ライフサイエンスコーパス: Ras GTPase-activating protein

1 f the neurofibromatosis type 1 (NF1) gene, a Ras GTPase activating protein.

2 th high levels of RAS-GTP had loss of NF1, a RAS GTPase activating protein.

3 directed against either pp60(src), RhoA, or Ras GTPase-activating protein.

4 n the NF1 gene that encodes neurofibromin, a RAS GTPase-activating protein.

5 The DAB2IP tumor suppressor encodes a RAS GTPase-activating protein.

6 the NF1 gene, which encodes neurofibromin, a RAS GTPase-activating protein.

7 hoprotein reported to bind the SH3 domain of Ras GTPase-activating protein.

8 that binds to the pleckstrin domain of p120 Ras GTPase-activating protein.

9 ppressor postulated to function in part as a Ras GTPase-activating protein.

10 nositol 3'-kinase, phospholipase Cgamma, and Ras-GTPase activating protein.

11 ed CAPRI and RASAL as related Ca2+-triggered Ras GTPase-activating proteins.

12 We identified the synaptic Ras GTPase activating protein 1 (Syngap1), encoded by a

13 otein (CREB) phosphorylation via RASA1 (p120 Ras GTPase-activating protein 1) down-regulation, wherea

14 rat homolog, but not its mutant defective in Ras GTPase activating protein activity, reverses miR-431

15 al known properties and functions, including Ras GTPase-activating protein activity, adenylyl cyclase

16 SYNGAP1, a synaptic Ras GTPase activating protein, and SHANK3, a synaptic sc

17 gene product, neurofibromin, functions as a Ras GTPase-activating protein, and has been proposed to

18 F receptors including phospholipase C gamma, Ras GTPase-activating protein, and phosphotyrosine phosp

19 The NF1 gene encodes for neurofibromin, a RAS GTPase-activating protein, and thus negatively regul

20 HB4 (ephrin receptor B4) and the RASA1 (p120 Ras GTPase-activating protein) are necessary for the dev

21 rategy and demonstrate its implementation on Ras GTPase-activating protein-binding protein 1 (G3BP1)

22 Stress granule (SG) formation mediated by Ras GTPase-activating protein-binding protein 1 (G3BP1)

23 ss granules are formed through the switch of Ras GTPase-activating protein-binding protein 1 (G3BP1)

24 s were enriched, including the SG-nucleating Ras GTPase-activating protein-binding protein 1 (G3BP1).

25 The Ras GTPase-activating protein-binding protein G3BP1 is a

26 Ras GTPase-activating protein-binding proteins 1 and 2 (

27 d Ras on the plasma membrane by means of the Ras GTPase-activating protein CAPRI.

28 Finally, we showed that Carabin Ras-GTPase-activating protein domain and calcineurin-int

29 completely rescued by expression of the GAP (RAS-GTPase activating protein) domain of neurofibromin.

30 Elimination of Ras GTPase-activating protein enhanced E-CD4 but decreas

31 (AIP1), a recently identified member of the Ras GTPase-activating protein family, is highly expresse

32 DAB2 interactive protein) is a member of the RAS-GTPase-activating protein family.

33 synGAP is a neuron-specific Ras GTPase-activating protein found in high concentratio

34 emonstrates that the loss of DAB2IP, a novel Ras-GTPase activating protein frequently found in many c

35 calcium-promoted Ras inactivator (CAPRI), a Ras GTPase-activating protein, functions as an adaptor f

36 sential for signaling and contains a R-Ras/M-Ras GTPase activating protein (GAP) domain that is divid

37 Moreover, the synaptic Ras GTPase activating protein (GAP) SynGAP is selectivel

38 la mutation on the interaction of H-Ras with Ras GTPase activating protein (GAP), neurofibromin 1 (NF

39 Ras signalling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity.

40 The NF1-encoded protein neurofibromin is a Ras GTPase-activating protein (GAP) and can directly lim

41 t their effects via an intracellular R-Ras/M-Ras GTPase-activating protein (GAP) domain or by activat

42 ut not GAPex-5DeltaGAP, a mutant lacking the Ras GTPase-activating protein (GAP) domain.

