ライフサイエンスコーパス: RNA

1 RNA interference (RNAi) is a natural process through whi

2 RNA oligonucleotides with a single incorporated zebulari

3 RNA polymerase II (RNA Pol II) contains a disordered C-t

4 RNA sequence analysis of pn-csERRalpha/gamma knockdown h

5 RNA-Seq profiling shows differential expression of many

6 PHIVs were on stable ART with HIV-1 RNA <400 copies/mL.

7 viral protein Gag selects full-length HIV-1 RNA from a large pool of mRNAs as virion genome during v

8 PHIV were on ART, with HIV-1 RNA levels <=400 copies/mL.

9 40 throat swabs were positive for SARS-CoV-2 RNA by quantitative PCR, suggesting community transmissi

10 umbers (>=500 copies/reaction) of SARS-CoV-2 RNA were consistently detected by the multiplex RT-qPCR.

11 piratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory samples is the standard method for di

12 e C. papaya chloroplast genome, there are 46 RNA editing loci with an average RNA editing efficiency

13 iptional modifications of ribonucleic acids (RNAs).

14 Despite their importance, ADAR RNA substrates have not been mapped extensively in vivo.

15 While m(6)A-modified adenoviral RNAs have been previously detected, the location and fun

16 t single nucleotide polymorphisms can affect RNA secondary structure, and here we show that single nu

17 t single nucleotide polymorphisms can affect RNA-protein interactions from outside binding motifs thr

18 will thus provide a general route to affect RNA biology.

19 pression regulation through the dynamic AGO2-RNA association for human neuronal development.

20 rrelated their sedimentation profiles to all RNAs, confirming known interactions and predicting new a

21 from outside binding motifs through altered RNA secondary structure.

22 scaffold with basic patches constituting an RNA-binding surface exhibiting a preference for binding

23 le X Mental Retardation Protein (FMRP) is an RNA binding protein that regulates translation and is re

24 The FinO-domain-protein ProQ is an RNA-binding protein that has been known to play a role i

25 of ~550,000 SNPs (Illumina 50 K SNP Chip and RNA-seq).

26 osteoclast ablation by denosumab (DMAb) and RNA-sequencing of bone biopsies from postmenopausal wome

27 DNA and RNA can adopt various secondary structures.

28 Translocation of DNA and RNA polymerases along their duplex substrates results in

29 tic parameters of cellular and viral DNA and RNA polymerases with respect to cellular levels of their

30 corporation of N6-methyl-(d)ATP into DNA and RNA.

31 ti-turnover enzyme; cleaves ssDNA, dsDNA and RNA targets in a single assay; and operates at elevated

32 constrained, and enriched for cis-eQTLs and RNA-binding protein (RBP) interactions.

33 odification, transcriptional regulation, and RNA processing, and thereby mediating developmental and

34 c" function, namely, the cleavage of another RNA sequence.

35 nal elements e.g. small RNAs, long antisense RNAs or untranslated regions (UTRs) of mRNA transcripts.

36 Chromatin-associated RNA (caRNA) has been proposed as a type of epigenomic mo

37 l regulates nuclear and chromatin-associated RNAs after chromosome condensation and nuclear envelope

38 Publicly available RNA-seq data is routinely used for retrospective analysi

39 here are 46 RNA editing loci with an average RNA editing efficiency of 63%.

40 Specifically, an interaction between B2 RNA and the Polycomb protein, EZH2, results in cleavage

41 results in cleavage of B2 RNA, release of B2 RNA from chromatin, and activation of thermal stress gen

42 omb protein, EZH2, results in cleavage of B2 RNA, release of B2 RNA from chromatin, and activation of

43 Our recent work demonstrated that B2 RNA binds stress genes to retard transcription elongatio

44 ay between the m6A target and a biotinylated RNA oligomer bearing a single m6A enzymatically labelled

45 during brain development, we sequenced both RNA fractions from homogenate prenatal and adult human p

46 as The Cancer Genome Atlas (TCGA), with both RNA-Seq and array-based platforms available.

47 may be applied to both single-cell and bulk RNA-seq.

