ライフサイエンスコーパス: REM

1 REM sleep frontal high delta power was a negative correl

2 REM sleep state-dependent inhibition of MCH neurons impa

3 REM sleep-active MCH neurons in the hypothalamus are thu

4 REM sleep-specific optogenetic silencing of LH(vgat) cel

5 REM-CA is an unconventional lipid-binding motif that con

6 REMs are the best-characterized nanodomain markers via a

7 ean (SD) 19.2 (12.7) vs 6.1 (5.7); p<0.001), REM-sleep behaviour disorder screening questionnaire (me

8 ities (HR = 1.69), constipation (HR = 1.67), REM atonia loss (HR = 1.54), and age (HR = 1.54).

9 PAC-Ti(4)O(7) REM was tested with tap water spiked with 0.11 mg L(-1)

10 i(4)O(7), PAC-Ti(4)O(7), and MWCNT-Ti(4)O(7) REMs, respectively.

11 However, the width of the 90% REM range for the contextual effects exceeded that of th

12 rs exclusively and abundantly during active (REM) sleep, a particularly prominent state in early deve

13 onic twitches of the whiskers during active (REM) sleep.

14 s restricted primarily to periods of active (REM) sleep.

15 eye movement (NREM) sleep but did not affect REM-wakefulness transitions.

16 during waking and paradoxical sleep (PS; aka REM) than during slow-wave sleep (SWS).

17 s wakefulness and also reduces NREM and also REM sleep.

18 understood how cocaine experience may alter REM sleep regulatory machinery, and what may serve to im

19 vity was greater in exploratory behavior and REM sleep than in quiet wakefulness and slow wave sleep,

20 Across the night, SWS decreased and REM increased, as observed in mammals and songbirds.

21 cataplexy, nighttime sleep disturbances, and REM-sleep-related phenomena (sleep paralysis, hallucinat

22 The wake-enhancing and REM-suppressing effects of R05263397 shown here in a diu

23 linear association between intelligence and REM anterior beta power was found in females but not mal

24 M) cycling, REM sleep reduction or loss, and REM sleep instruction in wakefulness.

25 263397 increased waking and reduced NREM and REM sleep, decreased gamma power during wake and NREM, a

26 During both NREM and REM sleep, mice showed large increases in cerebral blood

27 In both NREM and REM sleep, reports of dream experience were associated w

28 ated in KO compared with OE mice in NREM and REM sleep.

29 presence and absence of dreaming in NREM and REM sleep.

30 cephalon leads to decreases in both NREM and REM sleep.

31 kefulness from propofol anesthesia, NREM and REM sleep.

32 l areas in non-rapid eye movement (NREM) and REM sleep.

33 ial for dream mentation, in both non-REM and REM sleep across mammals.

34 ep, and increased ventilation in non-REM and REM sleep, independently of metabolic effects.

35 eam mentation occurs during both non-REM and REM sleep, indicates that all mammals have the potential

36 ignals was higher than the awake resting and REM states.

37 enuated by 47% and 36% during NREM sleep and REM sleep, respectively.

38 nificantly different between NREM states and REM.

39 Wake- and REM sleep-active MCH neurons were distinct populations t

40 , these VTA GABAergic neurons were wake- and REM sleep-active.

41 ic stimulation promotes both wakefulness and REM sleep, optogenetic stimulation of these neurons in s

42 positively correlated across wakefulness and REM sleep.

43 ed a key site for regulating wakefulness and REM sleep.

44 nderlie debilitating sleep disorders such as REM sleep behaviour disorder and narcolepsy.

45 Atypical REM sleep in other species, such as African elephants an

46 Building on this finding, baseline REM measurements may serve as a noninvasive biomarker fo

47 ely, there was no direct correlation between REM sleep and SCRs, indicating that REM may only modulat

48 ot enter REM, suggesting involvement of both REM and NREM sleep.

49 high, promoted wakefulness and reduced both REM and non-REM sleep without inducing hyperlocomotion.

