ライフサイエンスコーパス: RNA stability

1 nhibited HIV-1 replication by reducing viral RNA stability.

2 ate transcription, splicing, translation, or RNA stability.

3 plays a critical role in mRNA expression and RNA stability.

4 l ancillary factors that control editing and RNA stability.

5 an RNA phosphatase that regulates noncoding RNA stability.

6 senger RNAs by export-independent effects on RNA stability.

7 its low rate of transcription and messenger RNA stability.

8 e expression at the level of translation and RNA stability.

9 egion (3'-UTR) and inhibiting translation or RNA stability.

10 an, in part, be attributed to alterations in RNA stability.

11 in during the cell cycle correlate with SsrA RNA stability.

12 id not detectably affect mRNA translation or RNA stability.

13 *971T) accounts for the observed increase in RNA stability.

14 ted regulation of cyclooxygenase-2 messenger RNA stability.

15 ects on the transcription initiation rate or RNA stability.

16 ot just protein synthesis but also messenger RNA stability.

17 t be included in the predictions of tertiary RNA stability.

18 tion in the 3'untranslated region may affect RNA stability.

19 cause it could be accounted for by increased RNA stability.

20 nd deletion-mutant mRNAs were independent of RNA stability.

21 ne transcription but also affects coreceptor RNA stability.

22 e novo protein synthesis and does not affect RNA stability.

23 criptional mechanisms involving differential RNA stability.

24 tion occurs at the level of transcription or RNA stability.

25 s seen in nuclear RNA and was independent of RNA stability.

26 ction rate, folding, activity, and messenger RNA stability.

27 fore plays a significant role in determining RNA stability.

28 ting an effect at the transcription level or RNA stability.

29 ell surface HSA expression by modulating its RNA stability.

30 It did not appear to affect RNA stability.

31 mRNA should not be hampered by problems with RNA stability.

32 ription, indicating that SM enhances nuclear RNA stability.

33 l GAAA tetraloop, a motif known for enhanced RNA stability.

34 s partially controlled by gene expression or RNA stability.

35 reased gene transcription, with no effect on RNA stability.

36 of conditions that might have affected HIV-1 RNA stability.

37 but selection of these sites does not affect RNA stability.

38 echanisms, one of which is the modulation of RNA stability.

39 rotein levels, at least in part by modifying RNA stability.

40 crucial for the regulation of polyadenylated RNA stability.

41 ome biogenesis, translation, RNA export, and RNA stability.

42 f regulation of the level of translation and RNA stability.

43 res that influence translation and messenger RNA stability.

44 al efficiency and that m(6)A does not affect RNA stability.

45 ssect the individual roles of PAPD5/7 in HBV RNA stability.

46 by viruses to manipulate miRNA and messenger RNA stability.

47 rtening, a mechanism that globally increases RNA stability.

48 ociation with polysomes, while not affecting RNA stability.

49 omass, contamination with host cells and low RNA stability.

50 molecule RNA imaging without perturbation of RNA stability.

51 alternative splicing (AS), translation, and RNA stability.

52 polymerases (PAPs) implicated in regulating RNA stability.

53 l functions, including protein synthesis and RNA stability.

54 , is not entirely passive in this assault on RNA stability.

55 vation that binds to viral RNAs and enhances RNA stability.

56 t of CsrA on translation, RNA abundance, and RNA stability.

57 reduced lipid accumulation by reducing PLIN2 RNA stability.

58 identified with a function in mitochondrial RNA stability.

59 binding enhanced pestivirus translation and RNA stability.

60 without antisense transcription to regulate RNA stability.

61 ing splicing, transport, polyadenylation and RNA stability.

62 ALAT1 at the level of both transcription and RNA stability.

63 ther events in the RNA life cycle, including RNA stability.

64 require SM for efficient expression, such as RNA stability.

65 eliminates the miR-122 requirement for viral RNA stability.

66 ication rates of HCV RNA, but affected viral RNA stability.

67 affects each step of protein expression and RNA stability.

68 through translational efficiency rather than RNA stability.

69 ding sequences were associated with enhanced RNA stability.

70 of transcription, translation, splicing, and RNA stability.

71 aling of sRNAs to target mRNAs and to affect RNA stability.

72 NA, suggesting that REF/Aly promotes nuclear RNA stability.

73 rtance of RNA maturation as a determinant of RNA stability.

74 s, which are not accounted for by changes in RNA stability.

75 ligand binding sites and metal ion-dependent RNA stabilities.

76 e present simple calculations for estimating RNA stability against hydrolysis, and a model that links

77 s there was no significant difference in the RNA stability among these cell lines.

