ライフサイエンスコーパス: Ras GTPase

1 ied that encode a palmitoyltransferase for a Ras GTPase.

2 1 also activates the functionally distinct R-Ras GTPase.

3 have in common the ability to interact with ras GTPase.

4 ble to elicit the activation of both Ral and Ras GTPases.

5 ction and intermediate G proteins, including Ras GTPases.

6 y region retained activation by both Rho and Ras GTPases.

7 imited the ability of ExoS to ADP-ribosylate Ras GTPases.

8 ls, or the ability of ExoS to ADP-ribosylate Ras GTPases.

9 ucleotide exchange factors that activate the Ras GTPases.

10 ntain Rab, Rho, Arf, and Ran GTPases, but no Ras GTPases.

11 -promoting phorbol esters with activation of Ras GTPases.

12 fficiently than the oncogenic Ha-, K-, and N-Ras GTPases.

13 fically on Rho and not on the Rac, Cdc42, or Ras GTPases.

14 by binding p120RasGAP, a GAP protein for the Ras GTPases.

15 ponsible for the ubiquitination of classical RAS GTPases.

16 s catalytic activity or its interaction with RAS GTPases.

17 GTPases are directly activated by oncogenic Ras GTPases.

18 rovided a wealth of mechanistic insight into Ras GTPases.

19 ic MAP kinase activation by constitutive p21(ras) GTPases.

20 gGDS), a chaperone regulating prenylation of RAS GTPases(3).

21 discovery of a new downstream target for the Ras GTPases - a Nore1-Mst1 protein complex - reveals a m

22 pathway by controlling the ubiquitination of Ras GTPase-accelerating protein Ira2.

23 analysis reveals that Ubp3 interacts with a Ras GTPase-accelerating protein, Ira2, and regulates its

24 Ras GTPases act as "molecular switches", alternating bet

25 Ras GTPases act as molecular switches to control various

26 sential for signaling and contains a R-Ras/M-Ras GTPase activating protein (GAP) domain that is divid

27 Moreover, the synaptic Ras GTPase activating protein (GAP) SynGAP is selectivel

28 la mutation on the interaction of H-Ras with Ras GTPase activating protein (GAP), neurofibromin 1 (NF

29 ells while the phosphorylation/activation of Ras GTPase activating protein (Ras GAP) and mitogen acti

30 Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is

31 effect found in our previous studies of the Ras GTPase activating protein (RasGAP) and the elongatio

32 ras GTPase activating protein (rasGAP) is highly conserv

33 n (G125V) in the scat Rasa3 gene, encoding a Ras GTPase activating protein (RasGAP), and elucidate th

34 One key regulator of this cascade is the Nf1 Ras GTPase activating protein (RasGAP), which attenuates

35 We identified the synaptic Ras GTPase activating protein 1 (Syngap1), encoded by a

36 rat homolog, but not its mutant defective in Ras GTPase activating protein activity, reverses miR-431

37 A Ras GTPase activating protein tumor suppressor (RasGAP),

38 SYNGAP1, a synaptic Ras GTPase activating protein, and SHANK3, a synaptic sc

39 f the neurofibromatosis type 1 (NF1) gene, a Ras GTPase activating protein.

40 th high levels of RAS-GTP had loss of NF1, a RAS GTPase activating protein.

41 In addition to the two Ras GTPase activating proteins (GAPs; p120- and NF1-GAP)

42 precisely controlled by mechanisms involving Ras GTPase activating proteins (RasGAPs) responsible for

43 n of the effect of Ca2+ on Ras activity, and Ras GTPase activating-like protein (RASAL), which functi

44 The Ras-GTPase activating activity of p135 SynGAP is inhibit

45 ere we report that sphingosine can stimulate Ras-GTPase activating protein (GAP) activity in vitro, a

46 coded protein, neurofibromin, functions as a Ras-GTPase activating protein (GAP), nothing is known ab

47 Here, we report a novel synaptic Ras-GTPase activating protein (p135 SynGAP) that is a ma

48 ongly reduced by silencing expression of the Ras-GTPase activating protein (Ras-GAP) neurofibromin, a

49 coded protein, neurofibromin, functions as a Ras-GTPase activating protein (RasGAP).

50 emonstrates that the loss of DAB2IP, a novel Ras-GTPase activating protein frequently found in many c

51 SynGAP is a Ras-GTPase activating protein highly enriched at excitat

52 The Ras-GTPase activating protein SH3 domain-binding protein

53 completely rescued by expression of the GAP (RAS-GTPase activating protein) domain of neurofibromin.

