ライフサイエンスコーパス: RNA silencing

1 rocessing, and suppression of host antiviral RNA silencing.

2 roteins are involved in RISC function during RNA silencing.

3 he endomembrane system in various aspects of RNA silencing.

4 wed clearly that the virus was unaffected by RNA silencing.

5 is required to promote genome integrity and RNA silencing.

6 NA translation, pre-mRNA splicing, and micro-RNA silencing.

7 kinase R(PKR)-mediated immune response, and RNA silencing.

8 suppressor proteins that interfere with host RNA silencing.

9 SR) that can neutralize the effectiveness of RNA silencing.

10 artment required for siRNA amplification and RNA silencing.

11 ase RM62, a protein previously implicated in RNA silencing.

12 9 suppressor mutants are very susceptible to RNA silencing.

13 and disarm the host's essential effector of RNA silencing.

14 ring time control and has been implicated in RNA silencing.

15 mily proteins, are the central components in RNA silencing.

16 using specific pharmacologic inhibitors and RNA silencing.

17 ers can target ARGONAUTE1 (AGO1) to suppress RNA silencing.

18 ng RNAs that are known to be associated with RNA silencing.

19 d RNAs that can serve to initiate or amplify RNA silencing.

20 ncing complexes (miRISCs), thereby affecting RNA silencing.

21 es; RDRs 1, 2 and 6 have roles in anti-viral RNA silencing.

22 ith a remarkably high fidelity for efficient RNA silencing.

23 optosis when endogenous SfIAP was ablated by RNA silencing.

24 how that p37, the viral coat protein, blocks RNA silencing.

25 , including the expression of suppressors of RNA silencing.

26 or piRNAs in protecting essential genes from RNA silencing.

27 ed RNA (dsRNA) binding protein that inhibits RNA silencing, a major antiviral defense pathway in inse

28 in mammals, revealing that DUSP11-dependent RNA silencing activities are shared among diverse metazo

29 C3PO and PLCbeta raises the possibility that RNA silencing activity can affect the ability of PLCbeta

30 g pocket of the Dicer-2 PAZ domain decreased RNA silencing activity in vivo, showing the importance o

31 iphosphatase activity of DUSP11 promotes the RNA silencing activity of viral microRNAs (miRNAs) deriv

32 To enhance stringency, we employed RNA silencing alone and together with transcriptional re

33 ss this issue, we combined short interfering RNA silencing and a high-throughput imaging assay to ide

34 tory signaling cascades as well as antiviral RNA silencing and autophagy.

35 y to assess aphid performance on Arabidopsis RNA silencing and defence pathway mutants.

36 r-RIG-I family protein that is essential for RNA silencing and germline development in nematodes.

37 ts and of assessing the extent of non-coding RNA silencing and histone H4K16 deacetylation.

38 cant progress has been made in understanding RNA silencing and how viruses counter this apparently ub

39 has evolved to produce fungal suppressors of RNA silencing and indicates that PgtSR1s suppress both b

40 Sp1/Sp3 RNA silencing and mithramycin A treatment significantly

41 at went relatively unnoticed in the realm of RNA silencing and nonviral immune responses.

42 Through RNA silencing and over-expression experiments, we discov

43 Significantly, using Hic-5 small hairpin RNA silencing and overexpression systems, we show that H

44 Experiments using small interfering RNA silencing and pharmacological inhibition demonstrate

45 As) are known as the important components of RNA silencing and post-transcriptional gene regulation,

46 ) are small non-coding RNAs that function in RNA silencing and post-transcriptional regulation of gen

47 CPSF100 was reported to play a role in RNA silencing and promote flowering in Arabidopsis.

48 Using RNA silencing and receptor antagonists, we demonstrated

49 The second stems from the discovery of RNA silencing and the development of high-throughput seq

50 Plant ARGONAUTE1 (AGO1) is pivotal in RNA silencing, and hence is a major target for counterac

51 is known to be required for certain forms of RNA silencing, and mutants of the enzyme that result in

52 A human colon cancer cell line, RNA silencing, and pharmacologic approaches were used to

53 resistance proteins, transcription factors, RNA silencing, and splicing-associated proteins.

54 have important functions in suppressing the RNA silencing antiviral defense response and in viral RN

55 for an Argonaute gene in the induction of an RNA silencing antiviral defense response and the promoti

56 the C. parasitica Dicer gene dcl2-dependent RNA-silencing antiviral defense response.

