ライフサイエンスコーパス: Pi

1 Pi concentrations in all zones were reduced, at differen

2 Pi downregulated alphaKlotho, which also independently i

3 Pi efflux was also rescued in a dose-dependent manner by

4 Pi inhibits the phosphatase activity of the enzyme.

5 Pi promoted beclin 1 binding to its negative regulator B

6 Pi release step was initially made slow (70 s(-1)), but

7 Pi starvation induced the accumulation of barley APL tra

8 Pi uptake, metabolic recycling, and vacuolar sequestrati

9 Pi*ZZ carriers may develop lung and liver diseases.

10 Pi-starved M. mazei cells increased transcript abundance

11 intermedia, Campylobacter Rectus, Factor 2 (Pi/Prevotella nigrescens/Prevotella melaninogenica), and

12 Shift of the Sp(O(2))/Pi(O(2)) curve may be useful for prediction and measurem

13 We collected data from 554 Pi*ZZ adults (403 in an exploratory cohort, 151 in a con

14 For model A, a Pi jump induced a tension fall at a rate similar to the

15 lity of a Raspberry Pi microcontroller and a Pi camera, coupled with three ultraviolet light emitting

16 f the frog cross-bridge cycle by including a Pi release step either before (model A) or after (model

17 e AtNLA, OsNLA1 is not a target of miR827, a Pi starvation-induced microRNA.

18 Administration of a Pi-PEG reduced tumor formation and maintained diversity

19 Pharmacologically or genetically abrogating Pi transport, the impact of high Pi-induced cytotoxicity

20 nique mechanism functions in Pi acquisition, Pi translocation, and reproductive success.

21 By introducing additional Pi, higher than the concentration of 40 mM, we observed

22 nsion fall was caused by detachment of M.ADP.Pi myosin heads from actin and reversal of the first ten

23 th feedback by the energy state ([ATP]/[ADP][Pi ]) regulating the pathway.

24 this Xpr1 deficiency significantly affected Pi efflux.

25 ions as a chloroplast-localized low-affinity Pi transporter that mediates UV tolerance and rice yield

26 st envelope and functioned as a low-affinity Pi transporter.

27 ckslips and detachments can only occur after Pi release.

28 enetics-led target prioritization algorithm (Pi) of genome wide association studies (GWAS) data and a

29 ntain basal cytokinin responses and allocate Pi in the root system to sustain its growth.

30 of pH, spin probe concentration, pO(2), and Pi using a single contrast agent and Overhauser-enhanced

31 1 and VIH2 relay changes in cellular ATP and Pi concentrations to changes in PP-InsP levels, allowing

32 showed the lowest and ZOL the highest Ca and Pi contents in femur and maxilla (P < 0.05).

33 the eIF2*GTP*Met-tRNAiMet complex to GDP and Pi.

34 Vanadate and Pi uptake predominantly occurred via fiber cells located

35 Excluding iron, as well as Pi, rescues this altered [Ca(2+)](cyt) response and rest

36 ic mice that overexpress the AATD-associated Pi*Z variant.

37 Attenuated Pi efflux from PPIP5K KO cells was quantitatively phenoc

38 icroscopy was used to calibrate a FRET-based Pi sensor to determine absolute, rather than relative, P

39 forward kinesin steps can only occur before Pi release, whereas backslips and detachments can only o

40 To determine an association between Pi excess and physical activity in humans, we assessed t

41 To examine the interplay between Pi, autophagy, and alphaKlotho, we used the BK/BK mouse

42 ished in each zone by using cyanide to block Pi assimilation in wild-type plants and a vacuolar Pi tr

43 ubule expression of MFS2 and decreases blood Pi.

44 results showed that OsPHT2;1 was induced by Pi starvation and light exposure.

45 gh reactive oxygen species levels induced by Pi starvation.

46 reduced oxygen consumption rate mediated by Pi transport-dependent and ERK1/2-dependent metabolic Pi

47 l zones were reduced, at different rates, by Pi starvation, but the developmental pattern of Pi conce

48 entified new genes and pathways regulated by Pi starvation that were not described previously.

49 hronic Pi deprivation but can be reversed by Pi resupply.

50 lso simulated the effect Pi jump as in caged Pi experiments.

51 sults in the formation of Malpighian calcium-Pi stones, while RNAi-mediated knockdown of MFS2 increas

52 Cellular Pi efflux is heavily reliant on Xenotropic and Polytropi

53 rvation and the resulting decreased cellular Pi pool, the use of cytosolic free Ca(2+) ([Ca(2+)](cyt)

54 established, but the function of chloroplast Pi homeostasis is poorly understood in Oryza sativa (ric

55 ts during seedling development under chronic Pi deprivation but can be reversed by Pi resupply.

