel physiological function for PPAR-gamma in connective tissue homeostasis.

76 isome proliferator-activated receptor gamma (PPAR gamma) and lanthionine synthetase C-like 2 (LANCL2)

77 isome proliferator-activated receptor gamma (PPAR gamma).

78 isome proliferator-activated receptor gamma (PPAR gamma).

79 isome proliferator-activated receptor gamma (PPAR gamma; NR1C3) plays a central role in adipogenesis

80 isome proliferator-activated receptor-gamma (PPAR gamma) is a ligand-activated transcription factor o

81 isome proliferator-activated receptor gamma (PPAR-gamma) activation underlie the pathogenesis of ARVD

82 isome-proliferator-activated receptor gamma (PPAR-gamma) and downstream target genes were down-regula

83 isome proliferator-activated receptor gamma (PPAR-gamma) and glucose transporter 1 (GLUT-1) levels in

84 isome proliferator-activated receptor gamma (PPAR-gamma) and lower expression of the profibrogenic fa

85 isome proliferator-activated receptor gamma (PPAR-gamma) and thus counteracts Smad2/3-mediated inhibi

86 isome proliferator-activated receptor gamma (PPAR-gamma) expression.

87 isome proliferator-activated receptor gamma (PPAR-gamma) is a downstream target of sildenafil in the

88 isome proliferator-activated receptor gamma (PPAR-gamma) is an important regulator of uteroplacental

89 isome proliferator-activated receptor gamma (PPAR-gamma) is an important target in diabetes therapy,

90 isome proliferator-activated receptor gamma (PPAR-gamma) mRNA levels within the hypothalamus.

91 isome proliferator-activated receptor gamma (PPAR-gamma) possess anti-glial inflammation effects and

92 isome proliferator-activated receptor gamma (PPAR-gamma) protects against hypoxia-associated fetal gr

93 isome proliferator-activated receptor gamma (PPAR-gamma) signaling cascade using proteomics technolog

94 isome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated nuclear receptor that pr

95 isome proliferator-activated receptor gamma (PPAR-gamma), which is suppressed by HIV-1 replication.

96 isome proliferator-activated receptor gamma (PPAR-gamma)-dependent beta-oxidation of microbiota-deriv

97 isome proliferator-activated receptor gamma (PPAR-gamma).

98 isome proliferator-activated receptor gamma (PPAR-gamma).

99 isome proliferator-activated receptor-gamma (PPAR-gamma) abrogate the stimulation of collagen gene tr

100 isome proliferator-activated receptor-gamma (PPAR-gamma) agonist, rosiglitazone, an insulin sensitize

101 isome proliferator-activated receptor-gamma (PPAR-gamma) agonist, troglitazone, in a manner inhibited

102 isome proliferator-activated receptor-gamma (PPAR-gamma) agonists not only improve metabolic abnormal

103 isome proliferator-activated receptor-gamma (PPAR-gamma) and sterol regulatory element binding protei

104 isome proliferator-activated receptor-gamma (PPAR-gamma) expression both in vitro and in vivo during

105 isome proliferator-activated receptor-gamma (PPAR-gamma) in early proliferation and differentiation e

106 isome proliferator-activated receptor-gamma (PPAR-gamma) is a determinant of insulin sensitivity and

107 isome proliferator-activated receptor-gamma (PPAR-gamma) is a nuclear receptor that is activated by l

108 isome proliferator-activated receptor-gamma (PPAR-gamma) ligand that causes PPAR-gamma dissociation f

109 isome proliferator-activated receptor-gamma (PPAR-gamma) or the nuclear corepressor NCoR2.

110 isome proliferator-activated receptor-gamma (PPAR-gamma) protein were found in Acc2(-/-) mutant mice

111 isome proliferator-activated receptor-gamma (PPAR-gamma) systems and propose that these systems may r

112 isome proliferator-activated receptor-gamma (PPAR-gamma), a ligand-activated nuclear transcription fa

113 isome proliferator-activated receptor-gamma (PPAR-gamma), a master regulator of adipocyte differentia

114 isome proliferator-activated receptor-gamma (PPAR-gamma), may counterregulate inflammation in a tissu

115 isome proliferator-activated receptor-gamma (PPAR-gamma), which is induced by exposure to granulocyte

116 isome proliferator-activated receptor-gamma (PPAR-gamma).