54 992 receptors were associated with more SOS, Ras-GTPase activating protein, phosphatidylinositol 3-ki

55 Here, we describe the isolation of a novel Ras-GTPase activating protein, SynGAP, that interacts wi

56 that members of the Ras network of proteins, Ras-GTPase activating protein-SH3-domain-binding protein

57 nositol 3'-kinase, phospholipase Cgamma, and Ras-GTPase activating protein.

58 in the cleavage of the SG-nucleating protein Ras-GTPase activating SH3 domain-binding protein (G3BP1)

59 Here, we show that the synaptic Ras GTPase-activating (RASGAP) protein 1 (SYNGAP1, a top

60 in-dependent protein kinase II increases its Ras GTPase-activating activity by 70-95%.

61 GAP from the Rsu-1 transfectants showed less Ras GTPase-activating activity than GAP from control cel

62 However, a decrease in Ras GTPase-activating activity was detected in lysates o

63 Ras signalling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity.

64 The NF1-encoded protein neurofibromin is a Ras GTPase-activating protein (GAP) and can directly lim

65 t their effects via an intracellular R-Ras/M-Ras GTPase-activating protein (GAP) domain or by activat

66 ut not GAPex-5DeltaGAP, a mutant lacking the Ras GTPase-activating protein (GAP) domain.

67 One domain is homologous to Ras GTPase-activating protein (GAP) domains.

68 DAB2 interacting protein) is a member of the Ras GTPase-activating protein (GAP) family that has been

69 at Ras, through an effector-like function of Ras GTPase-activating protein (GAP) in neonatal cardiac

70 The Ras GTPase-activating protein (GAP) p120RasGAP inhibits

71 RASAL2 is a RAS GTPase-activating protein (GAP) that has been associ

72 romoted Ras inactivator), a Ca(2+)-dependent Ras GTPase-activating protein (GAP) that switches off th

73 To distinguish between inhibition of Ras by Ras GTPase-activating protein (GAP) versus a potential e

74 SynGAP is a synaptic Ras GTPase-activating protein (GAP) with four C-terminal

75 kDa by SDS-PAGE and associates with the p120 ras GTPase-activating protein (GAP).

76 The mammalian Ras GTPase-activating protein (p120Ras-GAP) interacts wi

77 In the present study, we identified a novel Ras GTPase-activating protein (Ras-GAP) as an ASK1-inter

78 Loss of the RAS GTPase-activating protein (RAS-GAP) NF1 drives aberr

79 l abolished the association of PDGFalphar to Ras GTPase-activating protein (Ras-GAP), but it did not

80 The NF1-encoded protein is a Ras GTPase-activating protein (RasGAP) [2].

81 NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss driv

82 acted with the SH3 domain and phosphorylated Ras GTPase-activating protein (RasGAP) and upregulated R

83 aptor Grb2-associated binder-1 (GAB1) on its RAS GTPase-activating protein (RASGAP) binding sites and

84 orylation of Dok-1, augmented recruitment of Ras GTPase-activating protein (RasGAP) by Dok-1, and inh

85 AP1 as a human protein related to a putative Ras GTPase-activating protein (RasGAP) from the fission

86 Specifically, we show that loss of the Ras GTPase-activating protein (RasGAP) gene DAB2IP induc

87 We have previously reported that Ras GTPase-activating protein (RasGAP) is involved in a

88 These screens converged on RASA2, a RAS GTPase-activating protein (RasGAP) that we identify

89 of activated Ras by blocking recruitment of Ras GTPase-activating protein (RasGAP) to the plasma mem

90 otifs in the C terminus and does not bind to Ras GTPase-activating protein (RasGAP) upon phosphorylat

91 y, including Nck adaptor protein (Nck), p120-Ras GTPase-activating protein (RasGAP), and the alpha- a

92 p62(dok) associates with the Ras GTPase-activating protein (RasGAP), but only when p6

93 predicted, growth-related targets, including Ras GTPase-activating protein (RasGAP), cyclin-dependent

94 peptide derived from the N2 fragment of p120 Ras GTPase-activating protein (RasGAP), sensitizes tumor

95 Dok, a 62-kDa Ras GTPase-activating protein (rasGAP)-associated phosph

96 A 62-kDa Ras GTPase-activating protein (RasGAP)-associated protei

97 docking platform for the SH2 domains of the Ras GTPase-activating protein (RasGAP).