48 vast and diverse virome that is dominated by RNA viruses, with major additional contributions from re

49 T, stimulates transcriptional elongation by RNA polymerase (Pol) II and regulates cell growth and di

50 of telomeres (ALT)], TERT mRNA expression by RNA-sequencing, whole-genome/exome sequencing, and clini

51 xpressed from an intron that is generated by RNA polymerase II transcribing the circular viral genome

52 per-enhancer activities can be quantified by RNA-seq and a user-friendly data portal, enabling a broa

53 of large curated datasets from human cancer RNA-Seq, where we identify novel putative biomarker gene

54 cotinamide adenine dinucleotide (NAD)-capped RNAs in mammalian cells and a role for DXO and the Nudix

55 dix hydrolase Nudt12 in decapping NAD-capped RNAs (deNADding) in cells.

56 FAP cell type was also found in single cell RNA-seq analysis in mouse.

57 The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution a

58 Using single-cell RNA sequencing coupled with high-resolution in situ hybr

59 Single-cell RNA sequencing of five TNBCs revealed two cancer-associa

60 ng disease.Methods: We performed single-cell RNA sequencing of sputum cells from nine subjects with C

61 Microarray analysis and single-cell RNA sequencing revealed that a number of cytokine-induci

62 Single-cell RNA sequencing uncovered three epicardial subpopulations

63 port for the first time in-depth single-cell RNA sequencing, combined with spatial transcriptomics an

64 Using allele-specific single-cell RNA sequencing, we here estimate the two noise component

65 Single-cell RNA-sequencing (scRNA-seq) allows us to dissect transcri

66 Using single-cell RNA-sequencing (scRNA-seq) and genetic reporter mice, we

67 we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 peripheral and

68 We analyzed previously generated single-cell RNA-sequencing (scRNA-seq) data of gastric corpus epithe

69 gy of blinding diseases, we used single-cell RNA-sequencing (scRNA-seq) to analyze the transcriptomes

70 Mechanistically, single-cell RNA-sequencing analyses of a mesenchymal niche model sho

71 viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy h

72 ession from different tissues in single-cell RNA-sequencing data.

73 ng framework, circDeep, to classify circular RNA from other lncRNA.

74 The role of circular RNAs (circRNAs) as biomarkers remains poorly characteriz

75 The long non-coding RNA NEAT1 serves as a scaffold for the assembly of paras

76 MicroRNA-27a/b are small non-coding RNAs which are reported to regulate inflammatory respons

77 or degradation of both coding and non-coding RNAs.

78 An MS-compatible RNA digestion buffer was developed to minimize the numbe

79 Among translation components, RNA association was most reduced for initiation factors

80 t into how cells and viruses use a conserved RNA phosphatase to regulate and respond to ppp-RNA speci

81 However, predicting a conserved RNA structure remains unreliable, even when using a comb

82 Compared to conventional RNA-Seq, hsRNA-Seq increased reads mapping to the Bacter

83 RIG-I-like receptors (RLR) are cytosolic RNA sensors that signal through the MAVS adaptor to acti

84 onal studies suggest that the loss of dAKAP1-RNA interactions reduces mitochondrial electron transpor

85 ce, C57BL/6J and BALB/cJ, and deploying deep RNA-Seq complemented with quantitative RT-PCR, we found

86 decreased in adr-1 mutants due to deficient RNA editing at a single adenosine in their 3'-UTR.

87 es by sculpting the transcriptome to degrade RNAs encoding growth-phase factors and, thus, support th

88 mice expressing a picornavirus RNA-dependent RNA polymerase (RdRP) outside the viral context (RdRP mi

89 ing are instead processed into RNA-dependent RNA polymerase 6-dependent small RNAs, resulting in thei

90 ssion problem, and have generated high depth RNA-sequencing on FUS mutants in parallel to FUS knockou

91 to decipher transcriptome changes under DI, RNA-seq was performed in C-76 and Val-C.

92 We applied nanopore-based direct RNA sequencing to characterize the developmental polyade

93 Here, we performed Direct RNA Sequencing (DRS) using the latest Oxford Nanopore Te

94 th coordinately and divergently to diversify RNAs.

95 eratures have measurable differences in DNA, RNA and protein composition that allow OGT prediction fr

96 input to predict binding of protein to DNA, RNA, and other proteins.

97 rminators after they are incorporated during RNA synthesis.

98 he absence of starch co-precipitation during RNA extraction resulted in enhanced yield and quality of

99 Together, our findings indicate that dynamic RNA methylation plays an important regulatory role in ol

100 ion of regional genes and a retinal enhancer RNA at this locus was assessed by qPCR.

