ライフサイエンスコーパス: PRDM1

1 as PR domain-containing 1, with ZNF domain (PRDM1)).

2 other molecules, and the absence of Blimp-1 (prdm1).

3 gnaling through the protein PR/SET domain 1 (PRDM1).

4 e transcription factor Blimp1 (also known as Prdm1).

5 izing the anti-proliferative factor Blimp-1 (Prdm1).

6 igh PRDM1alpha mRNA levels but low levels of PRDM1.

7 igh PRDM1alpha mRNA expression and unmutated PRDM1.

8 phocyte-induced maturation protein (Blimp-1)/PRDM1.

9 yhc3, and all differentiate independently of Prdm1.

10 ession of the transcription factors KLF4 and PRDM1.

11 nner in differentiating B cells and targeted Prdm1.

12 importance of Bcl-6-dependent repression of prdm1.

13 cis-regulatory elements, including those of Prdm1.

14 ntrolled, including GRHL3, ZNF750, KLF4, and PRDM1.

15 urthermore, we show that Blimp1 (also called Prdm1), a let-7 target and a master regulator of PGC spe

16 Expression of Blimp-1 (Prdm1), a transcription factor necessary for cytolytic C

17 own to interact and repress transcription of PRDM1, a key driver of plasma cell differentiation.

18 r responses triggered by VLVs and found that PRDM1, a master regulator in cell differentiation, was s

19 Here, we show that nrd is a mutation in prdm1, a SET/zinc-finger domain transcription factor.

20 cus, E-proteins contributed to Igk, Igh, and Prdm1 activation in plasmablasts.

21 Additionally, Prdm1 activity is essential for proper development of sl

22 itch fibre characteristics in the absence of Prdm1 activity, whereas those that do not express smyhc1

23 We show that Prdm1 acts independently of Aire, a crucial transcriptio

24 In mouse embryos, mutation of Prdm1 affects branchial arch development and leads to pe

25 h either deletion or silencing of the paired PRDM1 allele.

26 by the activity of the transcription factor Prdm1 (also called Ubo or Blimp1) in response to Hedgeho

27 monstrate that the transcriptional repressor PRDM1 (also known as Blimp-1 or PRDI-BF1) is a critical

28 induction of PR domain-containing protein 1 (PRDM1; also known as Blimp-1), a critical regulator of p

29 In TFH cells, Fgl2 induces the expression of Prdm1 and a panel of checkpoint molecules, including PD1

30 Higher concentration of IRF-4 induced Prdm1 and consequently the transition from a germinal ce

31 Ezh2 activates Id3 while silencing Id2, Prdm1 and Eomes, promoting the expansion of memory precu

32 e more accessible in stem-like cells whereas Prdm1 and Id2 were more accessible in exhausted CD8 T ce

33 oliferation of memory CD8(+) T cells through Prdm1 and Id3.

34 ates that the functional interaction between PRDM1 and IFN-regulated pathways antedates the evolution

35 igen presentation in DCs, demonstrating that PRDM1 and IRF8/PU.1 counter-regulate expression.

36 f GWAS and provide evidence that variants in PRDM1 and NDP52 determine susceptibility to CD.

37 These data underscore dual targeting of PRDM1 and NR4A3 as a promising approach to advance adopt

38 sponses, effects that were not achieved with PRDM1 and NR4A3 single knockout alone.

39 Dual knockout of PRDM1 and NR4A3 skewed CAR T cell phenotypes away from T

40 on-associated molecules such as Tim-3, Lag3, Prdm1 and Pbx3, and Bat3 knockdown in myelin-antigen-spe

41 mme, including the transcriptional repressor PRDM1 and pluripotency factors POU5F1 and NANOG.

42 hat NANOG can bind and activate enhancers of Prdm1 and Prdm14 in EpiLCs in vitro; BLIMP1 (encoded by

43 However, combined ablation of Prdm1 and Tcf7 preserved a memory surface phenotype desp

44 and CD38(-) EB cells significantly expressed PRDM1 and TFAP2C, although PRDM1 mRNA in CD38(-) cells l

45 Prdm1 and Vsx2 also appear to redundantly restrict the c

46 cell fates are regulated in mice, we deleted Prdm1 and Vsx2 or their cell type-specific enhancers sim

47 ne or enhancer targeting effectively removed PRDM1 and VSX2 protein expression.