50 by non-rapid eye movement (NREM) sleep or by REM sleep, whether it results from plasticity increases

51 The so-called Cholinergic REM Induction Test revealed that REM sleep abnormalities

52 Here we show that chronic REM sleep disturbance, achieved in mice by chronic sleep

53 The carbon-Ti(4)O(7) composite REMs had high electrical conductivities (1832 to 2991 S

54 These composite REMs were evaluated for simultaneous adsorption and elec

55 olidation), the neural circuits that control REM sleep, and how dysfunction of REM sleep mechanisms u

56 movement - rapid eye movement (REM) cycling, REM sleep reduction or loss, and REM sleep instruction i

57 l Jouvet used the term paradoxical to define REM sleep because of the simultaneous occurrence of a co

58 r operating characteristic curves determined REM sleep without atonia cutoffs distinguishing synuclei

59 g revealed dynamic network activation during REM sleep and activation of a subset of the neurons duri

60 evailing thought, the DLPFC is active during REM sleep and likely interacting with other areas.

61 were found to be synchronously active during REM sleep, and also during the exploration of novel obje

62 silencing of this sparse ABN activity during REM sleep alters the structural remodeling of spines on

63 de a causal link between ABN activity during REM sleep and memory consolidation.

64 that dendritic calcium spikes arising during REM sleep are important for pruning and strengthening ne

65 However, whether presenting a CS during REM or NREM sleep enhances or extinguishes fear memory h

66 n contrast, the E/I balance decreased during REM sleep but only after pre-sleep training, and the dec

67 iring during NREM and diversification during REM.

68 cingulate cortex (ACC) and the DLPFC during REM sleep.

69 Here, we explored whether FAA during REM sleep and during evening resting wakefulness is rela

70 Results showed that FAA during REM sleep, and during evening resting wakefulness, predi

71 t brain energy expenditure is highest during REM because of heightened theta and gamma activity.

72 n of hypoglossal motor neurons (HMNs) during REM sleep.

73 mechanism for upper airway hypotonia during REM sleep.

74 an open upper airway become hypotonic during REM sleep.

75 Compared to NREM sleep, IEDs during REM sleep were of significantly shorter duration and spa

76 cortex interferes with dream movement during REM sleep, which is consistent with a causal contributio

77 led dynamic activation of MCH neurons during REM sleep and activation of a subset of the same neurons

78 st activity map of individual neurons during REM sleep, we use deep-brain calcium imaging in unrestra

79 nce, that dream mentation only occurs during REM sleep, we conclude that it is unlikely that monotrem

80 ay closure when asleep, in particular during REM sleep.

81 ay be involved in cognitive processes during REM sleep.

82 ring NREM sleep and reward processing during REM sleep in the reward group but not in the no-reward g

83 s during feeding that are reactivated during REM, but not non-REM, sleep.

84 d processing in the prefrontal region during REM sleep, and inhibited neural activation in the untrai

85 mice, that slow waves occur regularly during REM sleep, but only in primary sensory and motor areas a

86 rating movement and bodily sensations during REM sleep dreaming.

87 Stimulations during REM sleep elicited significantly reduced responses at po

88 alcium spikes increased substantially during REM sleep, and the blockade of these calcium spikes prev

89 with larger responses during SWS than during REM sleep.

90 inhibited by glycinergic transmission during REM sleep, hypoglossal motoneurons that control the uppe

91 ons firing rate distributions widened during REM due to differential changes in high- versus low-firi

92 these neurons selectively in sleep enhances REM sleep quality and quantity after long-term withdrawa

93 o observed in participants who did not enter REM, suggesting involvement of both REM and NREM sleep.

94 We conclude that sleep, especially REM sleep, is causal to successful consolidation of dang

95 were awakened 5 min after the onset of every REM stage after which they provided a dream report and r

96 ession after sleep deprivation and expedites REM-sleep recovery.

97 ryx, may alter their potential to experience REM dream mentation.

98 neural circuits to opportunistically express REM sleep when the need for thermoregulatory defense is

99 ostasis, KO mice accrued only half the extra REM sleep wild-type (WT) littermates obtained during rec

100 levels and provide a possible mechanism for REM sleep suppression of upper airway muscle activity.SI

101 ing of complex representations necessary for REM sleep-dependent memory consolidation.SIGNIFICANCE ST

102 motor task is learned, indicating a role for REM sleep in pruning to balance the number of new spines

103 Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations

104 psychological disorders marked by fragmented REM sleep.

