ライフサイエンスコーパス: RNA-dependent RNA polymerase

1 inhibitors of norovirus 3C-like protease and RNA dependent RNA polymerase.

2 ld have arisen as a secondary function of an RNA-dependent RNA polymerase.

3 virus replication, the methyltransferase and RNA-dependent RNA polymerase.

4 y an HEV variant harboring a mutation in the RNA-dependent RNA polymerase.

5 etermine the recognition of viral RNA by the RNA-dependent RNA polymerase.

6 mechanistic understanding of NS5B, the viral RNA-dependent RNA polymerase.

7 al agent specifically targeting HCV NS5B, an RNA-dependent RNA polymerase.

8 n plants by a process typically requiring an RNA-dependent RNA polymerase.

9 d but is suggested to target influenza virus RNA-dependent RNA polymerase.

10 targeting an assembly interface of the viral RNA-dependent RNA polymerase.

11 levels of siRNAs through the activity of an RNA-dependent RNA polymerase.

12 single open reading frame (ORF) encoding an RNA-dependent RNA polymerase.

13 RNA genomes of 2.2 to 4.4 kb, encoding only RNA-dependent RNA polymerase.

14 te in access to the genomic RNA by the viral RNA-dependent-RNA polymerase.

15 troviral RTs but remarkably similar to viral RNA-dependent RNA polymerases.

16 ral nucleotide when misincorporated by viral RNA-dependent RNA polymerases.

17 ovirus 3D(pol) are a common feature of viral RNA-dependent RNA polymerases.

18 amidate prodrug and is known to target viral RNA-dependent RNA polymerases.

19 terfering RNAs (siRNAs) that are produced by RNA-dependent RNA Polymerases.

20 tically transmitted RNAs coding for putative RNA-dependent RNA polymerases.

21 xhibit a non-spooled arrangement mediated by RNA-dependent RNA polymerases(11-14).

22 requires nuclear RNA polymerase IV (Pol IV), RNA-dependent RNA polymerase 2 (RDR2) and DICER-like 3 (

23 24-nt siRNAs are dependent on RNA Pol IV and RNA-DEPENDENT RNA POLYMERASE 2 (RDR2) and establish DNA

24 -dependent nat-siRNAs were also dependent on RNA-dependent RNA polymerase 2 (RDR2) and plant-specific

25 of a physical association between JMJ24 and RNA-dependent RNA polymerase 2 (RDR2), which represents

26 RNAs are globally reduced by mutation of the RNA-dependent RNA polymerase 2 encoded by modifier of pa

27 d Pol IV termination-dependent activation of RNA-DEPENDENT RNA POLYMERASE 2, which partners with Pol

28 ical, concerted action of RNA POLYMERASE IV, RNA-DEPENDENT RNA POLYMERASE-2, and DICER-LIKE-4.

29 , we found that METTL3 interacted with viral RNA-dependent RNA polymerase 3D and induced enhanced sum

30 analysis of cis and trans activities of the RNA-dependent RNA polymerase 3D.

31 , we proposed a model wherein the poliovirus RNA-dependent RNA polymerase (3D(pol)) uses a reiterativ

32 ructures, located in the region encoding the RNA-dependent RNA polymerase, 3D(pol), by site-directed

33 within the Picornaviridae family express an RNA-dependent RNA polymerase, 3D(pol), that is required

34 The poliovirus RNA-dependent RNA polymerase, 3Dpol, replicates the vira

35 lly activated siRNA (easiRNA) that depend on RNA DEPENDENT RNA POLYMERASE 6 (RDR6).

36 element mRNAs into small RNAs guided by the RNA-dependent RNA polymerase 6 (RDR6) protein and is the

37 n particular, the double-mutant of paps1 and rna-dependent rna polymerase 6 (rdr6) shows a synergisti

38 However, DCL2 facilitates the recruitment of RNA-DEPENDENT RNA POLYMERASE 6 (RDR6) to ARGONAUTE 1-der

39 econdary short interfering RNAs (siRNAs) via RNA-DEPENDENT RNA POLYMERASE 6 (RDR6), DCL4 and ARGONAUT

40 entified: RNA Polymerase IV (PolIV)-RdDM and RNA-dependent RNA Polymerase 6 (RDR6)-RdDM.

41 ents are converted to double-stranded RNA by RNA-dependent RNA polymerase 6 (RDR6).

