ライフサイエンスコーパス: Rho GTPase

1 lial and alveolar epithelial cells via small Rho GTPase.

2 ivision plane, bypassing the requirement for Rho GTPase.

3 s that serve as key downstream effectors for Rho GTPases.

4 or of ECT2, a GEF required for activation of Rho GTPases.

5 a in vitro through possible interaction with Rho GTPases.

6 e formation of the active GTP-bound state of Rho GTPases.

7 ly involve spatially localized activation of Rho GTPases.

8 by monitoring the activation state of small Rho GTPases.

9 P, a disruption that does not exist in other Rho GTPases.

10 on multiple cell types and signaling through Rho GTPases.

11 G-proteins or for other G-proteins, such as Rho GTPases.

12 aspects of cell morphogenesis by turning on Rho-GTPases.

13 mitochondrial membrane protein mitochondrial Rho GTPase 1 (Miro1) is a master regulator of mitochondr

14 e used cells deficient for the mitochondrial Rho-GTPase 1 (Miro1), an essential mediator of microtubu

15 The mitochondrial Rho-GTPase 1 protein (Miro1) regulates mitochondrial tra

16 Through studying Borg5 (Binder of the Rho GTPase 5), which belongs to a family of poorly under

17 RAC1 is a widely studied Rho GTPase, a class of molecules that modulate numerous

18 erated mechanical forces and the activity of Rho GTPases, a family of small GTP-binding proteins that

19 ad perturbations in four signaling pathways, Rho GTPases, actin, microtubule, and kinases-related pat

20 in cytoskeletal remodeling via regulation of Rho GTPases, acting as a negative regulator of ECT2, a G

21 Rho GTPases, activated by guanine nucleotide exchange fa

22 Rho GTPases, activated by Rho guanine nucleotide exchang

23 3D spheroids of human cells, we identify the Rho GTPase activating protein ARHGAP18 as an effector of

24 Oligophrenin-1 (Ophn1) encodes a Rho GTPase activating protein whose mutations cause X-li

25 ends on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and it

26 Deleted in Liver Cancer 1 (DLC1) is a RHO GTPase-activating protein (GAP) that negatively regu

27 The myosin Myo9b, a Rho GTPase-activating protein (GAP), negatively regulate

28 9, and S567) in the DLC1 tumor suppressor, a Rho GTPase-activating protein (RhoGAP) associated with f

29 ssociation of intronic variants in ARHGAP15 (Rho GTPase-activating protein 15; rs4662344-T: P=1.9 x 1

30 e 12 (MMP12)/MMP13, catenin alpha3 (CTNNA3), rho GTPase-activating protein 24 (ARHGAP24), angiopoieti

31 ll spreading through its interaction partner Rho GTPase-activating protein 29 (ArhGAP29), a GTPase ac

32 comprising the Cdc42-interactor IQGAP1, the Rho GTPase-activating protein ARHGAP10, and the integrin

33 emonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in smooth muscle

34 ty defect of macrophages lacking the RhoGAP (Rho GTPase-activating protein) myosin IXb (Myo9b).

35 otypically enriched Cadherin2 sequesters the Rho GTPase-activating protein, Gap21/23, to homotypic ju

36 r with its binding partner ARHGAP35/P190A, a RHO GTPase-activating protein, in the radial glia-like n

37 Here we show that ArhGAP30, a Rho GTPase-activating protein, is a pivotal regulator fo

38 with exception of the Crossveinless-c (Cv-c) Rho GTPase-activating protein, most effectors exert litt

39 RHO GTPase-activating proteins (RHOGAPs) are one of the

40 duces formation of the AKT kinase (AKT)/DLC1 Rho-GTPase-activating protein (DLC1) complex and thereby

41 neurons require Crossveinless-c, a specific Rho-GTPase-activating protein (Rho-Gap), to alter their

42 cell, which might install platforms allowing Rho-GTPase-activating protein (RhoGAP) activity to be fo

43 Here, we demonstrate that the Rho-GTPase-activating protein alpha2-chimaerin is specif

44 Homeostatic sleep control requires the Rho-GTPase-activating protein encoded by the crossveinle

45 hat through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitator

46 also linked to cell survival, by increasing Rho GTPase activation.

