ライフサイエンスコーパス: RNA-dependent protein kinase

1 y modulating the activity of double-stranded RNA-dependent protein kinase.

2 se R-motif exons of the interferon-inducible RNA-dependent protein kinase.

3 The double-stranded RNA-dependent protein kinase activating protein (PACT),

4 protein interferon-inducible double-stranded RNA-dependent protein kinase activator A), the product o

5 veal the existence in nuclear extracts of an RNA-dependent protein kinase activity that hyperphosphor

6 S, was dependent on CD14 activity but not on RNA-dependent protein kinase and could be inhibited by a

7 igoadenylate synthetase, and double-stranded-RNA-dependent protein kinase as well as those coding for

8 investigated the role of the double-stranded RNA-dependent protein kinase gene (pkr) in the regulatio

9 feron-alpha --> upward arrow double-stranded RNA-dependent protein kinase --> downward arrow c-Myc --

10 eta mRNA was MyD88- and PKR (double-stranded RNA-dependent protein kinase)-independent, but TIRAP (To

11 n [IFN-beta], IFN-gamma, protein Mx1 GTPase, RNA-dependent protein kinase, inducible nitric oxide syn

12 PKR (double-stranded RNA-dependent protein kinase) is an important component

13 , so we monitored the activity of PERK [PKR (RNA-dependent protein kinase)-like ER kinase (EIF2AK3)],

14 c translation initiator factor 2alpha kinase RNA-dependent protein kinase-like ER kinase (PERK) allow

15 tx1 activated the proximal ER stress sensors RNA-dependent protein kinase-like ER kinase and inositol

16 led by the activation of ER stress-inducible RNA-dependent protein kinase-like ER-integral (PERK) eIF

17 e anti-viral response, e.g., double-stranded RNA-dependent protein kinase, myxovirus resistance prote

18 a and IL-18 - as well as the double-stranded-RNA-dependent protein kinase pathway and RNaseL pathway,

19 nd inhibit activation of the double-stranded RNA-dependent protein kinase PKR in cell-free systems, a

20 RNA-dependent protein kinase PKR is an important regulat

21 The double-stranded (ds) RNA-dependent protein kinase PKR is considered to play a

22 The interferon-induced RNA-dependent protein kinase PKR is found in cells in a

23 d autophosphorylation of the double-stranded RNA-dependent protein kinase PKR leading to phosphorylat

24 nterestingly, absence of the double-stranded RNA-dependent protein kinase PKR led to a profound defec

25 d to be effective in blocking binding to the RNA-dependent protein kinase PKR, a cytoplasmic dsRNA-bi

26 t a major effector of the C phenotype is the RNA-dependent protein kinase PKR.

27 ith the pathway regulated by double-stranded RNA-dependent protein kinase PKR.

28 rotein synthesis mediated by double-stranded-RNA-dependent protein kinase PKR.

29 in synthesis mediated by the double-stranded-RNA-dependent protein kinase PKR.

30 is study quantified constitutive and induced RNA-dependent protein kinase (PKR) activation in Fanconi

31 gamma, and the activation of double-stranded RNA-dependent protein kinase (PKR) and eukaryotic initia

32 Phosphorylation of double-stranded RNA-dependent protein kinase (PKR) and eukaryotic initia

33 through the increase of the double-stranded RNA-dependent protein kinase (PKR) and following inactiv

34 olyinosinic-polycytidylic acid activated the RNA-dependent protein kinase (PKR) and induced significa

35 specific adenosine deaminase (ADAR1) and the RNA-dependent protein kinase (PKR) are both interferon-i

36 RNase L and RNA-dependent protein kinase (PKR) are effectors of the

37 virus 1 (HSV-1) results in the activation of RNA-dependent protein kinase (PKR) but that the alpha su

38 tranded RNA, which activates double-stranded RNA-dependent protein kinase (PKR) by mimicking viral in

39 re, we provide evidence that double-stranded RNA-dependent protein kinase (PKR) can respond to nutrie

40 The depletion of double-stranded RNA-dependent protein kinase (PKR) from these MEFs resto

41 study, the role of the double-stranded (ds) RNA-dependent protein kinase (PKR) in macrophage activat

42 repressed expression of the double-stranded RNA-dependent protein kinase (PKR) in the promonocytic U

43 Double stranded RNA-dependent protein kinase (PKR) is a double stranded

44 The double-stranded (ds) RNA-dependent protein kinase (PKR) is a primary regulato

45 h herpes simplex virus 1 the double-stranded RNA-dependent protein kinase (PKR) is activated but phos

46 The RNA-dependent protein kinase (PKR) is activated by bindi

47 Although the double-stranded RNA-dependent protein kinase (PKR) is activated during H

48 The human double-stranded RNA-dependent protein kinase (PKR) is an important compo

49 The RNA-dependent protein kinase (PKR) is an interferon-indu

50 The RNA-dependent protein kinase (PKR) is an interferon-indu

51 The RNA-dependent protein kinase (PKR) is an interferon-indu

52 RNA-dependent protein kinase (PKR) is an interferon-indu

53 ed upon virus infection, the double-stranded RNA-dependent protein kinase (PKR) is best known for tri

54 The RNA-dependent protein kinase (PKR) is implicated in the

55 situation and show that the double-stranded RNA-dependent protein kinase (PKR) is involved in the lo

56 we provide evidence that the double-stranded RNA-dependent protein kinase (PKR) is not required for v

57 The RNA-dependent protein kinase (PKR) is regulated by the b

58 s in which the activation of double-stranded RNA-dependent protein kinase (PKR) is suppressed.