48 directly activates the transcription factors Prdm1 and Vsx2 through cell type-specific enhancers.

49 PRDM1 and VSX2 work in opposition, such that PRDM1 promo

50 NR4A family of nuclear receptors, as well as Prdm1 and Xbp1 While deletion of Ldha prevented developm

51 issense mutations in PR domain-containing 1 (PRDM1) and associated these with CD.

52 he transcription factors Blimp-1 (encoded by Prdm1) and c-Maf co-dominantly regulate Il10 while negat

53 noted as the PRDI-BF1 (HGMW-approved symbol PRDM1) and RIZ (HGMW-approved symbol PRDM2) homologous r

54 including BiP (HSPA5), IRE1 (ERN1), Blimp-1 (PRDM1), and X-box binding protein 1 (XBP1).

55 The appearance of dermal papilla (PRDM1+) and hair follicle (SLC26A7+) fibroblasts coincid

56 hese genes provide evidence that nfat5, fos, prdm1, and dusp16 are novel direct targets of Blimp-1.

57 ranscription factors, including Tbx3, Gata5, Prdm1, and Pbx1.

58 Inducible, Cre-mediated deletion of Hspa5, Prdm1, and Xbp1 consistently induces cellular stress and

59 ion activators, including HOPX, GRHL3, KLF4, PRDM1, and ZNF750.

60 ive regulation of NK activation and position PRDM1 as a common regulator of the adaptive and innate i

61 nd the MHC, and identifies a unique role for PRDM1 as a key regulator of Ag presentation by MHC class

62 Our results identify PRDM1 as a potential modifier of phenotypic severity in

63 enetic defect in DLBCL cells and establishes PRDM1 as a potential tumor suppressor gene in DLBCL.

64 transcription factor binding motifs SRF and PRDM1 as important regulators of PIP3-sensitive mRNAs in

65 ified the transcriptional repressor Blimp-1 (PRDM1) as a downstream effector of the NF-kappaB, RelB/B

66 identified the transcription factor Blimp-1 (Prdm1) as a key IL-23-induced factor that drove the infl

67 n through the BCR rapidly induces endogenous PRDM1 at the level of transcription with minor changes i

68 ession has been confirmed at the mRNA level: PRDM1, ATG5, AIM1, and HACE1.

69 Mutations and methylation in PRDM1, ATG5, and AIM1 have been reported in NKTCL cell l

70 ropean ancestry: CD247, NAB1, PTTG1-MIR146A, PRDM1-ATG5, TNFAIP3, XKR6, MAPT-CRHR1, RPTOR-CHMP6-BAIAP

71 domain containing 1 with zinc finger domain (PRDM1)/B lymphocyte-induced maturation protein 1 (BLIMP1

72 Furthermore, although prdm1-/- B cells fail to induce XBP-1, XBP-1 cannot resc

73 oxic and exhaustion signatures was driven by PRDM1, BATF, ETV7, and TOX.

74 etic lineage development (e.g., HUWE1, IRF4, PRDM1, BATF3, TOX, ID2, IKZF3, and CDK6) or were hematop

75 oma cell lines express the highest levels of PRDM1 beta mRNA relative to the full-length form, while

76 nes have very low, but detectable, levels of PRDM1 beta.

77 PRDM1 binding also blocks IRF8-mediated activation depen

78 ncreased H3K27 acetylation in cHL, disrupted PRDM1 binding, and co-occurred with BCL6 expression in c

79 in LCLs inhibition of CDKN2C (p18INK4c) and PRDM1 (BLIMP-1) transcription results from direct bindin

80 cells in primary HL cases showed weak or no PRDM1/Blimp-1 expression.

81 Prdm1/Blimp-1 is a master regulator of gene expression i

82 Our studies here demonstrate that PRDM1/blimp-1 is also a target for microRNA (miRNA)-medi

83 Over-expression of miR-9 or let-7a reduced PRDM1/Blimp-1 levels in U266 cells by 30% to 50%, wherea

84 MiRNA-mediated down-regulation of PRDM1/Blimp-1 may contribute to the phenotype maintenanc

85 nding sites in the 3' untranslated region of PRDM1/blimp-1 mRNA and repressed luciferase reporter act

86 ound activators paralleled by recruitment of PRDM1/Blimp-1 to the promoter.