57 involving networks of host resistance genes, RNA silencing/antiviral defense genes, and crucial trans

58 Using gene deletion and small interference RNA silencing approach, we investigated the role of P-Re

59 , we conducted a genome-wide screen using an RNA-silencing approach and an assay for huntingtin prote

60 Argonaute (Ago) proteins function in RNA silencing as components of the RNA-induced silencing

61 role for Aub, independent of its function in RNA silencing, as a component of a nos mRNA localization

62 n evolutionary conserved protein involved in RNA silencing, as an antiviral gene against RNA viruses

63 Similarly, RNA silencing, as well as the overexpression of a benefi

64 y control and its role in the suppression of RNA silencing at endogenous genes and discuss the mechan

65 RNA silencing at the transcriptional and posttranscripti

66 including components of antiviral pathways (RNA silencing, autophagy, JAK/STAT, Toll, and Imd) and v

67 geting by Dicer-like enzymes, the first host RNA-silencing barrier.

68 in needed for virus assembly, suppression of RNA silencing-based antiviral defense, and long-distance

69 tional regulation of gene expression and the RNA silencing-based antiviral defense.

70 essors of RNA silencing (VSRs) to counteract RNA silencing-based host defenses.

71 keratinocytes by targeted small interfering RNA silencing before S. aureus exposure blocked the incr

72 s for the observed qualitative difference in RNA silencing between 21- and 22-nucleotide secondary si

73 Trpv4-small interfering RNA silencing blocked effects of Trpv4 activators by 70%

74 by small RNAs (sRNAs) of 20-25 nt in length, RNA silencing broadly governs a wide range of biological

75 rains, suggesting the avoidance of antiviral RNA silencing by CpMV1, which is consistent with its mit

76 than 2,000 C. elegans genes are targeted for RNA silencing by the mutator complex, a specialized smal

77 RNA silencing can be initiated by endogenous or exogenou

78 onaute (Ago), the catalytic component of the RNA silencing complex, was suggested as the central mech

79 PMV coinfections, expression of an antiviral RNA silencing component, SILENCING DEFECTIVE3, was suppr

80 epresses the transcriptional induction of an RNA silencing component.

81 e, and specific pharmacologic inhibitors and RNA-silencing confirmed that FPR contributes significant

82 Stigma-specific RNA-silencing constructs were used to suppress the expre

83 tiviral defense in plants, and indicate that RNA silencing contributes, alone or in conjunction with

84 mparison of CpMV1 accumulation among various RNA silencing-deficient and -competent strains showed cl

85 minant negative constructs and short hairpin RNA silencing demonstrated a role for MYO5A and MYO5B in

86 re known to be important partners of AGOs in RNA silencing effector complexes in yeast, plants, and a

87 nd stress response-related genes such as the RNA silencing effector gene ARGONAUTE 5 (AGO5).

88 rget transcripts may be a general feature of RNA-silencing effector complexes.

89 ression of these Phytophthora suppressors of RNA silencing enhances plant susceptibility to both a vi

90 The tug of war between RNA surveillance and RNA silencing ensures the appropriate partitioning of en

91 ng H2S levels, including enzymatic knockout, RNA silencing, enzymatic inhibition, and use of small mo

92 e have discovered a role for the Arabidopsis RNA silencing enzyme DICER-LIKE 4 (DCL4) in transcriptio

93 Nuclear RNA polymerase V (Pol V) is an RNA silencing enzyme recently shown to generate noncodin

94 hin coding loci in a mechanism that combines RNA silencing, epigenetic modification, and chromatin re

95 RNA silencing experiments revealed the link between AR s

96 l lines MTLn3 and MCF-7 is further proven by RNA silencing experiments that yield COS-7 showing lower

97 s of YAP in HCC cells via overexpression and RNA silencing experiments.

98 e expression in human tissues, and conducted RNA-silencing experiments for one novel association.

99 nase (MAPK)-dependent phosphorylation of the RNA-silencing factor HIV TAR-RNA-binding protein (TRBP)

100 of combining transcriptional repression and RNA silencing for stringent reduction of gene expression

101 RNA silencing functions as an antiviral defense through

102 formation, cell connectivity was reduced by RNA silencing gap junction Cx43.

