ライフサイエンスコーパス: RNA degradation

1 transcripts by translation inhibition and/or RNA degradation.

2 ation (A) site suggesting altered 3'-end pre-RNA degradation.

3 s to slower growth and a massive increase in RNA degradation.

4 ples requires optimal RNA yields and minimal RNA degradation.

5 that 5' decay is the primary pathway for HCV RNA degradation.

6 at consistent high levels prior to regulated RNA degradation.

7 hat RNase PH could play a role in structured RNA degradation.

8 uclease RNase L and consequently block viral RNA degradation.

9 e and must be regulated to avoid nonspecific RNA degradation.

10 (and the subsequent dNTP pools) derived from RNA degradation.

11 Pase in rRNA and mRNA 3'-end maturation, and RNA degradation.

12 script, thereby triggering nonsense-mediated RNA degradation.

13 n of RNA molecules alternate with periods of RNA degradation.

14 hat in plants, RNase MRP is involved in TBSV RNA degradation.

15 hosphorylase (PNPase) primarily functions in RNA degradation.

16 mall interfering RNAs (siRNAs), which direct RNA degradation.

17 ults in a 10-fold enhancement of the rate of RNA degradation.

18 oxidative cleavage of DNA and possibly also RNA degradation.

19 nce between nucleotide excision and template RNA degradation.

20 RNA-induced silencing complex to avoid viral RNA degradation.

21 ither by inhibiting translation or promoting RNA degradation.

22 n, decreased protein synthesis and increased RNA degradation.

23 nce between nucleotide excision and template RNA degradation.

24 either translation inhibition or accelerated RNA degradation.

25 triggering either translation repression or RNA degradation.

26 onserved pathway mediating sequence-specific RNA degradation.

27 functions that mediate its participation in RNA degradation.

28 eotidase that completes the terminal step of RNA degradation.

29 cessing, and failure to do so leads to rapid RNA degradation.

30 between the coding sequences and very rapid RNA degradation.

31 s corrected by cycloheximide, which inhibits RNA degradation.

32 rally controlled transcription and regulated RNA degradation.

33 mine the effects of specific 3'-sequences on RNA degradation.

34 nts and animals that induces double-stranded RNA degradation.

35 epleted strains, consistent with substantial RNA degradation.

36 as simple mechanisms for polyadenylation and RNA degradation.

37 may be limited by an alternative pathway for RNA degradation.

38 corresponding to the dsRNA through targeted RNA degradation.

39 id not result from indiscriminate protein or RNA degradation.

40 actions by activating RNase L, resulting in RNA degradation.

41 enhanced lytic replication by impeding KSHV RNA degradation.

42 that they are not subject to miRNA-mediated RNA degradation.

43 ailing assumptions about how this RBP drives RNA degradation.

44 n of type I IFN, PKR-mediated apoptosis, and RNA degradation.

45 death to preservation and the associated 5'-RNA degradation.

46 5, which would otherwise recruit DIS3L for Y RNA degradation.

47 as possible causative agents of the observed RNA degradation.

48 18 and 2009 pandemic strains, induces global RNA degradation.

49 transcript integrity number (TIN) to measure RNA degradation.

50 03 stabilizes rpl16 mRNA by impeding 5'-->3' RNA degradation.

51 of unintended off-target RNase H1 dependent RNA degradation.

52 inged RNP machine specialized for structured RNA degradation.

53 tes each further increase the rate of target RNA degradation.

54 avoiding the high temperatures that promote RNA degradation.

55 se DNA methylation independently of exosomal RNA degradation.

56 discovery of RNA-activated sequence-specific RNA degradation, a phenomenon now referred to as RNA sil

57 iveness 99.2%), enhances intracellular viral RNA degradation about 5-fold, and moderately inhibits vi

58 of virulence gene expression by controlling RNA degradation according to nutritional stress.

59 e not the consequence of miR-iab4/8-mediated RNA degradation acting on those sensitive mRNA species;

60 It is required, however, for RNA degradation activity of tegument-derived vhs and wil

61 Nrd1 stimulates the RNA degradation activity of the exosome in vitro.

62 unterintuitive outcome following the loss of RNA degradation activity suggests a major importance of

63 tinct from its RNA-activated single-stranded RNA degradation activity.

