ライフサイエンスコーパス: PPARGC1A

1 and transcription regulation (INSIG1, PPARG, PPARGC1A).

2 ctivated receptor gamma coactivator 1-alpha (Ppargc1a).

3 a coactivator 1alpha (PGC-1alpha, encoded by Ppargc1a).

4 and had a parallel pattern of expression to PPARGC1A.

5 prostaglandin signaling and cooperation with Ppargc1a.

6 ogenesis and known to interact with PPARs or PPARGC1A.

7 vity and combinatorial binding patterns with PPARGC1A.

8 PARG G allele (rs1801282) and noncarriers of PPARGC1A A allele (rs8192678) had 21 and 13% lower hepat

9 ceptor gamma-coactivator 1alpha; also called PPARGC1A) a coactivator of the Kdm5a target genes, is su

10 ctivated receptor gamma coactivator 1-alpha (PPARGC1A), a coactivator of the transcription factor PPA

11 in PPAR gamma (PPARG) co-activator 1 alpha (PPARGC1A), a gene encoding a co-activator of the LCPUFA-

12 ctivated receptor-gamma coactivator-1 alpha (PPARGC1A), a master transcriptional regulator of mitocho

13 Here we show that PGC-1alpha (Ppargc1a), a transcriptional coactivator that regulates

14 ARGC1a (also known as PGC-1alpha; encoded by Ppargc1a), a transcriptional coactivator that regulates

15 Expression of Ppargc1a, a central molecule for mitochondrial metabolis

16 activated receptor-y coactivator-1a (PGC-1a; PPARGC1A) activity.

17 Accordingly, neuronal deletion of Ppargc1a aggravated neurodegeneration during experimenta

18 Here we leveraged PPARGC1a (also known as PGC-1alpha; encoded by Ppargc1a)

19 lomyelitis, while neuronal overexpression of Ppargc1a ameliorated it.

20 related positively with expression levels of PPARGC1A and CDK4 and negatively with expression levels

21 PPARGC1A and CREB3L3 bound the Hamp promoter to activate

22 nistration of small interfering RNAs against Ppargc1a and Creb3l3.

23 Both PPARGC1A and HNF4A are required for the acquisition of r

24 ap of targets including a novel link between PPARGC1A and HSF1, a TF regulating the conserved heat sh

25 tudies have focused on the interplay between PPARGC1A and individual TFs, but little is known about h

26 to 8-br-cAMP with a 200% greater increase in Ppargc1a and Pck1 expression, and a 30% increase in G6pc

27 eta (PGC-1alpha and PGC-1beta, also known as Ppargc1a and Ppargc1b, respectively) and the downstream

28 ly higher expression levels of FABP4, FGF21, PPARGC1A and PRDM16 in VC-PACs.

29 inhibits, whereas Notch inhibition induces, Ppargc1a and Prdm16 transcription in white adipocytes.

30 epG2 cells were transfected with variants of PPARGC1A and protein and messenger RNA levels were measu

31 e agonist for AMPK signaling which activates PPARGC1a and serves as co-activator of PPARgamma.

32 pathways, including expression of the genes Ppargc1a and Ucp1.

33 tor (MC2R), MC3R, PPARG coactivator 1 alpha (PPARGC1A), and tumor necrosis factor (TNF), was changed

34 ltiple targets such as SIRT3, FOXO1, PRKAA1, PPARGC1A, and CREBBP directly regulate reactive oxygen s

35 tal role for a concerted action among PPARG, PPARGC1A, and INSIG1.