56 erstitial inorganic phosphate concentration (Pi) are important parameters of the malignant behavior o

57 In conclusion, Pi, alphaKlotho, and autophagy interact intricately to a

58 lead to increased Pi levels and constitutive Pi starvation responses.

59 pairs plant growth and leads to constitutive Pi starvation responses.

60 dy, we provide evidence that OsNLA1 controls Pi acquisition by directing the degradation of several O

61 To counteract, Pi-activated AKT signaling promotes cell survival by act

62 Minor indications of stomatal and cuticular Pi uptake were also observed.

63 t seem to be signaled through [Ca(2+)](cyt), Pi starvation strongly affects stress-induced [Ca(2+)](c

64 measuring the subsequent change in cytosolic Pi concentration over time.

65 High-resolution mapping of cytosolic Pi concentrations in different cells, tissues, and devel

66 to spatially resolve and quantify cytosolic Pi concentrations and the respective contributions of Pi

67 ion corresponded with steady-state cytosolic Pi concentrations.

68 ing, and vacuolar sequestration to cytosolic Pi homeostasis in Arabidopsis (Arabidopsis thaliana) roo

69 estingly, in the absence of sodium-dependent Pi transport activity, the PiT1-PiT2 heterodimerization

70 cantly correlated to the change of depurated Pi.

71 odialysis treatment confirmed that depurated Pi originates from the intracellular compartment.

72 p strength increased 6.2 times more than did Pi(max).

73 Dietary Pi may represent a novel and modifiable target to reduce

74 demonstrate a detrimental effect of dietary Pi excess on skeletal muscle fatty acid metabolism and e

75 To determine direct effects of dietary Pi on exercise capacity, oxygen uptake, serum nonesterif

76 the changes in our dietary pattern, dietary Pi overload engenders systemic phosphotoxicity, includin

77 role in Pi excretion, we found that dietary Pi induces MFS2 expression.

78 It is unknown whether dietary Pi excess contributes to exercise intolerance and physic

79 ATP levels change significantly in different Pi growth conditions.

80 At discharge, Pi(max) did not change, whereas handgrip strength increa

81 n-coding IPS1 RNA is highly expressed during Pi starvation, and the sequestration of miR399 molecules

82 ions do not allocate free Pi in roots during Pi starvation.

83 changes in phosphate (Pi) availability, i.e. Pi starvation, followed by incubation in Pi replete medi

84 We also simulated the effect Pi jump as in caged Pi experiments.

85 Elevated Pi activates mitogen-activated protein kinase (MAPK) sig

86 significant acidosis, hypoxia, and elevated Pi content.

87 vely regulated AsA production via endogenous Pi content control.

88 ystemic phosphotoxicity, including excessive Pi-related vascular calcification and chronic tissue inj

89 ith improved shoot growth under low external Pi supply and no deleterious effects under Pi-sufficient

90 ization was still regulated by extracellular Pi levels.

91 aken together, abnormally high extracellular Pi results in a broad spectrum of toxicity by rewiring c

92 Up to 10 mM extracellular Pi promotes cell proliferation by activating AKT signali

93 nd, vanadate was tested as a possible foliar Pi tracer using high-resolution laser ablation-inductive

94 ream open reading frame that is required for Pi-responsive expression regulation.

95 h low cZ concentrations do not allocate free Pi in roots during Pi starvation.

96 Livers from Pi*Z-overexpressing mice had steatosis and down-regulati

97 een shown to recognize a stabilizing GTP/GDP-Pi cap at the tip of growing MTs, but information about

98 lized MTs, which mimic the EB1-preferred GDP-Pi state of polymerized tubulin.

99 the rearrangements in the ribosome-EF-Tu-GDP-Pi-Lys-tRNA(Lys) complex following GTP hydrolysis by EF-

100 ly reflect intrinsic curvature of GTP or GDP.Pi tubulin and provide structural insights into the GTP-

101 nockdown of MFS2 increases blood (hemolymph) Pi and decreases formation of Malpighian tubule stones i

102 We found that abnormally high Pi directly mediates diverse cellular toxicity in a dose

103 abrogating Pi transport, the impact of high Pi-induced cytotoxicity could be reduced.

104 hian tubule stones in flies cultured on high Pi medium.