42 showed that cleavage by nta-miR6019 triggers RNA-dependent RNA polymerase 6- and ribonuclease Dicer-l

43 of NAD(+) capping are instead processed into RNA-dependent RNA polymerase 6-dependent small RNAs, res

44 secondary siRNAs in a manner that depends on RNA-dependent RNA polymerase 6.

45 ple copies of a major structural protein, an RNA-dependent RNA polymerase, a hexameric NTPase, and an

46 hin P90, focus formation required the entire RNA-dependent RNA polymerase (aa 1700 to 2116).

47 st of the IPR genes in a manner dependent on RNA-dependent RNA polymerase activity and on DRH-1.

48 roles for ncRNAs, as well as a novel Pol II RNA-dependent RNA polymerase activity that regulates an

49 nse program by sensing the products of viral RNA-dependent RNA polymerase activity.

50 ction of nsp8 (plus nsp7) for nsp12-mediated RNA-dependent RNA polymerase activity.

51 elity of foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase allows FMDV to exhibit high

52 g of heterotypic segments by influenza virus RNA-dependent RNA polymerase, an inhibitory effect of vi

53 ed as a core ring-like domain containing the RNA-dependent RNA polymerase and an appendage of globula

54 nt RNA polymerase and a DNA ligase to act as RNA-dependent RNA polymerase and RNA ligase, respectivel

55 ce gene was identified, shown to code for an RNA-dependent RNA polymerase and to be allelic with Ty-3

56 ve identified fidelity determinants in viral RNA-dependent RNA polymerases and have shown that RNA vi

57 onsisting of genomic RNA, nucleoprotein, the RNA-dependent RNA polymerase, and a polymerase cofactor,

58 iral replicase, on the activity of the viral RNA-dependent RNA polymerase, and an inhibitory effect o

59 ns-acting short interfering RNA3 pathway, an RNA-dependent RNA polymerase, and an XH/XP domain-contai

60 RNA1 encodes the RNA-dependent RNA polymerase, and RNA2 encodes the capsi

61 ease (3CLpro), papain-like protease (PLpro), RNA-dependent RNA polymerase, and spike (S) protein.

62 Viral RNA-dependent RNA polymerases are considered to be low-f

63 hod allows accurate fitting of the monomeric RNA-dependent RNA polymerase bound at the threefold axis

64 on-nucleoside organic inhibitor of the viral RNA-dependent RNA polymerase by means of high-throughput

65 Their viral RNA-dependent RNA polymerase can induce local conformati

66 ily release the RNA genome so that the viral RNA-dependent RNA polymerase can use it as the template

67 oronavirus 2, also known as 2019-nCoV) RdRp (RNA-dependent RNA polymerase) coding sequence, achieving

68 pecifically impairs the function of the hRSV RNA-dependent RNA polymerase complex notably by reducing

69 lymerase basic 2 (PB2) proteins comprise the RNA-dependent RNA polymerase complex responsible for vir

70 of polymerase lattices within the multimeric RNA-dependent RNA polymerase complex should facilitate a

71 of the genome are rendered accessible to the RNA-dependent RNA polymerase complex, possibly enabling

72 logs were shown to block the activity of the RNA-dependent RNA-polymerase complex of RSV.

73 omponents: a helical ribonucleocapsid and an RNA-dependent RNA polymerase composed of a catalytic sub

74 s is transcribed and replicated by the viral RNA-dependent RNA polymerase, composed of the subunits P

75 f viral RNA synthesis by the recombinant MNV RNA-dependent RNA polymerase, confirming that the stem-l

76 Influenza virus RNA-dependent RNA polymerase consists of three viral pro

77 The vesicular stomatitis virus (VSV) RNA-dependent RNA polymerase consists of two viral prote

78 We find that in this group of viruses, RNA-dependent RNA polymerases do not direct genome order

79 nd comprises a methyltransferase (MTase) and RNA dependent RNA polymerase domain.

80 P-OD associates with the RNA-dependent RNA polymerase domain of L and protrudes a

81 ociated N protein in the architecture of the RNA-dependent RNA polymerase domain of L.

82 The error-prone nature of RNA-dependent RNA polymerases drives the diversity of RN

83 alternative substrate inhibitor of the NS5B RNA-dependent RNA polymerase during HCV replication.