105 day SF procedure that selectively fragmented REM sleep, cholinergic output neurons (ChNs) in the mHb

106 ortex, naive participants were awakened from REM sleep and responded to a questionnaire on bodily sen

107 pectral slope discriminates wakefulness from REM sleep solely based on the neurophysiological brain s

108 ith REM sleep control, in turn revealing how REM sleep mechanisms themselves impact processes such as

109 on of negative delta (1-4 Hz) waves in human REM sleep by analyzing high-density EEG sleep recordings

110 oglossal motor output in-vivo and identifies REM sleep specific suppression of net motor excitability

111 Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early

112 s of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study' by Po

113 ory machinery, and what may serve to improve REM sleep after withdrawal.

114 type noise is shown to decrease from 3.08 in REM and 2.58 in NonREM to a value of 1.99 in the Waking

115 ccurred in all recorded neurons (n = 106) in REM sleep relative to quiet waking or non-REM sleep.

116 R1-KO) mice showed no significant changes in REM sleep as a function of T(a), even with increased sle

117 U0453595 attenuated age-related decreases in REM sleep duration in aged wildtype mice.

118 ence of dreams in human sleep, especially in REM sleep, and the detection of physiologically similar

119 the number of oxygen desaturation events in REM sleep, and increased ventilation in non-REM and REM

120 lness is related to affective experiences in REM sleep dreams.

121 Response thresholds were also greater in REM sleep (10 mW) compared to non-REM and waking (3 to 5

122 ed with T(a) warming, showing an increase in REM sleep expression beyond what T(a) warming in yellow

123 ) warming completely blocked the increase in REM sleep seen in YFP controls.

124 nd evoked delta activity, and an increase in REM sleep.

125 ol the upper airway muscles are inhibited in REM sleep by the combination of monoaminergic disfacilit

126 Compared to NREM sleep, IEDs location in REM sleep also showed a higher concordance with electrog

127 um in cognitive functions and that of MCH in REM sleep.

128 in mice has shown that it can also occur in REM sleep.

129 has shown that slow waves can also occur in REM sleep.

130 slow-wave sleep and some limited recovery in REM sleep when individuals with AUD stop drinking.

131 motor responses were specifically reduced in REM sleep (P < 0.001).

132 mone (MCH) neurons play an important role in REM sleep control.

133 mulations of LH MCH neural activity increase REM sleep after long-term withdrawal with important diff

134 r trauma exposure was sufficient to increase REM sleep duration during both the Light and Dark Phase,

135 ores, higher depression scores and increased REM sleep behaviour disorder symptoms compared to patien

136 at wild-type (WT) mice dynamically increased REM sleep durations specifically during warm T(a) pulsin

137 eficient for neurotensin exhibited increased REM sleep, implicating the involvement of the neuropepti

138 rol and function of this temperature-induced REM sleep expression have remained unknown.

139 We also hypothesized that isolated REM sleep behaviour disorder (iRBD) is a prodromal pheno

140 Transient, spindle-like "REM beta tufts" are described in the EEG of healthy subj

141 Reference Effect Measures (REM) were used to describe and compare the contribution

142 i(4)O(7) reactive electrochemical membranes (REMs) amended with powder-activated carbon (PAC) or mult

143 omposite reactive electrochemical membranes (REMs) were studied for adsorption and electrochemical re

144 ize strongly ferromagnetic rare-earth metal (REM) based SmCo and SmFeN nanoparticles (NPs) with ultra

145 hypothesize that the MCH system may modulate REM sleep as a function of T(a).

146 M. musculus, exhibit nearly three times more REM, and sleep almost exclusively with their eyes open.

147 Moreover, REM sleep also strengthens and maintains newly formed sp

148 ood pressure, urate, and rapid eye movement (REM) behaviour disorder scores.

149 non-rapid eye movement - rapid eye movement (REM) cycling, REM sleep reduction or loss, and REM sleep

150 sustained inhibition of rapid eye movement (REM) in vivo.

151 ls for the regulation of rapid eye movement (REM) sleep and non-REM sleep, how mutual inhibition betw

152 eurons are active during rapid eye movement (REM) sleep and wakefulness.