47 says the Sestd1-Dact1 interaction can induce Rho GTPase activation.

48 leukemia-associated RhoGEF (LARG)-dependent Rho GTPase activation.

49 either the endocytic regulator TRIP10 or the Rho GTPase activator VAV2 reduces E-cadherin levels at j

50 rin, actin reorganization, localized Rac and Rho GTPase activities, and the development of strong cel

51 mics and interactions between cellular-level Rho GTPase activity and contractility and multicellular-

52 Finally, blockade of Rho GTPase activity eliminated the impact of GNA13 on NF

53 the feedback between mechanical tension and Rho GTPase activity in a biphasic manner.

54 These results indicate that Rho GTPase activity is required to establish a planar po

55 During collective cell migration, waves of Rho GTPase activity mediate mechanical contraction/exten

56 Rho GTPase activity needs to be precisely tuned at disti

57 promote wound closure by local inhibition of Rho GTPase activity via a redox-sensitive motif.

58 sfunction was also associated with increased Rho GTPase activity via activation of MT-bound Rho-speci

59 gnals through Abl family kinases to restrain Rho GTPase activity, support Hippo pathway suppressor fu

60 how that SLAIN2 inactivation does not affect Rho GTPase activity, trafficking, and focal adhesion for

61 n remodeling through the control of ECT2 and Rho GTPase activity.

62 ply our approach to the control of the Cdc42 Rho GTPase activity.

63 Differences in PtdIns3K and Rho-GTPase activity were attributable to the activity of

64 nstrates unique and sequential functions for Rho GTPase adaptors in regulating MAPK pathways.

65 pEM to experimental protein trajectories of Rho GTPases, an integral regulator of cytoskeletal dynam

66 on of Y256 of N-WASP via activation of small Rho GTPase and focal adhesion kinase mediates TGF-beta1-

67 horylation, which required the activation of Rho GTPase and focal adhesion kinase.

68 osyltransferase domain for inactivating host Rho GTPases and a cysteine protease domain for the deliv

69 n as effectors that specifically target host Rho GTPases and heterotrimeric G proteins, respectively.

70 viduals with SRNS abrogated interaction with RHO GTPases and increased active GTP-bound RAC1 and CDC4

71 esses regulated by Rasip1 through downstream Rho GTPases and NMII.

72 Although the role of typical Rho GTPases and other Rho-linked proteins in synaptic pl

73 By regulating actin cytoskeleton dynamics, Rho GTPases and their activators RhoGEFs are implicated

74 is intrinsically linked to the activation of Rho GTPases and their cytoskeletal-remodeling effectors.

75 As effectors of cytoskeletal dynamics, Rho GTPases and their regulators are likely involved, bu

76 on of the actomyosin cytoskeleton, through a Rho-GTPase and Rho-associated kinase (ROCK).

77 o metastasize and engages actin dynamics via Rho-GTPases and cofilin in this process.

78 of paxillin and activated p42/44-MAP kinase, Rho GTPase, and paxillin/GEF-H1/p42/44-MAPK association.

79 patiotemporal dynamics of F-actin and active Rho GTPase, and that Cdh6 is required for accumulation o

80 , likely secondary to elevated activation of RHO GTPases, and 2) increased salivary cell proliferatio

81 signaling molecules, including MAP kinases, Rho GTPases, and components of the Wnt signaling pathway

82 infections, parasitic infections, activated Rho GTPases, and endoplasmic reticulum (ER) stress.

83 mouse mutagenesis screen and identified the Rho GTPase antagonist p190RhoGAP as a critical regulator

84 Rho GTPases are activated by Rho guanine exchange factor

85 found in cancer and developmental disorders, Rho GTPases are activated most commonly in disease by in

86 e nucleotide exchange factors (Rho GEFs) and Rho GTPases are among the key regulators of cytokinesis.