101 havior and importance of protrusion-enriched RNAs.

102 Epitranscriptomic RNA modifications, including methylation of adenine and

103 use this underexploited resource to extract RNA and identify genes that characterize active (endocap

104 the direct enzymatic digestion of extracted RNA within the sample collection tube.

105 malization method, labeled MIXnorm, for FFPE RNA-seq data.

106 ues could be embedded in copies of the first RNA strand that is later used as a template.

107 Sixteen tape strips were collected for RNA-seq profiling from 19 infants/toddlers (<5 years old

108 al framework presented here is developed for RNA hairpin systems, the general method may be applied t

109 24 h, revealed significant changes only for RNA-binding motif 3 (Rbm3).

110 which are utilized in delivery platforms for RNA therapeutics.

111 Among all the global alignment tools for RNA 3D structures, STAR3D has become a valuable tool for

112 We launch a webserver for RNA structure prediction and design corresponding to too

113 -by-part-toward the ultimate goal of forming RNA and DNA by polymerization.

114 in response to a rise in intracellular free RNA concentrations.

115 oteins in regulating GSC division frequency, RNA-i against seven out of 35 G-protein coupled receptor

116 el molecules (UBXN4, MFSD12, and ACTR6) from RNA-seq served as potential prognostic markers for lung

117 sites nested within annotated ORFs and from RNAs previously considered noncoding, it is becoming cle

118 Further, RNA sequencing analysis revealed altered gene expression

119 fection [dpi]) and quantified viral (SIV gag RNA), synaptic (PSD-95; synaptophysin), axonal (neurofil

120 Our results suggest that Gag-RNA interactions occur at multiple RNA sites during geno

121 d region (UTR) play an important role in Gag:RNA interactions leading to genome packaging.

122 ite excitement around ProQ as a novel global RNA-binding protein, and its potential to serve as a mat

123 They also support the view that global RNA structure significantly modulates protein-RNA intera

124 Genotype-Tissue Expression Project (GTEx) RNA-seq data were used to construct the top 10% specific

125 epithelial cells using a focused dual guide RNA library targeting 852 DDR-associated genes.

126 cal applications such as the design of guide RNA for CRISPR experiments.

127 e small interfering RNAs (siRNAs) that guide RNA-directed DNA methylation.

128 eted to the CDKL5 promoter using three guide RNAs causes significant reactivation of the inactive all

129 minescence, calcium FLIPR, and short hairpin RNA-based gene-silencing assays.

130 Together our data show that DNA-PK has RNA-dependent, cNHEJ-independent functions during riboso

131 for hepatitis C were further tested for HCV RNA genotyping.

132 ng black patients, those with detectable HIV RNA, and those with lower CD4 cell counts (all P < .05).

133 of transcribing novel unspliced forms of HIV-RNA transcripts with competent open reading frames (ORFs

134 gling the effects of m(6)A on viral and host RNAs remains a challenge for the field.

135 uniquely advantageous model for studying how RNA triggers disease because: (i) Affected tissue is rou

136 However, RNA-seq has technical features that incumbent tests (e.g

137 Adenosine (A) to inosine (I) RNA editing contributes to transcript diversity and modu

138 To identify RNA binding proteins potentially driving these patterns,

139 RNA polymerase II (RNA Pol II) contains a disordered C-terminal domain (CTD

140 In RNA-Seq analyses of human brain samples from the NYGC AL

141 Finally, we observed a DNV burden in RNA-binding-protein regulatory sites (OR = 1.13, 95% CI

142 a highly interconnected network enriched in RNA-binding proteins (RBPs) and EV cargoes.

143 fic gene deletion of Traf3ip3 have increased RNA virus-triggered IFN-I production and reduced suscept

144 er groups, thereby liberating the individual RNA components for further analysis.

145 ny other regulatory mechanisms can influence RNA metabolism and the capacity of neurons to adapt.

146 ncing and the other configuration inhibiting RNA unwinding compared with the unconstrained protein.

147 (lncRNA) that we named Stem Cell Inhibitory RNA Transcript (SCIRT), which was markedly upregulated i

148 Integrated RNA sequencing, metabolomics, and molecular analyses sho

149 Through these interactions, RNAs mediate cellular processes such as the regulation o

150 se genes is ablated by p63 small interfering RNA as well.