87 PRDM1/Blimp-1, a master regulator for B cell terminal di

88 PRDM1/Blimp-1, a master regulator in terminal B-cell dif

89 HL cell lines correlated with low levels of PRDM1/Blimp-1.

90 ed in an approximately 2.6-fold induction in PRDM1/Blimp-1.

91 ube and colleagues have identified FOXO3 and PRDM1 (Blimp1) as tumor suppressor genes with a potentia

92 nd Igh enhancers and a distal element at the Prdm1 (Blimp1) locus, E-proteins contributed to Igk, Igh

93 llenge wild-type, Bcl6(fl/fl) Foxp3-Cre, and Prdm1 (Blimp1)(fl/fl) Foxp3-Cre mice to study the recipr

94 AIOLOS), TBX21 (T-bet), NFIL3 (E4BP4), ZEB2, PRDM1 (BLIMP1), and RORA mRNA levels are higher in CD56(

95 factors in B-cell differentiation: LMO2 and PRDM1 (Blimp1).

96 ng the zinc finger transcriptional repressor Prdm1/Blimp1 (PR domain containing 1, with ZNF domain; p

97 ls of the plasmablast differentiation marker PRDM1/Blimp1 and increased the abundance of c-Myc protei

98 at the zinc finger transcriptional repressor Prdm1/Blimp1 is essential for specification of spiral ar

99 Later in development Prdm1/Blimp1 is expressed in many other tissues, includi

100 misexpression and dominant-negative studies, Prdm1/Blimp1 was proposed to promote anterior endomesode

101 by the zinc finger transcriptional repressor Prdm1/Blimp1, an essential regulator of placenta develop

102 5b down-regulates the expression of IRF4 and PRDM1/BLIMP1, and memory B cell-enriched hsa-miR-223 dow

103 between MHC II and plasma cell markers MUM1, PRDM1/Blimp1, and XBP1s.

104 a differentiation-related BCL6 target gene (PRDM1), but not target genes involved in survival.

105 Thus, abnormal epigenetic down-regulation of PRDM1 by let-7 and other microRNAs may represent an alte

106 n experiments support a role of targeting of PRDM1 by microRNA let-7 family in mediating this down-re

107 In support of this role, knockdown of PRDM1 by shRNA in normal NK cells resulted in the positi

108 ate and propionate decrease B cell Aicda and Prdm1 by upregulating select miRNAs that target Aicda an

109 n of the master transcription factor Blimp-1/Prdm1 can be observed; when the canonical B cell promote

110 dritic cell-specific conditional knockout of Prdm1 (CKO mice) altered the presentation of antigen to

111 We show that PRDM1 co-repressors, G9a and HDAC2, are recruited to CII

112 inc-finger transcriptional repressor Blimp1 (Prdm1) controls gene expression patterns during differen

113 PRDM1 coordinately suppresses the release of IFN-gamma,

114 ine-specific deletion of Utf1 resulting from Prdm1-Cre mediated recombination are born with significa

115 neage tracing experiments exploiting a novel Prdm1.Cre-LacZ allele demonstrate that these Blimp1(+) c

116 Here we exploit a Prdm1.CreERT2-LacZ reporter allele for lineage tracing e

117 However, in the setting of PRDM1 deficiency, a negative epigenetic feedback program

118 Prdm1 down-regulated IL-2 signaling, whereas Prdm1-deficiency enhanced IL-2 signaling in mouse CD4(+)

119 erforin secretion decreased significantly in Prdm1-deficient cNK cells and liver ILC1s.

120 d partially ameliorated the inflamed skin in Prdm1-deficient mice.

121 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among oth

122 The ability to induce PRDM1 did correlate with differential transcriptional an

123 Although Prdm1 did not affect the killing function of cNK cells i

124 PRDM1 directly activates their expression by binding to

125 etween blood and peripheral tissues shared a PRDM1-dominant landscape.

126 Here, we show that overexpressing Prdm1 down-regulated IL-2 signaling, whereas Prdm1-defic

127 subsets characterized by high levels of PD1: Prdm1(+) effector regulatory T cells expressing immunore

128 ediated regulation of key PCD factors (IRF4, PRDM1, ELL2 and ARID3A).