103 In Caenorhabditis elegans, RNA silencing guided by primary siRNAs is inefficient an

104 RNA silencing has the potential to simultaneously alter

105 oms to cause disease and are consistent with RNA silencing having key roles in host defense.

106 class genes are required for siRNA-mediated RNA silencing in both germline and somatic cells, but th

107 Our analysis reveals that the miRNA-mediated RNA silencing in C. reinhardtii differs from that of hig

108 RNA silencing in Caenorhabditis elegans is transmitted b

109 ss referred to as RNA interference (RNAi) or RNA silencing in diverse organisms.

110 RNA-induced silencing complexes that mediate RNA silencing in eukaryotes.

111 RNA silencing in flowering plants generates a signal tha

112 r candidates were evaluated by small hairpin RNA silencing in HepaRG cells; the ability of receptor e

113 e production of proteins or the induction of RNA silencing in herbaceous plants.

114 lity of this mechanism in genome defense and RNA silencing in higher eukaryotes is suggested.

115 Our experiments reveal that RNA silencing in HIV-1 infected human cells severely att

116 Likewise, CD39 RNA silencing in HMC-1 increased ATP-induced renin relea

117 essing the untapped therapeutic potential of RNA silencing in humans.

118 Similarly, LSP1-targeted small interfering RNA silencing in murine endothelial cells mitigated mRNA

119 inia graminis f. sp. tritici (Pgt), suppress RNA silencing in plants and impede plant defenses by alt

120 e plant pathogen Phytophthora sojae suppress RNA silencing in plants by inhibiting the biogenesis of

121 RNA silencing in plants is a multivalent antiviral defen

122 RNA silencing in plants serves as a potent antiviral def

123 ce for a link between genomic imprinting and RNA silencing in plants.

124 encing caused by lack of piRNAs, we restored RNA silencing in RNAi-defective animals in the presence

125 d SUPPRESSOR OF GENE SILENCING3, implicating RNA silencing in the control of cuticular wax deposition

126 n, and biological function of miRNA-mediated RNA silencing in the model algal species,Chlamydomonas r

127 w that the YFV capsid (YFC) protein inhibits RNA silencing in the mosquito Aedes aegypti by interferi

128 In plants the role of RNA silencing in viral RNA degradation is well establish

129 The sequence-specific nature of systemic RNA silencing indicates that a nucleic acid is a compone

130 An expanded model of RNA silencing indicates that multiple turnover by revers

131 Plant viral suppressors of RNA silencing induce developmental defects similar to th

132 l workshop on ''Induction and Suppression of RNA Silencing: Insights from Plant Viral Infections'' wa

133 RNA silencing is a complex, highly conserved mechanism m

134 RNA silencing is a conserved eukaryotic gene expression

135 RNA silencing is a conserved regulatory mechanism in fun

136 RNA silencing is a major antiviral defense mechanism in

137 While RNA silencing is a potent antiviral defense in plants, w

138 RNA silencing is a process triggered by 21-24 small RNAs

139 RNA silencing is an essential gene-regulation mechanism

140 RNA silencing is an important antiviral mechanism in div

141 Target recognition in RNA silencing is governed by the "seed sequence" of a gu

142 while in other potyviruses the suppressor of RNA silencing is HCPro, we show here that P1N-PISPO exhi

143 bidopsis Dicer-like mutants, indicating that RNA silencing is responsible for Arabidopsis nonhost res

144 In plants, RNA silencing is triggered by the production of double-s

145 a either pharmacological blockade or in vivo RNA silencing led to decreased OPCs maturation and failu

146 spite the relevance of Argonaute proteins in RNA silencing, little is known about the structural step

147 Many factors involved in RNA silencing localize to protein- and RNA-rich nuclear

148 l RNA, as well as by directly inhibiting the RNA silencing machinery.

149 timuli can be modulated by components of the RNA silencing machinery.-Philip, F., Sahu, S., Golebiews

150 sulted in the isolation of components of the RNA-silencing machinery, RNA-DEPENDENT RNA POLYMERASE1 a

151 ed to disrupt higher-order structure and the RNA-silencing machinery.

152 (AGOs) are known to be key components of the RNA silencing mechanism in eukaryotes that, among other

153 mponents could provide not only insight into RNA silencing mechanism in soybean and sorghum but also

154 lated group of helicases is required for the RNA-silencing mechanism in Caenorhabditis elegans.

