ライフサイエンスコーパス: RNase

1 RNase AM was also found to generate the mature 5' end of

2 RNase BN levels decrease in stationary-phase cells, lead

3 RNase H1 deficiency led to an accumulation of replicatio

4 RNase H1 loss is tolerated by the parasite Trypanosoma b

5 RNase H2 is a holoenzyme, composed of 3 subunits (ribonu

6 RNase H2-initiated ribonucleotide excision repair (RER)

7 RNase IIIa/b hotspots are absent from most cancers, but

8 RNase J enzymes are metallohydrolases that are involved

9 RNase J1 is a homodimer with exonuclease activity aided

10 RNase J2, on the other hand, has endonuclease activity a

11 RNase L executes regulated RNA decay and halts global tr

12 RNase L is an IFN-regulated endoribonuclease that is act

13 RNase MRP is an essential eukaryotic ribonucleoprotein c

14 RNase MRP is related to the ribozyme-based RNase P, but

15 RNase P and MRP are highly conserved, multi-protein/RNA

16 RNase PNK belongs to the functionally diverse HEPN nucle

17 RNase T1, colicin E5, and mazF were applied in parallel

18 RNase-A-encapsulated AuNCs (RNase-A@AuNCs) displayed emi

19 RNase-A@AuNCs could successfully examine intestinal tumo

20 clease-followed-by-RNA-seq) revealed ~25,000 RNase E-dependent cleavage sites in Vibrio cholerae, sev

21 We propose that the 2-5A/RNase L pathway serves to rapidly and accurately suppres

22 na structure consisting of a ribonuclease-A (RNase-A) on the particle surfaces.

23 re, we demonstrate that interferon-activated RNase L signaling blocks rotavirus replication in a stra

24 ice of both types, suggesting that activated RNase L also has a proflaviviral effect.

25 Target recognition activates RNases and DNases that may either destroy foreign DNA di

26 Additionally, RNase AM was found to mature the 5' end of 16S rRNA, a r

27 ubunits in Suc density gradients, even after RNase treatment of stromal extracts.

28 h were protected within the vesicles against RNase treatment.

29 Previous allosteric RNase activators display poor selectivity and/or weak ce

30 -domain protein) to block its toxicity as an RNase.

31 Mutation of rnhA to encode an RNase HI variant that cannot interact with SSB but that

32 We apply ON-MS to determine the ONs from an RNase T1 digest of in vitro transcribed tRNA, which are

33 rating characteristic curves for RNase 3 and RNase 7 were 0.99 (95% confidence interval (CI): 0.96-1.

34 ggering kinase trans-autophosphorylation and RNase activation.

35 g peritonitis, RNase 3 increased 55-fold and RNase 7 levels increased 3-fold on average, whereas RNas

36 f RNA/DNA hybrids in absence of RNase H1 and RNase H2 leads to cell lethality under Rnr1 depletion.

37 ition to chromosomally encoded RNase HII and RNase HIII, Bacillus subtilis NCIB 3610 encodes a previo

38 ic ribonucleases (RNases) Mini-RNase III and RNase M5, respectively.

39 We identified E(2)-induced and RNase H1-sensitive antisense RNAs located at the 5' and

40 In contrast, the rates of AZA-induced and RNase L-dependent cell death were increased by transfect

41 s epidermidis RNase J paralogs, RNase J1 and RNase J2.

42 le 2'-5'-oligoadenylate synthetase (OAS) and RNase L pathway effectively suppresses the replication o

43 the antiviral proteins Rig-I, PKR, OAS, and RNase L to avSGs.

44 The ribosome and RNase P are cellular ribonucleoprotein complexes that pe

45 Consequently, loss of RnhP and RNase HIII impairs bacterial growth.

46 In addition, virus-encoded VP3 antagonizes RNase L activity both in vitro and in vivo These studies

47 y ZIKV production is impervious to antiviral RNase L activity, through a mechanism of viral RNA prote

48 Functional studies assessing RNase 7's contributions to urinary tract defense are lim

49 Here, we report that an exosome-associated RNase, EXOSC10, sculpts the transcriptome to facilitate

50 RNS3), and with murine eosinophil-associated RNases.

51 RNase-A-encapsulated AuNCs (RNase-A@AuNCs) displayed emissions at 1050 nm with a 1.9

52 YbeY is a highly conserved bacterial RNase that has been implicated in multiple roles.

53 Discovery of the role of bacterial RNase J1 in termination of transcription suggests common

54 RNase MRP is related to the ribozyme-based RNase P, but it has evolved to have distinct cellular ro

55 nd P54nrb via RRM1 and RRM2, while they bind RNase H1 primarily via the hybrid binding domain, howeve

56 palindromic repeat (CRISPR) system with both RNase and DNase activity.

