ライフサイエンスコーパス: Ras superfamily

1 Oncogenic mutations were identified in the Ras superfamily.

2 nsduction proteins, including members of the Ras superfamily.

3 eins that form the largest family within the Ras superfamily.

4 enylation, including the oncoproteins of the RAS superfamily.

5 nsduction proteins, including members of the Ras superfamily.

6 nus) identified previously in members of the Ras superfamily.

7 tein that defines a distinct subgroup of the Ras superfamily.

8 egulated by the Spg1 GTPase, a member of the Ras superfamily.

9 ty with previously identified members of the Ras superfamily.

10 l specialization of different members of the Ras superfamily.

11 form a novel subfamily of GTPases within the Ras superfamily.

12 nd RBEL1B, that function as novel GTPases of Ras superfamily.

13 Rap1 is a small GTPase that belongs to Ras superfamily.

14 ylated proteins, most notably GTPases in the Ras superfamily.

15 ane association of many small GTPases in the Ras superfamily.

16 s, kinases, phosphatases, and members of the RAS superfamily.

17 nal protein, whereas in other members of the Ras superfamily a separate GAP molecule interacts with t

18 Unexpectedly, Ras superfamily analyses revealed several large (5+) lin

19 ases represent the largest branch of the p21 Ras superfamily and are recognized as key players in ves

20 Rho family GTPases are a part of the Ras superfamily and are signaling hubs for many cellular

21 ExoS) ADPRT activity include proteins in the Ras superfamily and ERM family proteins.

22 RhoC-GTPase is a member of the Ras-superfamily and is involved in cell polarity and mot

23 Genes encoding the small GTPases of the Ras superfamily are among the most frequently mutated or

24 Small GTPases of the Ras superfamily are essential regulators of intracellula

25 ulating data indicate that activation of the RAS superfamily are poor biomarkers of statin sensitivit

26 ike protein, and MglA, a small GTPase of the Ras superfamily, as essential for both motility systems.

27 ination (NDU) is a critical regulator of the Ras superfamily, but its relevance to Rho proteins remai

28 The Ras superfamily can be further divided into several smal

29 The Ras superfamily consists of a large group of monomeric G

30 Small G-proteins of the Ras superfamily control the temporal and spatial coordin

31 topic expression of different members of the RAS superfamily did not uniformly sensitize cells to flu

32 This finding suggests that GTPases of the Ras superfamily each may share common features of GEF-me

33 Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP bindin

34 iological function for this new farnesylated Ras superfamily G-protein.

35 ferential display was used to identify a new Ras superfamily gene (Dexras1) induced by dexamethasone

36 microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estro

37 specifically in 43-day-old rats included the Ras superfamily genes and genes associated with protein

38 s of RERG are strikingly different from most Ras superfamily GTP-binding pro-teins and suggest that t

39 Rheb is a unique member of the Ras superfamily GTP-binding proteins.

40 Ras superfamily GTPase activation and inactivation occur

41 Rac is a Ras superfamily GTPase that, when activated, functions d

42 ontrol protein 42 homolog (Cdc42) protein, a Ras superfamily GTPase, regulates cellular activities, i

43 by Rheb (Ras homologue enriched in brain), a Ras superfamily GTPase.

44 cleotide-free state, defining a new class of Ras-superfamily GTPase effectors that function as guanin

45 The GTP/GDP nucleotide switch in Ras superfamily GTPases generally involves differential

46 2 (RAC2) is a member of the RHO subclass of RAS superfamily GTPases required for proper immune funct

47 to be common to other NKCD motif-containing Ras superfamily GTPases, as NO/O2 also facilitates GNE o

48 observed in many autoinhibited effectors of Ras superfamily GTPases, suggesting evolutionary pressur

49 rosine-phosphorylated Eph receptors to small Ras superfamily GTPases.

50 The Ras-superfamily GTPases are central controllers of cell

51 ion to the rule that only GTP-bound forms of Ras-superfamily GTPases have active conformations.

52 on of membrane-dependent properties of other Ras-superfamily GTPases.

