ライフサイエンスコーパス: RNAi

1 RNAi analysis of other SAGA complex components shows tha

2 RNAi and rescue experiments show that PDF from these cel

3 RNAi based suppression of BjuGalpha1 displayed compromis

4 RNAi depletion of the Cmi (also known as Lpt) subunit th

5 RNAi is being developed as a tool for integrated pest ma

6 RNAi knockdown of microsomal prostaglandin E synthase-1,

7 RNAi mediated silencing of pectin degrading enzyme of R.

8 RNAi pathways are also involved in suppressing sex ratio

9 RNAi plants of TaABCB1 gene resulted in reduced plant he

10 RNAi reduction of Se-sEH interfered with hemocyte-spread

11 RNAi silenced lines of S. viridis (SvBAHD05) presented a

12 RNAi suppression of MSH1 results in phenotype variabilit

13 RNAi targeting ZC3H5 causes accumulation of precytokinet

14 RNAi-5x was applied either as double-stranded RNA (dsRNA

15 RNAi-5x-specific siRNAs were significantly, three to fiv

16 RNAi-mediated depletion of JNK pathway components inhibi

17 RNAi-mediated FOXF1 silencing in LR-MSCs was associated

18 RNAi-mediated knock-down of PcGSS1 and PcGSS2 expression

19 RNAi-mediated knockdown of Caenorhabditis elegans bcat-1

20 RNAi-mediated knockdown of Of-odd-skipped, paired and sl

21 RNAi-mediated knockdown of PERK or eIF2alpha abrogated t

22 RNAi-mediated knockdown of Ya genes reduces M. persicae

23 RNAi-mediated MELK depletion impairs growth and causes G

24 RNAi-mediated rnh1 knockdown did not influence growth or

25 RNAi-mediated transient and stable silencing of PDC1 exp

26 ferent approaches to suppress progeny, pop-1 RNAi was used to avoid FUdR use.

27 drial hyperactivity," is required for bcat-1(RNAi) neurotoxicity.

28 A one-time injection of AAV9-M7.8L RNAi in 3-day-old humanized regulatory light chain mutan

29 dule lengthened period similarly to Nipped-A RNAi knockdown and weakened rhythmicity, whereas reducin

30 and produce double-stranded RNA to activate RNAi and repress host gene expression, thereby altering

31 function in Caenorhabditis elegans activates RNAi-directed silencing via induction of a pathway homol

32 ost after exoglycosidase treatment and after RNAi-based silencing of TbSTT3A, the oligosaccharyltrans

33 An RNAi loss-of-function screen in breast cancer cells targ

34 An RNAi screen on splicing factors identified the little st

35 By deploying an RNAi-based genetic screen for bak1/serk4 cell death supp

36 Here we develop an RNAi-RbcS tobacco (Nicotiana tabacum) master-line, tobRr

37 To address this caveat, we generated an RNAi suppressor-defective mutant of invertebrate iridesc

38 We screened an RNAi library targeting ubiquitin E3 ligases and observed

39 Through an RNAi screen and generation of a lentigenic mouse, we fou

40 Through an RNAi screen, we identified FBXO44 as an essential repres

41 Through an RNAi-based screen, we identified a gene, pdm3, required

42 Here, resorting to an RNAi screen in Drosophila for suppressors of a constitut

43 Using an RNAi approach, we find that HDAC2, but not HDAC1, inhibi

44 To test this hypothesis, we utilized an RNAi strategy to directly downregulate PV levels in the

45 ll plant lineages, very few studies analysed RNAi mechanisms with this respect.

46 bination of CRISPR-mediated gene editing and RNAi-mediated gene silencing in human cells, here we ana

47 trolled by MAFG and observe that genetic and RNAi-mediated LincIRS2 loss causes elevated blood glucos

48 Using a small kinase inhibitor and RNAi-based gene silencing to disrupt EPHB4 activity, we

49 Meiosis- and RNAi-related genes often coamplify on recently formed X

50 ed pluripotent stem cell-derived neurons and RNAi-based knockdown in Drosophila models.

51 d Electron microscopy, quantitative PCR, and RNAi-mediated depletion, we report here that the ELYS or

52 discoveries on these key roles of sRNAs and RNAi machinery.

53 Kalanchoe guard cells, both in wild-type and RNAi mutants with impaired Mal metabolism.

54 (PBac) transposon insertion in the 3'UTR and RNAi flies, we determined that fly rrp4 was also essenti

55 /7-defective mutants because of an antiviral RNAi response to dsRNA.

