ライフサイエンスコーパス: PRBC

1 PRBC transfusions in preterm infants are associated with

2 PRBC+plasma had the greatest benefit [hazard ratio (HR)

3 PRBCs activate inflammatory genes in circulating leukocy

4 PRBCs inhibited T-cell activation more efficiently than

5 utcome when comparing patients who had a 1:1 PRBC:FFP ratio with those who did not receive any FFP.

6 27 patients, 942 (31.1%) received at least 1 PRBC transfusion, intraoperatively in 264 patients (8.7%

7 A total of 5901 PRBC units were transfused for a median of 2 (interquart

8 .037) and transfusional requirements (2 vs 6 PRBC; P = 0.08) and SAEs lower (15% vs. 47%; P = 0.077)

9 ed before and then at 6, 12 and 24 h after a PRBC transfusion.

10 ransfusion target for patients who receive a PRBC transfusion should be 9 g/dL or more and less than

11 protein expressed on the surface of adherent PRBCs.

12 a (HR 0.57; 95% CI 0.36-0.91, P = 0.017) and PRBC (HR 0.68; 95% CI 0.49-0.95, P = 0.025) versus cryst

13 groups: crystalloid only; PRBC; plasma; and PRBC+plasma.

14 We hypothesized that packed red blood (PRBC) transfusions are associated with kidney inflammati

15 ight percent (n = 250) of them received both PRBCs and FFP.

16 Patients were stratified by PRBC:FFP transfusion ratio over the first 24 hours.

17 n-related radical reactions are modulated by PRBCs.

18 al TCR signal transduction was unaffected by PRBCs, ruling out mechanisms based on secreted factors a

19 impact of transfused packed red blood cell (PRBC) age on perioperative morbidity among patients unde

20 transfusion for each packed red blood cell (PRBC) transfused was recorded, in minutes, for all patie

21 unt of intraoperative packed red blood cell (PRBC) transfusion and occurrence of primary graft dysfun

22 Packed red blood cell (PRBC) transfusions are used to treat anemia in patients

23 d to receive standard packed red blood cell (PRBC) transfusions obtained from RBCs of adult donors (A

24 of patients receiving packed red blood cell (PRBC) using a liberal trigger hemoglobin concentration (

25 of patients receiving packed red blood cell (PRBC) using a liberal trigger hemoglobin concentration (

26 gated whether use of packed red blood cells (PRBC) and lyophilised plasma (LyoPlas) was superior to u

27 and transfusions of packed red blood cells (PRBC).

28 blood cultures with packed red blood cells (PRBCs) and three Gram-positive, four Gram-negative, and

29 for a single unit of packed red blood cells (PRBCs) based on actual institutional acquisition costs (

30 P) in a 1:1 ratio to packed red blood cells (PRBCs) has led many civilian trauma centers to adopt thi

31 usion of plasma from packed red blood cells (PRBCs) or antibodies (OX18 and OX27) against MHC class I

32 more than 6 units of packed red blood cells (PRBCs) within the first 12 hours of injury is the strong

33 efits of prehospital packed red blood cells (PRBCs), plasma, or transfusion of both products among tr

34 od, whole blood, and packed red blood cells (PRBCs).

35 ter than 10 units of packed red blood cells [PRBCs] in less than 24 hrs) than civilian injured.

36 identical in external appearance, containing PRBC-LyoPlas or 0.9% sodium chloride were prepared by bl

37 ivided between crystalloid and crystalloid + PRBC.

38 d LPRBCs and provides a mechanism to deliver PRBCs in a wide variety of settings.

39 d cytoadherence of parasitized erythrocytes (PRBC) to endothelial cells.

40 smodium falciparum parasitized erythrocytes (PRBCs) to microvascular endothelium contributes directly

41 consideration should be given to 1 : 1 FFP :PRBC transfusion, and in severe cases, rFVIIa.

42 ication of PfEMP1 as a malarial receptor for PRBC adherence to host proteins.

43 rrival were similar across treatment groups (PRBC-LyoPlas 11 [7%] of 148 compared with 0.9% sodium ch

44 ve risk factors for renal failure, including PRBC transfusion data.

45 ational expert consensus guideline informing PRBC transfusion practices for patients with cervical ca

46 required direct cell-cell contact and intact PRBCs.

47 Mild trypsinization of intact PRBCs of P. falciparum strains shown to express antigeni

48 rtiles based on the amount of intraoperative PRBC transfusion (0, 1-4, and >4 units) were significant

49 gistic regression showed that intraoperative PRBC transfusion of >4 units was significantly ( P < 0.0

50 he potential confounding affect of numerical PRBC data on ARF.

51 Estimated total costs of PRBC transfusion ranged from $880,000 to $3,040,000, wit

52 throcytes by merozoites and cytoadherence of PRBC to endothelial cells by increasing negative repulsi

53 ed to receive either up to two units each of PRBC and LyoPlas or up to 1 L of 0.9% sodium chloride ad

54 The effect of PRBC age (ie, storage duration before transfusion) on pe

55 lyses were performed to assess the effect of PRBC age on perioperative morbidity.

