ライフサイエンスコーパス: PRC1

1 ecruitment of Polycomb repressive complex 1 (PRC1).

2 a subunit of polycomb repressive complex 1 (PRC1).

3 by canonical polycomb repressive complex 1 (PRC1).

4 complex) and polycomb-repressive complex 1 (PRC1).

5 with the core Polycomb repressive complex 1 (PRC1).

6 ibit no detectable kinetochore enrichment of Prc1.

7 aradigm of cooperativity between SWI/SNF and PRC1.

8 D binding factor required to recruit PCGF3/5-PRC1.

9 nd the participation of a yet poorly defined PRC1.

10 een MTs cross-linked by full-length, dimeric PRC1.

11 he geometry of the MT arrays cross-linked by PRC1.

12 nstrating cat7l genetically interacts with a PRC1.

13 lular processes are specifically targeted by PRC1.

14 me, and requires the microtubule crosslinker PRC1.

15 e the role of Rnf2, the enzymatic subunit of PRC1.

16 CL2 as the top prometastatic gene induced by PRC1.

17 became comparable to the wild type (WT) and prc1-1 complemented by WT CESA6 in regard to plant growt

18 We found that the mutant phenotypes of prc1-1, a cesa6 null mutant, were rescued by the chimeri

19 directly regulates Igf2, likely through the PRC1.1 complex; the repressive histone mark H2AK119Ub is

20 Together, the results suggest that the PRC1.1 components BCOR and KDM2B work together to enhanc

21 Overall, our data suggests that BCOR-PRC1.1 disruption leads to Igf2 overexpression, which tr

22 ents of the Polycomb repressive complex 1.1 (PRC1.1), BCL6 corepressor (BCOR) and KDM2B, which helps

23 Polycomb group protein that associates with PRC1.2 (containing PCGF2/MEL18) and PRC1.4 (containing P

24 ly both CBX protein accumulation and loss of PRC1/2 epigenetic marks are reversible.

25 In parallel, binding of PRC1/2 to target genes is strongly reduced, coinciding w

26 e function of polycomb repressive complexes (PRC1/2).

27 tes with PRC1.2 (containing PCGF2/MEL18) and PRC1.4 (containing PCGF4/BMI1), modulates the localizati

28 e localization of USP7 and bridges USP7 with PRC1.4, allowing for the stabilization of BMI1.

29 of RING1B and BMI1, a specific component of PRC1.4.

30 of the function of an atypical PRC1 complex (PRC1.6), in which MAX is one of the components.

31 e but not mutant E2F promoters by repressive PRC1.6/E2F6 and DREAM/E2F4 complexes.

32 ion, RNF2, the dominant catalytic subunit of PRC1, activates transcription of Sall4, which codes for

33 ncRNAs), but few specific lncRNAs that guide PRC1 activity are known.

34 ich PcG protein BMI1 is overexpressed or the PRC1 activity is deregulated.

35 fficiently down-regulate BMI1 expression and PRC1 activity, and induce premature senescence in breast

36 We propose a model whereby PRC1 acts in concert with specific lncRNAs and that CAT7

37 om the spindle midzone through inhibition of PRC1, allowing centralspindlin to function as a regulato

38 fly embryos, with analogous co-occupancy of PRC1 and a Br140 ortholog, BRD1, at bivalent loci in hum

39 t are crucial for central spindle formation, PRC1 and centralspindlin.

40 et of midbody regulatory proteins, including PRC1 and CYK4/MKLP1.

41 We found PRC1 and EB3 in the bridging fibre, suggesting that it c

42 necessary for H2A ubiquitination activity of PRC1 and for clonogenic potential of U2OS cells.

43 est that Cg can recruit Ph in the absence of PRC1 and illustrate the diversity and redundancy of PcG

44 istone H2A (H2Aub), the catalytic product of PRC1 and key for its repressive activity.

45 n the conserved cytokinesis midzone proteins Prc1 and Kif4A.