56 Viruses evade antiviral RNAi by expressing virulence factors known as viral supp

57 de (AMP) genes but dispensable for antiviral RNAi.

58 from its previously known role in antiviral RNAi.

59 ing evidence for the regulation of antiviral RNAi by the jasmonate hormone signaling in plants.

60 s DCV replication independently of antiviral RNAi, and VINR-knockout adult flies exhibit enhanced dis

61 r and viral factors that impact on antiviral RNAi and the contexts in which this system might be at p

62 e viral suppression of the primary antiviral RNAi immunity.

63 is the use of a 'green' alternative known as RNAi, which involves the delivery of siRNAs that downreg

64 tic screens in mammalian cell lines, such as RNAi and CRISPR-Cas9 screens, have made major contributi

65 modulation with other technologies, such as RNAi and genome editing.

66 denine phosphoribosyltransferase (APT)-based RNAi technology (APTi) in Physcomitrella patens that imp

67 Here, we apply an imaging-based RNAi phenotypic cell migration screen using two highly m

68 Using a microscopy-based RNAi screen, here we identified an important role of the

69 We posit that interplay between RNAi and Polycomb repression is a widely conserved pheno

70 By RNAi and RNA-seq in resistant cells, we found that the A

71 Silencing of H. schachtii ACC by RNAi induced similar phenotypes and thus mimics the effe

72 K36me3 and that in cells MINA53 depletion by RNAi also increases the local level of H3K36me3 at LTR.

73 ther validated using knockdown of DvABCB1 by RNAi which rendered WCR larvae insensitive to a Cry3A to

74 lyzing stably controlled KDM5B expression by RNAi or doxycycline-induced overexpression.

75 Impeding Sh1 growth by RNAi to cofilin and Arp2/3 perturbed the DTC-Sh1 interfa

76 In dynamin 1-depleted MPCs by RNAi, alpha-tubulin showed a dispersed linear filament-l

77 y decreases when EpCAM levels are reduced by RNAi.

78 In addition, knock down of RSK by RNAi in Aplysia sensory neurons impairs LTF, suggesting

79 Targeting SIRT1 by RNAi led to elevated H3 lysine 9 acetylation on the prom

80 butable to the down-regulation of MpNa(v) by RNAi.

81 advantages of gene depletion by CRISPR-Cas9, RNAi, or conditional knockout for melanoma modeling.

82 loxane slab-based approach to confine cells, RNAi-based vimentin silencing, vimentin overexpression,

83 though absent from Saccharomyces cerevisiae, RNAi is present in other budding-yeast species, includin

84 lines of chilli and tomato expressing CgCOM1-RNAi construct employing Agrobacterium-mediated transfor

85 idopsidis sRNA (HpasRNA) functionality in ck-RNAi, we designed a novel CRISPR endoribonuclease Csy4/G

86 ence are established, the significance of ck-RNAi in distinct plant pathogens is not clear.

87 m, a mechanism termed cross-kingdom RNAi (ck-RNAi).

88 The Ck1alpha(RNAi) -induced WC defect is related to adherens junction

89 es in variants of the two strains containing RNAi-sensitizing mutations.

90 With a high-content RNAi imaging screen targeting more than 2,000 human lncR

91 exes weeks after dosing, enabling continuous RNAi activity over time.

92 CsCLV3-RNAi led to increased number of petals and carpels, wher

93 Meanwhile, CsIVP-RNAi plants were more resistant to downy mildew and accu

94 ves upon the multiple limitations of current RNAi techniques.

95 able element silenced by the Dicer-dependent RNAi pathway.

96 On the other hand, two different RNAi sequences that modulate the CCAAT/enhancer-binding

97 retrotransposons is dependent on downstream RNAi factors and P granule components but is independent

98 Muscle-restricted dpp RNAi promotes foraging and feeding initiation, whereas d

99 In Drosophila, RNAi mediated knockdown of Alk led to decreased triglyce

100 Through a DUB RNAi screen, we found OTUD5 as a specific stabilizer of

101 of ER association with astral MTs in dynein RNAi cells, revealing activation of an M-phase specific

102 targeted using allele-specific gene-editing, RNAi, or small-molecule approaches.

