ライフサイエンスコーパス: RNA conformation

1 egions of the fold that support the gene-off RNA conformation.

2 ow these elements work together to determine RNA conformation.

3 g through the formation of an autoinhibitory RNA conformation.

4 determining importance of electrostatics in RNA conformation.

5 ding pathway that leads to an aberrant SRP19-RNA conformation.

6 that the pH change significantly alters the RNA conformation.

7 ctions in the stabilisation of the Tat-bound RNA conformation.

8 p region but does not dramatically alter the RNA conformation.

9 ting that EZH2 promotes a cleavage-competent RNA conformation.

10 o an inactive telomerase RNP with an altered RNA conformation.

11 It therefore may well affect RNA conformation.

12 of PRC2-RNA interactions crucially depend on RNA conformation.

13 coexistence of multiple docked and undocked RNA conformations.

14 e, suggesting a means for sensitively tuning RNA conformations.

15 roscopic probes of the transiently populated RNA conformations.

16 romoting formation of and stabilizing active RNA conformations.

17 cules such as proteins to stabilize specific RNA conformations.

18 o that for other backbones that favor A-form RNA conformations.

19 ctions require transitions among alternative RNA conformations.

20 of RNA sequences that bind to Za and adopt Z-RNA conformations.

21 Our results reveal alternative RNA conformations across the genome and at the critical

22 To probe the RNA conformations adopted during initial replication, we

23 ot, and potentially the predicted telomerase RNA conformation, affects polymerization to cause the ob

24 ve configurations, including a left-handed Z-RNA conformation and a compact purine Triplet.

25 pressure shows a stabilizing effect on the A-RNA conformation and a destabilization of the left-hande

26 ne uracil), which enables the correlation of RNA conformation and recognition under equilibrium and i

27 itions of the tetraloop into the canonical A-RNA conformation and the presence of two alternative con

28 the importance of their role in determining RNA conformation and their evolutionary origin.

29 ingle molecule fluorescence assay to monitor RNA conformation and virus assembly in real time, with t

30 of pseudouridine, which include stabilizing RNA conformations and destabilizing interactions with va

31 ginine to form binding surfaces for specific RNA conformations and distinct levels of RNA structural

32 fferent IAV genome segments acquire distinct RNA conformations and form both intra- and intersegment

33 of interrogating nonequilibrium steady-state RNA conformations and the adjustable period of [Mg(2+)]-

34 ws formation of less stable from more stable RNA conformations and thus RNA structure conversion agai

35 understanding of how riboswitches fold, what RNA conformations are required for ligand recognition, a

36 ter resonance energy transfer reports on the RNA conformation as a function of either mono- or divale

37 stretch with two predicted interconvertible RNA conformations, as known from riboswitches, which mig

38 bserved an anomalously broad distribution of RNA conformations at intermediate ion concentrations tha

39 Here, we present six libraries of discrete RNA conformations based on a simplified pseudo-torsional

40 and orientations, we robustly clustered all RNA conformations by employing unique methods to remove

41 everal metal ion binding sites important for RNA conformation can accommodate chemically distinct ion

42 Changes in RNA conformation can alter gene expression.

43 Learning how native RNA conformations can be stabilized relative to unfolded

44 The RNA conformation changed upon the introduction of the sy

45 inant construct of the DGCR8 protein and the RNA conformation changes that result.

46 mming (MC-Sym) fragment assembly to generate RNA conformations constrained by secondary structure.

47 These spontaneous changes in RNA conformation correlate quantitatively with those tha

48 h high nanomolar affinity and that modulates RNA conformation during cotranscriptional folding.

49 rategy whereby RNA-associated metal ions and RNA conformation exhibit exceptional plasticity in respo

50 to accurately estimate the probability of an RNA conformation from sequence.

51 the reconstruction of coexisting alternative RNA conformations from structure probing data are paving

52 1), C4'(n+1)), which can be used to describe RNA conformation in much the same way that varphi and ps

53 with argininamide serves as a model for the RNA conformation in the tat-TAR complex.

54 nging to the DEAD-box superfamily can affect RNA conformation in vitro.

55 roteins in multi-subunit RNPs together favor RNA conformations in a dynamic ensemble for functional g

56 lays the foundation for rapidly determining RNA conformations in a structural genomics context, and

57 ng (SAXS), we elucidate the ensemble of Bvht RNA conformations in solution, revealing that Bvht lncRN

58 These data indicate that two highly distinct RNA conformations in the H4a and H4b region can mediate

59 RNA conformation is both highly dependent on and sensiti

60 riophages MS2 and Qbeta for which a dominant RNA conformation is found inside the assembled viral cap

61 The helical RNA conformation is nearest that of A form DNA.

62 and the link between secondary structure and RNA conformation is only beginning to be understood.

63 Near physiological salt concentrations, RNA conformation is sensitive to both helix length and j

64 This change in RNA conformation likely affects the RNA's suitability fo

65 These changes in the RNA conformation place the N1 positions of A1492 and A14

66 ition to its important function in sculpting RNA conformation, plays an underappreciated role in modu

67 ve to factors that influence the ensemble of RNA conformations present in the partially unfolded stat

68 Thus, ligands may stabilize existing RNA conformations rather than inducing new ones.

69 anding hypothesis(6-8) that heterogeneity in RNA conformation regulates splice-site use and viral gen

70 ethyladenosine, m (6)A 37, adopted an A-form RNA conformation (rmsd approximately 0.6 A) as determine

71 ing scheme, our CRF model is then applied to RNA conformation sampling.

72 specifically to TAR and induces a change in RNA conformation similar to that induced by Tat peptides

73 coded by poly(A), favors a peptidyl-transfer RNA conformation suboptimal for peptide bond formation.

74 ategy to further stabilize a natively folded RNA conformation suggests an important element of modula

75 ties" is, however, challenging because bound RNA conformations tend to have equilibrium populations i

76 aled that the selected sequences restored an RNA conformation that facilitates recognition of the AAU

77 y valuable for exploring adaptive changes in RNA conformation that occur in response to biologically

78 First, the RNA conformation that presents an accessible rut site pr

79 The RNA conformation that promotes Rho-dependent termination

80 ding of S8 leads to a dramatic change in the RNA conformation that restores the signature S8 recognit

81 its associated coding region by favoring an RNA conformation that sequesters RARE.

82 bias the free-energy landscape toward a few RNA conformations that are competent to add the secondar

83 roscopy revealed distinct mutually exclusive RNA conformations that are differentially populated in t

84 energy transfer (smFRET) to probe the viral RNA conformations that occur during RNAP binding and ini

85 Locally, Mg(2+) association affects RNA conformation through tertiary bridging interactions;

86 c fields within protein pores, aiming to map RNA conformations to ionic currents as RNA translocates

87 unphosphorylated p40AUF1 induces a condensed RNA conformation upon ARE substrates.

88 t decreased RNA hydrogen bonding and changed RNA conformation upon IRP1 binding and illustrate how sm

89 iFoldRNA rapidly explores RNA conformations using discrete molecular dynamics simu

90 ectrophoresis experiments showed that the 3' RNA conformation was indeed altered by nucleotide substi

91 ong the ribosomal RNA, stabilizing transient RNA conformations, while RNA folding and the early stage

92 ndicated the presence of a highly structured RNA conformation with a significant amount of A-form hel

93 The evolution of RNA conformation with Mg(2+) concentration ([Mg(2+)]) is

94 gel electrophoresis is a sensitive probe of RNA conformation with the capability to detect differenc

95 This method reports only on the RNA conformation within the complex and suggests that th