129 The induced PRDM1-encoded protein localizes to its target genes in v

130 Prdm1 encodes a transcriptional repressor that we show i

131 , STAT1 directly regulates the expression of Prdm1 (encodes BLIMP-1) by binding to its promoter, and

132 lupus susceptibility genes such as IRF5 and PRDM1 (encoding for IFN regulatory factor 5 [IRF]5 and B

133 ssociated with decreased basal expression of PRDM1 (encoding PR domain containing 1, with ZNF domain)

134 Mice with a T cell-specific deletion of Prdm1, encoding Blimp-1, have aberrant T cell homeostasi

135 Low expression of PRDM1, encoding the BLIMP1 transcription factor, defined

136 and functional characterization of zebrafish prdm1 exhibiting a dynamic and evolutionarily conserved

137 ion pressure with progressive elimination of PRDM1-expressing cells, which was enhanced when IL-2 con

138 an autoregulatory loop by which IL-2 induces Prdm1 expression and thus represses its own expression a

139 Accordingly, MTA3 and PRDM1 expression are mutually exclusive in germinal cent

140 drugs may offer possibilities to reactivate PRDM1 expression as part of novel differentiation therap

141 hey in turn repress PRDM1, whereas prolonged PRDM1 expression inhibits neural, neural crest and senso

142 des BLIMP-1) by binding to its promoter, and Prdm1 expression is reduced in Stat1(-/-) MZ B cells.

143 Ablation of PRDM1 expression leads to enhanced production of IFN-gam

144 Commensurately higher Blimp1/PRDM1 expression was detected in ERalpha-negative breast

145 tantly, we demonstrated that by upregulating PRDM1 expression, VLVs triggered differentiation signali

146 We observed a progressive increase in PRDM1 expression--in particular, PRDM1alpha--in normal N

147 AT3 and IRF4, which are required for optimal Prdm1 expression.

148 FoxO1 phosphorylation, indirectly promoting Prdm1 expression.

149 T(H)1/NK/ILC1 effector genes in LPLs, while Prdm1(fl/fl)Cd4(Cre) and Maf(fl/fl)Cd4(Cre) mice exhibit

150 Double-deficient Prdm1(fl/fl)Maf(fl/fl)Cd4(Cre) mice infected with Helico

151 Analysis of prdm1 function by overexpression indicates that prdm1 fu

152 an alternative mechanism of reducing normal PRDM1 function in a subset of DLBCL with relatively high

153 2-expressing fibres, although independent of Prdm1 function, require Hh activity to form.

154 ss smyhc1 can differentiate independently of Prdm1 function.

155 In this article, we demonstrate that Prdm1 functions in TECs to prevent autoimmunity in mice.

156 ECs, but not wild-type TECs, indicating that Prdm1 functions in TECs to regulate autoantibody product

157 m1 function by overexpression indicates that prdm1 functions to promote the cell fate specification o

158 STAT4, ATF4, TP63, EGR1, CDKN2A, RBL1, E2F1, PRDM1, GATA3, and IRF4) at 18 hours after exposure to E.

159 These newly described features of the PRDM1 gene are highly analogous to the PRDM2 (RIZ) and P

160 IRF-5 stimulates transcription of the Prdm1 gene encoding Blimp-1 and binds to the IRF site in

161 Induction of PRDM1 gene expression was mediated by interaction of Bcl

162 a novel BCL6 binding site on intron 3 of the PRDM1 gene, and show that BCL6 recruits MTA3 to this sit

163 l development, which is transcribed from the PRDM1 gene.

164 nce of an alternative protein product of the PRDM1 gene.

165 scriptional and epigenetic regulation of the PRDM1 gene.

166 6, including cis-regulatory sequences of the PRDM1 gene.

167 the smyhc1-positive fibres express the ubo (prdm1) gene and adopt fast twitch fibre characteristics

168 Accordingly, the murine Irf5 and Prdm1 genes have been shown to play a role in lupus susc

169 17p13 and at 6q21, encompassing the TP53 and PRDM1 genes, respectively.

170 controlling the expression of the Aicda and Prdm1 genes, which encode AID and Blimp-1, respectively.