36 Gene products for HMOX1, NRF1, PPARGC1A, and TFAM, and mitochondrial DNA ND1 and D-loop

37 50 directly targets and represses Prdm16 and Ppargc1a, and that forced expression of miR-150 attenuat

38 iptional regulators of metabolism, PPARG and PPARGC1A, as well as SCD1, the rate-limiting enzyme for

39 a coactivator-1alpha (PGC-1alpha, encoded by Ppargc1a) by SIRT1 activators, our results illustrate ho

40 their co-activators Pgc1alpha (also known as Ppargc1a), CBP/p300 (Crebbp) and Src1 (Ncoa1) to the PPR

41 Another PPARGC1A coding variant (rs8192678) showed statistical i

42 ndividual TFs, but little is known about how PPARGC1A combines with all of its partners across the ge

43 ficient hearts, suggesting that up-regulated Ppargc1a confers increased mitochondrial metabolism and

44 s of down-regulated genes (e.g. AMPK, TORC2, PPARGC1A) correspond to a single common pathway importan

45 PPARGC1A DNA methylation percentages in muscle and SAT w

46 atment did not affect the heart size of Flcn/Ppargc1a doubly inactivated hearts, further supporting t

47 Deletion of Ppargc1a dramatically increased RGC loss, in association

48 regulation of thermogenesis associated genes PPARGC1A, ELOVL3 and PRDM16.

49 tablished (e.g. ERG) and underexplored (e.g. PPARGC1A, encodes PGC1alpha).

50 d is required for the transcription of Ucp1, Ppargc1a (encoding PGC-1alpha), and oxidative phosphoryl

51 of host tolerance to infection involving the Ppargc1a/Esrra axis in its influence on Mpc1/OXPHOS-depe

52 nhibition of HNF-1beta significantly reduced PPARGC1A expression and altered mitochondrial morphology

53 We also demonstrated downregulation of renal PPARGC1A expression in a patient with an HNF1B germinal

54 clear factor-1beta (HNF-1beta) in regulating PPARGC1A expression in AKI.

55 yperglycemia may contribute to the decreased PPARGC1A expression in O-GDM.

56 Dynamic Ppargc1a expression in the mouse hair cycle suggests a p

57 Reduced PPARGC1A expression significantly associated with worse

58 In BAT of DEX offspring, Ppargc1a expression was suppressed, together with reduce

59 Increasing physical activity, which induces PPARGC1A expression, is a potential strategy to slow DNA

60 zygous or homozygous disruption of Ppargc1a (Ppargc1a(f/+)Alb-cre(+/0) and Ppargc1a(f/f) Alb-cre(+/0)

61 Oxidative damage was observed in livers from Ppargc1a(f/+)Alb-cre(+/0) mice of each sex, in a cell-au

62 he increased liver damage observed in female Ppargc1a(f/+)Alb-cre(+/0) mice; while, compensatory incr

63 n of Ppargc1a (Ppargc1a(f/+)Alb-cre(+/0) and Ppargc1a(f/f) Alb-cre(+/0) mice, respectively) were fed

64 ed with complete loss of PGC1A expression in Ppargc1a(f/f)Alb-cre(+/0) female mice.

65 ne distributions of DNA sequence variants in PPARGC1A for association with NV AMD and interaction of

66 a Tug1-binding element (TBE) upstream of the Ppargc1a gene and showed that Tug1 binds with the TBE to

67 The PPARGC1A gene encodes PGC-1alpha, which regulates cellul

68 Decreased PPARGC1A gene expression in muscle has previously been a

69 The unaltered PPARGC1A gene expression in muscle of O-T1D suggests tha

70 PPARGC1A gene expression in muscle was lower in O-GDM co

71 activated receptor gamma coactivator-1alpha (Ppargc1a) gene encodes several PGC-1alpha isoforms that

72 n and examined the relationship between nine PPARGC1A genetic variants, DNA damage, type 2 diabetes,

73 variants showed significant association, and PPARGC1A haplotypes exhibited significant association af

74 ion of key lipid metabolism genes, including PPARGC1A, HMGCS2, and ABHD5.

75 E2F3 activated the mitochondrial sensor PPARGC1A in a Cdk4-dependent manner.

76 deficient hearts and indeed, inactivation of Ppargc1a in Flcn-deficient hearts significantly reduced

77 ir, mice harboring a conditional deletion of Ppargc1a in monocyte-derived macrophages or mice adminis

78 We confirm the role of PPARGC1A in muscle and show some support for inflammatio

79 , and gene expression and DNA methylation of PPARGC1A in skeletal muscle and SAT.