98 the process of Ras inactivation catalyzed by Ras GTPase-activating protein (RasGAP).

99 otein (CREB) phosphorylation via RASA1 (p120 Ras GTPase-activating protein 1) down-regulation, wherea

100 al known properties and functions, including Ras GTPase-activating protein activity, adenylyl cyclase

101 d Ras on the plasma membrane by means of the Ras GTPase-activating protein CAPRI.

102 Elimination of Ras GTPase-activating protein enhanced E-CD4 but decreas

103 (AIP1), a recently identified member of the Ras GTPase-activating protein family, is highly expresse

104 synGAP is a neuron-specific Ras GTPase-activating protein found in high concentratio

105 novel GTPase-activating protein containing a Ras GTPase-activating protein homology domain (N terminu

106 in signaling and prevent inactivation by the RAS GTPase-activating protein neurofibromin 1.

107 mutations in the NF1 gene, which encodes the RAS GTPase-activating protein neurofibromin.

108 Yeast 2-hybrid analyses identified the Ras GTPase-activating protein Rasa1, a known regulator o

109 g of LFA-1 to ICAM-1, including the Rap1 and Ras GTPase-activating protein RASA3.

110 tors (HERs), induced expression of G3BP, the Ras GTPase-activating protein SH3 domain-binding protein

111 We further show that nsp1 interacts with Ras GTPase-activating protein SH3 domain-binding protein

112 The Ras GTPase-activating protein SYNGAP1 plays a central ro

113 to citron, p135 SynGAP, an abundant synaptic Ras GTPase-activating protein that can bind to all three

114 RASA1 (also known as p120 RasGAP) is a Ras GTPase-activating protein that functions as a regula

115 SynGAP is a brain-specific ras GTPase-activating protein that is an abundant compon

116 e we report the characterisation of RASAL, a Ras GTPase-activating protein that senses the frequency

117 SYNGAP1 is a Ras GTPase-activating protein that underlies the formati

118 Ras GTPase-activating protein was found to be a caspase

119 HB4 (ephrin receptor B4) and the RASA1 (p120 Ras GTPase-activating protein) are necessary for the dev

120 RasGAP (Ras GTPase-activating protein) is a negative regulator a

121 ating protein (SynGAP) is a neuronal RasGAP (Ras GTPase-activating protein) that is selectively expre

122 gene product, neurofibromin, functions as a Ras GTPase-activating protein, and has been proposed to

123 F receptors including phospholipase C gamma, Ras GTPase-activating protein, and phosphotyrosine phosp

124 The NF1 gene encodes for neurofibromin, a RAS GTPase-activating protein, and thus negatively regul

125 calcium-promoted Ras inactivator (CAPRI), a Ras GTPase-activating protein, functions as an adaptor f

126 ity of, Bruton's tyrosine kinase (Btk) and a Ras GTPase-activating protein, Gap1m, in vitro and in vi

127 ith PLCgamma, phosphatidylinositol 3-kinase, Ras GTPase-activating protein, or protein tyrosine phosp

128 -back' mutants in which association with the Ras GTPase-activating protein, phosphatidylinositol 3-ki

129 as, suggesting that it may also compete with Ras GTPase-activating protein, thus contributing to the

130 ing protein homologous to mammalian synaptic Ras GTPase-activating protein, which modify daf-7 expres

131 rategy and demonstrate its implementation on Ras GTPase-activating protein-binding protein 1 (G3BP1)

132 Stress granule (SG) formation mediated by Ras GTPase-activating protein-binding protein 1 (G3BP1)

133 ss granules are formed through the switch of Ras GTPase-activating protein-binding protein 1 (G3BP1)

134 s were enriched, including the SG-nucleating Ras GTPase-activating protein-binding protein 1 (G3BP1).

135 The Ras GTPase-activating protein-binding protein G3BP1 is a

136 Ras GTPase-activating protein-binding proteins 1 and 2 (

137 hoprotein reported to bind the SH3 domain of Ras GTPase-activating protein.

138 that binds to the pleckstrin domain of p120 Ras GTPase-activating protein.

139 ppressor postulated to function in part as a Ras GTPase-activating protein.

140 directed against either pp60(src), RhoA, or Ras GTPase-activating protein.

141 n the NF1 gene that encodes neurofibromin, a RAS GTPase-activating protein.

142 The DAB2IP tumor suppressor encodes a RAS GTPase-activating protein.

143 the NF1 gene, which encodes neurofibromin, a RAS GTPase-activating protein.