59 red that viperin, ISG20, and double-stranded RNA-dependent protein kinase (PKR) noncytolytically inhi

60 AV L(pro) interfered with phosphorylation of RNA-dependent protein kinase (PKR) or eIF2alpha, indicat

61 The RNA-dependent protein kinase (PKR) plays an integral rol

62 The double-stranded (ds) RNA-dependent protein kinase (PKR) regulates protein syn

63 e interferon-inducible, double-stranded (ds) RNA-dependent protein kinase (PKR) regulates protein syn

64 N-terminal kinase (JNK) and double-stranded RNA-dependent protein kinase (PKR) to induce autophagy w

65 The gene encoding the interferon-inducible, RNA-dependent protein kinase (PKR) was isolated as lambd

66 Double-stranded RNA-dependent protein kinase (PKR), a ubiquitously expre

67 promotes the degradation of double-stranded RNA-dependent protein kinase (PKR), and it suppresses ho

68 d in an elevation in an IFN-responsive gene, RNA-dependent protein kinase (PKR), but not 2',5'-oligoa

69 the human eIF2alpha kinase, double-stranded-RNA-dependent protein kinase (PKR), impeded growth of S.

70 e proteasomal degradation of double-stranded RNA-dependent protein kinase (PKR), little is known abou

71 eIF-2alpha kinases including double-stranded RNA-dependent protein kinase (PKR), which has been recen

72 da7 induces andactivates the double-stranded RNA-dependent protein kinase (PKR), which leads to phosp

73 itro transcripts containing uridine activate RNA-dependent protein kinase (PKR), which then phosphory

74 the role of the ER resident protein kinase, RNA-dependent protein kinase (PKR)-like ER kinase (PERK)

75 ured cells due to their inability to prevent RNA-dependent protein kinase (PKR)-mediated inhibition o

76 ansgenic mouse strain in which double-strand RNA-dependent protein kinase (PKR)-mediated phosphorylat

77 cted, which results in the activation of the RNA-dependent protein kinase (PKR)-mediated stress respo

78 n is highly regulated by the double-stranded RNA-dependent protein kinase (PKR).

79 slational arrest mediated by double-stranded-RNA-dependent protein kinase (PKR).

80 on through activation of the double-stranded RNA-dependent protein kinase (PKR).

81 is mediated by activation of double-stranded RNA-dependent protein kinase (PKR).

82 protein synthesis involving double-stranded RNA-dependent protein kinase (PKR).

83 tor of P58(IPK), a cellular inhibitor of the RNA-dependent protein kinase (PKR).

84 optotic interferon-inducible double-stranded RNA-dependent protein kinase (PKR).

85 ation, suggesting a role for double-stranded RNA-dependent protein kinase (PKR).

86 alpha by up-regulating the expression of the RNA-dependent protein kinase (PKR).

87 here we identify a role for double-stranded RNA-dependent protein kinase (PKR, also known as EIF2AK2

88 RNA-specific adenosine deaminase [ADAR1] and RNA-dependent protein kinase [PKR]) in a tissue-specific

89 non-derepressible 2 [GCN2], double-stranded RNA-dependent protein kinase [PKR], heme-regulated eukar

90 rt that in HeLa cells, activation of a PERK (RNA-dependent protein kinase [PKR]-like ER kinase)-eIF2a

91 in vitro with and inhibits the IFN-induced, RNA-dependent protein kinase, PKR, and that NS5A interac

92 The antiviral RNA-dependent protein kinase, PKR, binds to viral double

93 plication indicated that the double-stranded RNA-dependent protein kinase, PKR, exerted some early an

94 -terminal region of the double-stranded (ds) RNA-dependent protein kinase, PKR, has been shown to med

95 is now apparent that the double-stranded (ds)RNA-dependent protein kinase, PKR, is a regulator of div

96 have shown recently that the double-stranded RNA-dependent protein kinase, PKR, is involved in transl

97 ctor 2 (eIF2alpha) by the interferon-induced RNA-dependent protein kinase, PKR, leads to inhibition o

98 y by the interferon-induced, double-stranded RNA-dependent protein kinase, PKR.

99 tRNA2-1 and down-regulate the phosphorylated RNA-dependent protein kinase (pPKR), whose activity has

100 The role of RNA-dependent protein kinase R (PKR) and its association

101 ulated gene products such as double-stranded RNA-dependent protein kinase R (PKR), 2',5'-oligoadenyla

102 nctions of the IFN-inducible double-stranded RNA-dependent protein kinase R or PKR.

103 anslation arrest mediated by double-stranded RNA-dependent protein kinase R.

104 t restored in the absence of double-stranded RNA-dependent protein kinase, RNase L, or IFN-alpha/beta

105 pkr gene encoding the interferon-inducible, RNA-dependent protein kinase was isolated as lambda phag

106 The double-stranded RNA-dependent protein kinase was not essential for DC ma

107 PKR is a doubled-stranded RNA-dependent protein kinase which is implicated in the