80 demonstrate the concurrent up-regulation of PPARGC1a in the epithelial compartment and androgen rece

81 activated receptor-gamma coactivator-1alpha (PPARGC1A) in skeletal muscle and subcutaneous adipose ti

82 he expression of thermogenic genes (Ucp1 and Ppargc1a) in subcutaneous WAT.

83 of key thermogenic genes, including Ucp1 and Ppargc1a, in beige adipocytes.

84 Ppargc1a inactivation restored phospho-AMPK-alpha levels

85 nteraction domains important for Ucp1 versus Ppargc1a induction by PRDM16.

86 PPARGC1A influences activation of the AMD-associated com

87 We propose that PPARGC1A influences development of type 2 diabetes and C

88 induced early and transient inflammation and PPARGC1A inhibition, which overlapped with downregulatio

89 A SNP in PPARGC1A interacted with alcohol consumption in African

90 activated receptor gamma-coactivator 1alpha (PPARGC1A) into myonuclei.

91 PPARGC1A is a transcriptional coactivator that binds to

92 sition of resistance to ERBB2 inhibition and PPARGC1A is instrumental in promoting a switch to depend

93 ted hearts, further supporting the idea that Ppargc1a is the critical element leading to deregulation

94 a) coactivator alpha (PGC-1alpha, encoded by Ppargc1a) is functionally regulated by the lncRNA taurin

95 Several functional candidate genes such as PPARGC1A, LDB2 and LCORL were found within or close to t

96 CDK4, E2F3, and PPARGC1A levels correlated positively with exercise and

97 -activated receptor-gamma coactivator-alpha (PPARGC1A) messenger RNA (mRNA) in skin fibroblast cultur

98 Vehicle-treated and naive Ppargc1a(-/-) mice also showed mild RGC loss, and surpri

99 Loss of the ROS and mitochondrial control in Ppargc1a(-/-) mice causes the death of paligenotic cells

100 nal ischaemia, Pgc1alpha(-/-) (also known as Ppargc1a(-/-)) mice develop local deficiency of the NAD

101 of starved mice also had increased levels of Ppargc1a mRNA and Creb3l3 mRNA, which encode a transcrip

102 Increased PPARGC1A mRNA expression directly correlated with reduce

103 eductions in palmitate- stimulated Cpt1a and Ppargc1a mRNA, ULK1 phosphorylation and autophagic/mitop

104 ence motifs corresponding to known and novel PPARGC1A network partners.

105 els of antioxidant enzymes compared with the Ppargc1a(+/+) on the same diet.

106 ses expression of PPARG coactivator 1 alpha (PPARGC1A or PGC1a protein) at the level of transcription

107 d receptor-gamma (PPARG) coactivator 1alpha (PPARGC1A or PGC1A) is inversely correlated with liver fa

108 TH did not blunt fibrosis in Ppargc1a- or Pink1-knockout mice, suggesting dependence

109 Moreover, Ppargc1a-overexpressing neurons showed a higher mitochon

110 transcription factor MITF drives PGC1alpha (PPARGC1A) overexpression in a subset of human melanomas

111 chondrial biogenesis and their key regulator Ppargc1a Overnutrition worsened excitotoxicity-induced m

112 Induction of the gluconeogenic genes Ppargc1a, Pck1, and G6pc by glucagon or 8-br-cAMP was su

113 fragmentation factor alpha-like effector A), Ppargc1a (Peroxisome Proliferator-Activated Receptor Gam

114 on noncanonical targets, including Nampt and Ppargc1a [peroxisome proliferator-activated receptor-gam

115 the transcriptional mitochondrial regulator Ppargc1a (Pgc1alpha) and ROS regulator Nf2el2 (Nrf2).