64 This RNA-degradation activity specifically targeted both the

65 RNA degradation affects RNA-seq quality when profiling t

66 plication of steric blocking ASOs to promote RNA degradation allows one to explore more nucleotide mo

67 cleavage and requires host Xrn1 to complete RNA degradation, although the mechanism of targeting and

68 n length that are generated as byproducts of RNA degradation and abortive transcription initiation.

69 to-dissociate cell types and is free of both RNA degradation and artifactual transcriptional stress r

70 g a common hydrolytic cleavage mechanism for RNA degradation and DNA editing, respectively.

71 ated by sense transgenes (S-PTGS) results in RNA degradation and DNA methylation of the transcribed r

72 Our findings redefine the role of RNase E in RNA degradation and explain how unpaired 5'-terminal nuc

73 e mechanisms that control the specificity of RNA degradation and how RNA degradation processes intera

74 genes in metazoans by accelerating messenger RNA degradation and inhibiting translation, thereby redu

75 nd modification of transcripts, translation, RNA degradation and its regulation, is the central and m

76 e association correlate with reduced exosome RNA degradation and larger Ser2p CTD-modified RNA polyme

77 We find that most maternal RNA degradation and most new transcription correlate wit

78 eukaryotic transcriptomes through noncoding RNA degradation and mRNA quality control, including exos

79 N gene expression prevents cellular RNA degradation and partially rescues the dramatic trans

80 and mitochondria, concurrent with cytosolic RNA degradation and pleiotropic cellular effects, includ

81 major enzymes with 3' to 5' single-stranded RNA degradation and processing activities, can interact

82 omplex of 3'-5' exoribonucleases involved in RNA degradation and processing events, degrades nonstop

83 RNase III is a key enzyme in the pathways of RNA degradation and processing in bacteria and has been

84 y of endoribonucleases has a central role in RNA degradation and processing.

85 tes and resulting in effective inhibition of RNA degradation and processing.

86 the host endoribonuclease RNase MRP in viral RNA degradation and recombination.

87 ious biological processes, such as splicing, RNA degradation and RNA-protein interaction.

88 The SARS-CoV nsp1 protein increases cellular RNA degradation and thus might facilitate SARS-CoV repli

89 NA cleavage is sufficient to trigger nuclear RNA degradation and transcription termination or whether

90 ase pairing is tolerated as a match for both RNA degradation and translation repression.

91 nscriptional regulation by means of targeted RNA degradation and translational arrest.

92 a conserved site in ATXN1's 5' UTR to induce RNA degradation and translational inhibition.

93 terized the distinctive patterns of maternal RNA degradation and zygotic gene activation, including t

94 A combination of translational repression, RNA degradation, and activation by germ plasm has also b

95 tivates the Csm6 HEPN domains for collateral RNA degradation, and how CARF domain-mediated cA6 cleava

96 s have been implicated in small RNA-mediated RNA degradation, and in degradation-independent translat

97 RAMP functions as an exosome cofactor during RNA degradation, and it has been speculated that this ro

98 ase 3, and cytochrome C, Annexin V staining, RNA degradation, and oligonucleosomal DNA cleavage).

99 es, including protein synthesis, protein and RNA degradation, and organelle remodeling.

100 A poly(U) extension did not promote rapid RNA degradation, and RNA turnover was slowed by the addi

101 with the exosome during cytoplasmic 3'-to-5' RNA degradation, and that CER7-dependent regulation of w

102 N-gamma include those involved in apoptosis, RNA degradation, and the inflammatory response.

103 ration is associated with a wave of maternal RNA degradation, and the resulting relative changes to t

104 d accumulated ribonucleotides, indicative of RNA degradation, and these processes were increased in B

105 Specific systems of nuclear RNA degradation appear to target and degrade aberrant pr

106 described in models in which termination and RNA degradation are coupled to the phosphorylation state

107 Together, our studies indicate RNA degradation as a step-wise process with a dedicated

108 by one of the seasonal strains, and massive RNA degradation as early as 4 h postinfection by the sea