78 se a dodecamer sequence element that confers RNA stability and 3'-end processing via an unknown mecha

79 -terminal domain (CTD), is essential for 7SK RNA stability and assembly with P-TEFb.

80 Our study reveals a link between RNA stability and CD4(+) T-cell homeostasis/adaptive act

81 widespread Np(4) capping, leading to altered RNA stability and consequent changes in gene expression.

82 Measurements of RNA stability and content indicated that decreased beta

83 xplanation for previous correlations between RNA stability and CYT-19 unfolding efficiency.

84 comparative role of PARP1 and PARylation in RNA stability and decay, adding a new dimension as to ho

85 while nascent RNA polyadenylation can affect RNA stability and decay.

86 at enhances EBV gene expression by enhancing RNA stability and export.

87 slation of the TRR is necessary for extended RNA stability and for expression of the transcriptional

88 emically modified nucleotides, which enhance RNA stability and increase affinity in Watson-Crick base

89 n of CAR gene transcription, whereas altered RNA stability and increased proteasomal protein degradat

90 est the effects of chemical modifications on RNA stability and inhibition of gene expression.

91 es, the role of 2' O-methyl modifications in RNA stability and innate immune sensing, and functions o

92 tion, how FXR1 regulates its targets through RNA stability and luciferase assays, and functional cons

93 uORFs can modulate translation or RNA stability and mediate inefficient translation of the

94 increased PE expression, prime editing guide RNA stability and modulation of DNA repair.

95 uding alternative splicing, polyadenylation, RNA stability and mRNA intracellular localization.

96 have revealed that selection acts on DNA and RNA stability and on translational accuracy.

97 the 5' end of the mRNA; it is essential for RNA stability and plays a role in translation.

98 discover cis-acting features associated with RNA stability and probe the relationship between RNA hal

99 ng neuronal development indicates changes in RNA stability and protein synthesis.

100 uggest that GS1 is regulated at the level of RNA stability and protein turnover.

101 Quantitative changes in transcription/RNA stability and qualitative differences in splicing ra

102 Pseudouridylation can increase RNA stability and rigidity, thereby impacting RNA splici

103 ative splicing, alternative polyadenylation, RNA stability and RNA localization.

104 modifications exhibit a range of effects on RNA stability and structure, depending on their location

105 nderstanding of the interactions determining RNA stability and structure.

106 We found that Cas9 is essential for guide RNA stability and that the nuclear Cas9-guide RNA comple

107 shes between mRNAs regulated at the level of RNA stability and those regulated at the level of transl

108 he contributions of tertiary interactions to RNA stability and to folding kinetics.

109 mRNAs and has been implicated in control of RNA stability and translation and selective cap-independ

110 family of RNA binding proteins that regulate RNA stability and translation by binding to specific seq

111 s that regulation of RBPs that modulate both RNA stability and translation may have a profound effect

112 ility that this 5' NAD(+) cap could modulate RNA stability and translation on specific subclasses of

113 rocessing and ribosome assembly and includes RNA stability and translation regulation within mitochon

114 -rich RNA motifs in their 3'-UTRs, enhancing RNA stability and translation through increased polyribo

115 rst nucleotide 3' to the mRNA CAP to promote RNA stability and translation(5)(,)(6)(,)(7)(,)(8).

116 RNA methylation fine tunes RNA stability and translation, altering cell fate.

117 , RNA processing and modification, messenger RNA stability and translation, and even protein degradat

118 such as chromatin structure, transcription, RNA stability and translation, and protein degradation a

119 ibitory effect of rapamycin was on messenger RNA stability and translation, rather than on IL-2 trans

120 post-transcriptionally to regulate messenger RNA stability and translation.

121 ements in chloroplast transcripts to promote RNA stability and translation.

122 m of Lin28b/Hmga2, which regulates messenger RNA stability and translation.

123 of RNA functions, including nuclear export, RNA stability and translation.

124 the role of AREs in mediating the messenger RNA stability and translation.

125 anism for post-transcriptional regulation of RNA stability and translational activity in various orga

126 r cellular ARE-BPs, leading to modulation of RNA stability and translational activity.

127 he 3' poly(A) tail is important in messenger RNA stability and translational efficiency.

128 A 3' untranslated regions (3'UTRs) to impact RNA stability and translational efficiency.

129 mRNA transcripts to modulate nuclear export, RNA stability and translational fate.

130 r proteins involved in pre-mRNA splicing and RNA stability and transport.

131 matin modification, transcription, messenger RNA stability and ubiquitination, and another implicated

132 l of incompletely spliced RNAs by increasing RNA stability and was associated with a twofold down-reg

133 en contain regulatory sequences that control RNA stability and/or translation.