155 icularly RNA viruses, plants have evolved an RNA-silencing mechanism relying on the generation by Dic

156 in plant antiviral immune responses, beyond RNA silencing mechanisms-advances that went relatively u

157 ing interactions between HIV-1 and host cell RNA silencing mechanisms.

158 spects of eukaryotic life, primarily through RNA silencing mechanisms.

159 RNA-silencing mechanisms control many aspects of gene re

160 ans by Orsay virus but is not active against RNA silencing mediated by microRNAs.

161 In eukaryotes, RNA silencing, mediated by small interfering RNAs, is an

162 We suggest that RNA silencing-mediated translation repression plays a st

163 l rDNA (encoding 18S, 5.8S and 26S ribosomal RNA) silencing (nucleolar dominance) and rRNA gene dosag

164 n contrast to the prevalent presumption that RNA silencing occurs in the cytosol, emerging evidence r

165 Small interfering RNA silencing of A20 prevents tolerance, whereas ectopic

166 this study, we report that small interfering RNA silencing of AID in plasmacytoma dramatically increa

167 muscle motor endplates and small interfering RNA silencing of ALG14 results in reduced cell-surface e

168 RNA silencing of BAG3 led to a marked reduction in Mcl-1

169 Selective RNA silencing of betaftz-f1 in Inka cells prevents ETH r

170 Short hairpin RNA silencing of Bnip3 inhibited apoptosis of the core c

171 oporin CAN/Nup214 in infected cells and that RNA silencing of CAN/Nup214 delays the onset of viral DN

172 Finally, using pharmacologic and RNA silencing of CHK1 or the associated MYC-related mech

173 ssing was minimally reduced by short hairpin RNA silencing of CTSC.

174 RNA silencing of DDX1 provided strong evidence that DDX1

175 express both TRAIL receptors, short hairpin RNA silencing of DR5 but not DR4 attenuated TRAIL-mediat

176 roliferation and enhanced apoptosis, whereas RNA silencing of Duxbl led to a decrease in apoptosis.

177 Short hairpin RNA silencing of either HDAC2 or HDAC4 is sufficient to

178 ifen, which is reversed by small interfering RNA silencing of FGFR1, suggesting that FGFR1 overexpres

179 RNA silencing of four of these glutaredoxin genes (AtGRX

180 Interestingly, RNA silencing of GATA-1 alone had no impact on EDN expre

181 While small interfering RNA silencing of HIF-1alpha mRNA and abolition of HIF-1a

182 Furthermore, short hairpin RNA silencing of inflammasome components abrogated hyper

183 Intracellular Ca(2+) chelation and RNA silencing of IP(3) receptors prevented preconditioni

184 Short hairpin RNA silencing of kindlin-2, but not c-Src, blocked sprou

185 Small interfering RNA silencing of MyD88 prevented an LPS-induced increase

186 RNA silencing of p53 up-regulated RGS13 expression in B

187 RNA silencing of Period 1 dramatically decreased express

188 RNA silencing of PPARdelta abrogated the inhibitory effe

189 ndered Arabidopsis more susceptible, whereas RNA silencing of RTP1 led to enhanced resistance to P. p

190 However, small interfering RNA silencing of Smad1 invoked proliferative responses t

191 through its ability to bind TRAX and reverse RNA silencing of specific genes, plays a key role in swi

192 d alphaSMA synthesis markedly decreased upon RNA silencing of SRF and myocardin.

193 of TGFBR2 kinase activity, small interfering RNA silencing of Tgfbr2 expression, or inhibition of SMA

194 02, 0.0009, and 0.02, respectively), whereas RNA silencing of the AR-RGN top key driver, PQBP1 (polyg

195 Finally, small interfering RNA silencing of the EGFR diminished SLS-induced egr-1 m

196 ession, our data support the hypothesis that RNA silencing of the host gene contributed to expulsion

197 Plant RNA silencing operates via RNA-directed DNA-methylation

198 activity inside HMC-1 cells by short hairpin RNA silencing or CTS-specific pharmacologic inhibitors s

199 ulations in ArPIKfyve/Sac3 protein levels by RNA silencing or overexpression in several mammalian cel

200 This gene silencing process is known as RNA silencing or RNA interference (RNAi) and, in plants

201 of syntaxin 5 function by small interfering RNA silencing or treatment with cyclized Retro-2 strongl

202 h as DNA methylation, histone modifications, RNA silencing, or a combination.