87 Rho GTPases are central regulators of the cytoskeleton a

88 remains unknown how activities of different Rho GTPases are coordinated by Rasip1 to direct tubuloge

89 Rho GTPases are critical signal transducers of multiple

90 Rho GTPases are frequent targets of virulence factors as

91 Rac-family Rho GTPases are implicated in leukocyte function; howeve

92 RHO GTPases are key regulators of the cytoskeletal archi

93 Rho GTPases are known to be involved in formin activatio

94 Rho GTPases are master regulators of the eukaryotic cyto

95 Rho GTPases are molecular "switches" that cycle between

96 Rho GTPases are molecular switches that modulate a varie

97 Recent studies suggest that Rho GTPases are necessary for LTP.

98 Our results reveal that the three Rho GTPases are necessary to control and coordinate acti

99 The GTP hydrolysis activities of Rho GTPases are stimulated by GTPase-activating proteins

100 Rho GTPases are the major players that guide cells throu

101 cular pathways downstream of Cdc42, Rac, and Rho GTPases are well documented, but we know surprisingl

102 sophila melanogaster cell wound repair model Rho GTPase arrays form in response to prepatterning by R

103 F7, a guanine nucleotide exchange factor for Rho GTPases, as one novel TIP-1-interacting protein in h

104 f CDC42 (cell division cycle 42), one of the Rho-GTPases associated with Th-cell differentiation, was

105 ions between C-terminal scaffold domains and Rho GTPases at the membrane.

106 Rho GTPase-based signaling networks control cellular dyn

107 Our results provide evidence for a RHO GTPase-based signalling mechanism to mediate sperm r

108 gy (DH) domain in a manner that occludes the Rho GTPase binding site, thereby suggesting the molecula

109 cell imaging including the use of FRET-based Rho GTPase biosensors.

110 ease-like catalytic triad, which inactivates Rho GTPases by deamidating a conserved asparagine in the

111 that medium folate regulates the function of Rho GTPases by enabling their carboxyl methylation and t

112 Excessive activation of small Rho GTPases by virulence factors of enteric pathogens al

113 Herein, we demonstrate that AMPylation of Rho GTPases by VopS is a multifaceted virulence mechanis

114 e factors (GEFs), the enzymes that stimulate Rho GTPases, can be a valuable therapeutic strategy to t

115 tream signaling molecules of TLR4, including Rho GTPase Cdc 42 and TRAF6.

116 forts that investigate how PARs regulate the Rho GTPase CDC-42, which in turn regulates the actin-myo

117 nick accelerates migration by activating the Rho GTPase Cdc42 and inducing fascin expression.

118 in part mediated by down-regulation of small Rho GTPase CdC42 and the protein target PAK1, but not by

119 Here, we show that the Rho GTPase Cdc42 controls synapse formation in monosynap

120 The Rho GTPase Cdc42 coordinates regulation of the actin and

121 The small Rho GTPase Cdc42, known to interact with Wiskott-Aldrich

122 a adenosine A1 receptor (A1R) induction of a Rho GTPase CDC42-dependent conformational change of the

123 with EXC-5/FGD, a predicted activator of the Rho GTPase Cdc42.

124 a guanine nucleotide exchange factor for the Rho-GTPase CDC42, which is known for its role in the ass

125 sion yeast Schizosaccharomyces pombe has six Rho GTPases (Cdc42 and Rho1-Rho5) and seven Rho GEFs (Sc

126 tin cytoskeleton through the activity of the Rho-GTPase, CDC42.

127 In yeast, the Rho GTPase Cdc42p regulates cell polarity, and through t

128 The highly conserved Rho-GTPase Cdc42p promotes yeast fusion through interact

129 in neurons through increased turnover of the Rho GTPase Cell Division Cycle 42 (Cdc42) protein.