84 us (HCV) replication as it carries the viral RNA-dependent RNA polymerase enzymatic activity.

85 The RNA-dependent RNA polymerase enzyme NS5B represents one

86 viruses replicate by using a virally encoded RNA-dependent RNA polymerase enzyme that has low fidelit

87 nhibitor of the HCV nonstructural protein 5B RNA-dependent RNA polymerase enzyme, was recently approv

88 h is transcribed and replicated by the viral-RNA-dependent RNA polymerase (FluPol(A)) composed of PB1

89 Influenza viruses encode a viral RNA-dependent RNA polymerase (FluPol), which is responsi

90 protease/helicase and NS5 methyltransferase/RNA-dependent RNA polymerase form part of the viral repl

91 of foot-and-mouth disease virus (FMDV), the RNA-dependent RNA polymerase, forms fibrils in vitro.

92 lete match to the nucleotide sequence of the RNA-dependent RNA polymerase from Drosophila X virus (DX

93 The RNA-dependent RNA polymerase from the Hepatitis C Virus

94 ular screening and partial sequencing of the RNA-dependent RNA polymerase gene.

95 The RNA-dependent RNA polymerase, glycoprotein precursor, nu

96 The segments encode an RNA-dependent RNA-polymerase, glycoprotein, non-structur

97 logical salt conditions, HCV NS5BDelta21, an RNA-dependent RNA polymerase, has poor affinity for the

98 genome is replicated and transcribed by the RNA-dependent RNA polymerase holoenzyme (subunits nsp7/n

99 marily a replicative process mediated by the RNA-dependent RNA polymerase; (iii) a mutation shown to

100 ability and poor activity of the avian virus RNA-dependent RNA polymerase in human cells.

101 a A virus mRNAs are transcribed by the viral RNA-dependent RNA polymerase in the cell nucleus before

102 bonucleosides form a novel class of HCV NS5B RNA-dependent RNA polymerase inhibitors, displaying EC50

103 include new NS3/4A protease inhibitors, NS5B RNA-dependent RNA polymerase inhibitors, NS5A inhibitors

104 pecifically, we show that the Nodamura virus RNA-dependent RNA polymerase interacts with the outer mi

105 Influenza virus mRNA synthesis by the RNA-dependent RNA polymerase involves binding and cleava

106 his context, heterotrimeric viral PA/PB1/PB2 RNA-dependent RNA polymerase is an attractive target for

107 The NS5B RNA-dependent RNA polymerase is an attractive target for

108 on of the endonuclease activity of influenza RNA-dependent RNA polymerase is attractive for the devel

109 The RNA-dependent RNA polymerase is responsible for genome r

110 is translocated by the single subunit viral RNA-dependent RNA polymerases is not yet understood.

111 The multifunctional RNA-dependent RNA polymerase L protein of vesicular stom

112 RNA complex constitutes the template for the RNA-dependent RNA polymerase L, which engages the nucleo

113 on between arenavirus nucleoprotein (NP) and RNA-dependent RNA polymerase (L protein), the two trans-

114 es are catalyzed by a complex comprising the RNA-dependent RNA polymerase (L) and the tetrameric phos

115 een the hemagglutinin-neuraminidase (HN) and RNA-dependent RNA polymerase (L) genes of the PIV5 genom

116 ion protein 35 (VP35), glycoprotein (GP) and RNA-dependent RNA polymerase (L) proteins.

117 The RNA-dependent-RNA polymerase (L) gene revealed phylogene

118 d the subsequent Pro(323)Leu mutation in the RNA-dependent RNA polymerase led to the precipitous spre

119 MuV RNA-dependent RNA polymerase minimally consists of the p

120 ocoris ostravirus 1) with a highly divergent RNA-dependent RNA polymerase missed by conventional BLAS

121 Our data uncover a new role for the viral RNA-dependent RNA polymerase NS5B and p7 proteins in con

122 our results demonstrate a novel role for the RNA-dependent RNA polymerase NS5B in HCV assembly.

123 The hepatitis C virus RNA-dependent RNA polymerase NS5B is responsible for the

124 replication complex consisting of NS5A, the RNA-dependent RNA polymerase NS5B, and c-Src.

125 eries of non-nucleoside boron-containing HCV RNA-dependent RNA polymerase (NS5B) inhibitors are descr

126 the surface of the thumb domain of the viral RNA-dependent RNA polymerase (NS5B).