53 GEFs) bind cAMP and selectively activate the Ras superfamily guanine nucleotide binding protein Rap1A

54 Many members of the Ras superfamily (Ha-Ras, N-Ras, TC21, and RhoA) are pren

55 Several small GTPases of the Ras superfamily have been shown to antagonize TGFbeta si

56 ese modified proteins include members of the Ras superfamily, heterotrimeric G-proteins, centromeric

57 The Ras superfamily includes the Ras, Rho, Ran, Arf, and Rab

58 A unifying feature of the RAS superfamily is a conserved GTPase cycle by which the

59 The Ras superfamily is a fascinating example of functional d

60 The Ras superfamily is comprised of at least four large fami

61 oteins and small GTP binding proteins of the Ras superfamily is that the former bind GTP or guanosine

62 Cdc42p, a Rho family GTPase of the Ras superfamily, is a key regulator of cell polarity and

63 ARF family of regulatory GTPases, within the RAS superfamily, is composed of ~30 members in mammals,

64 Dexras1 is the first Ras superfamily member identified that is induced in res

65 These experiments reveal a novel role for a Ras superfamily member in catalyzing cyclin E turnover d

66 canonical GTP/GDP switch that regulates most Ras superfamily members, our results reveal an unprecede

67 s proteins including many that interact with Ras superfamily members, such as p120 GAP.

68 The new member of the Ras superfamily of G-proteins, Rheb, has been identified

69 heb GTPases represent a unique family of the Ras superfamily of G-proteins.

70 The ras superfamily of GTP binding proteins encompasses a wi

71 RGK (Rem, Rad, and Gem/Kir) subfamily of the Ras superfamily of GTP binding proteins.

72 The Ras superfamily of GTP-binding proteins is involved in a

73 GAP) interacts with activated members of the Ras superfamily of GTP-binding proteins to accelerate th

74 ion factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical co

75 Cdc42Hs, a member of the Ras superfamily of GTP-binding proteins, initiates a cas

76 gle-point mutant of Cdc42Hs, a member of the Ras superfamily of GTP-binding proteins, that facilitate

77 Cdc42Hs, a member of the Ras superfamily of GTP-binding signal transduction prote

78 Cdc42Hs is a member of the Ras superfamily of GTPases and initiates a cascade that

79 RhoA belongs to the Ras superfamily of GTPases and is a key regulator of act

80 ted gene encoding a protein belonging to the RAS superfamily of GTPases and is located within an intr

81 in vivo functions of ARF-like members of the Ras superfamily of GTPases are relatively unexplored.

82 The Ras superfamily of GTPases have been revealed to be mast

83 The Ras superfamily of GTPases is involved in the modificati

84 Cdc42Hs is a member of the Ras superfamily of GTPases which, when active, initiates

85 /Sec4 family forms the largest branch of the Ras superfamily of GTPases, acting as essential regulato

86 ass IA PI3Ks are activated downstream of the Ras superfamily of GTPases, and Ras-PI3K interaction pla

87 as-related nuclear) protein, a member of the Ras superfamily of GTPases, is best known for its roles

88 Ran, a member of the Ras superfamily of GTPases, is predominantly localized i

89 ithin the ADP-ribosylation factor family and Ras superfamily of GTPases, is required for ciliary stru

90 RbgA, unlike many members of the Ras superfamily of GTPases, lacks a defined catalytic re

91 Within the Ras superfamily of GTPases, Rap1 and Rap2 are the closes

92 Rho, a member of the Ras superfamily of GTPases, regulates cytoskeletal rearr

93 GTP binding protein that is a member of the ras superfamily of GTPases, respectively.

94 The Ral proteins are members of the Ras superfamily of GTPases.

95 s, 1C and 1D, with signaling cascades of the Ras superfamily of GTPases.

96 The RhoH protein is a member of the Ras superfamily of guanosine triphosphate-binding protei

97 t that AlF4- does not mediate effects on the Ras superfamily of low molecular weight GTP-binding prot

98 Members of the Ras superfamily of monomeric GTP-binding proteins have b

99 ins can be uncoupled from prenylation of the RAS superfamily of oncoproteins.

100 at associate with the GTP-bound forms of the Ras superfamily of proteins are potential effector targe

101 RhoA, a member of the Ras superfamily of proteins, activates serum response el

102 s model and its general applicability to the Ras superfamily of proteins.

103 dissociation from Ral, another member of the Ras superfamily of proteins.

104 ases (GTPases) is composed of members of the Ras superfamily of proteins.

105 he ADP-ribosylation factor family within the Ras superfamily of regulatory GTPases.

106 (ARLs) are part of the ARF family within the RAS superfamily of regulatory GTPases.