130 significantly greater proportion of the two Rho GTPases cell division cycle 42 (CDC42) and Rac famil

131 Rho GTPases control both the actin cytoskeleton and adhe

132 Rho GTPases control various signaling pathways downstrea

133 ases mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fet

134 es revealed a smoke-induced up-regulation of Rho-GTPase-dependent actin cytoskeletal signaling that c

135 -bound form of the conserved small G protein Rho GTPase directly activates mTORC2 in AKT phosphorylat

136 e Salmonella effector SopE, we recapitulated Rho GTPase-driven actin polymerization at model phosphol

137 rlying this process, we examined the role of Rho GTPases during cardiac migration using inhibitory an

138 The downstream Rho GTPase effectors mediating actin polymerization thro

139 Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase effectors that control key aspects of the act

140 We performed two siRNA screens targeting Rho-GTPases effectors and guanine nucleotide exchange fa

141 tion clearance, as well as for regulation of Rho GTPase (enzyme that hydrolyzes GTP) activity.

142 Rac and Rho GTPases exert opposing effects on cell morphology an

143 he Galpha(s) subfamily regulates activity of Rho GTPases extends our understanding of Galpha(s) activ

144 Network analyses identified enrichment of Rho GTPase, extracellular matrix, focal adhesion and cyt

145 membrane dynamics; however, the roles of the Rho GTPase family are not limited to cell adhesion and m

146 molecular targets in PCa cells including the Rho GTPase family members (for example, CDC42, CDC42EP3,

147 ct diffusive states conserved across various Rho GTPase family members.

148 imeric G protein subunits and members of the Rho GTPase family of small G proteins.

149 The Rho GTPase family plays critical roles in actin and memb

150 , and YAP-TRIO-Merlin mediated regulation of Rho GTPase family proteins, enhancing cell migration.

151 tic-specific, GTPase-deficient member of the Rho GTPase family that was first identified as a hypermu

152 are linked to cell migration such as p38 and rho GTPase-family activation, F-actin polymerization, ad

153 ng experimental data of mechanically-induced Rho GTPase FilGAP release from actin-filamin crosslinks.

154 mplex neural systems presented new roles for Rho GTPases, filled by new family members.

155 ight the importance of CirA in coopting host Rho GTPases for establishment of Coxiella burnetii infec

156 Collectively, these findings identify a Rho GTPase-formin network that is critically involved in

157 l-cell adhesion factors and cytoskeletal and rho-GTPase genes.

158 Cdc42, a member of Rho GTPases (guanosine triphosphatases), participates in

159 Rho GTPases have previously been implicated in promoting

160 Expression of a constitutively active Rho GTPase, however, restored inflammatory signalling.

161 ructural plasticity, we examined the role of Rho GTPase in dendritic spine remodeling.

162 es our current understanding of the roles of Rho GTPases in early erythropoiesis, downstream of cytok

163 o suggest that the targeting action of other Rho GTPases in other organ cells, such as RhoA in vascul

164 nteracted with ARHGDIA, a known regulator of RHO GTPases in podocytes that is dysfunctional in some t

165 Our findings reveal a critical role for Rho GTPases in positioning Ras activation and thereby es

166 We have analysed the expression levels of Rho GTPases in primary T-ALL samples compared with norma

167 Further elucidation of the role of Rho GTPases in the erythroid lineage development may rev

168 hRNA library screen of all human kinases and Rho-GTPases in a patient-derived NF1 (-/-) Schwann cell

169 hRNA library screen of all human kinases and Rho-GTPases in a patient-derived NF1(-/-) Schwann cell l

170 ignaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.

171 Rho GTPases inactivation domain and Ras/Rap1-specific en

172 e levels of RhoGDIalpha, a stabilizer of the Rho GTPases including Cdc42.

173 f actin filaments and myosin-2 controlled by Rho GTPases, including Rho and Cdc42.

174 This original mechanism of regulation of a Rho-GTPase-independent formin, recruited by Spire at Rab

175 During angiogenesis, Rho-GTPases influence endothelial cell migration and cel

176 o observed in embryos that were treated with RHO GTPases inhibitor.