153 Waking and rapid eye movement (REM) sleep are characterized by ongoing irregular activi

154 Although quiet wake and rapid eye movement (REM) sleep are characterized by similar, long timescales

155 valence, and survival of rapid eye movement (REM) sleep behavior disorder (RBD) in patients who devel

156 The presence of probable rapid eye movement (REM) sleep behavior disorder was strongly associated wit

157 Rapid eye movement (REM) sleep behaviour disorder (RBD) is characterised by

158 waking life but also to rapid eye movement (REM) sleep dreams.

159 Although wake and rapid eye movement (REM) sleep exhibit long timescales, these long-range cor

160 kefulness and suppresses rapid-eye movement (REM) sleep in mice and rats and reduces cataplexy in two

161 Although rapid eye movement (REM) sleep is also associated with diminished arousal le

162 dy suggest that baseline rapid eye movement (REM) sleep may serve a protective function against enhan

163 preferentially increases rapid eye movement (REM) sleep over non-REM (NREM) sleep across species.

164 rence of dreaming during rapid eye movement (REM) sleep prompts interest in the role of REM sleep in

165 Notably, rapid eye movement (REM) sleep regulates emotional memory, and persistent RE

166 underlying mechanisms of rapid eye movement (REM) sleep remain unclear.

167 Rapid eye movement (REM) sleep serves an important function for processing a

168 during training enhanced rapid eye movement (REM) sleep time, increased oscillatory activities for re

169 While rapid eye movement (REM) sleep was marked by decreased hippocampal firing an

170 utility of quantitative rapid eye movement (REM) sleep without atonia analysis in the submentalis an

171 Wakefulness, rapid eye movement (REM) sleep, and non-rapid eye movement (NREM) sleep are

172 During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strong

173 ovement (NREM) sleep and rapid eye movement (REM) sleep, in six medication-refractory focal epilepsy

174 arcolepsy, a disorder of rapid eye movement (REM) sleep, is characterized by excessive daytime sleepi

175 eye movement (NREM) and rapid eye movement (REM) sleep, strongly consolidating the waking state for

176 ns, which were wake- and rapid eye movement (REM) sleep-active, produced wakefulness through projecti

177 ine which species 'have' rapid eye movement (REM) sleep.

178 ring sleep, particularly rapid eye movement (REM) sleep.

179 tribute to forgetting in rapid eye movement (REM) sleep.

180 eye movement (NREM) and rapid eye movement (REM) sleep.

181 hypopnea indices during rapid eye movement (REM) sleep.

182 cephalogram (EEG) during rapid eye movement (REM) sleep.

183 eye movement (NREM) and rapid eye movement (REM), characterized by quiescence and reduced responsive

184 t they are both wake and rapid eye movement (REM)-sleep active.

185 was lower than Awake and rapid eye movement (REM).

186 hanisms and functions of rapid-eye-movement (REM) sleep have occurred over the past decade.

187 has been identified with rapid eye-movement (REM) sleep, characterized by wake-like, globally 'activa

188 ep, in particular during rapid-eye-movement (REM) sleep.

189 vioral states, including rapid eye-movement (REM) sleep.

190 of 11 to 22 s) through the PAC-REM and MWCNT-REM with the application of a -1.1 V/SHE cathodic potent

191 It was estimated that ~46% of C in the MWCNT-REM and ~10% of C in the PAC-REM participated in adsorpt

192 nephrine levels, slow resting heart rate, no REM sleep behavior disorder, and preserved smell.

193 ted wakefulness and reduced both REM and non-REM sleep without inducing hyperlocomotion.

194 on of rapid eye movement (REM) sleep and non-REM sleep, how mutual inhibition between specific pathwa

195 e potential for dream mentation, in both non-REM and REM sleep across mammals.

196 that dream mentation occurs during both non-REM and REM sleep, indicates that all mammals have the p

197 d with non-REM sleep but stronger during non-REM sleep among deep-layer excitatory neurons.

198 tween the hippocampus and the BLA during non-REM sleep following training.

199 able entrainment of spindle power during non-REM sleep, nor of theta power during resting wakefulness

200 may not be continuously available during non-REM sleep, permitting the cortex to control thalamic spi

201 context for memory consolidation during non-REM sleep.

202 ong-range correlations break down during non-REM sleep.