134 tion usage, alternative TSS/polyA usage, and RNA stability) and integrates them with genetic data via

135 itic spine morphology, protein and messenger RNA stability, and catalytic activity were examined.

136 as ensuring translational fidelity, altering RNA stability, and conferring bacterial resistance to an

137 tes efficient nuclear-cytoplasmic transport, RNA stability, and cytoplasmic utilization of unspliced

138 ulating transcription, alternative splicing, RNA stability, and intracellular localization of the vir

139 nstability, promoter activity, RNA splicing, RNA stability, and neurite mRNA localization.

140 ative mRNA splicing, SR protein trafficking, RNA stability, and possibly the generation of autoantibo

141 al mechanisms, such as alternative splicing, RNA stability, and post-transcriptional modifications, a

142 tronic transcript cleavage, polyadenylation, RNA stability, and RNA editing.

143 influenced by factors such as DNA topology, RNA stability, and the presence of GC-rich regions.

144 are essential in gene regulation, splicing, RNA stability, and translation, making RNA a promising t

145 in architecture, transcription, RNA editing, RNA stability, and translation.

146 l processes in the cell, including splicing, RNA stability, and translation.

147 RNA processing through alternative splicing, RNA stability, and translation.

148 rocesses, including splicing, RNA transport, RNA stability, and translation.

149 ptional processes, such as RNA localization, RNA stability, and translational control.

150 , causing changes in translation initiation, RNA stability, and/or transcription elongation.

151 in level was not a consequence of changes in RNA stability, as indicated by Northern blot analysis.

152 ke 2 (ELAVL2), a brain-specific regulator of RNA stability, as presumptive targets of three of four e

153 cker, we categorize genes as allele-specific RNA stability (asRS) or allele-specific RNA transcriptio

154 Nuclear run-on transcription and RNA stability assays demonstrate that while beta 2m in M

155 Messenger RNA stability assays revealed that the increased mRNA le

156 Ribo-seq and genome-wide RNA stability assays show that AtPAB-binding efficiency

157 RNA stability assays showed that the effect is not media

158 RNA stability assays showed that the rate of E2A mRNA de

159 otein-RNA binding with concurrent changes in RNA stability at specific time points following activati

160 anscript production suggested differences in RNA stability between gene classes.

161 However, m6A methylation impacts not only RNA stability, but also other RNA metabolism processes.

162 Regulation of messenger RNA stability by AU-rich elements is an important means

163 ing proteins, Puf, regulates translation and RNA stability by binding to specific sequences in the 3'

164 mal to the 3' end indicates that it mediates RNA stability by blocking the assembly, but not the acti

165 and 31 PPT/PPT pairs were analyzed for HIV-1 RNA stability by HIVL.

166 tory mechanism whereby ADAR2 enhances target RNA stability by limiting the interaction of RNA-destabi

167 apoptosis can be controlled at the level of RNA stability by RNase L.

168 ion and a novel mutation that increases mtrC RNA stability conferred the highest levels of derepressi

169 on that the La protein may contribute to HBV RNA stability, constitutively and in response to inflamm

170 y mutation of either putL or RNA polymerase, RNA stability decreased more than 50-fold.

171 lification, with an additional effect on HCV RNA stability/degradation detectable at a dose of 250 U/

172 Control of RNA stability did not appear to be a primary component o

173 The RNA stability differences could not be attributed to hea

174 The extent to which RNA stability differs between individuals and its contri

175 Mg2+ has been shown to mediate RNA stability during chloroplast biogenesis, and our dat

176 Although m(6)A is established to influence RNA stability dynamics and translation efficiency, rapid

177 lation of viral RNA plays important roles in RNA stability, efficient translation, and immune evasion

178 ylated 5'-guanosine cap that is required for RNA stability, efficient translation, and protection fro

179 es of the rnc transcript comprise a portable RNA stability element (rncO) that contains all of the ci

180 ulates in cells by using a 3'-triple-helical RNA stability element for nuclear expression (ENE).

181 ry RNA elements, termed sRSEs for structural RNA stability elements, which are significantly overrepr

182 ing luciferase reporter assays and messenger RNA stability experiments.

183 To test the specificity of one such RNA stability factor, we used two known Chlamydomonas re

184 In particular, we found that the RNA-stability factor HuR binds to the COX-2 ARE, and ove

185 , signal transducers, transcription factors, RNA stability factors, and epigenetic modulators that ac

186 cluding inherent RNA shields, hijacking host RNA stability factors, incapacitating the host decay mac

187 cell types, a lack of protein expression or RNA stability failed to explain the inability of NSP1-1

188 On the other hand, the messenger RNA stability for ACO1 was found to be increased by GSH,

189 RNA m(5)C methylation, in turn, promotes RNA stability for those genes modulating mitochondrial f

190 les of the P-4 nuclease in the amastigote in RNA stability (gene expression) or DNA repair are discus

191 xperiments demonstrated that PD-L1 regulates RNA stability genome-wide.

