ライフサイエンスコーパス: RNA processing

1 the P lineage) and P-bodies (associated with RNA processing).

2 of gene regulation and transcription-coupled RNA processing.

3 such as DNA repair, chromatin regulation and RNA processing.

4 o identify novel roles of RBPs in regulating RNA processing.

5 including transcriptional co-activation and RNA processing.

6 assembly and thus possibly to pre-ribosomal RNA processing.

7 is known about its effects on other modes of RNA processing.

8 es and that EBP1 silencing hinders ribosomal RNA processing.

9 a mechanism that relates DNA mutagenesis to RNA processing.

10 mational code coordinating transcription and RNA processing.

11 eq experiments to probe the stochasticity of RNA processing.

12 amage, apoptosis, cell cycle regulation, and RNA processing.

13 nifestation of aberrant transcription and/or RNA processing.

14 NP-C with viral RNA and attenuation of viral RNA processing.

15 -SNF, chromatin modification, DNA repair and RNA processing.

16 ortant new role for E2 in viral and cellular RNA processing.

17 lear foci, leading to abnormal regulation of RNA processing.

18 ds (R-loops) formed during transcription and RNA processing.

19 mRNAs, highlight the role of PARP members in RNA processing.

20 nderstanding of TER evolution and non-coding RNA processing.

21 metabolism, nuclear import, translation, and RNA processing.

22 omoter binding, transcription initiation and RNA processing.

23 gene transcription, signal transduction, and RNA processing.

24 d in histone modification, transcription and RNA processing.

25 lesions caused altered pre-mRNA splicing and RNA processing.

26 RNA-binding protein, plays multiple roles in RNA processing.

27 s the first parvovirus protein implicated in RNA processing.

28 o function of U2AF and U2AF35 in alternative RNA processing.

29 be attributed to stage-regulated alternative RNA processing.

30 related processes, such as transcription and RNA processing.

31 of RNA processing factors and to defects in RNA processing.

32 ESCs, controls a network of genes related to RNA processing.

33 ships, RNA regulation of gene expression and RNA processing.

34 RNAs and proteins are crucial for regulating RNA processing.

35 lays important roles in regulating messenger RNA processing.

36 xtensive crosstalk between transcription and RNA processing.

37 orf6-mediated ubiquitination that facilitate RNA processing.

38 mbraneless organelles (MLOs) associated with RNA processing.

39 and a textbook aspect of co-transcriptional RNA processing.

40 ase activities with known roles in ribosomal RNA processing.

41 COP unveils the organizational complexity of RNA processing.

42 the mechanisms of poxvirus transcription and RNA processing.

43 ion and chromatin regulation, cell cycle and RNA processing.

44 ymerase complex, possibly enabling efficient RNA processing.

45 ulate chromatin structure, transcription and RNA processing(1-13).

46 tidyl-Prolyl Isomerase Like-1 (PPIL1) or Pre-RNA Processing-17 (PRP17).

47 plant innate immunity via inhibition of the RNA-processing 5'-3' exoribonucleases.

48 e group of uncharacterized genes involved in RNA processing, a number of whose products localize to t

49 However, the role of RNA exosome and its RNA processing activity on DNA mutagenesis/alteration ev

50 als older than 60 years, the contribution of RNA processing alterations to human hematopoietic stem a

51 for thousands of bona fide novel elements of RNA processing-alternative splice sites, introns, and cl

52 This provides a new tool to study RNA processing and a potential lead for small molecules

53 These effects were accompanied by defects in RNA processing and altered the expression of genes invol

54 (ISE2) is required for chloroplast ribosomal RNA processing and chloro-ribosome assembly.

55 tion initiation, elongation and termination, RNA processing and chromatin modification.

56 ciation with splicing factors, which recruit RNA processing and chromatin-modifying activities involv

57 Nuclear RNA exosomes catalyze a range of RNA processing and decay activities that are coordinated

58 s endonucleases that play important roles in RNA processing and decay in Escherichia coli and related

59 he nuclear RNA exosome complex that mediates RNA processing and decay, and is mutated in several canc

60 mt-RNA precursors indicative of impaired mt-RNA processing and defective mitochondrial protein synth

61 entification of the proteins responsible for RNA processing and degradation in this organelle is of g

62 conserved multiprotein complex essential for RNA processing and degradation.

