ライフサイエンスコーパス: Q-type calcium channel

1 hat the major target of roscovitine is the P/Q-type calcium channel.

2 fiers in the tightly regulated function of P/Q-type calcium channels.

3 s including CACNA1A, encoding for neuronal P/Q-type calcium channels.

4 dendritic calcium signaling is provided by P/Q-type calcium channels.

5 oding alpha1A, the pore-forming subunit of P/Q-type calcium channels.

6 o both gain- and loss-of-function of human P/Q-type calcium channels.

7 ght to be the pore-forming subunit of P- and Q-type calcium channels.

8 be located near the presynaptic N-type or P/Q-type calcium channels.

9 of fast neurotransmitters relies on N- and P/Q-type calcium channels.

10 d may be secondary to inhibition of N- and P/Q-type calcium channels.

11 ifferences in the inhibition of the N- and P/Q-type calcium channels.

12 The modulation appears to involve N- and P/Q-type calcium channels.

13 th virtually completely mediated by N- and P/Q-type calcium channels.

14 he pore-forming alpha1 subunit of CaV 2.1 (P/Q-type) calcium channels.

15 results suggest a novel processing of the P/Q-type calcium channel and a potential mechanism for the

16 part of this inhibition using recombinant P/Q-type calcium channels and M2 acetylcholine receptors i

17 x via high-voltage-activated (HVA) (N- and P/Q-type) calcium channels and calcium-activated potassium

18 ubunit of neuronal voltage-gated Ca(V)2.1 (P/Q-type) calcium channels and their wild-type (WT) litter

19 cts in CACNA1A, the alpha1A subunit of the P/Q-type calcium channel, and ataxin-7 (ATXN7), a componen

20 N-type and P/Q-type calcium channels are documented players in the re

21 N- and P/Q-type calcium channels are inhibited by G proteins, and

22 P/Q-type calcium channels are known to form clusters at th

23 nnel blocker agatoxin IVB, suggesting that P/Q-type calcium channels are the major targets involved i

24 We found that P/Q-type calcium channels are the primary voltage-gated Ca

25 ns in alpha1A, the pore-forming subunit of P/Q-type calcium channels, are linked to several human dis

26 sites, are supported by the activation of P/Q type calcium channels, as opposed to the expected pers

27 se in SCN neurons, primarily by modulating P/Q-type calcium channels at axon terminals.

28 Cs was greatly reduced (up to 100%) by the P/Q-type calcium channel blocker agatoxin IVB, suggesting

29 as reduced by 79+/-5% (n=110 cells) by the P/Q-type calcium channel blocker omega-agatoxin-TK (20 nM)

30 aptic calcium influx is through N-type and P/Q-type calcium channels, blocking these channels does no

31 In the absence of P/Q-type calcium channels, breathing, sighing, and neuromo

32 um current (Kir current) and depression of P/Q-type calcium channels by cannabinoids were prevented b

33 vitro function was studied in mice lacking P/Q-type calcium channels (Cav2.1), in which N-type calciu

34 been reported to slow the deactivation of P/Q-type calcium channels (CaV2.1).

35 Partial block of P/Q-type calcium channels concurrently eliminated dendriti

36 Finally, P/Q-type calcium channels do not couple to either SK or BK

37 t all vertebrates, including frog, use the P/Q-type calcium channel for neuromuscular transmission.

38 ll, our findings show that deletion of the P/Q-type calcium channel from DRN neurons is sufficient to

39 els and the CACNA1A gene, a brain-specific P/Q-type calcium channel gene associated with ataxia and h

40 Human and mouse P/Q-type calcium channel gene mutations initiate a complex

41 by N-type calcium channels, whereas L- and P/Q-type calcium channels had little, if any, contribution

42 Inborn errors of CACNA1A-encoded P/Q-type calcium channels impair synaptic transmission, pr

43 ANCE STATEMENT In this study, we show that P/Q-type calcium channel is mediating aggression in seroto

44 aptic transmission dependent on N-type and P/Q-type calcium channels is required for stable breathing

45 Thus, an important function of the P/Q-type calcium channels is to provide calcium for activa

46 2 subunit serves in vivo as a component of P/Q-type calcium channels, is indispensable for the centra

47 provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical glutamatergic s

48 identifies the developmental importance of P/Q-type calcium channel-mediated presynaptic glutamate re

49 onal distinctions is our identification of P/Q-type calcium channels mediating transmitter release in

50 t homozygous tottering (tg/tg) mice with a P/Q type calcium channel mutation.

51 These data suggest that although a P/Q-type calcium channel mutation is the primary defect in

52 ne of the pore-forming alpha1A subunit for P/Q-type calcium channel, or the CaV3.1 gene of the pore-f

53 Blocking P/Q-type calcium channels paradoxically mimics the effects

54 oltage-dependent calcium channels, but not P/Q-type calcium channels, prevented the inducible dystoni

55 n this study, we show that deletion of the P/Q-type calcium channel selectively from serotonergic neu

56 a bicistronic gene that encodes alpha1A, a P/Q-type calcium channel subunit and a C-terminal protein,

57 mutations (R192Q and S218L) in the CaV2.1 (P/Q-type) calcium channel subunit, pregabalin slowed the s

58 pected association of Ca2+/calmodulin with P/Q-type calcium channels that may contribute to calcium-d

59 the positive effect of roscovitine on the P/Q-type calcium channel, the major mediator of action pot

60 rine cell line causes robust inhibition of P/Q-type calcium channels via pertussis toxin-sensitive G-

61 residual ionic currents were observed when P/Q-type calcium channels were blocked by Cd(2+) or omega-

62 L-, N- and P/Q-type calcium channels were identified in LH neurons, w

63 to calcium entry into synaptic boutons via P/Q type calcium channels, whereas asynchronous release is

64 iated by an influx of calcium ions through P/Q-type calcium channels, which are densely localized in