171 The transcription factor Prdm1 has been implicated in autoimmune diseases in huma

172 Inactivating mutations of PRDM1 have been previously identified in a subset of non

173 ing intermediate expression of FOXP3, Bcl-6, PRDM1, IL-10, and IL-21.

174 than ZNF683, alongside a few immature TCF7(+)PRDM1(-) ILC1s.

175 of alternative mechanisms of down-regulating PRDM1 in a cohort of 25 primary DLBCL and six DLBCL cell

176 anced IL-2 signaling, whereas overexpressing PRDM1 in ATL cells suppressed IL-2 signaling.

177 NA (crRNA) generates an exon3 skip mutant of PRDM1 in CAR-Ts, which leads to increased proliferation,

178 udy unveiled a novel regulatory mechanism of Prdm1 in cNK cells and liver ILC1s, showing promising po

179 t of mouse TECs, and conditional deletion of Prdm1 in either Keratin 14- or Foxn1-expressing cells in

180 Deleting PRDM1 in human CD4(+) T cells and T(reg) cells also incr

181 GWAS, correlated with reduced expression of PRDM1 in ileal biopsy specimens and peripheral blood mon

182 Our studies reveal essential roles for prdm1 in limiting the function of the gastrula organizer

183 e required for the BCR-induced expression of PRDM1 in lymphoma cells and in PU.1-positive myeloma cel

184 that this is not due to a direct function of Prdm1 in neural crest cells.

185 We identified MYC and 4-1BBL as targets of PRDM1 in NK cells.

186 tumor suppressor gene, the reconstitution of PRDM1 in PRDM1-null NK cell lines led to G2/M cell cycle

187 highlight a previously unrecognized role for Prdm1 in regulating thymic epithelial function.

188 The activity of PRDM1 in silencing all three cell type-specific CIITA pr

189 in mice using cell type-specific deletion of Prdm1 in T and dendritic cells.

190 identified clonal inactivating mutations in PRDM1 in the diffuse large B-cell lymphoma (DLBCL) cell

191 Deletion of Prdm1 in the epidermis of adult mice also led to stronge

192 gene-exposure interaction that may implicate PRDM1 in the etiology of radiation therapy-induced SMNs.

193 ively, these data demonstrate a key role for PRDM1 in the negative regulation of NK activation and po

194 a crucial role for the transcription factor PRDM1 in the orderly transition from epiblast to defined

195 Mutation of Prdm1 in the SHF does not result in PTA, but leads to ar

196 produced by keratinocytes after deletion of Prdm1 in vitro was mediated by the transcriptional activ

197 networks individually regulated by FOXP3 and PRDM1, in addition to a network coregulated by FOXO1 and

198 This study identifies PRDM1 inactivation as a recurrent genetic defect in DLBC

199 PRDM1 induction was inversely correlated with the extent

200 Misexpression of prdm1 inhibits the formation of dorsoanterior structures

201 that FOXP1 directly represses expression of PRDM1, IRF4, and XBP1, transcriptional master regulators

202 iched for predicted binding sites for STAT6, PRDM1, IRF6, JDP2, NR2E1, and BCL6, suggesting a central

203 PRDM1 is a transcriptional repressor with essential role

204 tro and in vivo experiments showed that that PRDM1 is a tumor suppressor gene in ALCL models, likely

205 Here we show that PRDM1 is a tumor suppressor gene in NKCLs that is inacti

206 Activation of PRDM1 is associated with loss of the corepressor transdu

207 rved; when the canonical B cell promoter for Prdm1 is deleted, differentiating B cells exhibit flexib

208 zinc finger transcriptional repressor Blimp1/PRDM1 is essential for the establishment of epithelial c

209 prdm1 is expressed at the border of the neural plate wit

210 Prdm1 is expressed by a subset of mouse TECs, and condit

211 PRDM1 is initially expressed broadly in the entire epibl

212 These findings indicate that PRDM1 is poised for activation in lymphoma cells and the

213 In sum, the transcriptional repressor Blimp1/Prdm1 is required for terminal differentiation of SpA-TG

214 We find that PRDM1 is required for the loss of some pluripotency mark

215 hocyte-induced maturation protein 1 (BLIMP-1/PRDM1) is a master transcriptional repressor essential f

216 (PRDI-BF1-RIZ) domain zinc finger protein 1 (PRDM1) is a transcription repressor with a pivotal role

217 or fate determination, we found that Blimp1 (Prdm1) is expressed transiently in developing photorecep

218 Three distinct PRDM1 isoforms are selectively induced in the CD56(dim)

219 luding IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.