46 Kif4's binding partner PRC1 and MgcRacGAP, a component of the centralspindlin c

47 upon the Polyhomeotic component of canonical PRC1 and occurred independently of PRC1-catalyzed ubiqui

48 pins an activity-based communication between PRC1 and Polycomb repressive complex 2 (PRC2) which is r

49 Pull-downs of BioTAP-Scm captured PRC1 and PRC2 and additional repressive complexes, inclu

50 They form multiple complexes of which PRC1 and PRC2 are evolutionary conserved and obligatory

51 The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silenc

52 Polycomb group (PcG) complexes PRC1 and PRC2 are well known for silencing specific deve

53 uitment of the Polycomb repressive complexes PRC1 and PRC2 by Xist RNA is an important paradigm for c

54 PcG repression is targeted and suggest that PRC1 and PRC2 can communicate independently of histone m

55 In vitro, both PRC1 and PRC2 can recognize R-loops and open DNA bubbles

56 The Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications

57 the Polycomb group (PcG) proteins within the PRC1 and PRC2 complexes, and the Trithorax group (TrxG)

58 t GAGA-binding factors in the recruitment of PRC1 and PRC2 components to Polycomb-responsive DNA elem

59 Thus, these findings uncover that PRC1 and PRC2 employ distinct mechanisms to assemble on

60 Piwi interacts with Polycomb group complexes PRC1 and PRC2 in niche and germline cells to regulate ov

61 )-PRC1 complex initiates recruitment of both PRC1 and PRC2 in response to Xist RNA expression.

62 Jarid2 and define a key mechanism that links PRC1 and PRC2 in the establishment of Polycomb domains.

63 The targeting of PRC1 and PRC2 is poorly understood and was proposed to b

64 The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC) pluripo

65 PRC1 and PRC2 modify chromatin by catalysing histone H2A

66 The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental gene

67 The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome silencing in

68 ive genes, R-loop removal leads to decreased PRC1 and PRC2 recruitment and Pol II activation into a p

69 Our data support a model in which PRC1 and PRC2 reinforce each other's binding but suggest

70 both polycomb repressive component classes (PRC1 and PRC2) and grouped into four distinct clusters w

71 Polycomb Repressive Complexes (PRC1 and PRC2) regulate developmental transitions in pla

72 ion of polycomb repressor complexes 1 and 2 (PRC1 and PRC2).

73 plexes: Polycomb repressive complex 1 and 2 (PRC1 and PRC2).

74 modification-dependent communication between PRC1 and PRC2, repressive Polycomb chromatin domains can

75 partner, HNRNPK, compromises recruitment of PRC1 and PRC2.

76 enes are repressed by the Polycomb complexes PRC1 and PRC2.

77 ponent of the polycomb repressive complex 1 (PRC1) and emerging data support a role of BMI1 in cancer

78 Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene

79 Polycomb-repressive complex 1 (PRC1) and PRC2 maintain repression at many developmental

80 ar organisms, Polycomb Repressive Complex 1 (PRC1) and PRC2 repress target genes through histone modi

81 e we focus on Polycomb Repressive Complex 1 (PRC1) and trace the evolution of core components of cano

82 Prc1E, the egg orthologue of Prc1, and Kif4A were recruited to anti-parallel bundles

83 We conclude that Xist, PRC1, and SMCHD1 collaborate in an obligatory, sequentia

84 ic microtubules, the microtubule crosslinker PRC1, and the motor protein KIF4A.

85 -SAM interactions between chromatin-bound Ph/PRC1 are believed to compact chromatin and mediate long-

86 local load-bearing observed, whereas Eg5 and PRC1 are not detectably required, suggesting specializat

87 components of polycomb repressive complex 1 (PRC1)] are predominantly utilized in antimesometrial dec

88 In this study, we test the hypothesis that PRC1/Ase1 proteins use distinct microtubule-binding doma

89 equires the microtubule antiparallel bundler PRC1/Ase1 to recruit CLASP/Cls1 to stabilize microtubule

90 We also reveal that first PRC1-associated H2AK119Ub and then PRC2-associated H3K27

91 of the antiparallel microtubule crosslinker Prc1 at kinetochores via the Ndc80 complex.