116 with liver-specific hemizygous disruption of Ppargc1a placed on an obesogenic diet expressed increase

117 The transcriptional regulators HNF4A and PPARGC1A play a key role in this network rewiring.

118 PPARGC1A plays a pivotal role in regulating energy metab

119 cific hemizygous or homozygous disruption of Ppargc1a (Ppargc1a(f/+)Alb-cre(+/0) and Ppargc1a(f/f) Al

120 ted genes (including the master coactivators Ppargc1a, Ppargc1b, and their downstream targets) and pr

121 owed that Tug1 binds with the TBE to enhance Ppargc1a promoter activity.

122 Increased DNA methylation in Ppargc1a promoter had a fetal origin; elevated DNA methy

123 analysis confirmed HNF-1beta binding to the Ppargc1a promoter in mouse kidneys.

124 GC receptor/DNMT3b complex in binding to the Ppargc1a promoter, potentially driving its de novo DNA m

125 g pregnancy increases DNA methylation in the Ppargc1a promoter, which epigenetically impairs BAT ther

126 PGC-1a via decreasing PARIS occupancy on the PPARGC1A promoter.

127 MEF2A also bound the MEF2A and PPARGC1A promoters in ChIP, placing it within a feedback

128 PGC-1alpha (encoded by PPARGC1A) regulates adaptive metabolism and oxidative st

129 ligo patients, whereas its predicted targets PPARGC1A, RRM2, and TAOK1 were reciprocally up-regulated

130 Subjects with the PPARGC1A rs8192678 risk A allele had an increase in the

131 The PPARGC1A rs8192678 risk A allele is associated with an i

132 e evaluated the independent influence of the PPARGC1A rs8192678 risk A allele on pediatric NAFLD afte

133 , sex, and PNPLA3 rs738409 polymorphism, the PPARGC1A rs8192678 risk A allele was an independent risk

134 We aimed to test the hypothesis that the PPARGC1A rs8192678 risk A allele would influence the ris

135 ochondrial dysfunction during AKI partly via PPARGC1A signaling.

136 mong 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type

137 ed that seven genes (CDKN1A, ESR1, MAX, MYC, PPARGC1A, SP1, and STK11) and one novel MYC-centered pat

138 cription factor (PPARG co-activator 1 alpha, PPARGC1A) to age-related macular degeneration (AMD) and

139 he highest-docked targets, SIRT3, FOXO1, and PPARGC1A, to assess the stability and interactions.

140 r demonstrate that SCF/Kit directly promotes Ppargc1a transcription and mitochondrial biogenesis.

141 This SnapShot summarizes how regulation of Ppargc1a transcription, splicing, translation, protein s

142 In this study, we describe a core PPARGC1A transcriptional regulatory network operating in

143 ic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synt

144 irst mapped the genome-wide binding sites of PPARGC1A using chromatin-IP followed by high-throughput

145 Two independent PPARGC1A variants associated significantly with type 2 d

146 With respect to urinary 8-OHdG, PPARGC1A variants showed significant association, and PP

147 Carriers of minor alleles of two other PPARGC1A variants, both in strong linkage disequilibrium

148 in African Americans, and a different SNP in PPARGC1A was nominally associated in Caucasians.

149 erator-activated receptor gamma cofactor 1A (PPARGC1A) was 1.75-fold reduced with insulin resistance

150 eceptor-gamma coactivator (PGC)-1alpha gene (PPARGC1A) was identified to be associated with nonalcoho

151 17590046) in the transcriptional coactivator PPARGC1A were associated with essential tremor.

152 R-resident regulatory variant (rs3774923) in PPARGC1A were independently associated with NV AMD (exac

153 The targets SIRT3, FOXO1, and PPARGC1A were predicted to have the highest binding ener

154 tivated receptor gamma, coactivator 1 alpha (Ppargc1a), which acts upstream of Ptgs1-mediated prostag

155 In mice, neuronal overexpression of Ppargc1a, which encodes for PGC-1a, led to increased num

156 through direct transcriptional induction of PPARGC1a, which in turn activates PPARalpha to upregulat

157 affinity were exhibited by SIRT3, FOXO1, and PPARGC1A with the compound IMPHY000797.