57 that includes RNase H1, P54nrb and PSF; but RNase H1/P54nrb complexes were observed in only the cell

58 ve feedback in the IFN response amplified by RNase L-resistant molecules.

59 d the protein, Hfq, which reduce cleavage by RNase E.

60 mediately triggered cellular RNA cleavage by RNase L and arrested host protein synthesis.

61 ubstrate for endoribonucleolytic cleavage by RNase mitochondrial RNA processing (MRP) and mutations i

62 cesses including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-codi

63 elongating transcript sequencing followed by RNase digestion (RNET-seq), we analyzed RNAP pausing in

64 cause 1,N (6)-erA is incompletely incised by RNase H2.

65 role of antiviral stress granules induced by RNase L as an antiviral signaling hub to coordinate the

66 Perturbation of RNA-PRC2 interaction by RNase A, by a chemical inhibitor of transcription or by

67 coding region and reduce the target mRNA by RNase H1 while the mRNA resides in the ribosomes.

68 rient stress in culture, and is processed by RNase Y.

69 efficient 3' to 5' directional processing by RNase P in vitro.

70 nstrate that these fragments are produced by RNase 1, a highly active secreted nuclease.

71 a noncoding small RNA, SdhX, is produced by RNase E-dependent processing from the 3'UTR of the sdhCD

72 sRNA), showed that this sRNA is produced by RNase E-mediated maturation of the fabB 3'UTR, and, toge

73 aptamers peripheral to the path traveled by RNase E does not inhibit distal cleavage.

74 rt of the potent eosinophil granule cationic RNases during both differentiation and degranulation, en

75 acrophages (RNase 6), and mesothelial cells (RNase 7).

76 While other cellular RNases process oligoribonucleotides down to diribonucleo

77 ort a cryo-EM structure of the S. cerevisiae RNase MRP holoenzyme solved to 3.0 angstrom.

78 of the interaction between Escherichia coli RNase HI and the single-stranded DNA-binding protein (SS

79 -guided ribonuclease (RNase) with collateral RNase and single-strand DNase activities.

80 tudy, we describe a class of ATP-competitive RNase activators possessing high selectivity and strong

81 ver, modulating R-loop levels by controlling RNase HI expression does not alter G4 abundance quantifi

82 phosphodiesterase (PDE) domain to counteract RNase L-mediated antiviral signaling.

83 allele, which encodes a partially defective RNase P at the permissive temperature, we show here for

84 , recurrent, mutation (S1344L) in the DICER1 RNase IIIa domain in tumors from The Cancer Genome Atlas

85 AvSG assembly during RNase L activation is required for IRF3-mediated IFN pro

86 RNase L-dependent bodies (RLBs) form during RNase L activation.

87 ins enzymatic activity (rnhAK60E) eliminates RNase HI foci.

88 rare earth and silver-based NIR-II emitters, RNase-A@AuNCs had excellent biocompatibility, showing >5

89 w that, in addition to chromosomally encoded RNase HII and RNase HIII, Bacillus subtilis NCIB 3610 en

90 e stability, while the chromosomally encoded RNase HIII is important for chromosome stability and pla

91 We show that while chromosomally encoded RNase HIII is required for pBS32 hyper-replication, RnhP

92 tilis NCIB 3610 and that the plasmid-encoded RNase HI contributes to chromosome stability, while the

93 e found that rny (bb0504), the gene encoding RNase Y, is essential for B. burgdorferi growth, while s

94 o those sites by the regulatory endonuclease RNase E.

95 However, the antiviral endoribonuclease RNase L also alters SG formation, whereby only small pun

96 he interferon (IFN)-induced endoribonuclease RNase L, which results in degradation of viral and cellu

97 ain, and tandem kinase and endoribonuclease (RNase) cytoplasmic domains.

98 y RNA (sRNA) and the major endoribonuclease, RNase E.

99 ar sources of these RNases were eosinophils (RNase 3), macrophages (RNase 6), and mesothelial cells (

100 l features of two Staphylococcus epidermidis RNase J paralogs, RNase J1 and RNase J2.

101 rd in the field to use the 3'-5' exonuclease RNase R.

102 obacter baumannii, with a view to exploiting RNase E as an antibacterial target.