109 uv3p effects group I intron splicing through RNA degradation as part of the degradosome, or has a dir

110 a result, we do not have evidence to support RNA degradation as the mechanism that underlies Cas9-med

111 Many do not show characteristics of general RNA degradation, as seen for the accumulation of small f

112 In vitro RNA degradation assays confirmed its exoribonuclease pro

113 cipitation followed by Northern blotting and RNA degradation assays, we confirm that mature miR-221 i

114 N is a reliable and sensitive measure of the RNA degradation at both transcript and sample level.

115 -nucleotide polymorphisms, repeat sequences, RNA degradation biases and probes targeting genomic regi

116 d on oligo(dT) priming could be sensitive to RNA degradation; broken mRNA strands should give rise to

117 of viral RNA is important not only for viral RNA degradation but for RNA recombination as well, due t

118 ild-type cells were not due to sRNA-targeted RNA degradation but to direct DCL3 cleavage of miRNA and

119 It is interesting that while DNA and RNA degradation by activated Fe.BLM has been studied ext

120 ions to the 3' ends of RNA substrates affect RNA degradation by both of these enzymes.

121 boswitch has been found to alter the rate of RNA degradation by directly stimulating or inhibiting ne

122 (Np(4)Ns) have recently been shown to impact RNA degradation by inducing nucleoside tetraphosphate (N

123 ow that TRAMP does not significantly enhance RNA degradation by purified exosomes lacking Rrp6 in vit

124 rolase RppH, which triggers 5'-end-dependent RNA degradation by removing orthophosphate from the 5'-d

125 Although extensive RNA degradation by RNase H likely eliminates many potent

126 hat SmpB binding controls the timing of SsrA RNA degradation by RNase R.

127 A (dsRNA) is a potent trigger for programmed RNA degradation by the 2-5A/RNase L complex in cells of

128 omponent of TRAMP4, which stimulates nuclear RNA degradation by the exosome.

129 reports showed that purified TRAMP enhanced RNA degradation by the nuclear exosome in vitro.

130 (NNS) pathway in a process that is linked to RNA degradation by the nuclear exosome.

131 hese results demonstrate that siRNA-directed RNA degradation can take place in the nucleus, suggestin

132 While RNA degradation changed the community structure of the m

133 hsB and 333d41 failed to induce the cellular RNA degradation characteristic of HSV.

134 cal poly(A) polymerase PAPD5, or the exosome RNA degradation complex, partially restores TERC levels

135 the RNase H domain that reduced the rate of RNA degradation conferred high-level resistance to 3'-az

136 re wondered whether the capacity to activate RNA degradation could account for its requirement for gr

137 involved in RNA degradation, suggesting that RNA degradation could play a role in viral RNA recombina

138 Our splicing and RNA degradation data demonstrate the advantages of using

139 expression suggests novel signaling linking RNA degradation/decapping and regulation of translation.

140 tate between the rates of polymerization and RNA degradation determines the frequency of reverse tran

141 RNA degradation distorts the RNA-seq read coverage in a

142 termediaries in triggering sequence-specific RNA degradation during posttranscriptional gene silencin

143 e cytosolic ribonucleoprotein, implying that RNA degradation during reverse transcription may activat

144 suggests that Zld may also regulate maternal RNA degradation during the maternal-to-zygotic transitio

145 aluable approach used to neutralize in vitro RNA degradation effect and improve differential gene exp

146 with TIN scores could effectively neutralize RNA degradation effects by reducing false positives and

147 the viral endonuclease SOX and the cellular RNA degradation enzyme Xrn1 during lytic Kaposi's sarcom

148 tion, confirming inhibitory activity of this RNA-degradation enzyme.

149 We further show that NCBP3 competes with the RNA degradation factor ZC3H18 for binding CBC-bound tran

150 tome-wide RNA-binding profiles of 30 general RNA degradation factors in the yeast Saccharomyces cerev

151 he absence of an active P19 results in viral RNA degradation followed by recovery from infection.

152 exonucleolytic decay is the major pathway of RNA degradation following deadenylation in HeLa cytoplas

153 We have repeatedly observed extensive RNA degradation following trypsinization, a routine proc

154 ding new light on the importance of complete RNA degradation for transcriptional integrity.