63 d suggest combination treatments that target RNA processing and DNA repair pathways simultaneously as

64 rs (RPS15, IKZF3), and collectively identify RNA processing and export, MYC activity, and MAPK signal

65 Recent progress revealed the complexity of RNA processing and its association to human disorders.

66 Several steps of mitochondrial RNA processing and maturation, including RNA post-transc

67 DEAD-box helicases (DDXs) regulate RNA processing and metabolism by unwinding short double-

68 was validated by the functional rescue of mt-RNA processing and mitochondrial protein synthesis defec

69 ding translation, intracellular trafficking, RNA processing and modification, and signal transduction

70 erall effect in lowering cell metabolism and RNA processing and modification.

71 n were functionally enriched in translation, RNA processing and mRNA metabolic process.

72 s; however, they had little effect on global RNA processing and neuronal survival.

73 ng E1B55K or E4orf6 display defects in viral RNA processing and protein production, but previously id

74 m viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated,

75 In addition, changes in RNA processing and protein turnover were predominant in

76 and hnRNP-C relieves a restriction on viral RNA processing and reveal an unexpected role for non-deg

77 ction of this family of proteins goes beyond RNA processing and ribosome assembly and includes RNA st

78 as ribonuclear protein complexes involved in RNA processing and ribosome biogenesis.

79 monstrates that Akt differentially regulates RNA processing and splicing factors to drive T cell diff

80 of some DIs, particularly in genes encoding RNA processing and splicing factors.

81 orms and show their linkage to expression of RNA processing and splicing genes as well as resultant a

82 t down regulation of genes known to regulate RNA processing and splicing.

83 onserved enrichment in transcripts mediating RNA processing and stability.

84 Cotranscriptional RNA processing and surveillance factors mediate heteroch

85 eocytoplasmic transport, rRNA biogenesis, or RNA processing and surveillance was disrupted, 2) the bu

86 th a nuclear exosome that plays key roles in RNA processing and surveillance.

87 erous links exist between co-transcriptional RNA processing and the transcribing RNAPII.

88 how that global changes in transcription and RNA processing and their impact on translation can be an

89 The literature is divided between RNA processing and transcriptional functions for these s

90 RRM proteins are involved in other forms of RNA processing and translation, the primary function of

91 e through their regulation of transcription, RNA processing and translation.

92 roles in critical cellular functions such as RNA processing and translation.

93 ners involved in transcriptional regulation, RNA processing and transport, DNA repair, chromatin remo

94 THO ribonucleoprotein complex important for RNA processing and transport.

95 e transcriptome via controlled regulation of RNA processing and transport.

96 Understanding RNA processing and turnover requires knowledge of cleava

97 ssion, identified tissue-specific changes in RNA processing and uncovered transcriptome changes stron

98 in cytoskeleton dynamics, membrane dynamics, RNA processing and zinc ion binding.

99 alleles, and could therefore affect nuclear RNA processing and/or decay.

100 n m6A loss, and they encode RNA-methylation, RNA-processing and RNA-metabolism factors.

101 of the CTD in complex with Rtt103, a 3'-end RNA-processing and transcription termination factor.

102 ins involved in DNA replication, cell cycle, RNA processing, and chromosome processing.

103 ion of chromatin structure, gene expression, RNA processing, and DNA repair.

104 ion initiation to those that are involved in RNA processing, and implicates phosphorylation as a mech

105 ignaling predicted nephrotoxicity, modulated RNA processing, and inhibited cell migration.

106 tion, promoter activation, RNA synthesis and RNA processing, and it is known that SUMOylation, a post

107 itecture, transcription, posttranscriptional RNA processing, and RNA localization provided by multico

108 pe, productive elongation, cotranscriptional RNA processing, and termination.