103 ibosome-dependent toxins adopt a RelE-family RNase fold and inhibit translation by degrading mRNAs wh

104 receiver-operating characteristic curves for RNase 3 and RNase 7 were 0.99 (95% confidence interval (

105 platform alternative to the native fold for RNase P to bind and mature SRP RNA co-transcriptionally.

106 These findings assign a novel function for RNase 1, and position it as a strong candidate for gener

107 We propose a role during viral infection for RNase L-cleaved RNAs in inducing avSGs containing antivi

108 he first example of this novel mechanism for RNase regulation.

109 tprint length as quality control metrics for RNase digestion.

110 The domains responsible for RNase activity or oligomerization, were required for MCP

111 These findings indicate a major role for RNase AM in cellular RNA metabolism and establish a biol

112 not essential, indicating a broader role for RNase Y activity in the spirochete.

113 ic tRNA-derived fragments capable of forming RNase-protecting dimers.

114 glycan structures enzymatically cleaved from RNase-B.

115 E1alpha still clusters and, conversely, full RNase activity can be accomplished without clustering.

116 We conclude that all three functional RNase H enzymes are present in B. subtilis NCIB 3610 and

117 Furthermore, RNase H1 overexpression in primary breast cells from BRC

118 e hybrids, all organisms use ribonuclease H (RNase H) to specifically degrade the RNA portion.

119 affinity but do not recruit ribonuclease H1 (RNase H1).

120 is hydrolysis of R-loops by ribonuclease HI (RNase HI).

121 Comparison of EndoV with its homologs RNase H1 and Argonaute reveals the principles by which t

122 However, little is known of how RNase J paralogs differ in expression and activity.

123 strate was less efficiently cleaved by human RNase H2.

124 halves is recapitulated by recombinant human RNase 1 in our in vitro assay.

125 Application of PAIR-MaP to human RNase MRP and 2 bacterial messenger RNA 5' untranslated

126 Importantly, RNase H2A deficiency impairs resection overall, which we

127 on, demonstrating the importance of avSGs in RNase L-mediated host defense.

128 role for the bacterial RNA helicase CrhR in RNase E-dependent mRNA processing in Synechocystis and e

129 Cells deficient in RNase L or OAS1 to 3 are highly resistant to AZA, as are

130 ut Oas1a and Oas1b mRNA levels were lower in RNase L(+/+) mice of both types, suggesting that activat

131 t is unknown how CHH-pathogenic mutations in RNase MRP snoRNA interfere with skeletal development, an

132 the absence of increased ZIKV production in RNase L KO cells was not due to compensation by enhanced

133 immediately downstream of ES-linked VSGs in RNase H defective cells, which also have an increased am

134 PS-ASOs interact in a complex that includes RNase H1, P54nrb and PSF; but RNase H1/P54nrb complexes

135 -stranded RNA was detected by OAS3 to induce RNase L antiviral activity prior to ZIKV infection, we o

136 -loop in 5' leader of tRNAvalV that inhibits RNase P cleavage and further enforces directional proces

137 servations suggest that multiple interacting RNase J paralogs could provide a strategy for functional

138 ernalization by the cells, the intracellular RNase H acts as the "key" to specifically open the DNA/R

139 emonstrate that standard protocols involving RNase R can fail to digest >20% of all highly expressed

140 Here, we report that an IRE1alpha RNase-specific inhibitor, MKC8866, strongly inhibits pro

141 MGO can diminish IRE1alpha RNase activity by directly binding to IRE1alpha in vitro

142 found that CTCF self-association in vitro is RNase sensitive and that an internal RNA-binding region

143 depends on sensing ER stress but not on its RNase activity.

144 adenylate (2-5A) to activate ribonuclease L (RNase L), which cleaves RNA to inhibit virus replication

145 Interaction with SSB localizes RNase HI foci to DNA replication sites.

146 ses were eosinophils (RNase 3), macrophages (RNase 6), and mesothelial cells (RNase 7).

147 Using MAVS/RNase L double KO cells, we demonstrated that the absenc

148 -strand specific ribonucleases (RNases) Mini-RNase III and RNase M5, respectively.

149 a C-terminal posttranslational modification, RNase H that actively hydrolyzed RNA, and exenatide that

150 delivery polymers, the activity of modified RNase A was retained and notably promoted cytotoxicity i

151 while controlling PS chirality can modulate RNase H1 cleavage patterns, ASO sequence and design are

152 es in the DNA gap was sufficient to modulate RNase H1 cleavage patterns and combining these designs w

153 -fold reduction in virus yield in WT but not RNase L KO cells.