103 In Caenorhabditis elegans, RNAi can be achieved by feeding worms bacteria carrying

104 Enhanced RNAi triggered by mitochondrial dysfunction is necessary

105 NA sequencing is useful to compare exogenous RNAi delivery methods on peanut plants, and to analyze t

106 e vulnerabilities, we perform kinase-focused RNAi screens and uncover that SMARCA4-deficient SCCOHT c

107 n RNAs targeting GHSR (or a control AAV) for RNAi-mediated VAN-specific GHSR knockdown.

108 issection revealed that Mkt1 is required for RNAi-mediated post-transcriptional silencing, downstream

109 oding RNAs, including short hairpin RNAs for RNAi experiments and guide RNAs for CRISPR-mediated geno

110 have revealed additional conserved roles for RNAi proteins, such as Argonaute and Dicer, in chromosom

111 xogenous application of five gene fragments (RNAi-5x) related to aflatoxin biosynthesis in Aspergillu

112 Small interfering RNAs (siRNAs) derived from RNAi-5x were significantly more abundant at 48 h than at

113 Further, RNAi-mediated MELK depletion impairs proliferation of mu

114 We performed a high-throughput whole-genome RNAi screen to identify novel inhibitors of ciliogenesis

115 During microbial infection, host RNAi machinery is highly regulated and contributes to re

116 pacity of SmedTV to evade normal host immune/RNAi defenses under standard conditions, argues that fur

117 ells and immunofluorescence, immunoblotting, RNAi, subcellular fractionation, co-immunoprecipitation

118 Due to breakthroughs in RNAi and genome editing methods in the past decade, it i

119 APTi represents a fundamental improvement in RNAi technology and will contribute to the growing deman

120 be acting independently of its known role in RNAi.

121 are effector molecules of gene silencing in RNAi, and their modulation can lead to a wide response i

122 nogaster Using several approaches, including RNAi-mediated gene silencing, RNA-Seq- and quantitative

123 xpression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, s

124 a flexible choice between RNA interference (RNAi) and CRISPR-Cas9 genome editing for perturbation of

125 ntrol RNA viruses, such as RNA interference (RNAi) and Imd pathways.

126 fferent neuron types using RNA interference (RNAi) and mutants.

127 The RNA interference (RNAi) and PIWI-interacting RNA (piRNA) pathways, the ger

128 tions of recurrent loss of RNA interference (RNAi) and/or heterochromatin components on the trajector

129 Therefore, an RNA interference (RNAi) approach was adopted to reduce the expression of a

130 la x tremuloides) using an RNA interference (RNAi) approach.

131 The initiation of RNA interference (RNAi) by topically applied small interfering RNA has pot

132 iously, we have shown that RNA interference (RNAi) can prevent aflatoxin accumulation in transformed

133 RNA interference (RNAi) enables flexible and dynamic interrogation of enti

134 gether with the endogenous RNA interference (RNAi) factor ERI-6/7, a homolog of MOV10 helicase, a ret

135 Gene silencing by RNA interference (RNAi) has emerged as a powerful treatment strategy acros

136 alvi, to induce eukaryotic RNA interference (RNAi) immune responses.

137 RNA interference (RNAi) is a gene-silencing pathway that can play roles in

138 RNA interference (RNAi) is a natural process through which double-stranded

139 RNA interference (RNAi) is a valuable reverse genetics tool used in functi

140 RNA interference (RNAi) is a valuable technique to determine gene function

141 RNA interference (RNAi) is an antiviral pathway common to many eukaryotes

142 RNA interference (RNAi) is an effective way of combating shrimp viruses by

143 Because RNA interference (RNAi) is increasingly explored for commercial applicatio

144 RNA interference (RNAi) of SE51385 prevented down-regulation of immune res

145 he core steps of antiviral RNA interference (RNAi) pathway in plants and animals.

146 characterized in Entamoeba RNA interference (RNAi) pathway proteins, including Argonaute, were also p

147 n and the germline nuclear RNA interference (RNAi) pathway, as well as MET-2 and SET-32, which direct

148 Inactivation of the RNA interference (RNAi) pathway, which suppresses TE movement in many orga

149 iological mechanism of the RNA interference (RNAi) pathway.

150 insects is mediated by the RNA interference (RNAi) pathway.