203 d maintain breathing automaticity during non-REM sleep.

204 usands of downstates and spindles during non-REM sleep.

205 The loss of consciousness in non-REM (NREM) sleep or to GAs is characterized by: (a) delt

206 However, dreaming also occurs in non-REM (NREM) sleep, characterized by prominent low-frequen

207 REM sleep, and increased ventilation in non-REM and REM sleep, independently of metabolic effects.

208 , these long timescales are abrogated in non-REM sleep.

209 bition reduced wakefulness and increased non-REM (NREM) sleep.

210 0 mW compared to non-rapid eye movement (non-REM) sleep and wakefulness (each P < 0.05, n = 7).

211 hat occur during non-rapid-eye-movement (non-REM) sleep(1-8) and whose disruption impairs spatial mem

212 that are reactivated during REM, but not non-REM, sleep.

213 related to EEG oscillatory parameters of non-REM sleep serving as markers of sleep-dependent memory c

214 active exclusively in the DOWN state of non-REM sleep.

215 in REM sleep relative to quiet waking or non-REM sleep.

216 ases rapid eye movement (REM) sleep over non-REM (NREM) sleep across species.

217 sing CeA neurons promoted and suppressed non-REM (NREM) sleep, respectively, and optrode recording sh

218 This non-REM dream mentation may be different in the species wher

219 te of intermediate sleep (IS) similar to non-REM (NREM) stage 2.

220 greater in REM sleep (10 mW) compared to non-REM and waking (3 to 5 mW, P < 0.05), and the slopes of

221 o determine the thalamic contribution to non-REM oscillations (sharp-wave ripples, SWRs; slow/delta;

222 activity that occurs from wakefulness to non-REM sleep and reduces airway collapsibility.

223 In contrast, upon non-REM (NREM) sleep, firing rate distributions narrowed whi

224 ent whole-brain networks across the wake-non-REM sleep cycle.

225 on may be different in the species where non-REM is atypical, such as during unihemispheric sleep in

226 was stronger during waking compared with non-REM sleep but stronger during non-REM sleep among deep-l

227 LGN during poststimulus NREM sleep (but not REM or wake) disrupts coherence between LGN and V1 and a

228 received auditory cueing during NREM but not REM sleep showed impaired fear memory upon later present

229 Initial hopes that these abnormalities of REM sleep may serve as differential-diagnostic markers f

230 low-voltage fast desynchronized activity of REM sleep.

231 was significantly correlated with amount of REM, but was also observed in participants who did not e

232 Analyses of REM-CA mutants by single particle tracking demonstrate t

233 As previously reported in our analysis of REM sleep responses, we found different patterns of chan

234 By focusing on the components of REM sleep and discouraging continued reliance on a restr

235 s the historical origins of the discovery of REM sleep, the diversity of REM sleep expression across

236 Slow Wave Sleep, but also a disinhibition of REM (rapid eye movement) sleep, demonstrated as a shorte

237 the discovery of REM sleep, the diversity of REM sleep expression across and within species, the pote

238 at control REM sleep, and how dysfunction of REM sleep mechanisms underlie debilitating sleep disorde

239 nots, and more on the diverse expression of REM sleep components over development and across species

240 H system in the dynamic output expression of REM sleep during T(a) manipulation.

241 on a template derived from the expression of REM sleep in the adults of a small number of mammalian s

242 d within species, the potential functions of REM sleep (e.g., memory consolidation), the neural circu

243 ssed rapid progress in the identification of REM and NREM sleep neurons, which constitute highly dist

244 a shortening of REM latency, an increase of REM density, as well as total REM sleep time.

245 ults indicate that higher baseline levels of REM sleep predict reduced fear-related activity in, and

246 erefore, delta waves are an integral part of REM sleep in humans and the two identified subtypes (saw

247 um, an area implicated in dual regulation of REM and NREM sleep.

248 and advance our understanding of the role of REM and NREM sleep in memory consolidation.

249 These findings reveal an important role of REM sleep in experience-dependent synapse elimination an

250 (REM) sleep prompts interest in the role of REM sleep in hippocampal-dependent episodic memory.

251 ment) sleep, demonstrated as a shortening of REM latency, an increase of REM density, as well as tota

252 spatio-temporal physiological signatures of REM sleep, especially in humans.