154 host oligoadenylate synthetase-RNase L (OAS-RNase L) system, a potent antiviral pathway effective at

155 ccumulation of RNA/DNA hybrids in absence of RNase H1 and RNase H2 leads to cell lethality under Rnr1

156 suggest that IFNs escape from the action of RNase L on translation.

157 horothioate and more efficient activation of RNase H are the key advantages of mesyl phosphoramidate

158 The catalytic activity of RNase J is regulated by multiple mechanisms which includ

159 able resulting in reduction in the amount of RNase BN.

160 secondary structure modeling and analysis of RNase E cleavage of the rimO-crhR transcript in vitro su

161 is mediated by Microprocessor, comprised of RNase III enzyme Drosha and its cofactor DGCR8.

162 To evaluate the contribution of RNase L to the resistance phenotype in vivo, we created

163 results in the functional diversification of RNase MRP and its progenitor, RNase P, and demonstrate s

164 cei but no work has examined the function of RNase H2.

165 s treated with a small-molecule inhibitor of RNase L.

166 colorectal tumors associated lower levels of RNase H2 with shorter survival times.

167 cordance with the cocellular localization of RNase L, the pre-miRNA targets, and the compound.

168 eplication, RnhP compensates for the loss of RNase HIII activity on the chromosome.

169 The mechanisms of RNase L-driven translation repression, its contribution

170 investigate the effect of a null mutation of RNase 1 on the levels of tRNA halves and Y RNA fragments

171 have little impact on the folding pathway of RNase H.

172 probe the folding and unfolding pathways of RNase H (RNH) nascent chains stalled on the prokaryotic

173 as well as high stability in the presence of RNase A and in human plasma, comparatively more stable t

174 etal development, and aberrant processing of RNase MRP substrate RNAs is thought to be involved.

175 re for the first time that the processing of RNase P-dependent polycistronic tRNA operons to release

176 owed that such sRNAs are natural products of RNase E-mediated mRNA decay and associate with major RNA

177 We show that RNA cleavage products of RNase L activity induce the formation of antiviral stres

178 cellular and viral RNA cleavage products of RNase L bind pattern recognition receptors (PRRs), like

179 ional processing is an intrinsic property of RNase P and show how RNA sequence and structure context

180 conjunction with measurements of the rate of RNase H unfolding on and off the ribosome, their results

181 Reconstruction of RNase S on the artificial virus-like capsids afforded sp

182 uclease resistance, efficient recruitment of RNase H, and potent inhibition of key carcinogenesis pro

183 small RNA-dependent, positive regulation of RNase BN in exponential-phase cells is the first example

184 analyze the mechanism of this regulation of RNase BN.

185 ze substrate specificity and product size of RNase IIIs, we performed in vitro cleavage of dsRNAs by

186 ith the relaxed cleavage site specificity of RNase E, the endonuclease most important for governing m

187 rRNA in the ribosome and the RNA subunit of RNase P are the ribozyme components required for catalys

188 proteins affect TLC1 and the RNA subunits of RNase P/MRP in very different ways.

189 disease prior to PD initiation, and omental RNase 3 reactive cells increased in patients undergoing

190 human DNA polymerase eta (hpol eta), and on RNase H2-mediated incision.

191 f systematically controlling PS chirality on RNase H1 cleavage patterns, protein mislocalization phen

192 s contain multiple forms of the protein-only RNase P (PRORP) variant, prompting efforts to unravel th

193 Protein-only RNase P 1 (PRORP1) in Arabidopsis thaliana is an endorib

194 onsequently, cells lacking avSG formation or RNase L signaling produced less IFN and showed higher su

195 utants defective in either protein kinase or RNase activities, we found that both must be operative t

196 with only PKR and Rig-I and not with OAS or RNase L.

197 Like other RNase HI enzymes, RnhP incises Okazaki fragments, ribopa

198 imicked during infection with numerous other RNase L-activating viruses, thus identifying a distinct

199 Ribonuclease P (RNase P) is essential for the 5'-end maturation of tRNAs

200 n contrast, treatment with bovine pancreatic RNase A or human recombinant RNase1 interfered with leuk

201 Staphylococcus epidermidis RNase J paralogs, RNase J1 and RNase J2.

202 During peritonitis, RNase 3 increased 55-fold and RNase 7 levels increased 3

203 bound by the ZC3H12B's PilT N terminus (PIN) RNase domain, revealing a potential mechanism by which u

204 parison of lysates with and without previous RNase treatment enables the identification of difference

205 rsification of RNase MRP and its progenitor, RNase P, and demonstrate structural underpinnings of the

206 pletion of the ER chaperone binding protein, RNase-inactive IRE1alpha still clusters and, conversely,

207 y networks involving RNA chaperone proteins, RNases, sRNAs, and mRNAs.

