ライフサイエンスコーパス: RNA-induced silencing complex

1 ions in the formation of a stable Piwi RISC (RNA-induced silencing complex).

2 y a ribonucleoprotein complex known as RISC (RNA-induced silencing complex).

3 bodies and bind to Argonaute proteins of the RNA induced silencing complex.

4 g RNA-binding proteins and components of the RNA-induced silencing complex.

5 knockout mice deficient in components of the RNA-induced silencing complex.

6 helicase, and it is also a component of the RNA-induced silencing complex.

7 , an essential step in the activation of the RNA-induced silencing complex.

8 he degradation of the target mRNA within the RNA-induced silencing complex.

9 for the siRNA and biased strand loading into RNA-induced silencing complex.

10 so involved in loading and activation of the RNA-induced silencing complex.

11 and transfers the processed products to the RNA-induced silencing complex.

12 P) functions downstream to pass siRNA to the RNA-induced silencing complex.

13 that are subsequently incorporated into the RNA-induced silencing complex.

14 plex dictate which strand is loaded into the RNA-induced silencing complex.

15 erference (RNAi) is carried out by RISC, the RNA-induced silencing complex.

16 ational repression mediated by the AGO-miRNA RNA-induced silencing complex.

17 target specificity and association with the RNA-induced silencing complex.

18 that regulate gene expression as part of the RNA-induced silencing complex.

19 ute 2 (AGO2), the catalytic component of the RNA-induced silencing complex.

20 n between the 3'-untranslated region and the RNA-induced silencing complex.

21 d the presence of ATM in miR-181c-associated RNA-induced silencing complex.

22 investigated represents a functional minimal RNA-induced silencing complex.

23 nted miR-155 activity without saturating the RNA-induced silencing complex.

24 any mRNAs and non-coding RNAs are cleaved by RNA-induced silencing complexes.

25 As by Drosha and more efficient formation of RNA-induced silencing complexes.

26 Dicer enzymes and recruited by Argonauts to RNA-induced silencing complexes.

27 caque TRIM5alpha did, however, provide siRNA-RNA-induced silencing complex access to HIV-1 genomic RN

28 -142 efficiently recruits the APC mRNA to an RNA-induced silencing complex, activates the canonical W

29 own interactor of ALG-1 and component of the RNA-induced silencing complex, also resulted in a signif

30 set of miR-499 target mRNAs to cardiomyocyte RNA-induced silencing complexes, altering steady-state c

31 een for microRNAs that were recruited to the RNA-induced silencing complex and differentially express

32 (Ago) proteins are the key component of the RNA-induced silencing complex and mediate RNA interferen

33 ic small interfering RNAs (siRNAs) enter the RNA-induced silencing complex and one strand guides clea

34 ipts, or the removal of mRNAs cleaved by the RNA-induced silencing complex and other mRNAs prone to u

35 Genome-wide RNA-induced silencing complex and RNA sequencing identif

36 lanks complex is unlike previously described RNA-induced silencing complexes and associates with the

37 Rs, selects the miR strand to be loaded onto RNA-induced silencing complex, and determines proper miR

38 binds Argonaute2, a central component of the RNA-induced silencing complex, and miR-146a, a microRNA

39 detectable by Northern blot, are loaded into RNA-induced silencing complexes, and can effectively and

40 s well as the same level of loading into the RNA-induced silencing complex as siRNAs with a GalNAc-co

41 These proteins assemble into functional RNA-induced silencing complexes as transfection of small

42 When an siRNA or miRNA proceeds through the RNA-induced silencing complex assembly pathway, only one

43 ile intermediate during the miRNA biogenesis/RNA-induced silencing complex assembly, miRNA*, was belo

44 ng that 340R binds siRNA duplexes to prevent RNA-induced silencing complex assembly.

45 ssociation with AGO1, either during or after RNA-induced silencing complex assembly.