144 One insertion was in the gene encoding Ras GTPase-activating protein; its overexpression phenot

145 GAP1(m) is a member of the GAP1 family of Ras GTPase-activating proteins (GAPs) [1].

146 he tyrosine phosphorylation of two important Ras GTPase-activating proteins (GAPs), p120 Ras-GAP and

147 ced wild-type TC21 activity in vivo and that Ras GTPase-activating proteins (GAPs; p120-GAP and NF1-G

148 However, it is unknown which Ras GTPase-activating proteins (RasGAPs) inactivate Ras

149 Ras GTPase-activating proteins (RasGAPs) inhibit signal

150 Rasal, belonging to the GAP1 subfamily of Ras GTPase-activating proteins (RasGAPs) with dual RasGA

151 an include functional alteration of GTPases, Ras GTPase-activating proteins, Ras guanine exchange fac

152 ed CAPRI and RASAL as related Ca2+-triggered Ras GTPase-activating proteins.

153 s of FliI immunoprecipitates showed abundant Ras GTPase-activating-like protein (IQGAP1), which in im

154 has a high affinity for the adaptor protein Ras GTPase-activating-like protein 1 (Iqgap1), which fac

155 Here, we report the Ras GTPase-activating-like protein IQGAP1 functions as a

156 The Ras GTPase-activating-like protein IQGAP1 is a multimodu

157 iaD binds to the host cell protein IQGAP1 (a Ras GTPase-activating-like protein), thus displacing Rac

158 we have isolated a novel human gene, RASAL (Ras GTPase-activating-like) and its murine ortholog, MRA

159 s that contains a 216-amino acid domain with Ras-GTPase-activating protein (Ras-GAP) activity.

160 we demonstrate that RASAL2, which encodes a RAS-GTPase-activating protein (RAS-GAP), is a functional

161 Finally, we showed that Carabin Ras-GTPase-activating protein domain and calcineurin-int

162 DAB2 interactive protein) is a member of the RAS-GTPase-activating protein family.

163 SYNGAP1 is a Ras-GTPase-activating protein highly enriched at excitat

164 Ras-GRF mutant containing the PH domain from Ras-GTPase-activating protein in place of its own N-term

165 resis and identified by mass spectrometry as Ras-GTPase-activating protein SH3 domain-binding protein

166 teins (p85 (phosphoinositide 3-kinase), Vav, Ras-GTPase-activating protein SH3 domain-binding protein

167 Here, the Ras-GTPase-activating protein SH3 domain-binding protein

168 alyzed GTP hydrolysis in water, Ras, and Ras.Ras-GTPase-activating protein using quantum mechanics/mo

169 n as DAB2IP), a novel member of the Ras-GAP (Ras-GTPase-activating protein) protein family, opens its

170 Nf1, a tumor suppressor gene that encodes a Ras-GTPase-activating protein, results in hyperactivity

171 We discovered that DAB2IP, a novel Ras-GTPase-activating protein, was frequently epigenetic

172 xtracellular chemical gradients and position Ras GTPase activation and phosphatidylinositol (3,4,5)-t

173 NA maturation, and reveal a link between Rab/Ras GTPase activation and the process of pre-mRNA splici

174 stically, miR-132 regulated the mRNA for the Ras GTPase activator Rasa1, a novel target in neuronal f

175 At the molecular level, we identify Ras-GTPase-activing protein SH3-domain-binding protein 2

176 by deregulation of the previously documented Ras GTPase activities.

177 ino acid substitutions that reduce intrinsic Ras GTPase activity and confer resistance to GTPase-acti

178 t keystone regulatory residue that modulates Ras GTPase activity and ensures unidirectionality to the

179 -GAP (RRFFLDIA) block NF1-GAP stimulation of Ras GTPase activity and Ras-mediated activation of mitog

180 romin is a tumor suppressor protein that has Ras GTPase activity, thus attenuating the MAPK (mitogen-

181 pe I transmembrane receptor with intrinsic R-Ras GTPase activity, which regulates cytoskeletal remode

182 This is because Ras-GTPase activity sets the intrinsic response threshol

183 Upon GTP binding, RAS GTPases adopt an active conformation and interact wi

184 Raf-1 is a direct effector of the Ras GTPase and is the initiating kinase in this signalli

185 The M-Ras GTPase and its effector, the Shoc2 scaffold, are pro

186 We show that the Ras GTPase and Raf1 serine/threonine kinase are required

187 Mutations in Ras GTPase and various other components of the Ras signa

188 t frequently display activating mutations in Ras GTPases and activation of signal transducer and acti

189 a unique function of RIT1 compared to other Ras GTPases and elucidate a direct link between a signal

190 e Raf protein kinases are major effectors of Ras GTPases and key components of the transcriptional re

191 n-3 RING E3 ubiquitin ligase, binds specific RAS GTPases and promotes their ubiquitination and protea

192 While oncogenic Ras GTPases and R-Ras share extensive sequence homology,

193 exchange factor-like domain that binds both Ras GTPases and the scaffolding protein Cas.