105 Synergistically, high Pi-caused endoplasmic reticulum (ER) stress also contrib

106 tubule stones are a key element whereby high Pi diet reduces fly longevity previously reported by us.

107 dmill test in C57/BL6 mice fed either a high-Pi (2%) or normal-Pi (0.6%) diet for 12 weeks.

108 m Becn1(F121A) was abolished by chronic high-Pi diet which also shortened life span in the BK/BK;kl/k

109 d with the control diet, consumption of high-Pi diet for 12 weeks did not alter body weight or left v

110 vitro by incubating C2C12 myotubes with high-Pi media.

111 iques provided an approach to understand how Pi crosses the leaf surface and assimilates to meet plan

112 d fibrosis were 9- to 20-fold more common in Pi*ZZ carriers compared to non-carriers.

113 stroma Pi, we analyzed OsPHT2;1 function in Pi utilization and photoprotection.

114 regulated by a unique mechanism functions in Pi acquisition, Pi translocation, and reproductive succe

115 f liver enzymes were significantly higher in Pi*ZZ carriers vs controls.

116 .e. Pi starvation, followed by incubation in Pi replete media (overplus), in cells of the methanogeni

117 nd plants, the molecular players involved in Pi sensing in mammals remain unknown.

118 Consistent with its role in Pi excretion, we found that dietary Pi induces MFS2 expr

119 Rapid increases in [Pi] induced a biphasic force decay with an initial slow

120 e the root absorbing surface and to increase Pi concentrations in roots.

121 Disruption of OsNLA1 resulted in increased Pi uptake from roots as well as impaired pollen developm

122 in the kinase active site lead to increased Pi levels and constitutive Pi starvation responses.

123 t, is up-regulated in response to increasing Pi supply.

124 ith untreated P-deficient plants, indicating Pi remobilization.

125 PHO1 inhibits its translation and influences Pi homeostasis.

126 m nucleatum (Fn), and Prevotella intermedia (Pi) was done by quantitative polymerase chain reaction.

127 Tannerella forsythia, Prevotella intermedia (Pi), and Treponema denticola significantly more in group

128 ificant cell damage caused by the interwoven Pi-related biological processes.

129 sis, indicating a reduction in intracellular Pi concentration.

130 hemodialysis and decreases of intracellular Pi and betaATP content.

131 In this study, we investigated Pi-mediated cellular response in HEK293 and HeLa cells.

132 During phosphate ion (Pi) deprivation, PHR1 positively regulates MIR399 expres

133 entry pathways for inorganic phosphate ion (Pi) uptake remain unknown, and it is unclear whether fol

134 nically and Ca(2+)-induced force kinetics (k+Pi(1) approximately k-Pi approximately kTR approximately

135 uced force kinetics (k+Pi(1) approximately k-Pi approximately kTR approximately kACT).

136 ckout mice lacking one or both house-keeping Pi transporters Pit1 and Pit2 in skeletal muscle (sm), u

137 We here identify MFS2 as a key Pi transporter in fly renal (Malpighian) tubules.

138 subjecting to media containing 1 to 3 mmol/L Pi (pH 7.0) to simulate in vivo phosphate conditions.

139 The semi-supervised deep learning Pi model and the cosine score applied after median thres

140 y in the root apex is a consequence of local Pi sensing and the associated ER stress response, rather

141 tive study of mutants defective in the local Pi deficiency response, ER stress response, and autophag

142 XPR1-mediated Pi efflux was inhibited by reducing cellular InsP(8) syn

143 of the transporters/translocators mediating Pi import into chloroplasts.

144 ort-dependent and ERK1/2-dependent metabolic Pi sensing pathways.

145 ncodes a mitochondrial inner membrane ATP-Mg/Pi carrier.

146 The half-inhibition was at 6.0 mM Pi for model A and at 1.6 mM Pi for model B.

147 50 mM Pi inhibited the isometric tension of model A by ~50% bu

148 n was at 6.0 mM Pi for model A and at 1.6 mM Pi for model B.

149 Moreover, Pi efflux from PPIP5K KO cells was rescued by restoratio

150 2Lys substitution (called the Pi*Z mutation, Pi*ZZ genotype).

151 villi, and less abundant expression of Na(+)/Pi cotransporter 2, claudin-2, and aquaporin 1.

152 BL6 mice fed either a high-Pi (2%) or normal-Pi (0.6%) diet for 12 weeks.

153 ificant fibrosis was suspected in 20%-36% of Pi*ZZ carriers, whereas signs of advanced fibrosis were

154 ing severe steatosis, was detected in 39% of Pi*ZZ carriers vs 31% of controls.