155 ating that cytoplasmic 5'-to-3' and 3'-to-5' RNA degradation generally counteract S-PTGS, likely by r

156 Among these processes, mRNA decay and stable RNA degradation generally have been considered distinct,

157 phosphorylase (PNP) plays a central role in RNA degradation, generating a pool of ribonucleoside dip

158 nt years, our knowledge of the mechanisms of RNA degradation has increased considerably with discover

159 s defective for transcription repression and RNA degradation, hybrid formation requires Rad51p and Ra

160 that use water as a nucleophile to catalyze RNA degradation (hydrolytic RNases) and RNases that use

161 5'-End-dependent RNA degradation impacts virulence, stress responses, and

162 Small interfering RNAs (siRNAs) promote RNA degradation in a variety of processes and have impor

163 alpha1(I) collagen messenger RNA by blocking RNA degradation in activated HSCs.

164 Such an activity is important for messenger RNA degradation in bacteria, but this is, to our knowled

165 Poly(A) tails stimulate RNA degradation in bacteria, suggesting that this is the

166 RNA degradation in cells triggers PRC2 recruitment to Cp

167 rophosphatases, ApaH or RppH, triggers rapid RNA degradation in E. coli.

168 One of the main mechanisms of messenger RNA degradation in eukaryotes occurs by deadenylation-de

169 is an RNA pyrophosphohydrolase that triggers RNA degradation in H. pylori, whereas the other, HP0507,

170 P19/43 still suppresses RNAi-mediated viral RNA degradation in infected Nicotiana benthamiana, while

171 t the difference is not merely due to random RNA degradation in low pH samples; rather it reflects a

172 ons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cel

173 ristetraprolin (TTP) as a major regulator of RNA degradation in one noncanonical strategy.

174 l as accelerated kinetics of endogenous IL-2 RNA degradation in TCR gamma delta cells.

175 We have re-examined the initial events of RNA degradation in that organism by devising an assay to

176 ast, a parallel pathway for 5'-end-dependent RNA degradation in that species appears to involve an al

177 Delta20, Delta20R, and KOS caused comparable RNA degradation in the absence of actinomycin D.

178 NA cleavage events, and 5'-3' exonucleolytic RNA degradation in the mammalian Pol II termination proc

179 in the cytoplasm of human cells and induces RNA degradation in vitro, as does its purified bacterial

180 The influence of HpRppH on RNA degradation in vivo was examined by using RNA-seq to

181 eotide microarrays were used to study global RNA degradation in wild-type Escherichia coli MG1655.

182 hese fragments could be classified as stable RNA degradation intermediates (RNA degradants).

183 th this, sequencing of the 5' and 3' ends of RNA degradation intermediates in infected cells confirme

184 hput approaches for profiling the 5' ends of RNA degradation intermediates on a genome-wide scale are

185 ce, we found a predominance of 5' termini of RNA degradation intermediates that were separated by a l

186 sphate conversion to induce 5' end-dependent RNA degradation is a two-step process in E. coli involvi

187 Messenger RNA degradation is an essential step in gene expression

188 RNA degradation is crucial for regulating gene expressio

189 y enolase, a glycolytic enzyme whose role in RNA degradation is currently not understood.

190 More importantly, OSPE-mediated RNA degradation is found to downregulate the expression

191 Maternal RNA degradation is induced by the binding of proteins an

192 RNA immunoprecipitation studies confirm that RNA degradation is inhibited with short imatinib treatme

193 Increased RNA degradation is likely responsible for the repression

194 epletion of mRNA-binding domains involved in RNA degradation is observed.

195 RNA degradation is one of several ways for organisms to

196 at impairment of either 5'-to-3' or 3'-to-5' RNA degradation is sufficient to provoke the entry of tr

197 RNA degradation is tightly regulated to selectively targ

198 Because RNA degradation is ubiquitous in all cells, it is clear

199 In general, RNA degradation is via exoribonucleases that degrade RNA

200 In plants the role of RNA silencing in viral RNA degradation is well established, but its potential f

201 Whereas a role for Suv3p in RNA degradation is well established, the function of Suv

202 te replication and that virus-mediated small RNA degradation likely contributed to 2'OMe evolution.