109 se encoded by SDG8 is required for canonical RNA processing, and that RNA isoform switching is more p

110 contribute to the control of transcription, RNA processing, and the cytoplasmic fates of messenger R

111 odification, transcriptional regulation, and RNA processing, and thereby mediating developmental and

112 nes with products involved in transcription, RNA processing, and transcriptional regulation was more

113 rs of transcription, chromatin organization, RNA processing, and translation, such that lncRNAs can i

114 Multiple proteins involved in RNA processing are linked to ALS, including FUS and TDP4

115 indicating that these regions mediate normal RNA processing as well as pathological events.

116 llele-specific changes in gene expression or RNA processing, as well as changes in RNA editing in res

117 ; and detail the mechanics of DNA repair and RNA processing at low temperature, and speculate that P.

118 phila, the RNA-binding protein ELAV inhibits RNA processing at proximal polyadenylation sites, thereb

119 al RNA-binding proteins (RBPs) that regulate RNA processing at several levels, including localization

120 systematic differences in transcription and RNA processing between protein-coding and lincRNA genes

121 E2's role in multiple aspects of chloroplast RNA processing beyond group II intron splicing.

122 higher-order property of super-enhancers in RNA processing beyond transcription.

123 lular non-membranous RNA-granules, P-bodies (RNA processing bodies, PB) and stress granules (SG), are

124 Transcription elongation rates influence RNA processing, but sequence-specific regulation is poor

125 ss condensates such as those associated with RNA processing, but the rules that dictate their assembl

126 TD) coordinates transcription, splicing, and RNA processing by modulating its capacity to act as a la

127 RNA processing by ribonucleases and RNA modifying enzyme

128 nd efficiencies of degradosome machinery and RNA processing by RNaseR at low temperature.

129 genetic elements that can encode alternative RNA processing by their effects on RNA processivity, mos

130 sults implicate Ub signaling in coordinating RNA processing by TLR pathways during an immune response

131 ssion of its capsid proteins via alternative RNA processing, by both suppressing polyadenylation at a

132 by which genetic markers drive variation in RNA-processing, cataloguing and classifying alleles that

133 al biological functions, including messenger RNA processing, cell signalling and embryogenesis(1-4).

134 and apoptosis, and up-regulation of genes in RNA processing, cellular growth and proliferation.

135 brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle gene

136 nscription as well as positioning CDK9 as an RNA processing cofactor.

137 ater knowledge of the central role of SMN in RNA processing combined with deep characterization of an

138 1 associates with the Rix1(PELP1)-containing RNA processing complex RIXC and with the histone chapero

139 ERH interacts with multiple RNA processing complexes, including splicing regulators.

140 R, the central HUSH subunit, associates with RNA processing components.

141 These 3' RNA-processing components colocalized with FCA in the nu

142 In the context of RNA-processing condensates such as the nucleolus, this m

143 ced loss of m1A and m1Am arose with specific RNA processing conditions, human lymphoblast cells showe

144 However, little is known about how mitotic RNA processing contributes to spindle assembly.

145 Increasing evidence suggests that defective RNA processing contributes to the development of amyotro

146 oteostasis; many are hub genes - involved in RNA processing, cytoskeletal metabolism, intracellular t

147 our understanding of the broad importance of RNA processing deepens.

148 ption of RNA binding proteins and widespread RNA processing defects are increasingly recognized as cr

149 notypic rescue correlated with correction of RNA processing defects induced by SMN deficiency and neu

150 somal and U7 small-nuclear RNAs and corrects RNA processing defects induced by SMN deficiency in the

151 ly regulated, induces oncogenesis by causing RNA processing defects, for example, splicing defects.

152 mplex, underscoring its role as a non-coding RNA processing/degradation unit.

153 SYK was present in cytoplasmic RNA processing depots known as P-bodies formed during th

154 und that the affected genes were involved in RNA processing, DNA repair, and chromatin remodeling.

155 overexpressing mutant FUS, which will alter RNA processing due to FUS autoregulation.