92 epressor and the presence of a non-canonical PRC1-BCOR-CBX8 complex.

93 se domains changed during differentiation as PRC1 binding changed.

94 -A-resolution cryo-EM structure of monomeric PRC1 bound to MTs.

95 We propose that identification of PRC1-Br140 "bivalent complexes" in fly embryos supports

96 Here we confirm PRC1-Br140 and PRC1-Fs(1)h interactions and identify the

97 PRC1-Br140 bind developmental genes in fly embryos, with

98 Notably, the total loss of PRC1 but not canonical PRC1 in the skin leads to widespr

99 tivation and provides a new insight into how PRC1 can be involved in gene activation.

100 We find that PRC1 can bind PREs in the absence of PRC2 but at many PR

101 ouse embryonic stem cells, here we show that PRC1 can trigger transcriptional repression and Polycomb

102 discoveries provide compelling evidence that PRC1 catalysis is central to Polycomb system function an

103 Here, we directly test the requirement for PRC1 catalytic activity in Polycomb system function.

104 ivities occupy target sites independently of PRC1 catalytic activity, providing a putative mechanism

105 t Polycomb-mediated gene repression requires PRC1 catalytic activity.

106 embryonic stem cells that completely removes PRC1 catalytic activity.

107 canonical PRC1 and occurred independently of PRC1-catalyzed ubiquitylation.

108 bromodomain inhibitor JQ1 or a peptide-based PRC1 chromodomain ligand, which are capable of recruitin

109 to impairment of the function of an atypical PRC1 complex (PRC1.6), in which MAX is one of the compon

110 n of DPPA4 and other subunits of the variant PRC1 complex at both mRNA and protein levels.

111 l previously reported members of the variant PRC1 complex containing PCGF1, as well as proteins linke

112 framework for understanding the evolution of PRC1 complex diversity and it establishes Nematostella a

113 cal Polycomb group RING finger 3/5 (PCGF3/5)-PRC1 complex initiates recruitment of both PRC1 and PRC2

114 comb recruitment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine

115 (uH2AK119) through its association with the PRC1 complex.

116 structural and functional complexity of the PRC1 complex.

117 ponent of the polycomb repressive complex 1 (PRC1) complex that is overexpressed in breast and other

118 teins, CBX2,4,6,7,8, form mutually exclusive PRC1 complexes and are thought to play a role in the ass

119 2A signals recruitment of other noncanonical PRC1 complexes and of PRC2, the latter leading to deposi

120 We further demonstrate that variant PRC1 complexes are responsible for distinct pools of H2A

121 toire necessary to form all major vertebrate PRC1 complexes emerged early in animal evolution, over 5

122 the establishment of the large diversity of PRC1 complexes found in vertebrates, predates the bilate

123 re components of canonical and non-canonical PRC1 complexes in animals.

124 sted that a major expansion in the number of PRC1 complexes occurred in the vertebrate lineage.

125 Thus, the distinct PRC1 complexes present in vertebrates can differentially

126 tency genes, such as Sox2 and Nanog, through PRC1 complexes to ubiquitinate histone H2A at their prom

127 Furthermore, we show that variant PRC1 complexes with DNA-binding activities occupy target

128 iquitylation, signaling recruitment of other PRC1 complexes, and PRC2.

129 These include a set of canonical PRC1 complexes, each of which contains four core protein

130 tedly high degree of synergy between variant PRC1 complexes, which is fundamental to gene repression.

131 Conversely, the PRC1 component EMBRYONIC FLOWER (EMF1) participates in t

132 Here, we show that the PRC1 component polycomb group ring finger 6 (Pcgf6) is r

133 latory silencing mechanism that requires the PRC1 component polyhomeotic, resulting in a transformati

134 OTEIN1 (LHP1) is so far the only known plant PRC1 component that directly binds to H3K27me3, the hist

135 with like heterochromatin protein1 (LHP1), a PRC1 component, and associates with vernalization2 (VRN2

136 uman CAT7 RNA, enhanced by interference of a PRC1 component, and suppressed by interference of a know

137 le nuclear foci in a manner dependent on the PRC1 components BMI1, RNF1 (RING1a), and RNF2 (RING1b).