151 Nuclear RNA interference (RNAi) pathways work together with histone modifications

152 imilar phenotypes as CsIVP-RNA interference (RNAi) plants, including disturbed vascular configuration

153 In plants, RNA interference (RNAi) plays a pivotal role in growth and development, an

154 The RNA interference (RNAi) process encompasses the cellular mechanisms by whi

155 In Caenorhabditis elegans, RNA interference (RNAi) responses can transmit across generations via smal

156 e factors from cells using RNA interference (RNAi) results in myosin II-dependent unzipping of cadher

157 dentified in a genome-wide RNA interference (RNAi) screen and confirmed in primary human small airway

158 From an RNA interference (RNAi) screen for regulators of intestinal stem cell (ISC

159 we describe a large-scale RNA interference (RNAi) screen in adult Schistosoma mansoni that examined

160 romic repeats (CRISPR) and RNA interference (RNAi) screens, and these have provided a wealth of knowl

161 RNA interference (RNAi) targeted to the SmedTV sequence led to apparent cu

162 Using RNA interference (RNAi) to suppress isoprene emission, we show that this t

163 regeneration, postmitotic RNA interference (RNAi) was performed and dendrites or axons were removed

164 RNA interference (RNAi), a cellular process through which small RNAs targe

165 defense through antiviral RNA interference (RNAi), but less is known about its role in regulating tr

166 al alternatives, including RNA interference (RNAi), have been proposed in recent years to control ins

167 ty of WCR larvae by DvSSJ1 RNA interference (RNAi), we characterized transgenic plants expressing DvS

168 proceeded normally at the RNA interference (RNAi)-dependent element cenH but subsequent propagation

169 We demonstrate that RNA interference (RNAi)-mediated AeAmt1 protein knockdown leads to signifi

170 RNA interference (RNAi)-mediated downregulation of SlLHP1b advanced ripeni

171 RNA interference (RNAi)-mediated gene silencing revealed that a certain su

172 ernative option to mediate RNA interference (RNAi).

173 ct and modify them through RNA interference (RNAi).

174 fected by dicer-2-mediated RNA interference (RNAi).

175 f 15 candidate genes using RNA interference (RNAi): all affected life span and/or micro-environmental

176 used in future validation studies involving RNAi/overexpression approaches.

177 ungal pathogen Cryptococcus deuterogattii is RNAi-deficient and lacks active transposons in its genom

178 ration in backgrounds containing kinetochore RNAi transgenes.

179 t organism, a mechanism termed cross-kingdom RNAi (ck-RNAi).

180 f chitin-induced calcium spiking in the Lyk5-RNAi background.

181 ll lines and integrated non-Burkitt lymphoma RNAi screens and genetic data.

182 This symbiont-mediated RNAi approach is a tool for studying bee functional geno

183 arasitic Varroa mites by triggering the mite RNAi response.

184 By guiding chromatin modification, RNAi components promote chromosome segregation during bo

185 Moreover, RNAi knockdown of the Drosophila CLP1 orthologue, cbc, p

186 eed for a rigorous safety assessment of nano-RNAi products prior to deployment.

187 Additionally, neuronal RNAi-mediated knockdown of Cdk8 in flies results in semi

188 ospects for future advances, including novel RNAi pathway agents utilizing mechanisms beyond post-tra

189 Nuclear RNAi provides a highly tractable system to study RNA-med

190 omatin mark, H3K23me3, is induced by nuclear RNAi at both exogenous and endogenous targets in C. eleg

191 transcripts requires the host factor nuclear RNAi-defective 2 (NRDE2), which has previously been repo

192 Argonaute, hrde-1, are required for nuclear RNAi-induced H3K23me3 in vivo.

193 Both set-32 and the germline nuclear RNAi Argonaute, hrde-1, are required for nuclear RNAi-in

194 In the germline, nuclear RNAi can lead to trans-generational epigenetic inheritan

195 e strength and target specificity of nuclear RNAi in C. elegans, ensuring faithful inheritance of epi

196 rmine the potency and specificity of nuclear RNAi responses by gating small RNAs into specific nuclea

197 lly, they are negative regulators of nuclear RNAi triggered from exogenous sources.

198 that the regulation and function of nuclear RNAi-mediated heterochromatin are highly complex.

199 show that small RNAs, acting via the nuclear RNAi machinery and an HP1-like protein, are capable of d

200 lear-localized small RNAs engage the nuclear RNAi machinery to regulate gene expression and direct th

201 tional chromatin modification in the nuclear RNAi pathway and provides the field with a new target fo

202 histone mRNAs are misrouted into the nuclear RNAi pathway involving the Argonaute HRDE-1, concurrent

203 chromatin, likely acting through the nuclear RNAi pathway.