220 ncrease in cancer metastasis was observed in Prdm1 knockout mice.

221 PRDM1 knockout promoted TCF7-dependent CAR T cell stemne

222 While KLF4 and PRDM1 levels were unaltered, the expression levels of KL

223 ting PR domain-containing 1 with ZNF domain (PRDM1) levels in macrophages.

224 We observed monoallelic deletion of PRDM1 loci in 8 of 18 (44%) NKCL cases.

225 otifs and epigenetic remodeling of IL21R and PRDM1 loci.

226 In the human PRDM1 locus, CD40L treatment enhanced the ability of STA

227 oprecipitation (ChIP)-on-chip mapping of the PRDM1 locus, identifying a novel BCL6 binding site on in

228 nd demethylation of multiple elements at the Prdm1 locus.

229 scRNA-seq) data also provided evidences that Prdm1 maintains functional subsets of cNK cells and live

230 PRDM1 maps adjacent to a CD interval identified in GWAS

231 Disruption of homeostatic control by PRDM1 may be an important pathogenetic mechanism for NKC

232 At the end of the gastrula period, prdm1 morphant embryos have enlarged animal-vegetal and

233 icantly expressed PRDM1 and TFAP2C, although PRDM1 mRNA in CD38(-) cells lacked the 3'-UTR harboring

234 d mutation, and conversely overexpression of prdm1 mRNA rescues the nrd RB sensory neuron and neural

235 gulating select miRNAs that target Aicda and Prdm1 mRNA-3'UTRs through inhibition of histone deacetyl

236 Developmental arrest of Blimp1/Prdm1 mutant embryos at around embryonic day 10.5 (E10.5

237 a Tbx1 heterozygote background, conditional Prdm1 mutants have more pronounced arterial pole defects

238 were identified in a subset of DLBCL without PRDM1 mutations, the primarily non-GCB type, consistent

239 oped anti-nuclear Abs when transplanted with Prdm1 null TECs, but not wild-type TECs, indicating that

240 pressor gene, the reconstitution of PRDM1 in PRDM1-null NK cell lines led to G2/M cell cycle arrest,

241 in LPLs from infected mice in the absence of Prdm1 or Maf, revealing potential mechanisms of human di

242 Expression of FOXP1, Blimp-1/PRDM1, or BCL-2 was not correlated with the outcome in p

243 ecific interactions, like Pax5/Ebf1 vs. Pax5/Prdm1, or the role of different NF-kappaB dimers in diff

244 Using the sea urchin prdm1 ortholog, we demonstrate that the capacity of PRDM

245 retion in plasma cells by targeting Hrd1/p38/PRDM1 pathway.

246 A Morpholino-mediated depletion of prdm1 phenocopies the nrd mutation, and conversely overe

247 Therefore, PRDM1 plays multiple roles during ectodermal cell fate a

248 (B lymphocyte-induced maturation protein-1)/PRDM1 (PR domain-containing 1, with ZNF domain) binding

249 and butyrate dampened AICDA/Aicda (AID) and PRDM1/Prdm1 (Blimp-1) mRNAs by upregulating miR-155, miR

250 HM), and Bcl6, Bach2, or Pax5 (repressors of PRDM1/Prdm1 expression), as well as unchanged expression

251 ibitor-mediated silencing of AICDA/Aicda and PRDM1/Prdm1 was emphasized by unchanged expression of Ho

252 nd miR-23b, miR-30a, and miR-125b to silence PRDM1/Prdm1, in human and mouse B cells.

253 ich are not known to regulate AICDA/Aicda or PRDM1/Prdm1.

254 Several members such as PRDM1, PRDM14 and PRDM9, have been implicated in germ ce

255 ession of key germline transcription factors Prdm1, Prdm14 and Tfap2c, directly induce PGC-like cells

256 ic expression of the germ line-related genes PRDM1, PRDM14, LIN28A, DAZL, VASA and SYCP3 induced dire

257 ethylation augments STAT3 association at the Prdm1 promoter and a downstream enhancer, thus ensuring

258 In vivo genomic footprinting of the PRDM1 promoter in unstimulated lymphoma and myeloma cell

259 ing Blimp-1 and binds to the IRF site in the Prdm1 promoter.