155 Analysis of Pi transport in primary cultures of proximal tubular cel

156 AATD adults with the Pi*ZZ mutation, and of Pi*Z-overexpressing mice, we found evidence of liver ste

157 Carriers of Pi*ZZ had lower serum concentrations of triglyceride and

158 These results highlight the complexity of Pi dynamics in live plants and revealed developmental co

159 d increases in growth and total P content of Pi-deficient wild-type rice (Oryza sativa) seedlings.

160 trations and the respective contributions of Pi uptake, metabolic recycling, and vacuolar sequestrati

161 R stress response, we analyzed the effect of Pi limitation on autophagy.

162 To determine the direct effect of Pi on muscle metabolism and expression of genes involved

163 In conclusion, MFS2 mediates excretion of Pi in Drosophila, which is as in higher species under th

164 trol plants are reduced upon the increase of Pi concentration.

165 Subsequent incubation of Pi-starved M. mazei cells under Pi replete conditions, l

166 o higher PHO1 protein levels, independent of Pi availability.

167 starvation, but the developmental pattern of Pi concentration persisted.

168 The other phases of Pi-induced force kinetics that occur in the absence of "

169 show that coronin accelerates the release of Pi from actin filaments and promotes highly cooperative

170 lications for plant sensing and signaling of Pi.

171 ate that OsPT8 regulates the transduction of Pi signaling for development and negatively regulates ri

172 whether the expression of OsNLA1 depends on Pi supply and how it is regulated.

173 tains two PHR1 binding sites (P1BSs) and one Pi-responsive PHO element.

174 soil for nutrients need to adapt to optimize Pi uptake.

175 Inorganic orthophosphate (Pi) is an essential nutrient for plant growth, and its a

176 ant shoots accumulated higher ortophosphate (Pi) levels than shoots colonized with the full SynCom bu

177 directing the degradation of several OsPHT1 Pi transporters (i.e. OsPT1/2/4/7/8/12).

178 nts can absorb only the inorganic form of P (Pi), a large portion of soil P (organic and inorganic P

179 We found a significant increase in the PCr-Pi ratio (+23%; P=0.001) during dialysis, indicating a r

180 The primary outcome was a change in the PCr-Pi ratio during the session.

181 Phosphate (Pi) deficiency strongly limits plant growth, and plant r

182 Phosphate (Pi) is an essential nutrient for all organisms.

183 Low blood phosphate (Pi) reduces muscle function in hypophosphatemic disorder

184 he lesser known effects of excess phosphate (Pi), or phosphotoxicity.

185 Root growth inhibition from phosphate (Pi) deficiency is triggered by iron-stimulated, apoplast

186 itions, in response to changes in phosphate (Pi) availability, i.e. Pi starvation, followed by incuba

187 levels of extracellular inorganic phosphate (Pi) and pyrophosphate (PPi).

188 How inorganic phosphate (Pi) homeostasis is regulated in Drosophila is currently

189 Inorganic phosphate (Pi) is an essential nutrient for human health.

190 Inorganic phosphate (Pi) is often a limiting plant nutrient.

191 Inorganic phosphate (Pi) is used extensively as a preservative and a flavor e

192 lular and intracellular inorganic phosphate (Pi) levels is critical to most biochemical and physiolog

193 The availability of inorganic phosphate (Pi) limits plant growth and crop productivity on much of

194 in serum calcium (Ca), inorganic phosphate (Pi) or 25-hydroxyvitamin D were observed, whereas bone a

195 s of cellular fluxes of inorganic phosphate (Pi) supervises its structural roles in bones and teeth,

196 Phosphocreatine and inorganic phosphate (Pi) varied in opposite directions across gray matter and

197 quantify intracellular inorganic phosphate (Pi), phosphocreatine (PCr), and betaATP.

198 -diphosphate (dADP) and inorganic phosphate (Pi)] bound to prepowerstroke myosin induce an allosteric

199 Low phosphate (Pi) availability constrains plant development and seed p

200 Under low phosphate (Pi) conditions, the OsPT8-OX plants display better agron

201 play a crucial role in regulating phosphate (Pi) acquisition in roots, similar to that of Arabidopsis

202 ny eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors f

203 The mechanisms regulating phosphate (Pi) uptake are well established, but the function of chl

204 Similarly, phosphate (Pi) deficiency inversely affected miR397b and LAC2 expre

205 It is controversial whether the phosphate (Pi) release step in the cross-bridge cycle occurs before

206 e were given antibiotics or ABA-PEG20k-Pi20 (Pi-PEG), which inhibits collagenase production by bacter

207 oinositol pentakisphosphate kinases in plant Pi signal transduction cascades.