46 Here we show that human RISC (RNA-induced silencing complex) associates with a multipr

47 centration in plasma and liver, the temporal RNA-induced silencing complex binding profiles, mRNA red

48 sequences, indicating in planta miRNA-guided RNA-induced silencing complex cleavage of the recombinan

49 trated a novel interaction between the major RNA-induced silencing complex component Argounaute-2 (Ag

50 nique that identifies the mRNAs bound to the RNA-induced silencing complex component protein Argonaut

51 was identified by immunoprecipitation of the RNA-induced silencing complex components AIN-1 and AIN-2

52 The RNA-induced silencing complex, comprising Argonaute and

53 ng specific stoichiometric associations with RNA-induced silencing complex constituents argonaute-2 (

54 The results reveal the requirement of RNA-induced silencing complex constituents in the mitoch

55 in vitro Drosha/Dicer processing, and (iii) RNA-induced silencing complex-dependent targeting of wil

56 e for formation of nuclear-programmed active RNA induced silencing complexes directly in the nucleus.

57 otaxin-3, and thrombopoietin receptor to the RNA-induced silencing complex; downregulated these genes

58 hat they function, at least in part, via the RNA-induced silencing complex effector Ago1.

59 e performed the immunoprecipitation of RISC (RNA-induced Silencing Complex) followed by microarray an

60 ow that Nsf is specifically recruited to the RNA-induced silencing complex following induction of miR

61 ality in reconstituted, catalytically active RNA-induced silencing complexes following the incorporat

62 is an essential functional component in the RNA-induced silencing complex for miRNA-mediated gene si

63 Argonautes are recruited with miRNAs into an RNA-induced silencing complex for mRNA recognition (Figu

64 ngi, employ the host plant's Argonaute (AGO)/RNA-induced silencing complex for virulence.

65 degradation of the unwound sense strand and RNA-induced silencing complex formation, suggesting that

66 roRNAs exist mainly in high molecular weight RNA-induced silencing complexes (HMW-RISC) associated wi

67 enriched through immunoprecipitation of the RNA-induced silencing complex identified several transcr

68 Dicer and facilitates loading of miRNA onto RNA-induced silencing complexes, identifying a new role

69 RNA-sequencing data based on RNA Induced silencing Complex Immunoprecipitation (RISC-

70 type 2a RNA with miR-181c was observed in an RNA-induced silencing complex in Huh7.5 cells.

71 mbers (Tnrc6a/b/c) are key components of the RNA-induced silencing complex in microRNA (miRNA)-mediat

72 The slicer activity of the RNA-induced silencing complex is associated with argonau

73 e precision of the target specificity by the RNA-induced silencing complexes is reevaluated and redef

74 unforeseen increase in siRNA loading to the RNA-induced silencing complex, likely due to the unique

75 Argonaute-containing RNA-induced silencing complex loaded with the viral siRN

76 slated region of SOX2 mRNA together with the RNA-induced silencing complex miR145.

77 Silencing by the miRNA-guided RNA induced silencing complex (miRISC) is dependent on A

78 ulates expression of three components of the RNA-induced silencing complex, namely Dicer, Argonaute 1

79 iated by the RNA-protein effector complexes (RNA-induced silencing complex or RISC).

80 , an RNA-binding protein that is part of the RNA-induced silencing complex, plays a key role in miR-m

81 The presence of RNA-induced silencing complex proteins in these compartm

82 We asked whether the Argonaute (Ago)/RNA-induced silencing complex, providing the mRNA "slice

83 We propose that the RNA-induced silencing complex reprogramming occurs durin

84 The slicer activity of the RNA-induced silencing complex resides within its Argonau

85 The RNA induced silencing complex (RISC) contains at its cor

86 us in HSB2 cells and are associated with the RNA induced silencing complex (RISC) machinery.

87 d into Argonaute, the central protein in the RNA Induced Silencing Complex (RISC) that silences messe

88 for transport and for incorporation into the RNA induced silencing complex (RISC).

89 RNA guide strand, once it is loaded into the RNA induced silencing complex (RISC).

90 hen loaded into Argonaute1 (Ago1) within the RNA-induced silencing complex (RISC) [19, 20].