43 One domain is homologous to Ras GTPase-activating protein (GAP) domains.

44 DAB2 interacting protein) is a member of the Ras GTPase-activating protein (GAP) family that has been

45 at Ras, through an effector-like function of Ras GTPase-activating protein (GAP) in neonatal cardiac

46 The Ras GTPase-activating protein (GAP) p120RasGAP inhibits

47 RASAL2 is a RAS GTPase-activating protein (GAP) that has been associ

48 romoted Ras inactivator), a Ca(2+)-dependent Ras GTPase-activating protein (GAP) that switches off th

49 To distinguish between inhibition of Ras by Ras GTPase-activating protein (GAP) versus a potential e

50 SynGAP is a synaptic Ras GTPase-activating protein (GAP) with four C-terminal

51 kDa by SDS-PAGE and associates with the p120 ras GTPase-activating protein (GAP).

52 ere we report that sphingosine can stimulate Ras-GTPase activating protein (GAP) activity in vitro, a

53 coded protein, neurofibromin, functions as a Ras-GTPase activating protein (GAP), nothing is known ab

54 ity of, Bruton's tyrosine kinase (Btk) and a Ras GTPase-activating protein, Gap1m, in vitro and in vi

55 In addition to the two Ras GTPase activating proteins (GAPs; p120- and NF1-GAP)

56 GAP1(m) is a member of the GAP1 family of Ras GTPase-activating proteins (GAPs) [1].

57 he tyrosine phosphorylation of two important Ras GTPase-activating proteins (GAPs), p120 Ras-GAP and

58 ced wild-type TC21 activity in vivo and that Ras GTPase-activating proteins (GAPs; p120-GAP and NF1-G

59 SynGAP is a Ras-GTPase activating protein highly enriched at excitat

60 SYNGAP1 is a Ras-GTPase-activating protein highly enriched at excitat

61 novel GTPase-activating protein containing a Ras GTPase-activating protein homology domain (N terminu

62 Ras-GRF mutant containing the PH domain from Ras-GTPase-activating protein in place of its own N-term

63 RasGAP (Ras GTPase-activating protein) is a negative regulator a

64 One insertion was in the gene encoding Ras GTPase-activating protein; its overexpression phenot

65 in signaling and prevent inactivation by the RAS GTPase-activating protein neurofibromin 1.

66 mutations in the NF1 gene, which encodes the RAS GTPase-activating protein neurofibromin.

67 ith PLCgamma, phosphatidylinositol 3-kinase, Ras GTPase-activating protein, or protein tyrosine phosp

68 The mammalian Ras GTPase-activating protein (p120Ras-GAP) interacts wi

69 Here, we report a novel synaptic Ras-GTPase activating protein (p135 SynGAP) that is a ma

70 -back' mutants in which association with the Ras GTPase-activating protein, phosphatidylinositol 3-ki

71 992 receptors were associated with more SOS, Ras-GTPase activating protein, phosphatidylinositol 3-ki

72 n as DAB2IP), a novel member of the Ras-GAP (Ras-GTPase-activating protein) protein family, opens its

73 ells while the phosphorylation/activation of Ras GTPase activating protein (Ras GAP) and mitogen acti

74 Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is

75 In the present study, we identified a novel Ras GTPase-activating protein (Ras-GAP) as an ASK1-inter

76 Loss of the RAS GTPase-activating protein (RAS-GAP) NF1 drives aberr

77 l abolished the association of PDGFalphar to Ras GTPase-activating protein (Ras-GAP), but it did not

78 ongly reduced by silencing expression of the Ras-GTPase activating protein (Ras-GAP) neurofibromin, a

79 s that contains a 216-amino acid domain with Ras-GTPase-activating protein (Ras-GAP) activity.

80 we demonstrate that RASAL2, which encodes a RAS-GTPase-activating protein (RAS-GAP), is a functional

81 an include functional alteration of GTPases, Ras GTPase-activating proteins, Ras guanine exchange fac

82 Yeast 2-hybrid analyses identified the Ras GTPase-activating protein Rasa1, a known regulator o

83 g of LFA-1 to ICAM-1, including the Rap1 and Ras GTPase-activating protein RASA3.