138 rt that the post-translational regulation of PRC1 components CBX4 and CBX6 by ubiquitination influenc

139 Previous results showed that apparent PRC1 components perform discrete roles during plant deve

140 Thus, not only does USP7 stabilize PRC1 components, its catalytic activity is also necessar

141 chiometry of Cbx2 on chromatin but not other PRC1 components.

142 tes for other Polycomb repressive complex 1 (PRC1) components, others are not.

143 a mechanism underlying the assembly of CBX2-PRC1 condensates.

144 Residues in the spectrin domain of PRC1 contacting the MT are highly conserved and interact

145 The polycomb repressive complex 1 (PRC1), containing the core BMI1 and RING1A/B proteins, m

146 the mammalian Polycomb repressive complex 1 (PRC1), contains a compaction region that has the biochem

147 Overall, Cbx4/Ring1B-containing PRC1 controls decidualization via regulation of extracel

148 A catalytic inhibitor of PRC1 cooperates with immune checkpoint therapy to revers

149 These results reveal that PRC1 coordinates stemness with immune evasion and neoang

150 of PRC1 subunits, suggesting that Usp16 and PRC1 counterbalance each other to regulate cellular ubH2

151 nd functionally associated to both canonical PRC1 (cPRC1) and non-canonical PRC1 (ncPRC1) complexes.

152 We find that canonical PRC1 (cPRC1), but not variant PRC1, maintains gene silen

153 crotubule sliding velocity and the number of PRC1 crosslinks but do not depend on overlap length or P

154 p length marked by the cross-linking protein PRC1 decreases during anaphase as chromosome segregation

155 links but do not depend on overlap length or PRC1 density within overlaps.

156 ther, these discoveries reveal a new variant PRC1-dependent logic for Polycomb-mediated gene repressi

157 In addition, globular proteins (EB1 and PRC1) diffuse more slowly than an intrinsically disorder

158 we show that Polycomb-repressive complex 1 (PRC1) directs timely activation of germline genes during

159 Conversely, PRC1 does not restrict epidermal stratification during s

160 PRC1 domains differ from topologically associating domai

161 his system, we demonstrate that catalysis by PRC1 drives Polycomb chromatin domain formation and long

162 show that the Polycomb Repressor Complex 1 (PRC1) drives colonization of the bones and visceral orga

163 We find that canonical PRC1 E3 ligases such as PCGF4-RING1B have intrinsically

164 Our results suggest that PRC1 ensembles act similarly to a mechanical dashpot, pr

165 Impairment of PRC1 enzymatic activity does not directly disrupt these

166 subunit of a Polycomb repressive complex 1 (PRC1), establishes the unique epigenome of the male germ

167 ATF, FASLG, RGS16, SYNPO, SELE, PTPN7, WARS, PRC1, EXO1, RRM2, PBK, RAD54L, KIFC1, SPC25, PKMYT, HIST

168 netic disruption of the complex formation of PRC1 facilitates the targeting of Cbx7 to chromatin.

169 BRG1 interacts with SCML2, a testis-specific PRC1 factor that is associated with the repression of so

170 The Polycomb-repressive complex 1 (PRC1) family complexes are central to maintaining this r

171 ly on the conserved microtubule bundler Ase1/PRC1 for metaphase spindle organization, and simultaneou

172 eened for lncRNAs, which co-precipitate with PRC1 from chromatin and found candidates that impact pol

173 Ph SAM-dependent condensates can recruit PRC1 from extracts and enhance PRC1 ubiquitin ligase act

174 Here we confirm PRC1-Br140 and PRC1-Fs(1)h interactions and identify their genomic bind

175 NA-seq studies showed that the inhibition of PRC1 function affects 238 genes (154 up and 84 down) dur

176 ngs reveal that Mel18 is required to specify PRC1 function in both a context- and stage-specific mann

177 and synovial sarcoma-specific dependency on PRC1 function.