117 isome proliferator-activated receptor-gamma (PPAR-gamma).

118 gulator peroxisome activator receptor-gamma (PPAR-gamma).

119 isome proliferator-activated receptor-gamma (PPAR-gamma, encoded by Pparg) function that contributes

120 unction dominant-negative mutations in human PPAR gamma cause insulin resistance and severe early ons

121 e derivative, showed the highest activity in PPAR gamma transactivation assay (69% activation) with n

122 ity between telmisartan and rosiglitazone in PPAR gamma active site, two classes of benzimidazole der

123 LPS challenge studies in PPAR gamma-expressing and immune cell-specific PPAR gamm

124 We postulated that DNA sequence variation in PPAR gamma (PPARG) co-activator 1 alpha (PPARGC1A), a ge

125 These studies reveal a reversible defect in PPAR-gamma signaling in Cftr-deficient cells that can be

126 Also, the increase in PPAR-gamma activity was reversed in the presence of PPAR

127 eated with pioglitazone showed reductions in PPAR-gamma (Ser-273) phosphorylation.

128 ression of lipid metabolism genes, including PPAR-gamma, by directly methylating their promoters.

129 ion of PPAR-gamma target genes and increased PPAR-gamma DNA-binding activity.

130 We found that IH increased PPAR-gamma activity and modulated the expression of PPAR

131 We demonstrate that ABA increases PPAR gamma reporter activity in RAW 264.7 macrophages an

132 equire the mTORC2/AKT/ACLY pathway to induce PPAR-gamma and establish the epigenetic landscape during

133 Microbiota-induced PPAR-gamma signaling also limits the luminal bioavailabi

134 Here we present structures of intact PPAR-gamma and RXR-alpha as a heterodimer bound to DNA,

135 sults identify a signaling pathway involving PPAR-gamma, ERK, and MUC1 for TNF-alpha secretion induce

136 Three interfaces link PPAR-gamma and RXR-alpha, including some that are DNA de

137 e that ABA-mediated activation of macrophage PPAR gamma is dependent on lancl2 expression.

138 Our data suggest that targeting macrophage PPAR-gamma may be a promising therapeutic option in the

139 d RSV infections, suggesting that macrophage PPAR-gamma is vital for restricting severe host disease

140 In macrophages, PPAR-gamma activation suppresses inflammation by regulat

141 cation may be independent of ligand-mediated PPAR-gamma activation.

142 Thus, INT131 appears to selectively modulate PPAR gamma responses in an in vivo preclinical model, sh

143 l stem-cell lineage allocation by modulating PPAR-gamma activity through nuclear translocation.

144 PPAR-gamma-specific inhibitor and a mutated PPAR-gamma dominant negative plasmid, supporting our hyp

145 Myeloid PPAR-gamma deficiency resulted in enhanced host morbidit

146 As such, myeloid PPAR-gamma deficiency resulted in impaired inflammation

147 Cotransfection with dominant-negative PPAR gamma DNA eliminated the increase in luciferase act

148 Neuronal PPAR-gamma signaling is also required for the hepatic in

149 ng depends in part on the effect of neuronal PPAR-gamma signaling to limit thermogenesis and increase

150 nockout (BKO)) to determine whether neuronal PPAR-gamma signaling contributes to either weight gain o

151 y, antisense knockdown of PPAR-beta, but not PPAR-gamma, abrogated the stimulatory effect of gemfibro

152 ncreased the expression of PPAR-beta but not PPAR-gamma.

153 beta-catenin content and normalized nuclear PPAR-gamma in Ob-MSCs.

154 t mechanism possibly involving activation of PPAR gamma and suppression of NF-kappaB and nuclear fact

155 an breast cancer cells through activation of PPAR gamma and that n-3 PUFA-induced apoptosis is mediat

156 Suppression of SIRT1 or activation of PPAR gamma enhances Ero1-L alpha expression and stimulat

157 due to increased expression and activity of PPAR gamma, while other transcription factor pathways in

158 with a K(i) = 13.4 nM, but it was devoid of PPAR gamma activity.

159 oes not bind to the ligand-binding domain of PPAR gamma.

160 un to specifically address the importance of PPAR gamma in the vasculature.

161 gand-binding domain-independent mechanism of PPAR gamma activation.