194 e ability to stimulate Src tyrosine kinases, Ras-GTPases and transcriptional activation.

195 Ras GTPases are activated by RasGEFs and inactivated by

196 ng nontransformed fibroblasts, we found that Ras GTPases are dispensable for growth-factor-stimulated

197 Ras GTPases are frequently mutated in cancer and so far

198 The Ras GTPases are frequently mutated in human cancer, and,

199 RAS GTPases are highly conserved proteins involved in th

200 Ras GTPases are on/off switches regulating numerous cell

201 Ras GTPases are signaling switches that control critical

202 Activities of Ras GTPases are triggered by Ras GTPase guanine nucleoti

203 RAS GTPases associate with the biological membrane where

204 Using this system, we activated Ras GTPase at distinct intracellular locations and induc

205 Ras GTPases become functionally active when anchored to

206 upts Cas binding to SHEP1 without inhibiting Ras GTPase binding.

207 essential for tracking: inactivation of the Ras GTPase Bud1 and positioning of actin-independent ves

208 Regulation of Ras GTPases by GTPase-activating proteins (GAPs) is esse

209 al homology to p120(GAP).H-Ras suggests that Ras GTPases can bind to the plexin GAP region.

210 Signaling through Ras GTPases controls the activity of many transcription

211 The Ras-GTPase controls cell fate decisions through the bind

212 Deregulation of the RAS GTPase cycle due to mutations in the three RAS genes

213 ctivity and ensures unidirectionality to the Ras GTPase cycle.

214 Ras GTPases cycle between inactive GDP-bound and active

215 Ras GTPase cycles between its active GTP-bound form prom

216 The subcellular localization of RAS GTPases defines the operational compartment of the E

217 Although members of the Ras GTPase family control cell growth, differentiation,

218 fferentiation, and transformation, including Ras GTPase family members, require the covalent attachme

219 ARL13B belongs to the Ras GTPase family, and in other species is required for

220 Lipid-anchored Ras GTPases form transient, spatially segregated nanoclu

221 Ras GTPases function as binary switches in signaling pat

222 Ras GTPases function as binary switches in the signaling

223 The Ras GTPases function as molecular switches, regulating a

224 e shown that homozygous deletion of Nf1, the Ras GTPase gene underlying human neurofibromatosis type

225 A subset of Ras GTPase genes linked to membrane remodeling were upre

226 Activities of Ras GTPases are triggered by Ras GTPase guanine nucleotide exchange factors (RasGEFs)

227 Self-assembly of plasma membrane-associated Ras GTPases has major implications to the regulation of

228 Proteins of the rho subfamily of ras GTPases have been shown to be crucial components of

229 4-targeted tumors revealed inhibition of the RAS-GTPase, Hedgehog, and Notch pathways, along with evi

230 ctivity on RalA, Rap1A, and R-Ras but not Ha-Ras GTPases in cells.

231 l strain via substrate deformation activates Ras-GTPase, in particular the H-Ras isoform.

232 Rsr1, a Ras GTPase, interacts with Cdc42 and its associated prot

233 (Rabs are a family of Ras GTPases involved in membrane trafficking.) Both APPL

234 wo non-tagged endogenous proteins, actin and RAS GTPase, involved in complex functional networks sens

235 Regulated activation of the highly conserved Ras GTPase is a central event in the stimulation of cell

236 RAS GTPase is a highly conserved GTP-binding protein wit

237 Ras GTPase is a molecular switch controlling a number of

238 RAS GTPase is a prototype for nucleotide-binding protein

239 Here, we show that low expression of kappaB-Ras GTPases is frequently detected in PDAC and correlate

240 NF1, a tumor suppressor gene and RAS-GTPase, is one of the highly mutated genes in GBM.

241 Oncogenic mutations in the small Ras GTPases KRas, HRas, and NRas render the proteins con

242 The Ras GTPase links extracellular mitogens to intracellular

243 The Ras GTPase links extracellular signals to intracellular

244 of downstream effector pathways such as the RAS GTPase/MAP kinase (MAPK) signaling cascade is though