178 is overturns previous assumptions about BMI1/PRC1 functions during EBNA3C-mediated regulation, for th

179 Molecular dissection demonstrated that PRC1 functions with PRC2 to silence/dampen expression of

180 udy lays a foundation to examine the role of PRC1 in activating gene expression.

181 the potential clinical utility of targeting PRC1 in DNPC.

182 factor, linking MUC1-C with function of the PRC1 in epigenetic gene silencing.

183 that UBR5 functions in a linear pathway with PRC1 in inducing gene silencing at lesions.

184 Inactivation of PRC1 in male germ cells results in the gradual loss of a

185 ly, the total loss of PRC1 but not canonical PRC1 in the skin leads to widespread down-regulation of

186 suggesting a role for Cbx4/Ring1B-containing PRC1 in these processes.

187 e activity of Polycomb repressive complex 1 (PRC1) in coordination with SCML2.

188 functions of polycomb repressive complex 1 (PRC1) in development and gene silencing are thought to i

189 e function of Polycomb-repressive complex 1 (PRC1) in mouse skin development and identified PRC1's un

190 e the role of Polycomb-repressive complex 1 (PRC1) in shaping 3D genome organization in mouse embryon

191 Furthermore, RYBP is required for PRC1-independent recruitment of OCT4 to the promoter of

192 (PRC1)-mediated gene silencing and also via PRC1-independent transcriptional activities.

193 metastatic prostate cancer, and show that a PRC1 inhibitor can synergize with immune checkpoint inhi

194 ow that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2

195 It is, however, assumed that the PRC1 is excluded from constitutive heterochromatin in so

196 ect physical evidence that the nucleoplasmic PRC1 is monomeric, whereas PRC2 can dimerize in the nucl

197 lar mechanism for recognition of H3K27me3 by PRC1 is well defined, the interaction of PRC2 with H2AK1

198 The polycomb repressive complex 1 (PRC1) is a multi-subunit complex that plays critical rol

199 Polycomb repressive complex 1 (PRC1) is critical for mediating gene repression during d

200 e activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic sub

201 Polycomb repressive complex 1 (PRC1) is required for ubiquitination of histone H2A lysi

202 -9)), CHMP4C at 8q21 (P = 2 x 10(-11)) and a PRC1 junction at 15q26 (P = 7 x 10(-9)).

203 URKA, CKS2, CCNB2, CDK1 SLC19A1, E2F8, E2F1, PRC1, KIF11 for in depth validation.

204 t observed in cells and is controlled by the PRC1/KIF4A ratio.

205 microtubule bundle assembly is prevented via PRC1 knockdown.

206 inding but suggest that the key functions of PRC1 lie beyond the enzymatic capabilities of RING1B.

207 reveals that UbE2E1 is an in vivo E2 for the PRC1 ligase complex and thus plays an important role in

208 1b), a tomato Polycomb Repressive Complex 1 (PRC1)-like protein with a ripening-related expression pa

209 dentify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor.

210 It maps to the PRC1 locus, a type 2 diabetes susceptibility locus, but

211 Promoters located at PRC1 loop anchors regulate some of the most important de

212 ess likely to be expressed than those not at PRC1 loop anchors.

213 that canonical PRC1 (cPRC1), but not variant PRC1, maintains gene silencing through cell division upo

214 functions via polycomb repressive complex 1 (PRC1)-mediated gene silencing and also via PRC1-independ

215 t transcriptional activation and the loss of PRC1-mediated interactions are separable events.