127 ular targets for anti-HCV drugs is the viral RNA-dependent RNA polymerase, NS5B.

128 stributed within other regions of E, the NS5 RNA-dependent RNA polymerase (NS5POL) domain, and the TM

129 entary sequence of which codes for the viral RNA-dependent RNA polymerase (NS7).

130 nsp14 associates with the CoV RNA-dependent RNA polymerase (nsp12-RdRp), and nsp14-Exo

131 The Sindbis virus RNA-dependent RNA polymerase nsP4 possesses an amino-ter

132 The RNA-dependent RNA polymerase of influenza virus consists

133 remature termination of RNA synthesis by the RNA-dependent RNA polymerase of some viruses.

134 al clamp, conferring steric hindrance on the RNA-dependent RNA polymerases of diverse positive-strand

135 cles and if it showed positive results on an RNA-dependent RNA polymerase or open reading frame 1b ge

136 ost attention is focused on either the viral RNA-dependent RNA polymerase or the main viral protease,

137 ver the 5-fold vertices, and monomers of the RNA-dependent RNA polymerase (P2) attach to the inner su

138 One attractive target is the RNA-dependent RNA polymerase PA subunit.

139 mals may have replaced an ancient eukaryotic RNA-dependent RNA polymerase pathway to control transpos

140 The results show that the RNA-dependent RNA polymerase plays a crucial role in rec

141 ithin the N-terminal 270 amino acids and the RNA-dependent RNA polymerase (POL) activity within amino

142 at the local region is completed, the viral RNA-dependent RNA polymerase processes downstream, and t

143 products corresponding to virion-associated RNA-dependent RNA polymerase protein (RdRp), glycoprotei

144 with enzymatic activity, the viral large (L) RNA-dependent RNA polymerase protein.

145 Based on structural data of the RNA-dependent RNA polymerase, rational targeting of key

146 olymerases Pol IV and Pol V and the putative RNA-dependent RNA polymerase RDR2.

147 ring, channels transcripts to the associated RNA-dependent RNA polymerase RDR2.

148 The structure reveals that the RNA dependent RNA polymerase (RdRp) and capping (Cap) do

149 l PPIs including the homodimerization of the RNA dependent RNA polymerase (RdRp), the self-interactio

150 h the only protein present is the poliovirus RNA dependent RNA polymerase (RdRp), which recapitulates

151 replication, which is performed by the viral RNA dependent RNA polymerase (RdRp).

152 Foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase (RdRp) (3D(pol)) catalyzes

153 nce the amplification of the viral siRNAs by RNA-dependent RNA polymerase (RdRP) 1 (RDR1) and RDR6 an

154 s have suggested that multiple copies of the RNA-dependent RNA polymerase (RdRp) 3D are involved in t

155 merase, which has also been reported to have RNA-dependent RNA polymerase (RdRP) activity.

156 of two extensively interacting subunits: an RNA-dependent RNA polymerase (RdRP) and an NTPase VP4.

157 eEF1A) in control of activation of the viral RNA-dependent RNA polymerase (RdRp) and regulation of th

158 wo conserved amino acid substitutions in the RNA-dependent RNA polymerase (RdRp) and six in the capsi

159 substitutions in the thumb subdomain of the RNA-dependent RNA polymerase (RdRp) and the methyltransf

160 n with defined termini, containing the viral RNA-dependent RNA polymerase (RdRp) at one end and a loo

161 The viral RNA-dependent RNA polymerase (RdRp) causes the TSS/surro

162 The influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5' end o

163 Recently, we demonstrated that the viral RNA-dependent RNA polymerase (RdRP) complex can be an op

164 l interfering RNAs (endo-siRNAs) produced by RNA-dependent RNA polymerase (RdRP) complexes.

165 pped dsRNAs, the largest of which encodes an RNA-dependent RNA polymerase (RdRP) containing a unique

166 -terminal methyltransferase and a C-terminal RNA-dependent RNA polymerase (RdRp) domain.

167 protruding into an active site cavity of the RNA-dependent RNA polymerase (RdRp) domain.