151 RNAi) by topically applied small interfering RNA has potential applications for plant functional geno

152 ial use of allele-specific small interfering RNA in treating KID syndrome and other dominant genetic

153 letion of Mm47, as well as small interfering RNA studies in mice primary macrophages, showed that the

154 Notably, allele-specific small interfering RNA treatment caused only low-level off-target effects i

155 R-LIKE3 into 24-nucleotide small interfering RNAs (siRNAs) that guide RNA-directed DNA methylation.

156 of NAD(+) capping are instead processed into RNA-dependent RNA polymerase 6-dependent small RNAs, res

157 ctive triphosphate form of RDV (RDV-TP) into RNA.

158 udies show that PGC-1alpha binds to intronic RNA sequences, some of them controlling transcript level

159 dered proteins (IDPs) and nucleic acids like RNA and other polynucleotides play a key role in modulat

160 eumatoid arthritis to allow for longitudinal RNA sequencing (RNA-seq).

161 The Malat1 RNA is responsible for these effects, as antisense oligo

162 and its potential to serve as a matchmaking RNA chaperone, significant gaps remain in our understand

163 ypothesize a scenario where levels of mature RNA species or editing in the single T. cruzi mitochondr

164 We report that MCMV RNA contains a cap-independent translation element (CITE

165 oRNA (miRNA) target sites within a messenger RNA (mRNA) can act cooperatively, leading to more repres

166 e spliceosome removes introns from messenger RNA precursors (pre-mRNA).

167 scriptional regulation of AR mRNA (messenger RNA) in CRPC.

168 ne piRNA precursor transcripts and messenger RNAs encoding piRNA biogenesis factors.

169 We analyzed levels of messenger RNAs (mRNAs) encoding proteins involved in autophagy in

170 e blood cells (PWBCs), and circulating micro RNAs in plasma, are associated with female fertility, me

171 powerful technology for globally monitoring RNA translation; ranging from codon occupancy profiling,

172 that Gag-RNA interactions occur at multiple RNA sites during genome packaging; furthermore, there ar

173 Using nascent RNA sequencing, we show that an AS15 analogue triggers t

174 Noncoding RNA molecules have been implicated in critical roles cov

175 atively controlled by a novel long noncoding RNA (lncRNA) that we named Stem Cell Inhibitory RNA Tran

176 In this review, we focus on noncoding RNA-based studies conducted mainly in large-animal model

177 to selectively regulate coding and noncoding RNAs.

178 d, hence, expression of coding and noncoding RNAs.

179 eIF4E's association with noncoding RNAs strongly positions it to act beyond translation.

180 w that it efficiently crosslinks noncovalent RNA complexes with mimimal sequence bias and establish t

181 es of TRAMP components with multiple nuclear RNA binding proteins, revealing preferential colocalizat

182 Bioinformatics analysis of RNA sequencing data identifies non-productive splicing e

183 Analysis of a combination of RNA-seq, Capture Hi-C, and patient survival data suggest

184 sRNA delivery could increase the efficacy of RNA interference in insect pest species.

185 The initiation of RNA interference (RNAi) by topically applied small inter

186 Unlike mechanisms of RNA stabilization that depend on direct competition for

187 on resulted in enhanced yield and quality of RNA with RIN values of 7-9, quantified using a bioanalyz

188 robably through promoting the recruitment of RNA polymerase II to their promoters.

189 l growth control as the central regulator of RNA polymerase (Pol) III activity.

190 ive, similar to known negative regulators of RNA editing.

191 sphorylation in RPB1, the largest subunit of RNA polymerase (pol) II.

192 those that measure total cellular uptake of RNA therapeutics, which includes both productive and non

193 te that DXO also catalyzes the hydrolysis of RNAs bearing a 5'-hydroxyl group (5'-OH RNA).

194 ptamer generation, site-specific labeling of RNAs, semi-synthetic organism creation, and unnatural-am

195 s of RNAs bearing a 5'-hydroxyl group (5'-OH RNA).

196 PLP-1 orthologs localized on RNA granules may similarly contribute to germline gene s

197 review, we address how a broadly operational RNA regulatory complex interfaces with cell type-specifi

198 a noncanonical secondary structure of DNA or RNA which can enhance or repress gene expression, yet th

199 l method may be applied to investigate other RNA systems, such as multiway junctions or pseudoknots i

200 n corresponding to tools developed using our RNA-As-Graphs (RAG) approach.