245 Ras GTPase mediates several cellular signal transduction

246 endothelial cell apoptosis by attenuation of Ras GTPase methylation and activation and its downstream

247 Apart from the classic (H-, K-, and N-) Ras GTPases, only the R-Ras subfamily (R-Ras, R-Ras2/TC2

248 Ras GTPases play a crucial role in cell signaling pathwa

249 The Ras GTPase plays an essential role in many cellular sign

250 ystander tyrosine residue present in Ral and Ras GTPases provide a strategy that could lead to therap

251 Here we show a role for the Ras GTPase, R-Ras, in the functional adaptation of high

252 The RAF kinases activated by RAS GTPases regulate cell growth and division by signal

253 Rat sarcoma (Ras) GTPases regulate cell proliferation and survival th

254 These studies reveal that the Ras-GTPase regulator gefE is required for normal lineage

255 Mutations in K-Ras GTPase replacing Gly12 with either Asp or Val are co

256 tantly activated by both RhoA and individual Ras GTPases resulting in diverse upstream control of sig

257 elies on impaired protein degradation of the Ras GTPase RIT1.

258 and promotes proteasomal degradation of the RAS GTPase RIT1.

259 Ras GTPases signal by orchestrating a balance among seve

260 Activated RAS GTPase signalling is a critical driver of oncogenic

261 Members of the superfamily of Ras GTPase signalling proteins (monomeric G proteins) re

262 The proto-oncogene Ras GTPase stimulates transcription of p21Waf1/Cip1 (p21

263 n fusion and analyzed for protein stability, Ras GTPase stimulating activity, affinity for Ras-GTP, a

264 over, p120 N-terminal sequences enhanced the Ras GTPase-stimulating activity of the neurofibromin GAP

265 This identifies a second member of the Ras GTPase subfamily that can be ADP ribosylated by ExoS

266 it is one of the original members of a novel Ras GTPase subfamily that uses distinct effector pathway

267 rd Ras homologue enriched in brain (Rheb), a Ras GTPase superfamily member.

268 erence at Snowmass Village, Colorado, on the Ras GTPase superfamily provided testimony to the broad i

269 amplified by Rab5A, a small G protein of the Ras GTPase superfamily.

270 roteins constitute the largest branch of the Ras GTPase superfamily.

271 or synaptic plasticity, most notably in the Ras/GTPase superfamily, and in pathways that regulate cy

272 rminal hypervariable region (HVR) of Rho and Ras GTPases target these proteins to specific membrane c

273 y involved in the control of Ral, Rap, and R-Ras GTPases that may participate in the progression of b

274 colon cancers have a mutation in K-RAS or N-RAS, GTPases that operate as central hubs for multiple k

275 -state mechanisms, such as activation of the Ras GTPase, the diffusion-limited activation rate consta

276 re, we describe a novel mechanism connecting RAS GTPase to nutrient availability in fission yeast.

277 by MRL proteins interact with both talin and Ras GTPases to activate integrins.

278 connect the membrane targeting sequences in Ras GTPases to talin, thereby recruiting talin to the pl

279 protein containing leucine-rich repeats and Ras/GTPase, tyrosine kinase-like, and WD40 domains.

280 ne nucleotide exchange factors that activate Ras GTPases, ultimately leading to MAPK activation and m

281 ism for regulating the activation of Rac and Ras GTPases via the actin cytoskeleton.

282 n the major signaling cascade, activation of Ras GTPase, we constructed fusions of Grb2, Shc, H-Ras,

283 K) As this disease mutation is also found in RAS GTPases, we assessed GAP-stimulated GTP hydrolysis f

284 nto the regulation of integrin activation by Ras GTPases, we created a series of H-Ras/R-Ras chimeras

285 e discovery that activating mutations of the Ras GTPase were associated with 30% or more of human can

286 Ras GTPases were long thought to function exclusively fr

287 e activation; activation of Rac1, cdc42, and Ras GTPases were not affected.

288 K-Ras4B belongs to the family of p21 Ras GTPases, which play an important role in cell prolif

289 The DIRAS2 gene is coding for a small Ras GTPase with so far unknown function.

290 M/lamellipodin (MRL) proteins link activated Ras-GTPases with actin regulatory Ena/VASP proteins to i