203 V1-EP713 hypovirus lacking the suppressor of RNA silencing p29 than to wild-type CHV1-EP713.

204 -1/EP721 were unrelated to the suppressor of RNA silencing, p29, encoded by the two viruses.

205 evidences suggest that various components of RNA silencing pathway are involved in plant defense mach

206 ertebrate animals and plants, the mosquito's RNA silencing pathway comprises its primary antiviral de

207 ctions that further our understanding of the RNA silencing pathway in both model and non-model organi

208 r, these results have revealed a specialized RNA silencing pathway involving DCL2, AGO2, and HEN1 tha

209 The RNA silencing pathway is an intracellular innate respons

210 ange in expression of a key component of the RNA silencing pathway is associated with both vegetative

211 As effectors in the RNA silencing pathway, ARGONAUTE (AGO) proteins are targ

212 ute and Piwi proteins are key players in the RNA silencing pathway, with the former interacting with

213 which represents an evolved property of the RNA silencing pathway.

214 not correlate with a higher induction of the RNA-silencing pathway.

215 ications for nodavirus interaction with cell RNA silencing pathways and other aspects of virus contro

216 RdRP paralogs often participate in distinct RNA silencing pathways and show characteristic repertoir

217 xogenous RNAi, but their roles in endogenous RNA silencing pathways are not well-understood.

218 ntroversies related to the potential role of RNA silencing pathways as a defense against HIV-1 infect

219 RNA silencing pathways in Arabidopsis include five doubl

220 te (AGO) proteins are critical components of RNA silencing pathways that bind small RNAs and mediate

221 ective tool for regulating the activities of RNA silencing pathways, and the use of GW mimicry to com

222 te (Ago) proteins are important effectors in RNA silencing pathways, but they must interact with othe

223 are proposed to primarily act via endogenous RNA silencing pathways.

224 short (s)RNAs, the central component of all RNA silencing pathways.

225 the molecular mechanisms that are central to RNA silencing pathways.

226 e evolved specialized functions for distinct RNA silencing pathways.

227 ur results identify a role for AGO1 and AGO4 RNA-silencing pathways in low-oxygen signaling in Arabid

228 nto the mechanisms operating at the heart of RNA-silencing pathways.

229 al and morphological analyses, combined with RNA silencing, pharmacologic inhibition, and BACE2 overe

230 Therefore, it remains to be resolved whether RNA silencing plays a significant part in defending plan

231 In cells, Hmox1 or Nfe2l2 RNA silencing prevented IL-10 and IL-1Ra up-regulation,

232 evolved virulence proteins that target host RNA silencing processes to promote infection.

233 s in the organism by the inhibition of small RNA silencing processes.

234 ulation levels were compared among antiviral RNA silencing-proficient and -deficient strains in the E

235 Here we report that the viral suppressor of RNA silencing protein P0 triggers AGO1 degradation by th

236 arget for counteracting viral suppressors of RNA-silencing proteins (VSRs).

237 We review current links between RNA silencing, recovery and tolerance, and present a mod

238 AgTreT1 RNA silencing reduces the hemolymph trehalose concentrat

239 After an infectious blood meal, AgTreT1 RNA silencing reduces the number of P. falciparum oocyst

240 RNA silencing refers to a collection of gene regulatory

241 dividual AGOs yet the role played by many in RNA silencing-related antiviral defense is largely unkno

242 inding complex that contributes to essential RNA silencing-related pathways in the male germ line.

243 This indicates that a very robust antiviral RNA-silencing response was induced against all three vir

244 However, the extent to which RNA silencing restricts virus host range has been diffic

245 IL1B rapidly induced DUSP1 expression and RNA silencing revealed a transient role in feedback inhi

246 RNA silencing (RNAi) has a well-established role in anti

247 ck an analogous siRNA biogenesis pathway, an RNA silencing role for the mammalian PIR-1 homolog (dual

248 These data extend the significance of an RNA silencing signal to embrace epigenetics and transcri

249 egans can transport endogenous and exogenous RNA silencing signals between many different tissues via

250 OV) counters RNAi by encoding suppressors of RNA silencing (SRSs), we screened all EBOV proteins usin

251 y BrYV for facilitating viral suppressors of RNA silencing stability against degradation by plant cel

252 e subcellular location of small RNA-mediated RNA silencing still needs to be defined.