208 ted by ectopic expression of R-loop-removing RNase H1.

209 type in vivo, we created a line of resistant RNase L(-/-) mice.

210 mRNA fragments protected from ribonuclease (RNase) digestion by ribosomes.

211 Cas12g is an RNA-guided ribonuclease (RNase) with collateral RNase and single-strand DNase act

212 Members of the ribonuclease (RNase) III family regulate gene expression by processing

213 ors and require processing by Ribonucleases (RNases) to generate mature and functional rRNAs.

214 n eosinophil granule cationic ribonucleases (RNases), namely, eosinophil-derived neurotoxin (RNS2) an

215 by the double-strand specific ribonucleases (RNases) Mini-RNase III and RNase M5, respectively.

216 on by the RNA component of ribonucleoprotein RNase P and other catalytic RNAs, indicating convergence

217 -like capsids decorated with ribonuclease S (RNase S) on their exterior were constructed by the self-

218 containing all 17 SLF genes, SLFLike1, and S-RNase.

219 by the polymorphic S-locus, which contains S-RNase encoding the pistil determinant and 16-20 S-locus

220 However, S-RNase alone is not sufficient for either type of pollen

221 This reduction and increase in S-RNase activity by NaTrxh helps to explain why S-RNase al

222 ncompatible Solanaceae, the pistil protein S-RNase contributes to S-specific pollen rejection in cons

223 , NaTrxh, which interacts with and reduces S-RNase in vitro.

224 se activity by NaTrxh helps to explain why S-RNase alone could be insufficient for pollen rejection.

225 Organellar and secretory RNases, associated with different cellular compartments,

226 The methodology seizes RNase H enzyme activity to degrade the upstream and down

227 tion intermediate against the dsRNA-specific RNase III.

228 This event activates its non-specific RNase activity, which enables cleavage of an RNA oligonu

229 ibosomes are selectively cleaved by specific RNases, leading to their preferential deletion.

230 unit, accordingly inhibiting or stimulating RNase activity.

231 ZIKV and the host oligoadenylate synthetase-RNase L (OAS-RNase L) system, a potent antiviral pathway

232 y small punctate SG-like bodies that we term RNase L-dependent bodies (RLBs) form during RNase L acti

233 We also found that RNase H2 recognizes 1,N (6)-erA but has limited incision

234 ken together, these observations reveal that RNase L promotes the formation of a unique RNP complex t

235 The structures reveal that RNase PNK adopts a butterfly-like architecture, harborin

236 RNP-MaP revealed that RNase P and RMRP, two sequence-divergent but structurall

237 Here, I show that RNase AM, a recently identified 5' to 3' exonuclease, pe

238 Here we show that RNase H ASOs targeted to introns or exons robustly reduc

239 ribosomal force-profiling assay to show that RNase H forms a similar folding intermediate on and off

240 Furthermore, functional assays show that RNase J2 is essential for immunity against diverse mobil

241 affected by rnh1 knockdown, suggesting that RNase H1 also plays a role in integrating or coregulatin

242 The RNase L-cleaved dsRNAs signal to Rig-like helicases to a

243 The RNase Regnase-1 is a master RNA regulator in macrophages

244 adenosine deaminase RNA specific (ADAR), the RNase DICER1, and the dsRNA-activated kinase protein act

245 RNA substrates and, for Mini-III, anchor the RNase to the ribosome.

246 Although both clustering and the RNase activity are responsive to luminal stress conditio

247 (C(t)) values from the gene targets and the RNase P gene control in the CDC assay showed no signific

248 n vitro degradation of this structure by the RNase R exonuclease.

249 ucturally and biochemically characterise the RNase E catalytic domains from four pathogenic bacteria:

250 e RNP complex that may have roles during the RNase L-mediated antiviral response.

251 ese results identify a cellular role for the RNase HI/SSB interaction in helping to clear R-loops tha

252 nse oligonucleotides (ASOs) that harness the RNase H1 mechanism.