192 Aberrant regulation of RNA stability has an important role in many disease stat

193 ynamic regulation of poly(A) tail length and RNA stability have emerged as important modes of gene re

194 (4) Monovalent cation concentration affects RNA stability in a sequence-dependent manner.

195 d to play roles in transcription and nuclear RNA stability in addition to its more broadly characteri

196 chinery and changing the entire landscape of RNA stability in cells using virally encoded nucleases.

197 rates the functional importance of regulated RNA stability in germline development and provides a roa

198 Target complementarity also affects small RNA stability in human cells.

199 e furthermore found increased matK messenger RNA stability in mature tissue, while other chloroplast

200 tome analysis and inhibitor-free analysis of RNA stability in plants.

201 We conducted a genome-wide analysis of RNA stability in seven human HapMap lymphoblastoid cell

202 s and a long-day photoperiod enhanced StBEL5 RNA stability in shoot tips.

203 tripartite leader sequence did not increase RNA stability in the cytoplasm.

204 he RNA binding protein TARBP2, that controls RNA stability in the nucleus.

205 Thus H-NS appears to modulate RNA stability in vivo and in vitro.

206 tion enhances mitochondrial transcription or RNA stability in vivo.

207 be partly achieved at the level of messenger RNA stability, in which the targeted destruction of subs

208 tic replication but may contribute to target RNA stability independent of effects on RNA export, sugg

209 the nascent transcript and PHLDA1 messenger RNA stability, indicating both transcriptional and post-

210 Post-transcriptional regulation of RNA stability is a key step in gene expression control.

211 RNA stability is a major issue in RNA research and appli

212 However, it is unclear the extent to which RNA stability is altered under changing environmental co

213 mental and simulation results establish that RNA stability is largely determined by a combination of

214 RNA stability is meticulously controlled.

215 gest that this new mechanism for controlling RNA stability is not restricted to fishes but might also

216 ontrast, the contribution of site-binding to RNA stability is often quite small because of the large

217 Regulation of messenger RNA stability is pivotal for programmed gene expression

218 LCK expression in cancer cells by decreasing RNA stability, leading to increased cell proliferation.

219 d that cryptic 3'UTR extensions can increase RNA stability, leading to increased translation.

220 ting at the transcriptional level and at the RNA stability level.

221 difications play pivotal roles in regulating RNA stability, localization and function.

222 conserved post-transcriptional regulators of RNA stability, localization and translation.

223 chemical modification on mRNA that regulates RNA stability, localization, and gene expression.

224 ess of cell state transitions by controlling RNA stability, localization, or if, when, or where mRNAs

225 RNA stability measurements confirmed that the subcellula

226 RNA stability, mediated through adenine and uridine-rich

227 These NCCs can affect RNA stability, mitochondrial functions, and possibly mRN

228 ed in altering gene expression by regulating RNA stability, modulating translation elongation, and mo

229 CDSN*971T maps to a RNA stability motif and UV cross-linking analysis demons

230 d region (3'UTR), which lies within an AUUUA RNA stability motif.

231 NAs, little is known about the influences of RNA stability, mRNA quality control and compartmentaliza

232 f mRNA metabolism, including nuclear export, RNA stability, mRNA quality control, and translation.

233 pression processes, including transcription, RNA stability, mRNA transport, and translational control

234 s from transcription (SP5, YAP1, and RUNX1), RNA stability (MSI2), and protein stability (CUL4A).

235 es had similarity to proteins that influence RNA stability, namely a ribonuclease activator, the pumi

236 d alphaCP-2, implicated in the regulation of RNA stability of alpha-globin and tyrosine hydroxylase m

237 Subsequently, IGF2BP2 improved the RNA stability of FLT4 through m(6)A modification, thereb

238 xpression by modulating translation (but not RNA stability or localization).

239 chromatin organization, gene transcription, RNA stability or RNA translation is not well understood,

240 ERI3 is not required for maintaining DENV-2 RNA stability or translation of the viral polyprotein, b

241 an regulate epigenetic state, transcription, RNA stability or translation of their overlapping genes(

242 nction assays to pinpoint RBPs that regulate RNA stability or translation.

243 translation activity from simple effects on RNA stability or transport.