162 We investigated the role of PPAR gamma coactivator 1alpha (PGC-1alpha) in muscle dys

163 inireview, evidence for a protective role of PPAR gamma in the endothelium and vascular smooth muscle

164 ide synthase, was elevated in the absence of PPAR-gamma signaling.

165 Moreover, ligand activation of PPAR-gamma by rosiglitazone exacerbates osteoclast diffe

166 tion and suggest that impaired activation of PPAR-gamma contributes to the chronic inflammatory state

167 ts suggest that CBD may induce activation of PPAR-gamma in mast cells leading to secretion of G-CSF a

168 Activation of PPAR-gamma partially restored mitochondrial membrane pot

169 Activation of PPAR-gamma prevented HIV-1-induced claudin-5 down-regula

170 Pharmacological activation of PPAR-gamma thus may represent a novel therapeutic approa

171 tal Lyme arthritis through the activation of PPAR-gamma.

172 on of ZAG in the liver via the activation of PPAR-gamma.

173 nous administration of synthetic agonists of PPAR-gamma (pioglitazone and rosiglitazone) up-regulates

174 Both natural and synthetic agonists of PPAR-gamma abrogated the stimulation of collagen synthes

175 lts would encourage immediate application of PPAR-gamma agonists in treating patients with cortical d

176 a through cGMP- and PKG-dependent binding of PPAR-gamma to the TRPC6 promoter, which inhibits TRPC6 p

177 rotein response and suggest that blockade of PPAR-gamma (Ser-273) phosphorylation may prevent type 1

178 expression of a fusion protein consisting of PPAR-gamma and the viral transcriptional activator VP16

179 uced responses in either primary cultures of PPAR-gamma-null murine embryonic fibroblasts, or in norm

180 rough mechanisms involving downregulation of PPAR-gamma and increased activation of NF-kappaB.

181 m and IP is associated with dysregulation of PPAR-gamma.

182 we explored the anti-inflammatory effect of PPAR-gamma stimulation in vivo in cystic fibrosis transm

183 The effects of PPAR-gamma in the vascular cells translate into the bene

184 This study aims to explore expression of PPAR-gamma and NF-kappaB in placentas of women with peri

185 roups and analyzed to quantify expression of PPAR-gamma and NF-kappaB using real-time polymerase chai

186 IH significantly increased the expression of PPAR-gamma in tumor tissues obtained from xenograft mode

187 R-defective biliary epithelium expression of PPAR-gamma is increased but that this does not result in

188 Increased local expression of PPAR-gamma paralleled these changes.

189 mma activity and modulated the expression of PPAR-gamma regulated genes in GC cells.

190 DP-glucuronic acid altered the expression of PPAR-gamma target genes and increased PPAR-gamma DNA-bin

191 Expression of PPAR-gamma was downregulated in patients with preeclamps

192 Furthermore, PMN expression of PPAR-gamma was increased in sepsis patients and mice wit

193 These studies unravel a novel function of PPAR-gamma in controlling biliary epithelium inflammatio

194 Weighing the potential benefit and harm of PPAR-gamma activation and exploring the functional mecha

195 nic mice have demonstrated the importance of PPAR-gamma in these disorders.

196 ible for the AM/AMBP-1-mediated induction of PPAR-gamma and the anti-inflammatory effect.

197 Thus, inhibition of PPAR-gamma and GLUT-1 by E. coli K1 is a novel pathogeni

198 Importantly, inhibition of PPAR-gamma partially prevents the increase in tumorigene

199 us carcinomas are sensitive to inhibition of PPAR-gamma.

200 fibroblasts with RNAi-mediated knockdown of PPAR-gamma.

201 allowing the ligand-binding domain (LBD) of PPAR-gamma to contact multiple domains in both proteins.

202 BMSCs) from KO mice express higher levels of PPAR-gamma and lower levels of Runx2 mRNA, and this corr

203 ur hypothesis that IH can act as a ligand of PPAR-gamma.

204 trating T cells showed a progressive loss of PPAR-gamma coactivator 1alpha (PGC1alpha), which program

205 o identify potential molecular mechanisms of PPAR-gamma in the islet, we treated diabetic or glucose-

206 residues within the ligand-binding pocket of PPAR-gamma that are reported to be critical for its acti

207 , which could be reversed in the presence of PPAR-gamma inhibitor.

208 ced stimulation of COL1A2 in the presence of PPAR-gamma ligands.