203 upregulation of mRNA level, miRNAs-mediated RNA degradation, LIN-66-mediated translational inhibitio

204 is hypothesized to control processes such as RNA degradation, localization, and splicing.

205 RNP complexes from cell lysates suffers from RNA degradation, loss of interacting macromolecules and

206 olynucleotide phosphorylase (PNPase) form an RNA degradation machine that is scaffolded by Y RNA.

207 ndria, DNA replication, gene expression, and RNA degradation machineries coexist within a common nond

208 Key components of RNA degradation machineries, including UPF1, UPF3B, and

209 RNPs and stimulates their destruction by the RNA degradation machinery are still not completely eluci

210 ay be fundamental biochemical differences in RNA degradation machinery between E. coli and other bact

211 rated view of how different cofactors of the RNA degradation machinery cooperate to target and elimin

212 n recently studied and characterized; yet no RNA degradation machinery has been identified in the mam

213 We have ablated the cellular RNA degradation machinery in differentiated B cells and

214 7/Dip, which directly binds and inhibits the RNA degradation machinery of its bacterial host.

215 teins to the ARE and the modification of the RNA degradation machinery of the cell induced by the pre

216 ther flaviviruses commandeer the host cell's RNA degradation machinery to generate the small flavivir

217 P), which helps to recruit components of the RNA degradation machinery to the histone mRNA 3' end.

218 the highly conserved major cellular 3' to 5' RNA degradation machinery, as a physical interactor of C

219 posons that are also targeted by the exosome RNA degradation machinery.

220 ferent cofactors associated with the nuclear RNA degradation machinery.

221 bias, local sequence bias, positional bias, RNA degradation, mapping bias or other unknown reasons,

222 y double-stranded RNA is a sequence-specific RNA degradation mechanism highly conserved in eukaryotes

223 A interference (RNAi) is a sequence-specific RNA degradation mechanism that has been shown to play a

224 RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants

225 gene silencing (PTGS) is a sequence-specific RNA degradation mechanism that is widespread in eukaryot

226 ins by harboring a polyadenylation-dependent RNA degradation mechanism, but whether SUV3 participates

227 igger silencing through a homology-dependent RNA degradation mechanism.

228 ted and triggered through homology-dependent RNA degradation mechanisms, has been exploited as an eff

229 RNA and enhances sequence-specific messenger RNA degradation mediated by the RNA-initiated silencing

230 ation and quantification then post autoclave RNA degradation methodology should be employed, which ma

231 omain, and could therefore contribute to the RNA degradation observed in RNAi.

232 sh samples in a previous study suggests that RNA degradation occurred despite storage of the specimen

233 , we have examined the siRNA-mediated target RNA degradation of uPAR and MMP-9 in human glioma cell l

234 Bacterial RNA degradation often begins with conversion of the 5'-t

235 In Escherichia coli, RNA degradation often begins with conversion of the 5'-t

236 Bacterial RNA degradation often begins with conversion of the 5'-t

237 sed rat duodenum to determine the effects of RNA degradation on the analysis of gene expression.

238 d with chromatin, the effect of ASO-directed RNA degradation on transcription has never been document

239 xpression of off-target cellular proteins by RNA degradation or translation repression.

240 genes by translational repression, messenger RNA degradation, or both.

241 ing samples because of lack of viable tumor, RNA degradation, or insufficient clinical information, 2

242 y the recently described cytosolic messenger RNA degradation pathway for messages lacking termination

243 g the existence and maintenance of a nuclear RNA degradation pathway in metazoans.

244 The polyadenylation-stimulated RNA degradation pathway takes place in plant and algal o

245 ay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating th

246 The 2-5A system is an interferon-regulated RNA degradation pathway with antiviral, growth-inhibitor

247 ediated mRNA decay (NMD), a highly conserved RNA degradation pathway.

248 nonsense-mediated decay (NMD), a cytoplasmic RNA degradation pathway.

249 Here we describe the RNA degradation pathways against which miR-122 provides

250 RNA degradation pathways enable RNA processing, the regu

251 ence homology with RNA helicases involved in RNA degradation pathways in other organisms.