208 ant BK/BK;kl/kl mice exhibiting lower plasma Pi, improved weight gain, restored plasma and renal alph

209 kinase (JNK), which consequently potentiates Pi triggered lethal epithelial-mesenchymal transition (E

210 On enrollment, maximum inspiratory pressure (Pi(max)) was 41.3 (95% confidence interval, 39.4-43.2) c

211 Inspired oxygen partial pressure (Pi(O(2))) was decreased stepwise to achieve oxygen satur

212 In the scheme we propose, Pi release gates access to a weak binding K.ADP-K.ADP st

213 based on a 3D-printed mainframe, a Raspberry Pi computer, and high-definition camera system as well a

214 ional power and affordability of a Raspberry Pi microcontroller and a Pi camera, coupled with three u

215 copy technique, implemented with a Raspberry Pi single-board computer and color camera combined with

216 that uses a single-board computer (Raspberry Pi) with a passive infrared (IR) motion sensor, silicon

217 maging technology (e.g., scanners, Raspberry Pi, smartphones and other sub-$50 digital cameras) has l

218 We developed the Raspberry Pi Virtual Reality (PiVR) system to conduct closed-loop

219 l training of home cage mice using Raspberry Pi-based hardware.

220 ition and processing of data using Raspberry Pi.

221 The ospht2;1 had reduced Pi accumulation, plant growth and photosynthetic rates.

222 ion of any two systems significantly reduced Pi accumulation and growth in divergent environments.

223 KO of PPIP5Ks or XPR1 strongly reduced Pi efflux and accelerated differentiation to the mineral

224 eting, siRNA delivery and cancer regression (Pi et.al Nature Nanotechnology, 2018:13, 82-89; Li et al

225 InsP), suggesting that PP-InsPs may regulate Pi homeostasis.

226 that ALS3 cooperates with LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by

227 to determine absolute, rather than relative, Pi concentrations in live plants.

228 We found that both AtPTPN and ZmPTPN release Pi by hydrolyzing GDP/GMP/dGMP/IMP/dIMP, and that AtPTPN

229 s and revealed developmental control of root Pi homeostasis, which has potential implications for pla

230 ir microbiome, thus exacerbating the plant's Pi starvation.

231 , we assessed the relationship between serum Pi and actigraphy-determined physical activity level, as

232 There was no association between serum Pi and left ventricular ejection fraction or volumes.

233 icipants of the DHS-2 (n=1603), higher serum Pi was independently associated with reduced time spent

234 exhibit higher PHO1 protein levels and shoot Pi content.

235 ly, deletion of the uORF led to higher shoot Pi content and was associated with improved shoot growth

236 Increased shoot Pi content was linked to the absence of the PHO1 uORF in

237 consecutive days per year on which Southern Pied Babblers (Turdoides bicolor) will lose ~4% of body

238 ht into the role of OsPHT2;1-mediated stroma Pi, we analyzed OsPHT2;1 function in Pi utilization and

239 vels, allowing plants to maintain sufficient Pi levels.

240 such as Arabidopsis (Arabidopsis thaliana), Pi deprivation reshapes root system architecture to favo

241 We conclude that Pi-dependent activation of autophagy in the root apex is

242 oying ratiometric imaging, we delineate that Pi-starved roots have a normal response to extracellular

243 Altogether, these observations indicate that Pi uptake by S. aureus differs from established models a

244 We propose that Pi-starved plants increase the cZ : tZ ratio to maintain

245 In summary, our study reveals that Pi-induced OsNLA1 expression regulated by a unique mecha

246 idopsis (Arabidopsis thaliana), we show that Pi starvation, but not nitrogen starvation, strongly dam

247 We also show that Pi-starved plants increase the cis-zeatin (cZ) : trans-z

248 We conclude that, as in model A, the Pi release step is before the first tension-generating s

249 Root illumination alters the Pi starvation response (PSR) at different intensities.

250 nd that deletion of PiT1 or PiT2 blunted the Pi-dependent ERK1/2-mediated phosphorylation and subsequ

251 codes the Glu342Lys substitution (called the Pi*Z mutation, Pi*ZZ genotype).

