ライフサイエンスコーパス: Paget

1 Paget disease is a common bone disease characterized by

2 Paget disease is the most exaggerated example of abnorma

3 Paget disease of bone (PD) is characterized by excessive

4 Paget disease of bone (PDB) is a skeletal disorder chara

5 Paget disease of bone, or "osteitis deformans," is a bon

6 Paget's disease (PD) is characterized by focal and drama

7 Paget's disease is characterized by highly localized are

8 Paget's disease is often asymptomatic but can be associa

9 Paget's disease of bone (PDB) is a chronic skeletal diso

10 Paget's disease of bone (PDB) is a common disorder chara

11 Paget's disease of bone (PDB) is a common disorder chara

12 Paget's disease of bone (PDB) is a common disorder with

13 Paget's disease of bone (PDB) is a common disorder with

14 Paget's disease of bone (PDB) is characterised by focal

15 Paget's disease of bone (PDB) is characterized by focal

16 Paget's disease of bone (PDB) is the second most common

17 Paget's disease of bone is a common disease characterise

18 Although Paget disease is diagnosed economically with conventiona

19 static and nonmetastatic prostate cancer and Paget's disease.

20 iseases, including myopathies, dementias and Paget disease of bone (PDB), as it may define a new comm

21 with numerous neurodegenerative diseases and Paget's disease of bone (PDB), a degenerative bone disea

22 in osteoclasts, we hypothesized that FEO and Paget disease are allelic versions of the same locus.

23 hy (IBM), frontotemporal dementia (FTD), and Paget's disease of bone (PDB).

24 , including cancer-related hypercalcemia and Paget's disease of bone, studies have been initiated to

25 , including cancer-related hypercalcemia and Paget's disease of bone, studies were initiated to explo

26 tion (FTLD) with inclusion body myopathy and Paget disease of bone is a rare, autosomal dominant diso

27 flict two families, mainly with myopathy and Paget's disease of bone.

28 as been used in therapy for osteoporosis and Paget's disease for decades, human calcitonin (hCT) form

29 e treatment of osteopenia, osteoporosis, and Paget's disease of bone.

30 Otosclerosis and Paget disease are CT diagnoses.

31 ral" diseases such as multiple sclerosis and Paget's disease, and the controversy surrounding MV vacc

32 eat osteoporosis in postmenopausal women and Paget's disease of bone.

33 indings suggest that the association between Paget disease and osteosarcoma is the result of a single

34 (2018) bring Paget's disease into the genomics era, providing evidenc

35 ave been identified in four genes that cause Paget's disease and related syndromes.

36 e the fact that human mutations in VCP cause Paget disease of bone and frontotemporal dementia, an au

37 Besides, our cases challenge Paget's seed - soil theory for sites of metastasis.

38 Extramammary Paget disease (EMPD) is a rare, highly recurrent cutaneo

39 Extramammary Paget disease (EMPD) is commonly refractory to surgical

40 embers of four families with FEO or familial Paget disease of bone (PDB).

41 D18S42, a region tightly linked to familial Paget disease.

42 occur in one-third of patients with familial Paget disease and in a minority of patients with sporadi

43 oviding evidence for an epidermal origin for Paget's disease, as well as a high incidence of mutation

44 the gene(s) responsible for FEO and that for Paget disease are either closely linked or the same locu

45 ed bones compared with uninvolved bones from Paget's patients.

46 ugs that treat osteoporosis, hypercalcaemia, Paget's disease, type II diabetes, and obesity and are b

47 rugs used in the treatment of hypercalcemia, Paget's disease, osteoporosis, and malignancy.

48 n (VCP) cause inclusion body myopathy (IBM), Paget's disease of the bone, and frontotemporal dementia

49 f Paget disease was examined to determine if Paget disease was linked to genetic markers in the same

50 Moreover, as in Paget disease, serum levels of interleukin-6 are markedl

51 ontribute to the elevated numbers of OCLs in Paget's disease.

52 Osteoclasts (OCLs) in Paget's disease are markedly increased in number and siz

53 Osteosarcoma in Paget patients is the underlying basis for a significant

54 re not coordinately increased, as is seen in Paget disease.

55 Radiation-induced, Paget, metastatic, and multifocal osteosarcoma were excl

56 Almost 150 years have passed since Sir James Paget described the disease that bears his name, but the

57 Juvenile Paget's disease can result from osteoprotegerin deficien

58 Juvenile Paget's disease, an autosomal recessive osteopathy, is c

59 protegerin deficiency could explain juvenile Paget's disease because osteoprotegerin suppresses bone

60 ntly unrelated Navajo patients with juvenile Paget's disease for defects in the gene encoding osteopr

61 ride therapy (n = 20) and patients with mild Paget's disease (n = 5).

62 analysis of families with multigenerational Paget disease shows linkage to a region of chromosome 18

63 multisystem disease inclusion body myopathy, Paget disease of the bone and frontotemporal dementia (I

64 nt disease known as inclusion body myopathy, Paget disease with frontotemporal dementia (IBMPFD) and

65 ed in families with Inclusion Body Myopathy, Paget disease, and Frontotemporal Dementia (IBMPFD).