201 ene carrying the same code as the particular RNA of interest.

202 characterise physiological and pathological RNA targets of FUS.

203 of peripheral blood mononuclear cells (PBMC) RNA from subjects enrolled in the Clinical Trials in Org

204 f NF-kB, P-TEFb, and serine 2 phosphorylated RNA Polymerase II on the HEXIM1 gene.

205 at transgenic mice expressing a picornavirus RNA-dependent RNA polymerase (RdRP) outside the viral co

206 A phosphatase to regulate and respond to ppp-RNA species.

207 mpetition for binding sites among protective RNA-binding proteins and decay factors, PTBP1 promotes d

208 NA structure significantly modulates protein-RNA interaction dynamics and can facilitate real-time co

209 and MRP are highly conserved, multi-protein/RNA complexes with essential roles in processing ribosom

210 The dimeric complexes on Psi RNA require an intact dimer interface within Gag.

211 ation, we detected a higher abundance of PUN RNA in the cytoplasm compared to wild-type-infected cell

212 ion of full-length transcripts in short-read RNA-Seq data, which encourages the development of method

213 Compared to previous SBT methods, on real RNA-seq data, HowDe-SBT can construct the index in less

214 per we develop methods to add signal to real RNA-seq datasets.

215 We also compare these methods using real RNA-seq data from a study of major depressive disorder.T

216 Here, we globally identify ZMAT3-regulated RNAs and their binding sites at nucleotide resolution in

217 Y exerts its effect through small regulatory RNAs (sRNAs).

218 tly exploits the tendency of UPF1 to release RNA upon ATP binding and hydrolysis.

219 implemented a parallel detection of reporter RNAs.

220 Bacterial 16S ribosomal RNA analyses were performed on stool samples from 405 HI

221 16S ribosomal RNA gene sequencing was performed on sputum from 253 cli

222 low dietary fiber intake using 16S ribosomal RNA-based approaches.

223 NSP1 binds to 18S ribosomal RNA in the mRNA entry channel of the ribosome and leads

224 as that encoding the small subunit ribosomal RNA has revealed the extensive diversity of bacterial li

225 upon simultaneous hybridization to the same RNA target strand, serving here as a template.

226 Furthermore, Dicer cleaves all satellite RNAs in conjunction with MIWI.

227 Some negative-sense RNA viruses prime mRNA transcription using host 5' cap s

228 o use these three metrics to select sensible RNA-seq pipelines for the improved accuracy, precision,

229 is to allow for longitudinal RNA sequencing (RNA-seq).

230 th chromatin immunoprecipitation sequencing, RNA sequencing, and expression quantitative trait loci d

231 dentify cell types using multiplexed in situ RNA detection.

232 5582 results in the induction of HIV and SIV RNA expression in the blood and tissues of ART-suppresse

233 Small RNAs (sRNAs) regulate gene expression, play important ro

234 A-dependent RNA polymerase 6-dependent small RNAs, resulting in their continued turnover likely to fr

235 on-coding but functional elements e.g. small RNAs, long antisense RNAs or untranslated regions (UTRs)

236 g of the nuclear Argonaute NRDE-3 with small RNAs that normally effect maternal piRNAs, which prevent

237 chains of nucleic acids that target specific RNA transcripts through several mechanisms.

238 selectivity to discriminate against specific RNAs.

239 ity to preferentially interact with specific RNAs, Rrp6p utilizes its selectivity to discriminate aga

240 tive fold for RNase P to bind and mature SRP RNA co-transcriptionally.

241 es from the NYGC ALS cohort, truncated STMN2 RNA was confined to tissues and disease subtypes marked

242 iting a preference for binding double-strand RNA (dsRNA) over single-strand RNA (ssRNA).

243 double-strand RNA (dsRNA) over single-strand RNA (ssRNA).

244 atural process through which double-stranded RNA molecules can silence the gene carrying the same cod

245 to-5' exoribonucleases to degrade structured RNA during several forms of environmental stress.

246 ture, and function are similar in structured RNA and proteins.

247 prokaryotic expression profiling by tagging RNA in situ and sequencing (PETRI-seq)-a low-cost, high-

248 d suggest combination treatments that target RNA processing and DNA repair pathways simultaneously as

249 Small-molecule targeted RNA degradation will thus provide a general route to aff

250 passage, the nuclear stability of telomerase RNA no longer depends on Mex67.