168 First, the NS5 methyltransferase and RNA-dependent RNA polymerase (RdRP) domains form a conse

169 ich the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into o

170 itu structures of the intermediate stages of RNA-dependent RNA polymerase (RdRp) during transcription

171 scovered that knockdown of either csr-1, the RNA-dependent RNA polymerase (RdRP) ego-1, or the dicer-

172 These include the sequestration of the RNA-dependent RNA polymerase (RdRp) for functions other

173 ngle-stranded RNA virus that encodes its own RNA-dependent RNA polymerase (RdRp) for nucleic acid syn

174 fficiently used as primers by the hantaviral RNA-dependent RNA polymerase (RdRp) for transcription in

175 sid (ORF2) genes and occasionally within the RNA-dependent RNA polymerase (RdRP) gene.

176 on sequencing using primers specific for the RNA-dependent RNA polymerase (RDRP) gene.

177 ghlight the central role played by the viral RNA-dependent RNA polymerase (RdRp) in the recombination

178 which the respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) initiates mRNA trans

179 The viral RNA-dependent RNA polymerase (RdRp) is a promising thera

180 RNA-dependent RNA polymerase (RdRp) is essential to vira

181 cleotide incorporation fidelity of the viral RNA-dependent RNA polymerase (RdRp) is important for mai

182 The RNA-dependent RNA polymerase (RdRp) of hepatitis C virus

183 The RNA-dependent RNA polymerase (RdRP) of nonsegmented nega

184 a cell-based assay for RNA synthesis by the RNA-dependent RNA polymerase (RdRp) of noroviruses, we p

185 port an in vitro RNA synthesis assay for the RNA-dependent RNA polymerase (RdRP) of rabies virus (RAB

186 RDV targets the viral RNA-dependent RNA polymerase (RdRp) of severe acute resp

187 The reliance of the viral RNA-dependent RNA polymerase (RdRP) on host factors make

188 ruses (IAV) acquired through the error-prone RNA-dependent RNA polymerase (RdRP) or through genetic r

189 at transgenic mice expressing a picornavirus RNA-dependent RNA polymerase (RdRP) outside the viral co

190 alone and I212V-S460L in combination) in the RNA-dependent RNA polymerase (RdRp) region of the genome

191 Based on the partial RNA-dependent RNA polymerase (RdRp) region, they cluster

192 a distinct class of siRNAs synthesized by an RNA-dependent RNA polymerase (RdRP) requires the PIR-1 p

193 The viral RNA-dependent RNA polymerase (RdRP) resides within an ap

194 The hantavirus RNA-dependent RNA polymerase (RdRp) snatches 5' capped m

195 In this context, the viral RNA-dependent RNA polymerase (RdRP) subunits assembly ha

196 S) in C. elegans also involves RRF-1, a worm RNA-dependent RNA polymerase (RdRP) that is known to pro

197 ny eukaryotic organisms encode more than one RNA-dependent RNA polymerase (RdRP) that probably emerge

198 RNA viruses replicate via a virally encoded RNA-dependent RNA polymerase (RdRP) that uses a unique p

199 loped, double-strand RNA viruses, package an RNA-dependent RNA polymerase (RdRp) with each duplex of

200 However, genes for RNA-dependent RNA polymerase (RdRp), a hallmark of posit

201 Key to the viral life cycle is the RNA-dependent RNA polymerase (RdRp), a heterotrimeric co

202 Dengue virus (DENV) NS5 RNA-dependent RNA polymerase (RdRp), an important drug t

203 re dengue genome for interactions with viral RNA-dependent RNA polymerase (RdRp), and we identified t

204 th simple genomes that typically encode only RNA-dependent RNA polymerase (RdRP), capping enzyme and

205 influenza virus genome mainly depend on its RNA-dependent RNA polymerase (RdRP), composed of the PA,

206 SARS-CoV nsp12, the canonical RNA-dependent RNA polymerase (RdRp), exhibits poorly pro

207 ral (HCV) genome is accomplished by the NS5B RNA-dependent RNA polymerase (RdRp), for which mechanist

208 rotein template and the L protein, which has RNA-dependent RNA polymerase (RdRp), GDP polyribonucleot

209 ion of the downstream ORF, which encodes the RNA-dependent RNA polymerase (RdRp), has been proposed t

210 ing well-defined mutations in the poliovirus RNA-dependent RNA polymerase (RDRP), namely, a G64S muta

211 re, we show that transient expression of HCV RNA-dependent RNA polymerase (RdRp), NS5B, in mouse live

212 which encode a putative coat protein and an RNA-dependent RNA polymerase (RdRp), respectively.