177 Rhophilin-1 is a Rho GTPase-interacting protein, the biologic function of

178 ystematic RNA interference perturbation of a Rho GTPase interactome consisting of 219 proteins reveal

179 Localized activation of Rho GTPases is essential for multiple cellular functions

180 The activation of Rho GTPases is governed by Rho guanine nucleotide exchan

181 Rnd3, a small Rho GTPase, is involved in the regulation of cell actin

182 is" that consists of Wnt-FZD/ROR-Galpha12/13-Rho GTPases-Lats1/2 to promote YAP/TAZ activation and TE

183 nucleotide exchange factors (GEFs) activates Rho GTPases, leading to important roles for PREX protein

184 partitioning of charged polarity-regulating Rho GTPases like Rho1 or Cdc42 in a protein charge-depen

185 These findings suggest that distinct Rho GTPases may act as context-dependent integrators of

186 These results demonstrate that Rho GTPases may have a central role in regulating the br

187 n certain instances inhibition of individual Rho GTPases may paradoxically result in pro-neoplastic e

188 t cell migrations require cell polarization, Rho GTPase-mediated cytoskeletal rearrangements, and myo

189 has been suggested to code signals to induce Rho GTPase-mediated fibrosis, but it is obscure how the

190 GTPase DRP-1 but acts via the mitochondrial Rho GTPase MIRO-1 and cytosolic Ca(2+).

191 o PARKIN itself, its substrate mitochondrial Rho GTPase (MIRO), and UB.

192 interfere with the function of mitochondrial Rho GTPases Miro1 and Miro2.

193 regulated by three evolutionarily conserved Rho GTPases, notably, Rac1 activation is sufficient and

194 GLOSS2 (PAN2) and PAN1, and the small GTPase RHO GTPASE OF PLANTS (ROP) promote mother cell polarity

195 ar mechanotransduction and regulation of the Rho GTPase pathway.

196 h asthma.Conclusions: We found enrichment of Rho-GTPase pathways in obese asthmatic Th cells, identif

197 h-cell subtype proportions, were enriched in Rho-GTPase pathways.

198 91 up-regulated genes in the cell-cycle and Rho-GTPase pathways.

199 tenin mutants influenced p120(ctn)-dependent Rho GTPase phosphorylation and shifted cells towards dif

200 both GAPs regulate different spatiotemporal Rho GTPase pools, with distinct functions.

201 pression of RhoGDIalpha that in turn affects Rho GTPase protein levels, and thereby, controls cellula

202 Finally, we examined the role of the Rho GTPase proteins by injecting a selective inhibitor i

203 The Rho GTPase proteins Rac1, RhoA and Cdc42 have a central

204 The Rho GTPase Rac is crucially involved in controlling mult

205 The Rho GTPase Rac1 activates the WAVE regulatory complex (W

206 ns, using Src tyrosine kinase, GEF Vav2, and Rho GTPase Rac1 as examples.

207 The Rho GTPase Rac1 controls membrane spreading and stabiliz

208 Increased tension directly altered the small Rho GTPase Rac1, 3'-phosphoinositide, and cytoskeletal o

209 Since VAV2 serves as a GEF for the small Rho GTPase Rac1, a key player in cell motility and adhes

210 TKs), Src family PTK, focal adhesion kinase, Rho GTPase Rac1, and neural Wiskott-Aldrich syndrome pro

211 us potential host interactors, including the Rho GTPases Rac1 and Cdc42.

212 phosphoinositide 3-kinase in addition to the Rho GTPases Rac1 and Cdc42.

213 gnaling pathway and involves the PAR-1/c-Src/Rho GTPases Rac1 and Cdc42/c-Jun N-terminal kinase axis

214 ter was dependent on activation of the small Rho GTPases Rac1 and Rac2.

215 Here, we show that a Dictyostelium Rho GTPase, RacE, and a guanine nucleotide exchange fact

216 indirectly, through activation of the small Rho GTPase Ras-related C3 botulinum toxin substrate 1 (R

217 toma-associated protein and increases in the Rho GTPases Ras-related C3 botulinum toxin substrate 1 (

218 We show that Rho GTPase recruits Rho-kinase to adherens junctions and

219 multitude of RhoGEFs that activate a single Rho GTPase reflects the very specific role of each RhoGE

220 Rho GTPases regulate multiple cellular processes, such a

221 Ras homology (Rho) GTPases regulate cell polarity and signal transduct

222 nd some overall quantitative features of PKC-Rho GTPase regulation.