209 mma activity was reversed in the presence of PPAR-gamma-specific inhibitor and a mutated PPAR-gamma d

210 In turn, recruitment of PPAR-gamma-coactivator-1alpha (PGC-1alpha) and PGC-1beta

211 Thus, regulation of PPAR-gamma can be a therapeutic approach against HIV-1-i

212 onary barrier integrity), down-regulation of PPAR-gamma transcription, and expression in lung tissues

213 Our data suggest a critical role of PPAR-gamma expression in lung macrophages in the modulat

214 The role of PPAR-gamma in PMN responses, however, is not well charac

215 To characterize the role of PPAR-gamma in the fibrotic process in vivo, the syntheti

216 Stimulation of PPAR-gamma in vivo (rosiglitazone) significantly attenua

217 The suppression of PPAR-gamma and GLUT-1 by the bacteria in the brain micro

218 e after CSE induction through suppression of PPAR-gamma or ERK inhibited TACE activity and TNF-alpha

219 antly, NOC-mediated nuclear translocation of PPAR-gamma is blocked by a short peptide fragment of NOC

220 tant NOC facilitate nuclear translocation of PPAR-gamma.

221 ingitis, and pharmacological upregulation of PPAR-gamma and GLUT-1 levels may provide novel therapeut

222 esartan based on a partial agonist action on PPAR-gamma receptors.

223 iglitazone, suggesting that effect of NOC on PPAR-gamma nuclear translocation may be independent of l

224 down or application of antagonists of PKG or PPAR-gamma enhanced TRPC6 expression in podocytes and co

225 an angiotensin receptor blocker and partial PPAR-gamma agonist, has been shown to decrease visceral

226 Our results suggest that pharmacologic PPAR-gamma activation, via its vasoactive properties, ma

227 Our results suggest that pharmacological PPAR-gamma activation is a potential strategy for preven

228 scleroderma and suggest that pharmacological PPAR-gamma ligands, widely used as insulin sensitizers i

229 acental insufficiency, and reduced placental PPAR-gamma expression; PIO prevented approximately half

230 d fetal growth restriction reduces placental PPAR-gamma protein expression and placental vascularizat

231 ediated effects of the hormone by preventing PPAR-gamma inhibition by leptin, with subsequent increas

232 Rats receiving PPAR-gamma antagonists displayed proteinuria and increas

233 nsitizers that activate the nuclear receptor PPAR-gamma and have been shown to partially ameliorate a

234 h a mechanism involving the nuclear receptor PPAR-gamma.

235 peroxisome proliferator-activated receptor (PPAR-gamma/alpha/delta) agonists, sodium glucose cotrans

236 pioglitazone and rosiglitazone) up-regulates PPAR-gamma-dependent genes, while inhibiting the activat

237 al activation of the mitochondrial regulator PPAR-gamma coactivator 1beta (PGC-1beta) but not PGC-1al

238 Pretreatment with partial or selective PPAR-gamma agonists ameliorate the pathological outcomes

239 evaluate the effectiveness of the selective PPAR-gamma agonist pioglitazone (PIO) for preventing hyp

240 ogenesis and increasing insulin sensitivity, PPAR-gamma also plays critical roles in the vasculature.

241 Chromatin immunoprecipitation showed PPAR-gamma binding to the TRPC6 promoter.

242 GM-CSF and intact GM-CSF receptor signaling, PPAR-gamma was not sufficiently upregulated in developin

243 AR gamma-expressing and immune cell-specific PPAR gamma null mice demonstrate that ABA down-regulates

244 drugs thiazolidinediones (TZDs) are specific PPAR-gamma agonists.

245 e TRPC6 expression, as did podocyte-specific PPAR-gamma knockout mice, which were more sensitive to a

246 oliferator-activated receptor gamma subunit (PPAR-gamma), the master activator of adipogenesis.