252 lpha-1 antitrypsin peptide (AAT), called the Pi*ZZ genotype, causes a liver and lung disease called a

253 and counseling of individuals who carry the Pi*ZZ mutation.

254 tries, with AATD who were homozygous for the Pi*Z mutation, and 234 adults without the Pi*Z mutation

255 Homozygosity for the Pi*Z variant of the gene that encodes the alpha-1 antitr

256 Up to 4% of Europeans have the Pi*MZ genotype; we compared features of adults with and

257 Heterozygosity (the Pi*MZ genotype) is a risk factor for cirrhosis in indivi

258 od agreement and supports the claim that the Pi parameter is central to expansive growth rate of wall

259 uld help determine risk of subjects with the Pi*MZ genotype and aid in counseling.

260 aminases were increased in subjects with the Pi*MZ genotype compared with noncarriers.

261 Subjects with the Pi*MZ genotype did not have increased hepatic levels of

262 Adults with the Pi*MZ genotype have lower levels of serum transaminases,

263 Ten percent of subjects with the Pi*MZ genotype vs 4% of noncarriers had LSMs of 7.1 kPa

264 pha-1 Liver Cohort, from 419 adults with the Pi*MZ genotype, 309 adults with the Pi*ZZ genotype, and

265 n liver biopsies of 63% of subjects with the Pi*MZ genotype, vs 97% of subjects with the Pi*ZZ genoty

266 ted with LSMs >=7.1 kPa in subjects with the Pi*MZ genotype.

267 and biochemical features associated with the Pi*Z variant.

268 with the Pi*MZ genotype, 309 adults with the Pi*ZZ genotype, and 284 individuals without the variant

269 Pi*MZ genotype, vs 97% of subjects with the Pi*ZZ genotype, and increased with liver fibrosis stages

270 d lower liver stiffness than adults with the Pi*ZZ genotype, but higher than adults without the Pi*Z

271 In studies of AATD adults with the Pi*ZZ mutation, and of Pi*Z-overexpressing mice, we foun

272 in serum and lower LSMs than adults with the Pi*ZZ variant, but these were higher than in noncarriers

273 he Pi*Z mutation, and 234 adults without the Pi*Z mutation (controls), all without pre-existing liver

274 genotype, but higher than adults without the Pi*Z variant.

275 Therefore, Pi-stressed plants are susceptible to colonization by la

276 Our ca. 229 Ma age assignment to Pi. mertii partially fills the ghost lineage between you

277 s part of the developmental root response to Pi limitation and requires the genetic PDR2-LPR1 module.

278 anscriptional and physiological responses to Pi starvation in dark-grown roots.

279 tightly controlled, as it is highly toxic to Pi metabolism.

280 PHOSPHATE1 (PHO1) transfers Pi from root to shoot via Pi export into root xylem vess

281 Under Pi starvation and the resulting decreased cellular Pi po

282 ncubation of Pi-starved M. mazei cells under Pi replete conditions, led to a 237% increase in intrace

283 l Pi supply and no deleterious effects under Pi-sufficient conditions.

284 C, N, or S), it remains to be explored under Pi deprivation.

285 editing-toward improving plant growth under Pi-deficient conditions.

286 olonized with the full SynCom but only under Pi starvation conditions.

287 deposition in the root elongation zone under Pi deficiency increased with LAC2-dependent lignificatio

288 deposition in the root elongation zone under Pi-limited conditions was dependent on LAC2 expression.

289 Urinary Pi is freely filtered at the kidney glomerulus and is re

290 omorphic mouse (kl/kl) with impaired urinary Pi excretion, low autophagy, and premature organ dysfunc

291 supplies of this essential nutrient, we used Pi imaging to spatially resolve and quantify cytosolic P

292 ted that vanadate was a sensitive and useful Pi tracer.

293 imilation in wild-type plants and a vacuolar Pi transport mutant, and then measuring the subsequent c

294 tial profiles in the root, but only vacuolar Pi sequestration corresponded with steady-state cytosoli

295 e derived from the resulting Sp(O(2)) versus Pi(O(2)) curve and compared with current disease severit

296 1 (PHO1) transfers Pi from root to shoot via Pi export into root xylem vessels.

297 Which Pi transporters are required and whether hormonal change

298 These results indicate that, while Pi availability does not seem to be signaled through [Ca

299 In the Alpha-1 Liver Cohort, adults with Pi*MZ had lower levels of gamma-glutamyl transferase in

300 compared features of adults with and without Pi*MZ genotype among persons without preexisting liver d