84 effect found in our previous studies of the Ras GTPase activating protein (RasGAP) and the elongatio

85 ras GTPase activating protein (rasGAP) is highly conserv

86 n (G125V) in the scat Rasa3 gene, encoding a Ras GTPase activating protein (RasGAP), and elucidate th

87 One key regulator of this cascade is the Nf1 Ras GTPase activating protein (RasGAP), which attenuates

88 The NF1-encoded protein is a Ras GTPase-activating protein (RasGAP) [2].

89 NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss driv

90 acted with the SH3 domain and phosphorylated Ras GTPase-activating protein (RasGAP) and upregulated R

91 aptor Grb2-associated binder-1 (GAB1) on its RAS GTPase-activating protein (RASGAP) binding sites and

92 orylation of Dok-1, augmented recruitment of Ras GTPase-activating protein (RasGAP) by Dok-1, and inh

93 AP1 as a human protein related to a putative Ras GTPase-activating protein (RasGAP) from the fission

94 Specifically, we show that loss of the Ras GTPase-activating protein (RasGAP) gene DAB2IP induc

95 We have previously reported that Ras GTPase-activating protein (RasGAP) is involved in a

96 These screens converged on RASA2, a RAS GTPase-activating protein (RasGAP) that we identify

97 of activated Ras by blocking recruitment of Ras GTPase-activating protein (RasGAP) to the plasma mem

98 otifs in the C terminus and does not bind to Ras GTPase-activating protein (RasGAP) upon phosphorylat

99 y, including Nck adaptor protein (Nck), p120-Ras GTPase-activating protein (RasGAP), and the alpha- a

100 p62(dok) associates with the Ras GTPase-activating protein (RasGAP), but only when p6

101 predicted, growth-related targets, including Ras GTPase-activating protein (RasGAP), cyclin-dependent

102 peptide derived from the N2 fragment of p120 Ras GTPase-activating protein (RasGAP), sensitizes tumor

103 Dok, a 62-kDa Ras GTPase-activating protein (rasGAP)-associated phosph

104 A 62-kDa Ras GTPase-activating protein (RasGAP)-associated protei

105 docking platform for the SH2 domains of the Ras GTPase-activating protein (RasGAP).

106 the process of Ras inactivation catalyzed by Ras GTPase-activating protein (RasGAP).

107 coded protein, neurofibromin, functions as a Ras-GTPase activating protein (RasGAP).

108 precisely controlled by mechanisms involving Ras GTPase activating proteins (RasGAPs) responsible for

109 However, it is unknown which Ras GTPase-activating proteins (RasGAPs) inactivate Ras

110 Ras GTPase-activating proteins (RasGAPs) inhibit signal

111 Rasal, belonging to the GAP1 subfamily of Ras GTPase-activating proteins (RasGAPs) with dual RasGA

112 Nf1, a tumor suppressor gene that encodes a Ras-GTPase-activating protein, results in hyperactivity

113 We further show that nsp1 interacts with Ras GTPase-activating protein SH3 domain-binding protein

114 tors (HERs), induced expression of G3BP, the Ras GTPase-activating protein SH3 domain-binding protein

115 The Ras-GTPase activating protein SH3 domain-binding protein

116 Here, the Ras-GTPase-activating protein SH3 domain-binding protein

117 resis and identified by mass spectrometry as Ras-GTPase-activating protein SH3 domain-binding protein

118 teins (p85 (phosphoinositide 3-kinase), Vav, Ras-GTPase-activating protein SH3 domain-binding protein

119 that members of the Ras network of proteins, Ras-GTPase activating protein-SH3-domain-binding protein

120 Here, we describe the isolation of a novel Ras-GTPase activating protein, SynGAP, that interacts wi

121 The Ras GTPase-activating protein SYNGAP1 plays a central ro

122 to citron, p135 SynGAP, an abundant synaptic Ras GTPase-activating protein that can bind to all three

123 RASA1 (also known as p120 RasGAP) is a Ras GTPase-activating protein that functions as a regula

124 SynGAP is a brain-specific ras GTPase-activating protein that is an abundant compon

125 e we report the characterisation of RASAL, a Ras GTPase-activating protein that senses the frequency

126 SYNGAP1 is a Ras GTPase-activating protein that underlies the formati

127 ating protein (SynGAP) is a neuronal RasGAP (Ras GTPase-activating protein) that is selectively expre

128 as, suggesting that it may also compete with Ras GTPase-activating protein, thus contributing to the

129 A Ras GTPase activating protein tumor suppressor (RasGAP),

130 alyzed GTP hydrolysis in water, Ras, and Ras.Ras-GTPase-activating protein using quantum mechanics/mo

131 Ras GTPase-activating protein was found to be a caspase

132 We discovered that DAB2IP, a novel Ras-GTPase-activating protein, was frequently epigenetic

133 ing protein homologous to mammalian synaptic Ras GTPase-activating protein, which modify daf-7 expres