247 This suggests PPAR gamma pathways may be a fruitful drug target in PD.

248 nt of Cftr-deficient mice with the synthetic PPAR-gamma ligand rosiglitazone partially normalizes the

249 Increasing evidence suggests that PPAR gamma is involved in the regulation of vascular fun

250 We conclude that PPAR-gamma agonists exert a direct effect in diabetic is

251 vitro studies of INS-1 cells confirmed that PPAR-gamma binds to the putative PPRE sequence and regul

252 Our results demonstrate that PPAR-gamma activation directly improves beta cell functi

253 te recruiting monocytes, we demonstrate that PPAR-gamma expression in resident AM is likely important

254 Here we identify that PPAR-gamma expression in AM is crucial to suppress pulmo

255 Collectively, these results indicate that PPAR-gamma blocked Smad-mediated transcriptional respons

256 This study indicates that PPAR-gamma activation is involved in PMN chemotactic res

257 We show that PPAR-gamma coactivator (PGC)-1alpha and PGC-1beta are cr

258 Furthermore, we show that PPAR-gamma was critical for the expression of wound heal

259 These results suggest that PPAR-gamma agonists may benefit aging-related renal inju

260 The PPAR-gamma agonist rosiglitazone elicited similar change

261 The PPAR-gamma coactivator (PGC)-1 family of proteins plays

262 The PPAR-gamma LBD cooperates with both DNA-binding domains

263 itazone exerts this effect by activating the PPAR-gamma pathway.

264 f peroxisomes in POMC neurons induced by the PPAR-gamma agonist rosiglitazone decreased ROS levels an

265 This effect was abolished by the PPAR-gamma-specific antagonist, GW9662, suggesting that

266 IH may be mediated through modulation of the PPAR-gamma activation pathway in GC.

267 e effects resulting from the presence of the PPAR-gamma agonist may be secondary to improvements in e

268 the deleterious bone loss side effect of the PPAR-gamma agonist rosiglitazone.

269 In contrast, hepatic levels of the PPAR-gamma and PPAR-alpha proteins were significantly lo

270 Addition of the PPAR-gamma antagonist GW 9662 abrogated the effects of A

271 be partly due to increased expression of the PPAR-gamma co-activator 1-alpha.

272 asculature and the modulatory effects of the PPAR-gamma ligands.

273 lpha homodimer is different from that of the PPAR-gamma-RXR-alpha heterodimer, even when both NR comp

274 Here, we found that the PPAR-gamma agonist pioglitazone protected against renal

275 In BMSCs exposed to the PPAR-gamma (peroxisome proliferator-activated receptor-g

276 diabetic or glucose-intolerant mice with the PPAR-gamma agonist pioglitazone or with a control.

277 apsigargin-treated INS-1 beta cells with the PPAR-gamma agonist resulted in the reduction of endoplas

278 Treatment with the PPAR-gamma agonist rosiglitazone reversed the phenotype.

279 Finally, treatment with the PPAR-gamma antagonist GW9662 significantly reversed the

280 -dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14

281 Therefore, PPAR-gamma and its ligands have a previously unrecognize

282 Thiazolidinediones, PPAR gamma agonists, lower blood pressure and have prote

283 bolism, and cell signaling, in part, through PPAR gamma.

284 o-lipotoxicity and possibly directly through PPAR-gamma agonism in patients ofT2DM with hypertriglyce

285 hibits TRPC6 expression in podocytes through PPAR-gamma-dependent mechanisms, thereby counteracting p

286 at hyperactive PPAR signaling, either due to PPAR gamma gene amplification or RXRA hot-spot mutation

287 stinct pattern of coregulator recruitment to PPAR gamma.

288 m, which lacks deadenylase activity, bind to PPAR-gamma and markedly enhance PPAR-gamma transcription

289 its activity and could competitively bind to PPAR-gamma.

290 stimulates brown adipogenesis by binding to PPAR-gamma (peroxisome-proliferator-activated receptor-g

291 FRE exhibited 82.6% binding to PPAR-gamma.

292 that promote reverse cholesterol transport (PPAR-gamma, LXR-alpha, and ABCG1) and macrophage emigrat

293 Unexpectedly, PPAR-gamma expression by VAT Treg cells was necessary fo

294 l fibrosis, and subcutaneous lipoatrophy via PPAR-gamma in a mouse model of scleroderma and suggest t

295 atty acids in MC3T3 cells increased in vitro PPAR-gamma activity and inhibited beta-catenin activity.

296 In vitro, PPAR-gamma activation with pioglitazone switched macroph

297 e viral transcriptional activator VP16 (VP16-PPAR-gamma), led to positive energy balance in rats.

298 lography revealed that INT131 interacts with PPAR gamma through a distinct binding mode, forming prim

299 that inhibits its physical interaction with PPAR-gamma.

300 o-PGE2 signaling cascade that interacts with PPAR-gamma, Smad2/3, and TAP63.