253 Here, we characterize how the RNase and DNase activities associated with Type III-B im

254 Somatic mutations in the RNase IIIb domain of DICER1 arise in cancer and disrupt

255 al RNA processing (MRP) and mutations in the RNase MRP small nucleolar RNA (snoRNA) subunit of the RN

256 Time-resolved correlations in the RNase P RNA-a functional RNA with a complex structure st

257 -linked to two sites of the S-peptide in the RNase S complex in a manner that the alpha-helical conte

258 decompose, leading to the inhibition of the RNase activity of IRE-1.

259 In addition, due to the fast kinetics of the RNase endonuclease reaction, the loaded H(1)/H(2) was qu

260 small nucleolar RNA (snoRNA) subunit of the RNase MRP complex cause cartilage-hair hypoplasia (CHH),

261 We show that some of the RNase MRP proteins shared with RNase P undergo an unexpe

262 at either the DNase activity of Cas10 or the RNase activity of Csx1 can effectively direct successful

263 rsts using a timer mechanism to regulate the RNase activity of the Csm6 HEPN domain.

264 are IFN-induced enzymes that synthesize the RNase L activator 2-5A in response to dsRNA.

265 three AMPs to a tyrosine residue next to the RNase domain of HepT in Shewanella oneidensis.

266 ribed RNA sequence-specifically triggers the RNase activity of Cas13a.

267 echnology can reduce gene expression via the RNase H1 or RISC pathways and can increase gene expressi

268 nscriptase, which extends its Thumb with the RNase H domain.

269 gene targets (p=0.152 and p=0.092), with the RNase P target performing significantly better in the 3D

270 aturation in bacteria by revealing how these RNases recognize and process double-stranded pre-rRNA.

271 cryoelectron microscopy structures of these RNases poised to cleave their pre-rRNA substrates within

272 The cellular sources of these RNases were eosinophils (RNase 3), macrophages (RNase 6)

273 Discrete omental reservoirs of these RNases were evident in patients with end stage kidney di

274 ications regarding the main function of this RNase complex, which seems to be primarily in early pre-

275 Even though RNase H ASOs can reduce the level of RNA associated with

276 6S rRNA, a reaction previously attributed to RNase G.

277 P, Pro-AMP, betaPro-AMP and Phe-AMP bound to RNase A as crystallization chaperone showed how well the

278 igh GC skew which are partially resistant to RNase H.

279 B9s-b and FB9s-r, were markedly resistant to RNase-catalyzed degradation, with a half-life of ~5 days

280 PARP-1 proteolysis efficacy is sensitive to RNase A and promoted by added RNA.

281 at sRNAs exhibit differential sensitivity to RNase E, likely a consequence of a hierarchy of sRNA fea

282 nse oligonucleotide (ASO) drugs that trigger RNase H1 cleavage of target RNAs have been developed to

283 tisense oligonucleotides (ASOs) that trigger RNase-H-mediated cleavage are commonly used to knock dow

284 s (miRNAs) are sequentially processed by two RNase III enzymes, Drosha and Dicer.

285 IB 3610 encodes a previously uncharacterized RNase HI protein, RnhP, on the endogenous plasmid pBS32.

286 cteria and eukaryotes, in which an unrelated RNase Xrn2/Rat1 plays a similar role.

287 ith a UTI history had 1.5-fold lower urinary RNase 7 concentrations.

288 Blocking VEGFR2, RNase application, or VWF deficiency interfered with pla

289 ANG is a secretory vertebrate RNase that enters neuronal cells and cleaves a subset of

290 levels increased 3-fold on average, whereas RNase 6 levels were unchanged.

291 of antiviral mRNAs as the mechanism by which RNase L reprograms translation in response to dsRNA.

292 osphorylation, and an IRE1alpha mutant whose RNase domain is responsive to ligands that bind the kina

293 ied ONs from native total tRNA digested with RNase T1.

294 can dramatically modulate interactions with RNase H1 as evidenced by changes in RNA cleavage pattern

295 ome RNA targets are difficult to reduce with RNase H1 activating ASOs and some ASOs display a shorter

296 t some of the RNase MRP proteins shared with RNase P undergo an unexpected RNA-driven remodeling that

297 vesicular extracellular samples treated with RNase inhibitors (RI).

298 ed by digesting the enriched interfaces with RNases or proteases to release the RBPs or protein-bound

299 ridization assays and enzymatic probing with RNases illuminated how RNA binding specificity and disso

300 The high-resolution structures of yeast RNase for mitochondrial RNA processing (MRP), a catalyti