91 tematically evaluated the impact of iE-VP on RNA-Induced Silencing Complex (RISC) activity, where bac

92 junctions recruit the core components of the RNA-induced silencing complex (RISC) Ago2, GW182, and PA

93 to distinguish and quantify free siRNA from RNA-induced silencing complex (RISC) and Argonaute 2 (Ag

94 o-localization with proteins involved in the RNA-induced silencing complex (RISC) and demonstrated en

95 on of small interfering RNAs (siRNAs) by the RNA-induced silencing complex (RISC) and its precursor,

96 A (aiRNA) of 15 bp was incorporated into the RNA-induced silencing complex (RISC) and mediated sequen

97 quence at position 2-7/8, is loaded into the RNA-induced silencing complex (RISC) and targets complem

98 fferent siRNAs may lead to saturation of the RNA-induced silencing complex (RISC) and to the degradat

99 ed into Argonaute (AGO) proteins to form the RNA-induced silencing complex (RISC) and used as guides

100 Complexes in the Drosophila RNA-induced silencing complex (RISC) assembly pathway ca

101 labile intermediate in the miRNA biogenesis/RNA-induced silencing complex (RISC) assembly pathway, m

102 During RNA-induced silencing complex (RISC) assembly the guide

103 ched variants in parallel in gene silencing, RNA-induced silencing complex (RISC) assembly, stability

104 ing essential survival genes are loaded into RNA-induced silencing complex (RISC) complexes, resultin

105 king and immunoprecipitation (iCLIP) for the RNA-induced silencing complex (RISC) component AGO2 and

106 ered the recruitment of TOP2A transcripts to RNA-induced silencing complex (RISC) components and to c

107 The cytoplasmic RNA-induced silencing complex (RISC) contains dsRNA bind

108 omain containing 1 (SND1), a nuclease in the RNA-induced silencing complex (RISC) facilitating RNAi-m

109 As in the nucleus, whereas the DICER and the RNA-induced silencing complex (RISC) further process and

110 Utilizing antisense and siRNA-mediated RNA-induced silencing complex (RISC) gene reduction we s

111 Furthermore, RNA-induced silencing complex (RISC) immunoprecipitation

112 RNA-induced silencing complex (RISC) is composed of miRN

113 cally regulated and its interaction with the RNA-induced silencing complex (RISC) is compromised in M

114 hich these fragments are associated with the RNA-induced silencing complex (RISC) is mostly unknown.

115 nding of microRNA (miRNA) to mRNA within the RNA-induced silencing complex (RISC) leads to either tra

116 ns (C. elegans), the interaction between the RNA-induced silencing complex (RISC) loaded with primary

117 tle is known about whether components of the RNA-induced silencing complex (RISC) mediate the biogene

118 ated RNAs associated with Argonaute 2 in the RNA-induced silencing complex (RISC) of cyclosporine A (

119 The RNA-induced silencing complex (RISC) or the RISC complex

120 hod for miRNA target discovery that combined RNA-induced silencing complex (RISC) purification with m

121 , like RNA viruses, are also targeted by the RNA-induced silencing complex (RISC) remains controversi

122 Assembly of the RNA-induced silencing complex (RISC) requires formation

123 ASOs that function through RNase H or the RNA-induced silencing complex (RISC) result in enzymatic

124 r activation due in part to induction of the RNA-induced silencing complex (RISC) scaffold protein GW

125 n-cleavage-based gene repression through the RNA-induced silencing complex (RISC) that consists of on

126 (miRNAs) block access of toxic sRNAs to the RNA-induced silencing complex (RISC) that mediates RNAi,

127 RPL5, co-operatively with RPL11, guides the RNA-induced silencing complex (RISC) to c-Myc mRNA and m

128 s RNA into siRNAs and miRNAs, which direct a RNA-induced silencing complex (RISC) to cleave mRNA or b

129 ral-derived siRNAs are incorporated into the RNA-induced silencing complex (RISC) to guide degradatio

130 tides in length and helps load them into the RNA-induced silencing complex (RISC) to guide the cleava

131 er to generate mature miRNAs that direct the RNA-induced silencing complex (RISC) to messenger RNAs w