253 developments in our current understanding of REM sleep biology and pathobiology.

254 This study supports the localizing value of REM IEDs over NREM IEDs and suggests that HD-EEG may be

255 Total sleep or REM sleep deprivation also prevented MD- and FC-induced

256 s significantly reduced after total sleep or REM sleep deprivation.

257 esidence time of 11 to 22 s) through the PAC-REM and MWCNT-REM with the application of a -1.1 V/SHE c

258 C in the MWCNT-REM and ~10% of C in the PAC-REM participated in adsorption reactions.

259 Sleep disturbance, particularly REM sleep disturbance, profoundly impacts emotion regula

260 p regulates emotional memory, and persistent REM sleep impairment after cocaine withdrawal negatively

261 y physiological changes during the preceding REM period.

262 these neurons in sleep selectively promotes REM sleep.

263 g, whereas lesions of the PPT in cats reduce REM sleep.

264 on of GABAergic PPT neurons slightly reduced REM sleep.

265 ives wakefulness, whereas inhibition reduces REM sleep theta activity.

266 he lateral hypothalamus (LH), which regulate REM sleep initiation and maintenance.

267 th widely distributed, but locally regulated REM sleep slow oscillations.

268 A recent study shows that restless REM sleep impedes this overnight process, providing insi

269 e hypoglossal motor nucleus (MoXII) restores REM sleep genioglossus activity, highlighting the import

270 results not only demonstrate that selective REM sleep disturbance leads to hyperactivity of mHb ChNs

271 haviors, including rapid eye movement sleep (REM sleep), a sleep phase when the brain is as active as

272 EEG) traces during rapid-eye movement sleep (REM) has intrigued scientists for decades.

273 , and particularly rapid eye movement sleep (REM), has been implicated in the modulation of neural ac

274 ve sleep (SWS) and rapid eye movement sleep (REM), raising the question of why and how specialized sl

275 ur results suggest that elevated submentalis REM sleep without atonia appears to be a potentially use

276 ditory CS was re-presented during subsequent REM or NREM sleep.

277 ABNs that are reactivated during subsequent REM sleep against a backdrop of overall reduced ABN acti

278 Almost all antidepressant agents suppress REM sleep and a time-and-dose-response relationship betw

279 inal histone fold, as well as the C-terminal REM (rat sarcoma exchange motif), CDC25 (cell division c

280 We found that REM constituted 26.5% of total sleep, comparable to huma

281 Together, these findings indicate that REM sleep has multifaceted functions in brain developmen

282 These findings indicate that REM sleep is a spatially and temporally heterogeneous st

283 between REM sleep and SCRs, indicating that REM may only modulate fear acquisition indirectly.

284 Cholinergic REM Induction Test revealed that REM sleep abnormalities can be mimicked by administratio

285 d in healthy adult individuals, we show that REM sleep is characterized by prominent delta waves also

286 Here we show that REM sleep prunes newly formed postsynaptic dendritic spi

287 increased the residence times of NDMA in the REMs by a factor of 3.8 to 5.4 and therefore allowed for

288 These REM based NPs are important magnetic building blocks for

289 This REM sleep-dependent elimination of new spines facilitate

290 Sawtooth waves, which are exclusive to REM sleep, share many characteristics with ponto-genicul

291 r possessed the precursors that gave rise to REM and SWS at one or more loci in the parallel evolutio

292 an increase of REM density, as well as total REM sleep time.

293 and-dose-response relationship between total REM sleep suppression and therapeutic response to treatm

294 nsylvania Smell Identification Test (UPSIT), REM Sleep Behavior Disorder screening questionnaire (RBD

295 The mechanism of vinylphosphonate REM-GTP is discussed in detail for initiation and propag

296 he EEG, EMG, and autonomic profiles of wake, REM, and NREM states and several key features of their t

297 tify a key molecular substrate through which REM sleep disturbance may alter affect regulation.

298 ormance gains independent of learning, while REM sleep decreases plasticity to stabilize learning in

299 y separate arousal and action neurons, while REM and NREM sleep neurons are part of the central somat

300 interrogation of brain circuitry linked with REM sleep control, in turn revealing how REM sleep mecha