56 Preadsorption of PRBC extracts with anti-PfEMP1 antibodies, CD36, or TSP

57 Because preincubation of PRBC with sulfated glycosaminoglycans and treatment of t

58 erance of data indicates that transfusion of PRBC in the population of patients with ischemic heart d

59 ly increased with increasing transfusions of PRBC (P<0.001).

60 Transfusions of PRBC are known to directly increase the risk of new onse

61 Mortality was lower per-unit of PRBC (HR 0.69; 95% CI 0.52-0.92, p = 0.009) and plasma (

62 (31.4%) patients received at least 1 unit of PRBC that had been stored for >/=35 days ("older" blood)

63 hed for all studies investigating the use of PRBC in medical and surgical patients with cardiac disea

64 core to determine if early aggressive use of PRBC:FFP improved outcome.

65 Inhibitory activity of PRBCs required direct cell-cell contact and intact PRBCs

66 ic approach to block or reverse adherence of PRBCs to host cell receptors can now be pursued with the

67 Data regarding the storage duration of PRBCs, clinicopathologic characteristics, and perioperat

68 Mean number of PRBCs and FFP transfused were 7.7 +/- 12 U, 6 U, and 5 +

69 s of unstimulated T-cells in the presence of PRBCs.

70 n T-cells were stimulated in the presence of PRBCs.

71 efine a liberal Hb trigger as transfusion of PRBCs for an intraoperative Hb level of 10 g/dL or great

72 observations associated with transfusion of PRBCs.

73 lorectal resection and received >/=1 unit of PRBCs between 2009 and 2014 at the Johns Hopkins Hospita

74 an 24-hour transfusion volume was 4 units of PRBCs (IQR 2-8), and mortality was 14%.

75 A total of 4000 units of PRBCs (range, 0-167 units/patient) were transfused in th

76 atelets, often given well before 10 units of PRBCs have been transfused; the early use of recombinant

77 s, intraoperative transfusion of >4 units of PRBCs was associated with an increased risk of grade 3 P

78 More than 1 in 10 units of PRBCs were transfused using a liberal Hb trigger.

79 ital resuscitation groups: crystalloid only; PRBC; plasma; and PRBC+plasma.

80 dopting a restrictive trigger, total overall PRBC transfusion costs may have been reduced by $100,320

81 al blood products when available, preferably PRBC+plasma.

82 Patients receiving prehospital PRBC+plasma had the greatest mortality benefit.

83 The trial did not show that prehospital PRBC-LyoPlas resuscitation was superior to 0.9% sodium c

84 detergent extracts of surface-radioiodinated PRBCs using several endothelial cell receptors known to

85 We have studied effects of packed RBCs (PRBCs) on T-cell receptor (TCR) signaling and the molecu

86 ients undergoing major surgery often receive PRBC transfusions.

87 Numbers of surgical patients who received PRBC transfusion, estimated cost per transfusion, and es

88 associated with 23% lower odds of receiving PRBC transfusion (odds ratio = 0.77, 95% confidence inte

89 was associated with fewer patients receiving PRBC transfusion using a liberal trigger hemoglobin conc

90 ease in the proportion of patients receiving PRBC using a restrictive trigger hemoglobin concentratio

91 ease in the proportion of patients receiving PRBC using a restrictive trigger hemoglobin concentratio

92 In line with previous reports, PRBCs attenuated the expression of T-cell activation mar

93 received 3.5 mL each of leuko-reduced stored PRBC and SS (simulating a major transfusion).

94 trated ALI in response to plasma from stored PRBCs, both prestorage leukoreduced and unmodified, and

95 endothelial cell receptors known to support PRBC adherence, including CD36, thrombospondin (TSP), an

96 The PRBC group had a significantly different expression prof

97 nexpected serious adverse events, one in the PRBC-LyoPlas (cerebral infarct) and one in the 0.9% sodi

98 9 days (IQR 1 to 34) for participants in the PRBC-LyoPlas group and 7 days (0 to 31) for people in th

99 syndrome in nine (6%) of 142 patients in the PRBC-LyoPlas group and three (2%) of 130 in 0.9% sodium

100 ologists and nurses, who were blinded to the PRBC type.

101 ntrolling for all significant variables, the PRBC:FFP ratio did not predict intensive care unit days,

102 correlated with the binding phenotype of the PRBCs from which PfEMP1 was extracted.

103 4%) of 199 participants randomly assigned to PRBC-LyoPlas and 136 (65%) of 210 randomly assigned to 0

104 teams randomly assigned 432 participants to PRBC-LyoPlas (n=209) or to 0.9% sodium chloride (n=223).

105 PRBC variable (P<0.0001; OR=1.23/transfused PRBC) to the model attenuates the purported independent

106 After adding transfused PRBC data 11,198 patients remained for risk-adjusted ass

107 th, and without, consideration of transfused PRBC.

108 ddition of the highly significant transfused PRBC variable (P<0.0001; OR=1.23/transfused PRBC) to the

109 Risk-adjusted analysis without transfused PRBC in the model suggests that aprotinin significantly

110 roups 2 and 3 received greater than 15 units PRBCs-the former as early resuscitation, whereas the lat

111 thawed plasma in ratios approaching 1:1 with PRBCs; the early use of platelets, often given well befo