156 such as DNA replication, transcription, and RNA processing each depend on the concerted action of ma

157 ing RNA RNase component of the mitochondrial RNA processing endoribonuclease (RMRP) give rise to the

158 o the role of RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) in cellular physi

159 Here, we report structures of the U6 RNA processing enzyme Usb1 from yeast and a substrate an

160 ivities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcript

161 itment and activation of a cotranscriptional RNA processing enzyme, Xrn2.

162 (PRORPs) are a recently discovered class of RNA processing enzymes that catalyze maturation of the 5

163 Mutations in RNA-processing enzymes are increasingly linked to human

164 ibonucleoprotein (RNP) granules enriched for RNA-processing enzymes, termed processing bodies (PBs).

165 that ubiquinitation of RNAPII is induced by RNA processing events and linked to transcriptional paus

166 requires quantitative analyses of transient RNA processing events in living cells.

167 essing factors suggesting that CDK12 affects RNA processing events in two distinct ways: Indirectly t

168 ed its application to dissect variability in RNA processing events such as splicing.

169 of the global changes in gene expression and RNA processing events that occur as L. major transforms

170 isoforms preferentially modified alternative RNA processing events without widespread failure to reco

171 important regulators of post-transcriptional RNA processing events, yet their identities and function

172 1 regulates multiple nuclear and cytoplasmic RNA processing events.

173 and regulatory proteins modulate concurrent RNA-processing events, instruct RNA polymerase where to

174 hanistically, ANG induces cell-type-specific RNA-processing events: tRNA-derived stress-induced small

175 recruits cap-binding complexes that mediate RNA processing, export and translation.

176 t the pentatricopeptide repeat (PPR) protein RNA PROCESSING FACTOR 4 (RPF4) supports the generation o

177 a conserved lncRNA that interacts with a key RNA processing factor and regulates neurogenesis from em

178 The cellular RNA processing factor CPSF6 interacted with NP1 in trans

179 th neurodegenerative diseases, including the RNA processing factor TDP43.

180 activates the promoter of the cellular SRSF3 RNA processing factor.

181 , which has mostly been studied as a general RNA-processing factor in yeast and cultured cells.

182 Here, we identified the RNA-processing factor Nudt21 as a novel regulator of cel

183 ng through direct physical interactions with RNA processing factors and by regulating their expressio

184 s, enables identification of novel ribosomal RNA processing factors and sites, and suggests that asso

185 letion also leads to a loss of expression of RNA processing factors and to defects in RNA processing.

186 n modifiers, transcriptional regulators, and RNA processing factors during the transcription cycle.

187 omplex in association with cotranscriptional RNA processing factors including the RNA-dependent ATPas

188 Among the RNA processing factors phosphorylated by Cdk9 was the 5'

189 dynamic interaction platform for a myriad of RNA processing factors that regulate gene expression.

190 Here we describe a role for the RNA processing factors THRAP3 and BCLAF1 in the regulati

191 RNA pol II serving as a platform to recruit RNA processing factors to nascent transcripts.

192 tory mechanisms rely on a complex network of RNA processing factors to prevent untimely gene expressi

193 it directly interacts with polymerase II and RNA processing factors within splicing speckles.

194 These mutant RNAs alter the activities of RNA processing factors, including MBNL proteins, leading

195 modulating the activity of transcription or RNA processing factors, these regulatory RNAs perform cr

196 lease (NYN) - that are present in some other RNA processing factors.

197 and found that they associate with numerous RNA processing factors.

198 ing proteins reveals a strong enrichment for RNA-processing factors suggesting that CDK12 affects RNA

199 ed multisubunit RNA polymerases (vRNAPs) and RNA-processing factors to generate m(7)G-capped mRNAs in

200 l disease and highlighting the importance of RNA processing for correct mitochondrial function.

201 tive separation of nuclear transcription and RNA processing from cytosolic translation(1).

202 case Mtr4 (and senataxin) with the noncoding RNA processing function of RNA exosome determine the str

203 ighly involved in five biological processes: RNA processing; gene transcription; ribosomal proteins;

204 induced splicing alterations are enriched in RNA processing genes, ribosomal genes, and recurrently m

205 ne network (AR-RGN) causal for CAD involving RNA processing genes.