132 ciating with Argonaute (Ago) proteins in the RNA-induced silencing complex (RISC) to modulate protein

133 n of messenger RNAs (mRNAs) by directing the RNA-induced silencing complex (RISC) to their sequence-s

134 RNAs from the miR-379/410 cluster direct the RNA-induced silencing complex (RISC) to transcriptional

135 sis, mature miRNAs are incorporated into the RNA-induced silencing complex (RISC) where they interact

136 ls, this microRNA can be associated with the RNA-induced silencing complex (RISC) which is required f

137 The miRNA is incorporated into the RNA-Induced Silencing Complex (RISC) with Argonaute prot

138 l infection via poly-ADP-ribosylation of the RNA-induced silencing complex (RISC), a core component o

139 ner for Dicer and a crucial component of the RNA-induced silencing complex (RISC), a critical element

140 RNAi is mediated by RNA-induced silencing complex (RISC), a sequence-specifi

141 four major steps: assembly of siRNA with the RNA-induced silencing complex (RISC), activation of the

142 RNA metabolism, including components of the RNA-induced silencing complex (RISC), and colocalize wit

143 and loading of the antisense strand into the RNA-induced silencing complex (RISC), are more critical

144 (hAgo2), the catalytic core component of the RNA-induced silencing complex (RISC), can be recruited t

145 nd degradation in a process mediated by Ago2/RNA-induced silencing complex (RISC), certain siRNAs hav

146 Argonaute 2 (Ago2), a key component of the RNA-induced silencing complex (RISC), has been shown to

147 naute-2 protein (Ago2), a major component of RNA-induced silencing complex (RISC), has been viewed as

148 rgonaute proteins, the catalytic core of the RNA-induced silencing complex (RISC), in the conserved R

149 P2rx7 mRNA was selectively uploaded into the RNA-induced silencing complex (RISC), suggesting microRN

150 te proteins and small RNAs together form the RNA-induced silencing complex (RISC), the central effect

151 alyze which HSV-1 miRNAs are loaded into the RNA-induced silencing complex (RISC), the key effector o

152 that the central catalytic component of the RNA-induced silencing complex (RISC), the nuclease Argon

153 (siRNAs) by Dicer and incorporated into the RNA-induced silencing complex (RISC), triggers gene sile

154 These vsiRNAs are incorporated into the RNA-induced silencing complex (RISC), where AGO2 cleaves

155 ctional machinery of the RNAi pathway is the RNA-induced silencing complex (RISC), wherein Argonaute2

156 tic engine of RNA interference (RNAi) is the RNA-induced silencing complex (RISC), wherein the endori

157 Argonaute proteins lie at the heart of the RNA-induced silencing complex (RISC), wherein they use s

158 ds, then assembled with proteins to form the RNA-induced silencing complex (RISC), which catalyzes ta

159 ic gene regulatory mechanism mediated by the RNA-induced silencing complex (RISC), which is composed

160 ut are defective in the production of active RNA-induced silencing complex (RISC), which mediates tar

161 Here, we integrate the RNA-induced silencing complex (RISC), which occupies mat

162 The RNA-induced silencing complex (RISC), which powers RNA i

163 or small interfering RNAs (siRNAs) form the RNA-induced silencing complex (RISC), which represses ta

164 ARGONAUTE-2 and associated miRNAs form the RNA-induced silencing complex (RISC), which targets mRNA

165 AGO7 associates with miR390 to form an RNA-Induced Silencing Complex (RISC), which triggers the

166 rough a ribonucleoprotein complex called the RNA-induced silencing complex (RISC), which, in mammals,

167 Targeted gene silencing by RNAi requires the RNA-induced silencing complex (RISC), whose core compone

168 Only one siRNA strand assembles into the RNA-induced silencing complex (RISC), with preference gi

169 -stranded RNAs (dsRNAs) and interaction with RNA-induced silencing complex (RISC)-associated AGO1/AGO

170 s C virus (HCV) replication by recruiting an RNA-induced silencing complex (RISC)-like complex contai

171 srPSTVds were biologically active in guiding RNA-induced silencing complex (RISC)-mediated cleavage,

172 A new study shows how RNA-induced silencing complex (RISC)-mediated posttransc

173 are being actively down-regulated in miRNA- RNA-induced silencing complex (RISC)-messengerRNA (mRNA)

174 d that Argonaute 2 (AGO2)-a component of the RNA-induced silencing complex (RISC)-physically interact

175 NoV B2 binds to pre-Dicer substrate RNA and RNA-induced silencing complex (RISC)-processed RNAs and

176 regulatory mechanism that is mediated by the RNA-induced silencing complex (RISC).