216 n of imaging and Hi-C analyses, we show that PRC1-mediated long-range interactions are independent of

217 PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recr

218 AtBMI1, a PRC1 member, represses micro RNA156 (miR156) to trigger

219 Immunofluorescence analyses revealed that PRC1 members are co-localized with its functional histon

220 duced lesions on chromatin, depletion of the PRC1 members or UBR5 alone derepressed transcription elo

221 odies, leading to speculation that canonical PRC1 might be found in a separate phase from the rest of

222 efine discrete Polycomb Repressor Complex 1 (PRC1) multi-protein complexes with diverse subunit compo

223 oth canonical PRC1 (cPRC1) and non-canonical PRC1 (ncPRC1) complexes.

224 of 11 overexpressed ARE-mRNAs (CDC6, KIF11, PRC1, NEK2, NCAPG, CENPA, NUF2, KIF18A, CENPE, PBK, TOP2

225 namic and developmentally regulated model of PRC1 occupancy at constitutive heterochromatin, and wher

226 nable to interact with either condensin I or PRC1 or are deficient for Aurora kinase regulation.

227 that of trithorax group proteins, but not of PRC1 or PRC2 complexes, suggesting that Pcgf6 functions

228 In turn, ablating PRC1 or PRC2 impairs Xist spreading.

229 ], we captured all PcG-repressive complex 1 (PRC1) or PRC2 core components and Sex comb on midleg (Sc

230 On the other hand, depleting Xist, PRC1, or HNRNPK precludes re-emergence of S1/S2 structur

231 In contrast to canonical PRC1, Pcgf6 acts as a positive regulator of transcriptio

232 Thus, PRC1 physically constrains developmental transcription f

233 The Polycomb PRC1 plays essential roles in development and disease pa

234 in expression and colocalization of Scm with PRC1, PRC2, and H3K27me3 in embryos and cultured cells u

235 ropose that Scm is a key mediator connecting PRC1, PRC2, and transcriptional silencing.

236 Furthermore, this colocalization requires PRC1, PRC2, and TrxG complexes, which are essential regu

237 ining Polycomb repressive complexes 1 and 2 (PRC1/PRC2) along the inactive X (Xi).

238 In contrast, PRC1 promotes expression of critical epidermal adhesion

239 We additionally found that PRC1 promotes MT assembly even in the presence of the MT

240 rogramming by Polycomb Repressive Complex 1 (PRC1) promotes an inflammatory tumor microenvironment in

241 g protein MAP65-1-a member of the MAP65/Ase1/PRC1 protein family, implicated in central spindle forma

242 One example is PRC1 (protein regulator of cytokinesis 1), which cross-l

243 rved that the Polycomb repressive complex 1 (PRC1) protein chromobox 2 (CBX2), a member of the CBX pr

244 tead, we found that Pc-repressive complex 1 (PRC1) purifies with coactivators Fs(1)h [female sterile

245 We show here that reconstituted PRC1 readily phase-separates into droplets in vitro at l

246 n et al. report a mechanism of non-canonical PRC1 recruitment by BCL6 in collaboration with EZH2-medi

247 However, the molecular mechanism for PCGF3/5-PRC1 recruitment by Xist RNA is not understood.

248 s, as expected, but does not affect R-loops, PRC1 recruitment, or transcriptional repression of R-loo

249 t lncRNAs that independently evolved to tune PRC1 repression at individual loci.

250 The E3 ligase activity of PRC1 resides in the RING1A/B subunit when paired with on

251 two pools of KIF4A depend on condensin I and PRC1, respectively.

252 Loss of PRC1 resulted in blistering skin, reminiscent of human s

253 rgeting of the vacuolar carboxypeptidase CPY/Prc1, resulting in an extracellular localization.

254 zymatic activity compared with non-canonical PRC1 RING dimers.

255 C1) in mouse skin development and identified PRC1's unique function independent of PRC2.

256 pressive complex (PRC)2 subunit SUZ12 and of PRC1 subunit BMI1 were assessed for their importance in

257 (SAM) in the Polycomb Repressive Complex 1 (PRC1) subunit Polyhomeotic (Ph) has been shown to play a

258 ion of the non-canonical polycomb complex 1 (PRC1) subunit RYBP.