206 first parvovirus protein to be implicated in RNA processing, governs access to the MVC capsid gene by

207 e expression of a critical protein family in RNA processing, heterogeneous nuclear ribonucleoprotein

208 lycoprotein modeling, crowd-sourced science, RNA processing, hydrogen bond networks, and amyloid form

209 QTL affecting 3' RNA processing identify new functional motifs leading to

210 of chromatin structure, gene expression, and RNA processing in a wide range of biological systems, in

211 HATASE-LIKE1 [CPL1]) plays multiple roles in RNA processing in Arabidopsis thaliana Here, we found th

212 Our work describes a key complex for 21U RNA processing in C. elegans and strengthens the view th

213 ecific transcriptional responses and altered RNA processing in each cell type, with Tnfr1 required fo

214 ations have led to a better understanding of RNA processing in health and disease.

215 er regulator of stress response, mediates B2 RNA processing in hippocampal cells and is activated dur

216 a role for aberrant regulation of messenger RNA processing in MCL pathobiology.

217 g, and highlight the involvement of aberrant RNA processing in neuromuscular disease pathogenesis.

218 anscriptome, highlighting important roles of RNA processing in virus-host interactions.

219 A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA

220 rotein that controls gene expression through RNA processing, in particular, regulation of splicing.

221 thermore, MATR3 controls critical aspects of RNA processing including alternative polyadenylation and

222 ar protein (hnRNP) has multiple functions in RNA processing including intracellular trafficking.

223 c variants in mediating post-transcriptional RNA processing, including alternative splicing.

224 e transformed our understanding of mammalian RNA processing, including facilitating the discovery of

225 h many factors involved in transcription and RNA processing, including selective groups of hnRNP prot

226 les of RNA structure in almost every step of RNA processing, including transcription, splicing, trans

227 ent transcriptome contains unstable RNAs and RNA processing intermediates and suggest that polyadenyl

228 ith 5-EU revealed nascent and unstable RNAs, RNA processing intermediates generated by splicing, and

229 polymerase II (Pol II) along with associated RNA processing intermediates.

230 Emerging evidence suggests that RNA processing is crucial for the regulation of these fa

231 spindle assembly and challenge the idea that RNA processing is globally repressed during mitosis.

232 Given that the disruption of RNA processing is increasingly implicated in neurologica

233 Thus, ERH regulation of RNA processing is needed to ensure faithful DNA replicat

234 vidence that the removal of upstream ORFs by RNA processing is not typically required for the transla

235 A critical step in uncovering rules of RNA processing is to study the in vivo regulatory networ

236 in transcription time, degradation rate, and RNA-processing kinetics.

237 se hippocampus due to increased levels of B2 RNA processing, leading to constitutively elevated B2 RN

238 t that co-transcriptional recruitment of the RNA processing machinery to nascent mitotic transcripts

239 The exosome complex is the most important RNA processing machinery within the cell.

240 g an imprecision of the transcription and/or RNA processing machinery.

241 genes using the host cell transcription and RNA processing machinery.

242 uclear replicating DNA virus reliant on host RNA processing machinery.

243 ngle cannabis exposure rapidly targets a key RNA processing mechanism linked to brain transcriptome f

244 Alternative polyadenylation (APA) is an RNA-processing mechanism on the 3' terminus that generat

245 leeping sickness and is known for its unique RNA processing mechanisms that are common to all the kin

246 ranscripts that may result from differential RNA processing mechanisms.

247 onucleolytic cleavage by RNase mitochondrial RNA processing (MRP) and mutations in the RNase MRP smal

248 structures of yeast RNase for mitochondrial RNA processing (MRP), a catalytic ribonucleoprotein (RNP

249 RNA processing mutants have been broadly implicated in g

250 al conditions as well as transcriptional and RNA processing mutants.

251 1 plays a critical role in the regulation of RNA processing, mutation of the gene encoding this ubiqu

252 Alternate RNA processing of caspase-9 generates the splice variant

253 ung tumors, but not blood, were enriched for RNA processing ontologies.