223 vertebrate species, TRIO is a well-conserved Rho GTPase regulator that is highly expressed in the dev

224 Rather, BAI1 associates with the Rho-GTPase regulatory protein Bcr late in development an

225 Here we show that RhoG, a Rho GTPase related to Rac, modulates FA dynamics.

226 croscopy and RT-PCR expression of Rac1/CdC42 Rho GTPases, responsible for actin remodeling, we show t

227 New methods to directly visualize Rho GTPases reveal how a protein called RhoGDI regulates

228 Moreover, investigating the role of Rho GTPases revealed that Cdc42 attenuates MMP-1 express

229 a-catenin) and RHO guanosine triphosphatase [RHO GTPase, RHO], two signaling pathways previously show

230 The Rho GTPases-Rho, Rac, and Cdc42-control an enormous vari

231 anization of actin filaments mediated by two Rho GTPases, Rho1p and Cdc42p.

232 The Rho GTPases RhoA and Rac1 function as master regulators

233 statin caused the translocation of the small Rho GTPases RhoA, Cdc42, and Rac1/2/3 from cell membrane

234 ugh a wealth of data exists on the canonical Rho GTPases RhoA, Rac1, and Cdc42, several other family

235 orphological switch that signals through the Rho-GTPase RhoA.

236 e spatiotemporally coordinated activation of Rho GTPases (RhoA, Cdc42 and Rac1) in migrating glioblas

237 y of actin cytoskeleton regulators, that is, Rho GTPases (RhoA, Rac1, and Cdc42).

238 Among the Rho GTPases, RhoA, Rac1 and Cdc42 are best characterized

239 In the current study, we identified Rho GTPases, RhoA, Rac1, and Cdc42, as potential upstrea

240 c Ca(2+) pools, which leads to a decrease in Rho-GTPases, RhoA and Rac1, and Ca(2+)-dependent Calpain

241 thy and have elucidated the role of atypical Rho GTPase RhoBTB in Drosophila neurological function an

242 The atypical Rho GTPase Rnd3 is selectively expressed by OFF SACs and

243 s dependent on the expression of an atypical RHO-GTPase, RND3/RHOE, together with its binding partner

244 hange factor (PIX; Arhgef6), an activator of Rho GTPases, showed greatly increased motility and alter

245 To test the hypothesis that dysregulated Rho GTPase signaling and a resulting fibrotic activity w

246 , p190RhoGAP-A and -B, are key regulators of Rho GTPase signaling and are essential for actin cytoske

247 ession of the ADFH domain of mAbp1 increased Rho GTPase signaling and breast cancer cell invasion.

248 y integrating guidance signals with the ROP1 Rho GTPase signaling and coordinating intracellular sign

249 inding partners that differentially regulate Rho GTPase signaling and MTLn3 breast cancer cell invasi

250 hat LLG1 is a component of the FER-regulated RHO GTPase signaling complex and that fer and llg1 mutan

251 IPs in mutant HTT toxicity, we show that the Rho GTPase signaling components, BAIAP2, EZR, PIK3R1, PA

252 Agonist-induced activation of Rho GTPase signaling leads to endothelial cell (EC) perm

253 e a starting point to dissect spatiotemporal Rho GTPase signaling networks that regulate neurite outg

254 Apical constriction depends on a Rho GTPase signaling pathway (T48/Fog) that is deployed

255 Surprisingly, RNA-Seq analysis of the Rho GTPase signaling transcriptome revealed high express

256 HD, including mammalian target of rapamycin, Rho GTPase signaling, and oxidative stress response.

257 cancer-associated fibroblasts and linked to Rho GTPase signaling.

258 esion associated signalosome, which triggers Rho GTPase signaling.

259 podocyte function, likely through regulating RHO GTPase signaling.