107 Members of the Ras superfamily of signaling proteins modulate fundament

108 ta indicate that AGS1/RASD1, a member of the Ras superfamily of small G-proteins that often promotes

109 TC21 is a highly oncogenic member of the Ras superfamily of small GTP binding proteins.

110 Rap1 is a member of the Ras superfamily of small GTP-binding proteins and has 2

111 Rap1 is a member of the Ras superfamily of small GTP-binding proteins and is loc

112 TC21 is a member of the Ras superfamily of small GTP-binding proteins and, like

113 genes detected include a novel member of the Ras superfamily of small GTP-binding proteins, a novel S

114 R-Ras is a member of the RAS superfamily of small GTP-binding proteins.

115 phic pathways include those regulated by the Ras superfamily of small GTPases and a separate calcineu

116 Ral proteins are members of the Ras superfamily of small GTPases and are involved in sig

117 the Rala and Ralb genes, are members of the RAS superfamily of small GTPases and can act as downstre

118 Rab7 belongs to the Ras superfamily of small GTPases and is a master regulat

119 Members of the Ras superfamily of small GTPases and the heterotrimeric

120 Members of the Ras superfamily of small GTPases are frequently mutated

121 The Ras superfamily of small GTPases are guanine-nucleotide-

122 The Ras superfamily of small GTPases comprises a group of mo

123 embers of the Ras and Rho subfamilies of the Ras superfamily of small GTPases function as molecular s

124 , is distinguished from other members of the Ras superfamily of small GTPases in that its members pos

125 The Ras superfamily of small GTPases is a group of more than

126 uman members) comprise a major branch of the Ras superfamily of small GTPases, and aberrant Rho GTPas

127 Two members of the Ras superfamily of small GTPases, K-Ras and RhoA, activa

128 nction at cellular membranes and include the Ras superfamily of small GTPases, nuclear lamins, the ga

129 the most extensively studied members of the Ras superfamily of small GTPases, Rac1 is an intracellul

130 R-Ras is a member of the Ras superfamily of small GTPases, which are regulators o

131 of homology characteristic of members of the Ras superfamily of small GTPases.

132 rms TC21, R-Ras and M-Ras are members of the Ras superfamily of small GTPases.

133 , we demonstrate that Rab32, a member of the Ras superfamily of small molecular weight G-proteins, in

134 hologies thus establishes a link between the Ras superfamily of small regulatory GTPases and the acti

135 R-Ras3/M-Ras is a member of the RAS superfamily of small-molecular-weight GTP-binding pr

136 f the Rho-type GTPases as a subfamily of the Ras-superfamily of small GTP-binding proteins in the dev

137 cleotide-binding proteins and members of the Ras superfamily, originally identified and purified by t

138 a guanine nucleotide exchange factor for the Ras superfamily protein Arf6 that helps assemble and sta

139 Rap1 GTPase-activating protein, inhibits the RAS superfamily protein Rap1 by facilitating hydrolysis

140 G-protein-like domain (GLD) with homology to Ras superfamily proteins and a PH domain.

141 Ras superfamily proteins participate in TGF-beta-mediate

142 minal fragment of RGL2 (RGL2 C-158) bound to Ras superfamily proteins which shared identical effector

143 he release of tightly bound GDP from various Ras superfamily proteins, including RhoA, Rac1, K-Ras, R

144 Like most Ras superfamily proteins, the GTPase domain of Ras homol

145 a broad range of GTPase-deficient mutants of Ras superfamily proteins.

146 Although structurally similar, Ras-superfamily proteins are functionally diverse.

147 ntaxin, in addition to a small GTPase of the ras superfamily, rab3, were present on cortical granules

148 Like other small G proteins of the Ras superfamily, Rap1 is activated by distinct guanine n

149 ing representatives from two branches of the Ras superfamily, Ras and Rho.

150 fied membrane proteins include 30 members of ras superfamily, receptors (e.g., EGF receptor, integrin

151 The GTPases of the Ras superfamily regulate cell growth, membrane traffic a

152 Members of the Ras superfamily regulate many cellular processes.

153 Ran is a small GTP-binding protein of the Ras superfamily regulating fundamental cellular processe

154 ntify and characterize a novel member of the Ras superfamily, RRP22.

155 ated signaling to include direct coupling to Ras superfamily signaling.

156 ort that ADP-ribosylation factor 6 (ARF6), a Ras superfamily small GTPase, is abundantly expressed in

157 Thus, we identify a new member of the Ras superfamily that can serve as a potential tumor supp

158 omeric GTP binding proteins belonging to the ras superfamily that function throughout the secretory p

159 ix proteins within the larger Arf family and Ras superfamily that regulate membrane traffic.

160 tyrosine kinases and small G-proteins of the Ras superfamily that stimulate specific isoforms of phos

161 Within the Ras superfamily, the Arf family is composed of 30 member

162 locentrotus purpuratus genome: the monomeric Ras superfamily, the heterotrimeric G proteins, the dyna

163 ta) cooperates with oncogenic members of the Ras superfamily to promote cellular transformation and t

164 osylation factor 6 (ARF6) is a member of the Ras superfamily, which is critical to a wide variety of

165 em is a small GTP-binding protein within the Ras superfamily whose function has not been determined.

166 small GTP-binding protein is a member of the Ras superfamily with significant homology to both Ras an