260 RNA analysis and analysis of the PRDM1 promoters demonstrate that PRDI-BF1 beta is genera

261 PRDM1 and VSX2 work in opposition, such that PRDM1 promotes photoreceptor fate and VSX2 bipolar cell

262 th ZNF domain) and impaired induction of the PRDM1 protein after radiation exposure.

263 ed abundant mature EOMES(-) ILC1s expressing PRDM1 rather than ZNF683, alongside a few immature TCF7(

264 The zinc finger transcription factor Blimp1/PRDM1 regulates gene expression in diverse cell types.

265 the transcription factor Blimp-1 (encoded by Prdm1) repressed expression of the gene encoding catheps

266 Here we investigate Blimp1/Prdm1 requirements in the trophoblast cell lineage.

267 PRDM1 response elements are defined at the IFNG and TNF

268 PRDM1 responsiveness was associated with other markers o

269 ession of ERAP1, TAPASIN, MECL1, and LMP7 by PRDM1 results in failure to up-regulate surface MHC clas

270 -6) replication, P = 1 x 10(-9) overall) and PRDM1 (rs548234, P = 1 x 10(-5) replication, P = 2 x 10(

271 ic model where the evolutionary emergence of PRDM1-S and epigenetic priming of AP-1/IRF may be key dr

272 binding as candidate upstream regulators of PRDM1-S expression and T(reg) dysfunction.

273 This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune disea

274 r Gfi1, Sox4, Brca2, Snf1lk, Nfkb1, Pou2af1, Prdm1, Stat6, and Blnk.

275 te that the pioneer TF FOXA coordinates with PRDM1 TF to recruit nucleosome remodeling and deacetylat

276 fied an IL-21 response element downstream of Prdm1 that binds the transcription factors STAT3 and IRF

277 n factors (e.g., Nfatc2, Fos, Jun, Ets1, and Prdm1) that are critical for PD-1 transcription, exubera

278 egulatory domain zinc finger protein 1 gene (PRDM1) that encodes the positive regulatory domain I bin

279 of PR domain containing 1, with ZNF domain (Prdm1), the gene encoding Blimp-1, in adult mice caused

280 Blimp1 (Prdm1), the key determinant of primordial germ cells (PG

281 ave identified two intronic regions of mouse prdm1, the gene encoding B lymphocyte-induced maturation

282 ted genetic manipulation of cells expressing Prdm1, the gene encoding Blimp-1.

283 ated mice with a B cell-specific deletion of prdm1, the gene encoding Blimp-1.

284 e is currently known about the regulation of PRDM1, the gene encoding PRDI-BF1.

285 rdm14 in EpiLCs in vitro; BLIMP1 (encoded by Prdm1) then directly induces Tfap2c.

286 rtholog, we demonstrate that the capacity of PRDM1 to repress the IFN response of such promoters is e

287 red fluorescent protein, under regulation by Prdm1 transcriptional elements, and we achieved transduc

288 Conversely, interference with Prdm1 translation using antisense morpholino oligonucleo

289 Third, Prdm1:TVB-mRFP transgenic animals could provide an inval

290 -3)]-expressing CD8(+) T cells with elevated PRDM1 was associated with poor outcomes.

291 noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding.

292 emonstrated that VLV-induced upregulation of PRDM1 was necessary and sufficient to reactivate KSHV by

293 While expression of BLIMP1 (encoded by Prdm1) was a common target, IL-10 and IL-35 differential

294 Losses of TP53 and/or PRDM1 were present in 52% of ALK(-)ALCL, and in 29% of a

295 nants become expressed, they in turn repress PRDM1, whereas prolonged PRDM1 expression inhibits neura

296 ed excess Bcl-6 to repress its direct target Prdm1 (which encodes the transcriptional repressor Blimp

297 transcription factor Blimp-1 (also known as Prdm1), which is a widely conserved bilaterian gene know

298 n of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation and

299 expression of key plasma cell genes such as Prdm1, Xbp1, and CD138.

300 ivating transcription factors (GRHL3, OVOL1, PRDM1, ZNF750) to advance terminal differentiation.