253 RNA silencing studies in microvascular endothelial cells

254 K2-null MCs showed impaired responses to Ag, RNA silencing studies on other MC types indicated a domi

255 Overexpression and RNA silencing studies revealed that GPx8 is involved in

256 This domain was required for RNA silencing suppression activity and infection in Nico

257 reveal a further layer of complexity of the RNA silencing suppression activity within the Potyvirida

258 a family of PSR1-like effectors also possess RNA silencing suppression activity.

259 These findings identify RNA silencing suppression as a common strategy used by p

260 Our results identify common features between RNA silencing suppression of plant and animal viruses.

261 phase kinase-associated protein 1 (SKP1) and RNA silencing suppression, it is the autophagy pathway t

262 ates stability of P0(Br) to ensure efficient RNA silencing suppression.

263 ant viruses counter this host restriction by RNA silencing suppressor (RSS) activity of a double-stra

264 VP35 is also an RNA silencing suppressor (RSS).

265 es viral accumulation by targeting the viral RNA silencing suppressor helper-component proteinase (HC

266 nce for a mechanism by which a virus-encoded RNA silencing suppressor represses the transcriptional i

267 nthamiana revealed that P1N-PISPO acts as an RNA silencing suppressor, a role normally associated wit

268 n, NbP3IP, was shown to interact with p3, an RNA-silencing suppressor protein encoded by Rice stripe

269 ntermeasure, many viruses have evolved viral RNA silencing suppressors (RSS) that tightly, and presum

270 s indicate that prokaryotes possess a unique RNA silencing system that functions by homology-dependen

271 , which are known to have a highly effective RNA silencing system.

272 kdown of p53 expression by small interfering RNA silencing technology significantly repressed the cap

273 omembrane system is an integral component of RNA silencing that has been long overlooked and predict

274 nimal kingdoms and suppress a common step in RNA silencing that is downstream of small RNA maturation

275 We also discuss RNA silencing that occurs between organisms.

276 uses has been found to encode suppressors of RNA silencing, the mechanisms by which flaviviruses anta

277 ave an important role in gene regulation and RNA silencing therapy, but it is challenging to detect t

278 A proviral role to subvert RNA silencing through binding of these host RNP proteins

279 upporting the notion that TCV VSR suppresses RNA silencing through directly interacting with AGO2.

280 We used RNA silencing to ablate factors required for multiplicat

281 Dicer enzymes function at the core of RNA silencing to defend against exogenous RNA or to regu

282 The importance of RNA silencing to HSV-1 replication was confirmed by a si

283 Many organisms including plants use RNA silencing to regulate development and physiology, an

284 binding protein that controls flowering and RNA silencing, to control the expression of alternativel

285 tance (R) and other defence-related genes by RNA silencing, viral infections incite perturbations of

286 Here we describe a viral suppressor of RNA silencing (VSR) encoded by the prototype flavivirus,

287 t viruses are known to encode suppressors of RNA silencing (VSR) that can neutralize the effectivenes

288 o target PVX lacking its viral suppressor of RNA silencing (VSR), P25, but that only AGO2 and AGO5 ar

289 ruses evolved to encode viral suppressors of RNA silencing (VSRs) that interfere with the function of

290 Viruses express viral suppressors of RNA silencing (VSRs) to counteract RNA silencing-based h

291 ific proteins, known as viral suppressors of RNA silencing (VSRs), as a counterdefense.

292 Using human-specific small interfering RNA silencing, we could demonstrate that an extra copy o

293 5,7-trihydroxyflavone (apigenin), as well as RNA silencing, we found that the invasive phenotype of M

294 Without SID-3, cells perform RNA silencing well but import dsRNA poorly.

295 like (DCL) genes and other genes involved in RNA silencing were cloned into a vector under an estroge

296 IP(3) receptor antagonist Xestospongin C and RNA silencing were used to investigate preconditioning m

297 elected endogenous RNAs are degraded through RNA silencing, which is a genome defense mechanism used

298 nisms for plant antiviral immunity relies on RNA silencing, which is often suppressed by co-evolving

299 own to be directly associated with anti-TBSV RNA silencing, while its inactivation does not influence

300 rtion of ORF A, functions as a suppressor of RNA silencing, while protease p48, derived from the N-te