213 The VRC consists of the p92 virus-coded RNA-dependent RNA polymerase (RdRp), the viral p33 RNA c

214 dsRNA1 ORF contains motifs representative of RNA-dependent RNA polymerase (RdRp), whereas the dsRNA2

215 synthesis is catalyzed by a multifunctional RNA-dependent RNA polymerase (RdRP), which is composed o

216 etween mitochondrial membranes and the viral RNA-dependent RNA polymerase (RdRp), which is mediated b

217 The virus-coded RNA-dependent RNA polymerase (RdRp), which is responsibl

218 plication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase (RdRp), which is the likely

219 component of the VRC is the virally encoded RNA-dependent RNA polymerase (RdRp), which should be act

220 nically express low levels of a picornaviral RNA-dependent RNA polymerase (RdRP), which synthesizes d

221 A expression with a concomitant depletion of RNA-dependent RNA polymerase (RdRP)-derived secondary sm

222 They all make their own RNA-dependent RNA polymerase (RdRp).

223 hich are known as inhibitors of the HCV NS5B RNA-dependent RNA polymerase (RdRp).

224 on the regulation of VP1, the virus-encoded RNA-dependent RNA polymerase (RdRp).

225 (siRNAs) are amplified from target mRNAs by RNA-dependent RNA polymerase (RdRP).

226 via template switching by the virus-encoded RNA-dependent RNA polymerase (RdRP).

227 and replication of the viral genome by viral RNA-dependent RNA polymerase (RdRp).

228 s is transcribed and replicated by the viral RNA-dependent RNA polymerase (RdRP).

229 tide misincorporation frequency of the viral RNA-dependent RNA polymerase (RdRp).

230 sites in the L gene-which encodes the viral RNA-dependent RNA polymerase (RdRp).

231 sid protein (N-RNA), and associated with the RNA-dependent RNA polymerase (RdRP).

232 espread conformational shift upon binding to RNA-dependent RNA polymerase (RdRp).

233 l-based assay for the human NoV GII.4 strain RNA-dependent RNA polymerase (RdRp).

234 d by endogenous RNA transcription through an RNA-dependent RNA polymerase (RdRp).

235 e of ~3 kb, encoding only a highly conserved RNA-dependent RNA polymerase (RdRp).

236 incorporated into RNA by the virally encoded RNA-dependent RNA polymerase (RdRp).

237 RNA viruses encoding high- or low-fidelity RNA-dependent RNA polymerases (RdRp) are attenuated.

238 (or Main) protease (3CL(pro)) and the nsp12 RNA-dependent RNA-polymerase (RdRp) are the best charact

239 Using an in vitro assay for the RNA-dependent RNA-polymerase (RdRP) of the arenavirus Ma

240 bed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp).

241 viral nucleocapsid protein and bound by the RNA-dependent RNA-polymerase (RdRP).

242 optimization of non-nucleoside dengue viral RNA-dependent-RNA polymerase (RdRp) inhibitors are descr

243 The viral RNA-dependent-RNA-polymerase (RdRp) is a promising targe

244 in, which comprises three enzymatic domains (RNA-dependent RNA polymerase [RdRp], polyribonucleotidyl

245 1 dephosphorylates ppp-RNAs made by cellular RNA-dependent RNA polymerases (RdRPs) and is required fo

246 RNA-dependent RNA polymerases (RdRps) are key to the rep

247 RNA-dependent RNA polymerases (RdRps) are used by RNA vi

248 RNA-dependent RNA polymerases (RdRps) are used by RNA vi

249 Positive-sense RNA viruses encode RNA-dependent RNA polymerases (RdRps) essential for geno

250 Recombinant RNA-dependent RNA polymerases (RdRps) from the human nor

251 All viral RNA-dependent RNA polymerases (RdRps) have a conserved s

252 Picornaviral RNA-dependent RNA polymerases (RdRPs) have low replicati

253 through the production of small RNAs by two RNA-dependent RNA polymerases (RdRPs) that are thought t

254 atively low fidelity SARS-CoV and SARS-CoV-2 RNA-dependent RNA polymerases (RdRps), serving as an imm

255 te for the absence of piRNAs, both involving RNA-dependent RNA polymerases (RdRPs).