244 eterious, impairing transcription, splicing, RNA stability, or protein function, as well as imposing

245 RNA maturation and modulation of RNA stability play important roles in chloroplast gene e

246 ene, is a zinc-finger protein that regulates RNA stability primarily through association with 3' untr

247 Biologically, the ability to sense RNA stability probably biases DEAD-box proteins to act p

248 ded RNA-binding proteins (RBPs) that control RNA stability, processing, and degradation.

249 The m(7)GpppN cap promotes RNA stability, processing, transport, and translation.

250 RNA stability protein ILF3 mediates cytokine-induced ang

251 data suggest that in endothelial cells, the RNA stability protein, ILF3, plays a novel and central r

252 quence-specific guides to regulate messenger RNA stability, protein synthesis, chromatin organization

253 Here, we discover the landscape of RNA stability regulation in the cerebral cortex and demo

254 Our study highlights the importance of RNA stability regulation through UTR primary sequences,

255 st widespread interindividual differences in RNA stability related to DNA sequence and composition va

256 T cells from healthy donors increases HIV-1 RNA stability, rendering the cells permissive for HIV-1

257 terations affect transcription efficiency or RNA stability, resulting in unequal transcript abundance

258 sights into the complex relationship between RNA stability, RNA granule formation, and the antiviral

259 anscriptional mark, such as gene expression, RNA stability, RNA structure and translation.

260 ssing, although the relationship between Alu RNA stability, scAlu RNA production, and retroposition h

261 ibozyme:substrate duplexes and that increase RNA stability should be optimized.

262 According to this approach, low ribosomal RNA stability should decrease the precision of protein s

263 nd various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization.

264 ne expression, influencing processes such as RNA stability, splicing, and translation.

265 al gene expression, including transcription, RNA stability, splicing, export, and translation.

266 ons driving the post-transcriptional fate of RNA: stability, splicing, storage, and translation.

267 RNA stability studies and nuclear run-off assays indicat

268 RNA stability studies found that alternative exon splici

269 r amounts of GGT, and a rifampicin messenger RNA stability study showed that one reason for this coul

270 functional RNA domains within roX1, assaying RNA stability, targeting of the MSL proteins to the X, a

271 ortant link between DNA damage signaling and RNA stability that may be relevant to cell cycle regulat

272 f eukaryotic mRNAs regulates translation and RNA stability through an association with the poly(A)-bi

273 1 promotes SIRT1 expression by affecting its RNA stability through HuR, an RNA-binding protein that i

274 in many cellular processes, from modulating RNA stability to altering translation efficiency.

275 measurements are used with other measures of RNA stability to develop an overall picture of the energ

276 a that localize key sequence determinants of RNA stability to the 3' end of RNA7.2 and suggest that s

277 y significant association between non-coding RNA stability, transcript length and predicted secondary

278 ns (Pabs), play critical roles in regulating RNA stability, translation, and nuclear export.

279 nance of mitochondrial genome, mitochondrial RNA stability, translation, and respiratory function.

280 tions they play at both the molecular (e.g., RNA stability, translation, and transport) and organisma

281 gene regulation, including gene expression, RNA stability, translation, RNA structure and histone mo

282 the most common RNA modifications, impacting RNA stability, transport, and translation.

283 o stress is vital, yet the global changes in RNA stability under these conditions remain unclear.

284 free, genome-wide analysis of polyadenylated RNA stability via 5-EU pulse-chase experiments revealed

285 cpeC RNA stability was comparable in F. diplosiphon cells gro

286 Increased messenger RNA stability was detected in HEK293 cells, indicating t

287 RNA stability was determined after actinomycin D treatme

288 Surprisingly, RNA stability was not increased by C3P3, suggesting a di

289 RNA stability was studied by examining the turnover of a

290 of the changes in mRNA abundance were due to RNA stability, we found a smaller but more interesting p

291 RNA stabilities were equivalent.

292 Again, RNA stabilities were equivalent.

293 oter, and their effects on transcription and RNA stability were evaluated both in vitro and in vivo.

294 up-regulated by both increased synthesis and RNA stability while down-regulated genes were suppressed

295 On the basis of these trends in RNA stability with group I ion size, it is argued that t

296 ng preferential association of regulators of RNA stability with US and PS transcripts and, unexpected

297 e for opposing effects of polyadenylation on RNA stability within a single organelle and suggests a n

298 xperiments with 5-EU allowed us to determine RNA stabilities without the need for chemical transcript

299 by transcriptional regulation and messenger RNA stability, yet the latter is often overlooked in stu

300 ted regions regulate mRNA trans-splicing and RNA stability, yet where UTRs begin and end is known for