204 that were comparable to previously observed RNAi-mediated depletion of SETD1A.

205 lications, the risk and safety assessment of RNAi-based genetically modified plants is also elucidate

206 c 5'-to-3' exoribonuclease, as a cofactor of RNAi in budding yeast.

207 Methods for the delivery of RNAi effectors into plants, such as the carbon dot formu

208 this technology is the efficient delivery of RNAi effectors into the cell.

209 he foundation for non-transgenic delivery of RNAi in controlling aflatoxins in peanut.

210 ey advances in the design and development of RNAi drugs leading up to this landmark achievement, the

211 In 2006, the discovery of RNAi was awarded the Nobel Prize in Medicine and its suc

212 A brief overview on the discovery of RNAi, its mechanism, and limitations are included.

213 dings have implications for the evolution of RNAi since the last eukaryotic common ancestor, and they

214 important information about the existence of RNAi machinery and key genes of R. solani which can be t

215 ide a more complete view of the functions of RNAi.

216 The induction of RNAi also requires the conserved RNA decapping enzyme EO

217 gs provide new insight into the mechanism of RNAi-mediated post-transcriptional silencing in fission

218 In this review, the potential of RNAi in the field of organ transplantation will be discu

219 hallenge hampering the exciting potential of RNAi therapeutics in ophthalmology is to find an effecti

220 stablishing survival itself as a reporter of RNAi.

221 how the feasibility, efficacy, and safety of RNAi therapeutics directed towards human restrictive car

222 pite two decades of study, the full scope of RNAi in mammalian cells has remained obscure.

223 entified the 340R protein as a suppressor of RNAi.

224 pathogen Phytophthora encodes suppressors of RNAi (PSRs), which enhance plant susceptibility.

225 ulence factors known as viral suppressors of RNAi (VSR).

226 Use of RNAi to induce ROS production in the brain recapitulates

227 host while avoiding endogenous antiviral or RNAi mechanisms.

228 tosis was reduced ~70%, and ETS1 deletion or RNAi-mediated BCL-xL suppression increased apoptosis.

229 ied either as double-stranded RNA (dsRNA) or RNAi plasmid DNA (dsDNA).

230 Furthermore, pharmacological or RNAi inhibition of the mevalonate pathway restricts the

231 pendencies in Burkitt lymphoma, we performed RNAi-based, loss-of-function screening in eight Burkitt

232 By performing RNAi experiments for three poorly investigated EGFR isof

233 r-1 replicated many phenotypes from previous RNAi-based studies and discovered a new sperm-specific r

234 In particular, PttCLE47 RNAi trees exhibited a narrower secondary xylem zone wit

235 Unexpectedly, robust RNAi-mediated depletion of TORC1 components caused arres

236 tion protein gammaTubulin was reduced in Ror RNAi neurons, and this effect was strongest during dendr

237 lution studies that will benefit large-scale RNAi and drug screens and in systems beyond C. elegans e

238 ened several MRT cell lines with large-scale RNAi, CRISPR-Cas9, and small-molecule libraries to ident

239 knowledge with large-scale drug sensitivity, RNAi, and CRISPR-Cas9 screening data from 460 cell lines

240 Similarly, RNAi-mediated knockdown of Tom70 in the developing eye c

241 siRNA/RNAi-mediated knockdown in healthy human iPSC-derived ca

242 es were significantly upregulated in SlLHP1b RNAi fruits and downregulated in overexpressing fruits c

243 Tissue-specific RNAi targeting these genes also caused severe WC defects

244 IV-1 IN degradation, we performed a targeted RNAi screen using a library of siRNAs against all compon

245 easurements of cell stiffness, we found that RNAi-mediated depletion of vimentin increases LBBM by ~5

246 We observed that RNAi-mediated dElys depletion leads to aberrant developm

247 We further show that RNAi depletion of IL-17RD enhances Toll-like receptor an

248 We show that RNAi depletion of KIF14 specifically leads to defects in

249 Here we show that RNAi pathways play a key role in maintaining germline ge

250 th telomeric sequences and here we show that RNAi-mediated depletion of TbPolIE transcripts results i

251 Small RNAs and the RNAi machinery also participate in the resolution of DNA

252 sequent processing of the transcripts by the RNAi machinery are required for heterochromatin assembly

253 mut-16 mutants, lacking a key protein in the RNAi pathway, at elevated temperature we found that gene

254 mostly in the male germline, misdirects the RNAi response to transposable elements and impairs TEI.