251 rally, they provide additional evidence that RNA virus IBs are important immunomodulatory complexes w

252 The RNA exosome is an essential ribonuclease complex require

253 Here, we compared the RNA-sequenced transcriptomes of ~100 laser captured micr

254 Thus, REPAIRx markedly expands the RNA editing toolkit and illustrates a novel strategy for

255 Interestingly, DNA flanking the RNA-5' side of R-loops is not intrinsically unstable.

256 ncRNA genes, revealing new insights into the RNA structure-function relationship, determining cis- an

257 5, which encodes a structural subunit of the RNA exosome.

258 xperiments, we introduce an extension of the RNA velocity method that leverages estimates of unproces

259 In the light of the RNA world scenarios, it is an interesting question, if c

260 Here, we report the identification of the RNA-binding protein HuR/ELAVL1 as a central oncogenic dr

261 We show that the phosphorylation of the RNA-DNA binding protein fused in sarcoma (FUS) is higher

262 ive orientations had opposite effects on the RNA-unwinding activity of the N-terminal cassette, with

263 alyses of representative genes validated the RNA-Seq results.

264 dy, we analyze the folding stability of this RNA genome relative to the structural landscape of other

265 Here we present Hybridization of Probes to RNA for sequencing (HyPR-seq), a method to sensitively q

266 of medically important mites based on total RNA sequencing data sets generated in this study as well

267 C200 by transfection of in vitro transcribed RNA and transient expression from transfected plasmids.

268 depend on the presence of co-transcriptional RNA/DNA hybrids (R-loops) that form in infected cells du

269 The role of post-transcriptional RNA modification is of growing interest.

270 Due to differential transfer RNA supply within the cell, synonymous codons are not us

271 tic perturbations causing uncharged transfer RNA (tRNA) accumulation activated ISR reporter transcrip

272 sly undescribed CRISPR-Cas systems, transfer RNAs (tRNAs), tRNA synthetases, tRNA-modification enzyme

273 cleotide addition, can stimulate translesion RNA synthesis by Escherichia coli RNAP without altering

274 unctions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellula

275 These studies demonstrate a strategy to tune RNA structure-targeting compounds to the cellular locali

276 ity is independent of the nucleic acid type (RNA or DNA), its strandedness (single or double), and it

277 Using RNA sequencing and drug screening, we find that treatmen

278 Using RNA-seq and ChIP-seq approaches we identified genes regu

279 Using RNA-seq profiling of the intima of lesions, here we iden

280 Gene expression was analyzed using RNA-Seq and RT-PCR.

281 gene expression associated with CUD by using RNA sequencing of dorsal-lateral prefrontal cortex neuro

282 of G12D and G12V mice were identified using RNA sequencing and reverse-phase protein array analyses.

283 cyte-derived macrophages and microglia using RNA sequencing.

284 chorioamniotic membranes were studied using RNA microarray and immunohistochemistry.

285 We addressed this using RNA sequencing metagenomics(4-6) of placental samples fr

286 ng E1B55K or E4orf6 display defects in viral RNA processing and protein production, but previously id

287 unctionally redundant binding sites in viral RNA.

288 ) exhibited similar plaque morphology, viral RNA profile, and replication kinetics.

289 HIV-1 reverse transcription, in which viral RNA genome is converted into double-stranded DNA, is tha

290 ructural landscape of other well-known viral RNAs.

291 L significantly increased the level of viral RNAs without altering the level of cccDNA.

292 We investigated the role of in vivo RNA secondary structure in miRNA cleavage by developing

293 fects in KID-KCs, as detected by genome-wide RNA sequencing.

294 during development, we performed genome-wide RNA tomography sequencing on zebrafish, chicken, mouse,

295 to form stress granules by coacervating with RNA in the cytoplasm during stress and may be involved i

296 tion, if charge transfer can be coupled with RNA function.

297 ecular mechanisms ProQ uses to interact with RNA.

298 We describe the well-known interactions with RNA polymerase as well as a broader range of cellular ta

299 Here, we integrate SVs with RNA-sequencing from human post-mortem brains to quantify

300 epeat deficient Xist rescues binding of Xist RNA to Spen and results in strictly local gene silencing