260 turbed system and in the context of modified Rho GTPase signaling.

261 1beta altered the cell cycle (108 genes) and Rho GTPases signaling (72 genes) in chondrocytes, while

262 ulator of filopodia formation, which couples Rho-GTPase signaling to actin cytoskeleton and membrane

263 regulator of filopodia dynamics that couples Rho-GTPase signaling to cytoskeleton and membrane remode

264 dermal growth factor receptor signaling, and Rho-GTPase signaling, commonly active in tumorigenesis a

265 Activation of c-Jun downstream of oncogenic Rho GTPase signalling leads to elevated GLS gene express

266 rin receptors sense these changes triggering Rho GTPase signals that modulate RPE tight junctions and

267 enous Yap activation by lats1/2 knockdown or Rho-GTPase stimulation mimicked Yap overexpression and i

268 cells contain more activated Rac1 than other Rho GTPases such as RhoA and Cdc42.

269 is widely acknowledged, the role of atypical Rho GTPases (such as RHOBTB2) in neurodevelopment has ba

270 Because other Rho GTPases, such as RhoA and Cdc42, also possess the GX

271 Rho GTPases, such as RhoA, Rac1, and Cdc42, are importan

272 mplications in the design and application of Rho GTPase targeting strategies in future cancer therapi

273 deficient mice, we define the poorly studied Rho GTPase TC10 as an immunomodulatory molecule playing

274 Wounding triggers the formation of arrays of Rho GTPases that act as signaling centers that modulate

275 pathway involving SWIP-13/ERK8 activation of Rho GTPases that dictates DAT surface expression and fun

276 guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at

277 is a guanine nucleotide exchange factor for Rho GTPases that is overexpressed in many cancers and in

278 anine nucleotide exchange factors (GEFs) for RHO GTPases that regulate intracellular actin dynamics.

279 rhotekin, as well as abnormal activation of Rho GTPases that was accompanied with impaired motility

280 dent on the levels of Miro1, a mitochondrial Rho-GTPase that regulates intercellular mitochondrial mo

281 In turn, coordinated crosstalk among the Rho GTPases themselves, as well as with the cytoskeleton

282 ors that alter the activation state of small Rho GTPases, thereby manipulating the host cell cytoskel

283 tracellular redistribution and activation of Rho GTPases, this study suggests that TIP-1 holds potent

284 In vivo, GBM invasion is mediated by Rho GTPases through unidentified downstream effectors.

285 dispensable for uptake and instead recruits Rho GTPase to promote biogenesis of the bacterial vacuol

286 REM-1) and the ICAM-1(+) neutrophils involve Rho GTPase to promote NETosis.

287 rate the competing activities of the Rac and Rho GTPases to control cell morphology.

288 Unlike other effector proteins that subvert Rho GTPases to modulate uptake, CirA is the first effect

289 ormed by oncogenic Dbl, which hyperactivates Rho GTPases, together with (13)C-labeled glutamine and s

290 f plasma membrane cholesterol and disrupting Rho GTPase trafficking-a process required for cell adhes

291 K, MAPK, and PI3K); and (c) association with Rho GTPases, tyrosine kinase receptors, Toll-like recept

292 Conformation antibodies against active RHO GTPase were also obtained.

293 protein 42) and its effector Borg (binder of Rho GTPases), which act as up-stream regulators of septi

294 iated actin polymerization and activation of Rho GTPase, which appear to be essential for EMyT induct

295 Rho GAPs are important regulators of Rho GTPases, which are involved in various steps of cyto

296 tochondrial ROS (mtROS) levels and activates Rho GTPases, which then induces F-actin formation.

297 TCL/RhoJ is a Cdc42-related Rho GTPase with reported activities in endothelial cell

298 ive binding motif (CRIB) of coronin binds to Rho GTPases with a preference for GDP-loaded Rac.

299 Complex spatiotemporal interaction of Rho GTPases with microtubules (MTs) and MT-associated pr

300 ot apoptosis induced by global inhibition of Rho GTPases with ToxB.