256 RDV is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps).

257 mplification of initial silencing signals by RNA-dependent RNA polymerases (RdRPs).

258 quires an siRNA amplification step involving RNA-dependent RNA polymerases (RdRPs).

259 ed host thanks to dedicated, virally-encoded RNA-dependent RNA polymerases (RdRps).

260 oduction of double-stranded RNAs (dsRNAs) by RNA-DEPENDENT RNA POLYMERASEs (RDRs) and proceeds throug

261 Cellular RNA-dependent RNA polymerases (RDRs) catalyze synthesis

262 Hepatitis C virus (HCV) RNA-dependent RNA polymerase replicates the viral genomi

263 NS5B is the RNA-dependent RNA polymerase responsible for replicating

264 The C-terminal domain is an RNA-dependent RNA polymerase responsible for viral RNA s

265 sponsible for virus replication and cellular RNA-dependent RNA polymerases responsible for gene silen

266 of mutations in virus-derived siRNAs: viral RNA-dependent RNA polymerases responsible for virus repl

267 me of influenza viruses is replicated by the RNA-dependent RNA polymerase (RNAP) via a complementary

268 NA) genome, which is replicated by the viral RNA-dependent RNA polymerase (RNAP).

269 re that is recognized and bound by the viral RNA-dependent RNA polymerase (RNAP); however, no 3D stru

270 The RDE-10/RDE-11 complex and the RNA-dependent RNA polymerase RRF-1 then engage the targe

271 independent of rde-4 but likely requires the RNA-dependent RNA polymerase RRF-1, suggesting a critica

272 findings further our understanding of viral RNA-dependent RNA polymerase structure-function relation

273 nit, and the RDRC complex, which contains an RNA-dependent RNA polymerase subunit.

274 c RNA whose appearance is independent of the RNA-dependent RNA polymerase, suggesting that the telome

275 Non-structural protein 5B (NS5B) is the RNA-dependent RNA polymerase that catalyzes replication

276 NS5B is the RNA-dependent RNA polymerase that catalyzes the replicat

277 (HCV) non-structural protein 5B (NS5B) is an RNA-dependent RNA polymerase that is essentially require

278 Nonstructural protein 9 (Nsp9) is the RNA-dependent RNA polymerase that plays a critical role

279 RSV has an RNA-dependent RNA polymerase that transcribes and replic

280 such as influenza, encode large, multidomain RNA-dependent RNA polymerases that can both transcribe a

281 1 (PA-PB1) subunits of influenza virus (Flu) RNA-dependent RNA polymerase, this paper is devoted to t

282 ties of Phlebovirus nucleocapsid protein and RNA-dependent RNA polymerase to recognize the untranslat

283 lication showed the contribution of cellular RNA-dependent RNA polymerases to the generation of mutat

284 tered inside the nucleocapsid when the viral RNA-dependent RNA polymerase uses it as the template for

285 agment screen on the dengue virus serotype 3 RNA-dependent RNA polymerase using x-ray crystallography

286 l double-stranded RNA (dsRNA) genome and the RNA-dependent RNA polymerase VP1.

287 me and RNA processing enzymes, including the RNA-dependent RNA polymerase (VP1).

288 dies have revealed the position of the viral RNA-dependent RNA polymerase, VP1, within the inner caps

289 For NSVs, the viral RNA-dependent RNA polymerase (vRdRp) must gain access to

290 The viral RNA-dependent RNA polymerase (vRdRp) of MuV consists of

291 The viral RNA-dependent RNA polymerase (vRdRp) of paramyxovirus co

292 The viral RNA-dependent RNA polymerases (vRdRps) of nonsegmented,

293 s, identified in the p7 polypeptide and NS5B RNA-dependent RNA polymerase, were sufficient to increas

294 lyzed by the NS5B (nonstructural protein 5B) RNA-dependent RNA polymerase, which is a major target of

295 The virus encodes an RNA-dependent RNA polymerase, which replicates and trans

296 G tails promote gene silencing by recruiting RNA-dependent RNA polymerases, which use pUG-tailed RNAs

297 ling those of RNA primases or even canonical RNA-dependent RNA polymerases, while more recent studies

298 P forms the viral RNA-dependent RNA polymerase with the large protein (L).

299 nhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all H

300 ty in RNA viruses has been attributed to the RNA-dependent RNA polymerases, with mutations in RdRps f