254 s particularly useful to analyze products of RNA processing or turnover, and functional RNAs that are

255 , through the direct inhibition of RIOK1 and RNA processing pathway.

256 ation plays a particularly prominent role in RNA processing pathways of kinetoplastid protists typifi

257 Here, we discuss recent insights into how RNA processing pathways participate in DNA damage recogn

258 N is expressed ubiquitously and functions in RNA processing pathways that include trafficking of mRNA

259 g elongation with chromatin modification and RNA-processing pathways.

260 m, adhesion molecule composition, as well as RNA-processing properties.

261 a 3' to 5' exoribonuclease, RRP6 (ribosomal RNA processing protein 6), as a CELF1-interacting protei

262 of the B cell genome depends upon localized RNA processing protein complex formation in the nucleus.

263 The DNA and RNA processing protein TDP-43 undergoes both functional

264 omponent 2 (EXOSC2), also known as ribosomal RNA-processing protein 4 (RRP4), were recently identifie

265 The RNA-processing protein TDP-43 is central to the pathogen

266 at are caused by mutations in another global RNA-processing protein, hGle1.

267 lar processes, including cell proliferation, RNA processing, protein translation, autophagy, apoptosi

268 rotein superfamily, as well as proteases and RNA processing proteins.

269 Causative mutations in the global RNA-processing proteins TDP-43 and FUS among others, as

270 abolism regulators, translation factors, and RNA-processing proteins.

271 membrane-less organelles enriched in RNA and RNA-processing proteins.

272 Similar alterations in RNA processing rates may contribute to mechanisms of RNA

273 yered liquids that may facilitate sequential RNA processing reactions in a variety of RNP bodies.

274 ition that small RNAs provide specificity to RNA processing reactions through base pairing in diverse

275 ression levels) and post-transcriptional (3' RNA processing) regulation across multiple stages of met

276 ation of RPS28 mRNA blocks pre-18S ribosomal RNA processing, resulting in a reduction in the number o

277 ls, hnRNPLL mediates a genome-wide switch of RNA processing, resulting in loss of B-cell lymphoma 6 (

278 iptome have enabled an unprecedented view of RNA processing, revealing many previously unknown non-ca

279 We propose that, in addition to its RNA processing role, UAP56/DDX39B is a key helicase requ

280 essed transcripts and mapped the genome-wide RNA processing sites (PSSs) in a methanogenic archaeon.

281 e human proteome and play important roles in RNA processing, splicing, export, stability, packaging,

282 influence many cellular processes, including RNA processing, stability, localization, and translation

283 rains, interrogating regulation at different RNA processing stages and uncovering novel transcripts.

284 with spatial and temporal control of various RNA-processing steps, which could regulate the compositi

285 ts, and are enriched in functions related to RNA processing such as SF3B1 spliceosomal factor.

286 ofiles of nascent RNA and co-transcriptional RNA processing that are associated with different CTD ph

287 chanistically, PLXNB2 mediates intracellular RNA processing that contribute to cell growth, survival,

288 RNA degradation pathways enable RNA processing, the regulation of RNA levels, and the su

289 eases but to exert their effects on cellular RNA processing they must first cross the plasma membrane

290 (m(6)A) has recently been shown to regulate RNA processing through alternative splicing, RNA stabili

291 phosphorylation, CDK12 and CDK13 may affect RNA processing through direct physical interactions with

292 dies show the processes of RNA synthesis and RNA processing to be spatio-temporally coordinated, indi

293 However, the mechanism linking RNA processing to FLD function had not been established.

294 his syndrome, senataxin (SETX), functions in RNA processing to protect the integrity of the genome.

295 The contribution of RNA processing to tumorigenesis is understudied.

296 tion of RNAs, and describe how by modulating RNA processing, translation, and decay PARPs impact mult

297 f diverse host systems, including signaling, RNA processing, translation, metabolism, nuclear integri

298 nd long noncoding RNA (lncRNA) with roles in RNA processing, transport, and stability.

299 s with functions relating to translation and RNA processing were overrepresented in genes with increa

300 ations of this mechanism for efficient micro-RNA processing will be discussed.