177 RNAs (siRNAs) before incorporation into the RNA-induced silencing complex (RISC).

178 from association with the miR-1293-specified RNA-induced silencing complex (RISC).

179 e effector of RNA interference (RNAi) is the RNA-induced silencing complex (RISC).

180 gonaute2 (Ago2), a critical component of the RNA-induced silencing complex (RISC).

181 t strand is preferentially assembled into an RNA-induced silencing complex (RISC).

182 assemble into Argonaute proteins to form the RNA-induced silencing complex (RISC).

183 (dAgo1) or human Argonaute-2 (hAgo2) of the RNA-induced silencing complex (RISC).

184 fer further insights into the working of the RNA-induced silencing complex (RISC).

185 be major groove steric effects in the active RNA-induced silencing complex (RISC).

186 RNA species that instill specificity to the RNA-induced silencing complex (RISC).

187 and the action of proteins assembled in the RNA-induced silencing complex (RISC).

188 lease, and Gemin3 helicase-components of the RNA-induced silencing complex (RISC).

189 f VIG, a part of the Drosophila melanogaster RNA-induced silencing complex (RISC).

190 cer presumably to prevent programming of the RNA-induced silencing complex (RISC).

191 iRNA) guide degradation of target RNA by the RNA-induced silencing complex (RISC).

192 (guide) strand to enhance its binding to the RNA-induced silencing complex (RISC).

193 vo, were computationally examined within the RNA-induced silencing complex (RISC).

194 This protein synthesis is regulated by the RNA-induced silencing complex (RISC).

195 nce is implemented through the action of the RNA-induced silencing complex (RISC).

196 ein AGO1, a component of the miRNA-dependent RNA-induced silencing complex (RISC).

197 endonuclease, Argonaute2 (Ago2), within the RNA-induced silencing complex (RISC).

198 ) proteins constitute a key component of the RNA-induced silencing complex (RISC).

199 y a ribonucleoprotein complex referred to as RNA-induced silencing complex (RISC).

200 estruction is catalyzed by the siRNA-guided, RNA-induced silencing complex (RISC).

201 nts of the RNA interference effector complex RNA-induced silencing complex (RISC).

202 is carried out by the small double-stranded RNA-induced silencing complex (RISC).

203 (miRNAs) to form the functional core of the RNA-induced silencing complex (RISC).

204 ediated by short (s) RNAs acting through the RNA-induced silencing complex (RISC).

205 ausing the transcripts to be degraded by the RNA-induced silencing complex (RISC).

206 ugh the activation of Argonaute 2 within the RNA-induced silencing complex (RISC).

207 rfering RNAs (siRNAs) that are active in the RNA-induced silencing complex (RISC).

208 ed from translational inhibition mediated by RNA-induced silencing complex (RISC).

209 ute 2 (AGO2), the catalytic component of the RNA-induced silencing complex (RISC).

210 ent gene silencing approach controlled by an RNA-induced silencing complex (RISC).

211 nction in RNA silencing as components of the RNA-induced silencing complex (RISC).

212 (Ago) proteins, essential components of the RNA-induced silencing complex (RISC).

213 t modulate protein expression as part of the RNA-induced silencing complex (RISC).

214 plexes devoid of essential components of the RNA-induced silencing complex (RISC).

215 reby constitute the central component of the RNA-induced silencing complex (RISC).