252 Saccharomyces cerevisiae cells deficient for RNA degradation pathways revealed that about half of the

253 eps in normal RNA biogenesis or function and RNA degradation pathways.

254 A-directed methylation pathway distinct from RNA degradation pathways.

255 nce between nucleotide excision and template RNA degradation plays an important role in nucleoside re

256 Regulation of RNA degradation plays an important role in the control o

257 lytic exosome complex is central for nuclear RNA degradation, primarily targeting non-coding RNAs.

258 The assay requires less than 10 min so that RNA degradation problems are avoided.

259 nuclear transcriptome, including a ribosomal RNA degradation procedure that minimizes pre-ribosomal R

260 gene silencing (PTGS) is a sequence-specific RNA degradation process conserved in fungi, plants and a

261 gene silencing (VIGS) is a sequence-specific RNA degradation process that can be used to downregulate

262 S), or RNA silencing, is a sequence-specific RNA degradation process that targets foreign RNA, includ

263 l the specificity of RNA degradation and how RNA degradation processes interact with translation, RNA

264 on as well, due to the participation of some RNA degradation products in the RNA recombination proces

265 ves the TBSV RNA in vitro, resulting in TBSV RNA degradation products similar in size to those observ

266 nce mechanism based on random association of RNA degradation products with Argonaute triggers siRNA a

267 s two distinct ligand binding sites to sense RNA degradation products, although it remains unclear ho

268 d resulted in the accumulation of structured RNA degradation products.

269 ge or strand release, determines the overall RNA degradation rate and that the unwinding step size is

270 Titration of poly(A) into RNA degradation reactions has no effect on turnover of p

271 cillator based on in vitro transcription and RNA degradation reactions to drive a variety of "load" p

272 at FIERY1 (FRY1), which is involved in 5'-3' RNA degradation, regulates miRNA abundance and function

273 Ubiquitin and RNA degradation-related pathway genes were selectively d

274 eak in vitro activity, indicating that rapid RNA degradation requires activating cofactors.

275 yptic transcripts and show that, contrary to RNA degradation-sensitive ones, they often overlap with

276 n transcriptional repression, RNA export and RNA degradation show increased hybrid formation and asso

277 xon splicing sites, and SH RNAs, location of RNA degradation signals, identification of alternative s

278 metabolism, protein synthesis and turnover, RNA degradation, snRNA modification, and snoRNP biogenes

279 five suppressor genes are likely involved in RNA degradation, suggesting that RNA degradation could p

280 provides reproducible staining with minimal RNA degradation suitable for tissues with moderate to hi

281 cripts activate the host's sequence-specific RNA degradation system.

282 ased, sequence-specific, posttranscriptional RNA-degradation system that was programmed by the transg

283 accumulate, implying the existence of active RNA degradation systems.

284 In yeast mitochondria, RNA degradation takes place through the coordinated acti

285 increase AZT resistance by reducing template RNA degradation, thereby providing additional time for R

286 A and rRNA 3'-ends, but also participates in RNA degradation through exonucleolytic digestion and pol

287 RNA degradation, together with RNA synthesis, controls t

288 s through a variety of mechanisms, including RNA degradation, translation inhibition, and transcripti

289 pression through sequence-specific messenger RNA degradation, translational repression, or transcript

290 RNA degradation via the ribonuclease H (RNase H) activit

291 The rate of RNA degradation was constant throughout the transcriptio

292 ibonucleases by trypsin reagent proteases to RNA degradation was examined.

293 l changes in exRNA population when enzymatic RNA degradation was inhibited.

294 sures largely fails to remove the effects of RNA degradation when RNA quality associates with the out

295 nce between nucleotide excision and template RNA degradation, which in turn increased AZT resistance.

296 ipts for detection, can tolerate significant RNA degradation, while still yielding high quality expre

297 Small-molecule targeted RNA degradation will thus provide a general route to aff

298 d complex macromolecular assembly that links RNA degradation with central carbon metabolism.

299 RNA degradation would also explain why only 11 (52%) of

300 isingly, even samples exhibiting significant RNA degradation yielded robust gene expression results,