259 EIN1 (LHP1), a Polycomb Repressive Complex1 (PRC1) subunit.

260 s; however, the condensate formation of CBX2-PRC1 subunits depends on CBX2, suggesting a mechanism un

261 UbE2E1 interacts with PRC1 subunits including Ring1A and Ring1B.

262 xpression was partly rescued by knockdown of PRC1 subunits, suggesting that Usp16 and PRC1 counterbal

263 2 condensate formation does not require CBX2-PRC1 subunits; however, the condensate formation of CBX2

264 ions describing the intrinsic flexibility of PRC1, suggests that the MT-spectrin domain interface det

265 that contains upregulated factors including Prc1 supports kinetochore-independent pathways for spind

266 ogic inhibition of glucose transporter 1 and PRC1 synergistically promoted ER stress and suppressed t

267 t, and suppressed by interference of a known PRC1 target gene, demonstrating cat7l genetically intera

268 veals differential regulation of a subset of PRC1-target genes including HSC-associated transcription

269 cause loss of direct binding between BAF and PRC1 that occurs independently of chromatin.

270 produced by the mitotic crosslinking protein PRC1 that resist microtubule sliding.

271 component of polycomb-repressive complex 1 (PRC1) that catalyzes H2Aub on chromatin.

272 of a variant Polycomb repressive complex 1 (PRC1) that is essential for normal development.

273 a subunit of Polycomb Repressive Complex 1 (PRC1) that mediates epigenetic gene repression and acts

274 component of Polycomb repressive complex 1 (PRC1), the E3 ligase complex responsible for histone H2A

275 Subunits of polycomb repressive complex 1 (PRC1), the major histone H2A ubiquitin ligase, are criti

276 tion and the degradation of proteins such as PRC1, the Protein Regulator of Cytokinesis, to ensure th

277 y is also necessary to maintain a functional PRC1, thereby ensuring appropriate levels of repressive

278 sence of PRC2 but at many PREs PRC2 requires PRC1 to be targeted.

279 Targeting of PRC1 to chromatin is thought to be mediated by the Cbx f

280 ing H2A deubiquitinases functions along with PRC1 to control H2A ubiquitination (ubH2A) level and reg

281 igenetic silencing of PcG targets by linking PRC1 to formation of a repressive higher-order structure

282 ch coordinates with the H2A ubiquitin ligase PRC1 to regulate hematopoiesis, and revealed cell cycle

283 one of six Pcgf paralogs, uniquely regulates PRC1 to specify mesoderm cell fate in embryonic stem cel

284 inant model of PRC2-dependent recruitment of PRC1 to target genes.

285 itment of the polycomb-repressive complex 1 (PRC1) to a subset of its target loci.

286 tional maintenance, mostly in the absence of PRC1, to fully transform hematopoietic progenitors.

287 tubule bundles appear capped despite dynamic PRC1 turnover and submicrometer proximity to growing mic

288 PRC1-type complexes also have global roles.

289 s can recruit PRC1 from extracts and enhance PRC1 ubiquitin ligase activity towards histone H2A.

290 Coincidentally, the PRC1 ubiquitin ligase RNF2 is activated while a histone

291 if EMF1, LHP1, and AtBMI1 exist in a common PRC1 variant, their role in repression depends on the fu

292 ant development, suggesting the existence of PRC1 variants; however, it is not clear in how many proc

293 hat canonical Polycomb repressive complex 1 (PRC1), which mediates higher-order chromatin structures,

294 ponent of the Polycomb Repressive Complex 1 (PRC1), which plays a key role in maintaining epigenetic

295 Knock-down of PRC1, which disrupts the spindle midzone, revealed the e

296 vide important insights into the function of PRC1, while highlighting the complexity of this regulato

297 thought to play a role in the association of PRC1 with chromatin.

298 Upon expressing a mutant PRC1 with reduced microtubule affinity, bundles assemble

299 er, evidence indicates that diverse forms of PRC1, with shared components, are a common theme in plan

300 e new genes we identified: HAUS6, KANSL1 and PRC1, with the latter comparable to MYC.