216 Other proteins of the RNA-induced silencing complex (RISC; SND1, PACT, and FXR

217 ore of the L1 domain to preserve the overall RNA-induced silencing complexes (RISC) architecture and

218 e expression studies on the miRNA content of RNA-induced silencing complexes (RISC) in HUVECs exposed

219 phosphorylated forms that may associate with RNA-induced silencing complexes (RISC).

220 mmon set of cellular proteins (Dicer and the RNA-induced silencing complex [RISC]) to elicit RNA inte

221 F1A is a novel component of the Ago2-centred RNA-induced silencing complexes (RISCs) and augments Ago

222 bclasses of 26G RNAs that sort into specific RNA-induced silencing complexes (RISCs) and differential

223 ximately 22 nt noncoding RNAs, assemble into RNA-induced silencing complexes (RISCs) and localize to

224 ack structures, miRNAs are incorporated into RNA-induced silencing complexes (RISCs) before targeting

225 y of microRNA ribonucleoproteins (miRNPs) or RNA-induced silencing complexes (RISCs) is essential for

226 bsequently, siRNAs are incorporated into the RNA-induced silencing complexes (RISCs) that contain Arg

227 eotide (nt) small RNAs (sRNAs) to constitute RNA-induced silencing complexes (RISCs) to regulate gene

228 RNA interference (RNAi) is mediated by RNA-induced silencing complexes (RISCs), which are guide

229 family of ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs), which can be pr

230 ed onto Argonaute proteins they can form the RNA-induced silencing complexes (RISCs), which mediate R

231 (AGO) proteins in effector complexes, termed RNA-induced silencing complexes (RISCs), which regulate

232 (Ago)-containing effector complexes known as RNA-induced silencing complexes (RISCs), which they guid

233 tructural steps of small RNA loading to form RNA-induced silencing complexes (RISCs).

234 go) proteins are essential components of the RNA-induced silencing complexes (RISCs).

235 oaded into Argonaute (AGO) proteins, forming RNA-induced silencing complexes (RISCs).

236 aute (Ago), GW182, and FXR1 proteins to form RNA-induced silencing complexes (RISCs).

237 engines of miRNA-directed gene silencing are RNA-induced silencing complexes (RISCs).

238 ) or small interfering RNAs (siRNAs) forming RNA-induced silencing complexes (RISCs/miRNPs).

239 Furthermore, we identified and validated the RNA-induced silencing complex RNA helicase MOV10 as a no

240 We performed unbiased RNA-induced silencing complex sequencing on wild-type an

241 go2 immunoprecipitation with RNA sequencing (RNA-induced silencing complex sequencing) was used for u

242 The loaded AGO-containing RNA-induced silencing complex specifically recognizes a

243 ation of Argonaute (Ago), a component of the RNA-induced silencing complex that binds miRNAs complexe

244 double-stranded RNAs is incorporated into an RNA-induced silencing complex that can either suppress p

245 Argonaute-2 (Ago2) is a key component of the RNA-induced silencing complex that mediates downregulati

246 ute proteins form the functional core of the RNA-induced silencing complexes that mediate RNA silenci

247 ger strands and facilitate the activation of RNA-induced silencing complex, the effector complex of R

248 and 5-phosphate is required for loading into RNA-induced silencing complex, the synthetic addition of

249 his prevents the programming of an antiviral RNA-induced silencing complex to avoid viral RNA degrada

250 e of messenger RNAs (mRNAs) by directing the RNA-induced silencing complex to sequence-specific targe

251 The mature miRNA guides the RNA-induced silencing complex to target RNAs with comple

252 They guide RNA-induced silencing complexes to complementary target

253 MicroRNAs (miRNAs) guide RNA-induced silencing complexes to target RNAs based on

254 Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequ

255 exosomes, deadenylases, decapping complexes, RNA-induced silencing complexes) to the 3'-untranslated

256 Target recruitment to RNA-induced silencing complex was assessed by using anti

257 t argonaute 2 (AGO2), a key component of the RNA-induced silencing complex, was a substrate of PTP1B

258 amount of siRNA at its site of action RISC (RNA-induced silencing complex) were evaluated using endo

259 ease activity, including that conferred by a RNA-induced silencing complex, which is likely the cause