66 ition, resulting in Inclusion Body Myopathy, Paget disease, and Frontotemporal Dementia (IBMPFD).

67 mutant that causes inclusion body myopathy, Paget's disease of bone, and frontotemporal dementia in

68 henotypes including inclusion body myopathy, Paget's disease of the bone, and frontotemporal dementia

69 ns are the cause of inclusion body myopathy, Paget's disease of the bone, and frontotemporal dementia

70 insonism, frontotemporal dementia, myopathy, Paget's disease, or a combination of these.

71 ations in the VCP gene, results in myopathy, Paget's disease of bone (PBD) and frontotemporal dementi

72 Approximately 1% of Paget patients develop osteosarcoma, which represents an

73 62 gene have been identified in up to 30% of Paget's patients.

74 ion in marrow samples from affected bones of Paget's patients with that in normal marrow.

75 SQSTM1 gene, coding for p62, are a cause of Paget disease of bone and amyotrophic lateral sclerosis

76 culoskeletal and neurologic complications of Paget disease, including fracture, basilar impression, s

77 prevent the development of complications of Paget's disease of bone, and further work is needed to a

78 cause a predisposition to the development of Paget disease by increasing the sensitivity of osteoclas

79 e yields samples which permit a diagnosis of Paget's disease without surgical biopsy.

80 the mutations of which lead to rare forms of Paget's disease of bone (PDB)-like syndrome-such as incl

81 re, a large kindred with a high incidence of Paget disease was examined to determine if Paget disease

82 Medical management of Paget's disease of bone is based on giving inhibitors of

83 e molecular etiology and cellular origins of Paget's disease remain poorly understood.

84 role of MV in the abnormal OCL phenotype of Paget's disease, we transduced normal OCL precursors wit

85 FTD; only 1 family had clinical symptoms of Paget disease of bone, and only 1 family had clinical sy

86 en shown to be effective in the treatment of Paget disease of bone and other metabolic bone diseases

87 and inclusion body myopathy with early-onset Paget disease and fronto-temporal dementia.

88 on body myopathy associated with early-onset Paget disease of bone and frontotemporal dementia (hIBMP

89 destruction in postmenopausal osteoporosis, Paget's disease, bone metastasis, and hypercalcemia of m

90 asts are valuable for treating osteoporosis, Paget's disease, and inflammation of bone associated wit

91 We report a case of polyostotic Paget's disease of bone that caused an unusual pattern o

92 ene linked to amyotrophic lateral sclerosis, Paget disease of bone, and glaucoma, a major blinding di

93 Patients with SQSTM1 mutations have severe Paget's disease of bone and a high degree of penetrance

94 are a common cause of familial and sporadic Paget's disease of bone.

95 and in a minority of patients with sporadic Paget disease, with the P392L amino acid substitution be

96 Stephen Paget initially identified the role of host-tumor intera

97 Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has re

98 Recognizing that Paget's disease can not only cause absent but also expan

99 This case suggests that Paget's disease should be considered as a diagnostic pos

100 l primary human marrow stromal cells and the Paget's marrow-derived PSV10 stromal cell line to induce

101 Of 264 patients with effort thrombosis (Paget-Schroetter syndrome), 211 were treated by urokinas

102 is evidence for a major genetic component to Paget disease, with up to 40% of patients having affecte

103 stm1/p62 whose mutations have been linked to Paget's disease of bone.

104 ent evidence suggests that predisposition to Paget disease may have a genetic component.

105 lled inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPF

106 Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPF

107 ease inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia, the m

108 ajor inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia-linked

109 der, inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia/amyotr

110 ated inclusion body myopathy associated with Paget disease of bone, frontotemporal dementia and amyot

111 variants in SQSTM1 have been associated with Paget disease of the bone and might contribute to neurod

112 low/intermediate-grade DCIS associated with Paget disease were true positive only at scintigraphy.

113 Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBM

114 Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBM

115 nclusion body myopathy (IBM) associated with Paget's disease of bone and frontotemporal dementia (IBM

116 Inclusion body myopathy associated with Paget's disease of the bone and fronto-temporal dementia

117 ause inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia

118 n as inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia.

119 nclusion body myopathy (IBM) associated with Paget's disease of the bone, fronto-temporal dementia an

120 mutations cause inclusion body myopathy with Paget disease and frontotemporal dementia.

121 Inclusion body myopathy with Paget disease of the bone and frontotemporal dementia (I

122 m patients with inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBM

123 ted syndrome of inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia

124 es that include inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia,

125 Analysis of osteosarcomas from patients with Paget disease revealed that these tumors also undergo LO

126 Of 45 patients with Paget disease who underwent MR imaging, 33 (26 men, seve

127 of SQSTM1 occur in about10% of patients with Paget's disease of bone (PDB), but it is unclear whether

128 ding p62 are commonly found in patients with Paget's disease of bone and largely cluster within the C