255 Phenotyping of the RNAi nematodes indicated that all tested genes decrease

256 Segregation of the RNAi transgene produces non-genetic msh1 'memory' with m

257 on's function depends on the identity of the RNAi-targeted gene.

258 These findings indicate that the RNAi pathway plays a key role in preventing aberrant exp

259 Indeed, by using the RNAi and overexpression strategies, we found that human

260 next step for the progression of therapeutic RNAi applications beyond liver.

261 These RNAi sequences were covered by subsequent layers of poly

262 Through RNAi screening, we identify akt1 and a previously unchar

263 nducibly lose developmental capacity through RNAi-mediated silencing of the QS signaling machinery ("

264 Gene silencing through RNAi has been used successfully in a broad range of dise

265 onents of the complement-like system through RNAi largely restores ookinete-to-oocyst transition but

266 s of R. solani which can be targeted through RNAi to develop pathogen-derived resistance, thus openin

267 argeted gene knockouts and a high-throughput RNAi assay enabled the first characterisation of the los

268 r morphology, we conducted a high-throughput RNAi screen to identify epigenetic regulators that are r

269 Worms subjected to RNAi against M01F1.3 and ZC410.7 manifest larval arrest

270 eat-2, and daf-16) and animals subjected to RNAi knockdown of age-related genes (age-1 and daf-16).

271 First discovered in 1998, today RNAi represents the foundation underlying complex biolog

272 CgCOM1 siRNA in transgenic chilli and tomato RNAi lines was confirmed by stem-loop RT-PCR.

273 arious tumor-inhibitory effects of transient RNAi-mediated depletion of NRP1, NRP2 and GIPC1, alone o

274 ilizing mechanisms beyond post-translational RNAi silencing.

275 randed RNA molecules can efficiently trigger RNAi silencing of specific genes, but their therapeutic

276 Through an unbiased RNAi screen, knockdown of OTUD5 is shown to significantl

277 53 in tumor suppression, we perform unbiased RNAi and CRISPR-Cas9-based genetic screens in vivo.

278 We analyzed expression patterns and used RNAi-based methods to investigate the functions of homol

279 In this study we have used RNAi technology to show, for the first time, that the in

280 ree of them were functionally analyzed using RNAi.

281 Finally, using RNAi and haplotype-resolved Hi-C, we show that disruptio

282 ockdown of Basigin in perineurial glia using RNAi results in significant shortening of the ventral ne

283 Genetically inhibiting MLC1 in GSCs using RNAi-mediated gene silencing results in diminished growt

284 Here using RNAi, endogenous epitope tagging, immunofluorescence mic

285 Here, using RNAi, in situ epitope tagging of proteins, GST pulldown,

286 In addition, studies using RNAi to target genes related to IRI in liver, kidney, lu

287 epair of cisplatin-DNA lesions in vivo using RNAi nanocarriers, and motivate further exploration of A

288 rampant on young sex chromosomes and utilize RNAi to defend the genome against selfish elements that

289 rmine if they altered circadian behavior via RNAi knockdown in clock cells.

290 Together, our work indicates that viral RNAi suppressors may completely mask antiviral immunity.

291 PyN AIS innervation, we performed an in vivo RNAi screen of PyN-expressed axonal cell adhesion molecu

292 nregulation of both M1BP and wg, by using wg(RNAi), shows a significant rescue of a reduced eye or a

293 properties of cellular transformation, while RNAi knockdown of SEMA4C promotes adhesion and reduces c

294 Here, we perform a genome-wide RNAi screen and identify the BET protein BRD4 as an evol

295 tance mechanisms, we performed a genome-wide RNAi screen in BRCA2-deficient mouse embryonic stem cell

296 itself regulated, we conducted a genome-wide RNAi screen, looking for new regulators of moesin activi

297 Here we report the results of a kinome-wide RNAi screen for cellular pathways involved in AKI-associ

298 translation elongation factor 2 (eEF2) with RNAi.

299 NA structure, function, and interaction with RNAi proteins.

300 g the disparate growth effects observed with RNAi, pharmacological inhibition, and CRISPR remain uncl