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1 rmed using the Linear Array genotyping test (Roche).
2 M was sequenced (RNA-Seq) using GS FLX+ (454/Roche).
3 16S 454 FLX titanium series pyrosequencing (Roche).
4 ared with laboratory pVL assessment (TaqMan, Roche).
5 French Ministry of Health and Hoffmann-La Roche.
6 ma Research Trust, Lymphoma Association, and Roche.
7 h Network, the Medical Research Council, and Roche.
8 t protease inhibitor (saquinavir, Hoffman La-Roche, 1995) and two decades since the approval of the f
9 nomes exon pilot project generated using the Roche 454 and Illumina sequencing platforms, and were ab
10 Users can turn a collection of reads (from Roche 454 chemistry) or assembled contigs (from any sequ
12 us strain genome sequencing was performed on Roche 454 GS FLX Titanium, then AB SOLiD instruments.
13 umina (Genome Analyzer, HiSeq, MiSeq, .etc), Roche 454 GS System, Applied Biosystems SOLiD System, He
22 rom selected multiplex T1D families, we used Roche 454 sequencing with Conexio Genomics ASSIGN ATF 45
25 resulting sample with both Illumina GAII and Roche 454, and obtained data with equally high specifici
31 Yoka poxvirus genome using a combination of Roche/454 and Illumina next-generation sequencing techno
32 inGAP can be applied to the mapping of both Roche/454 and Illumina reads with no restriction of read
34 detection assay is made compatible with the Roche/454 Genome Sequencer FLX Titanium next-generation
37 s up to 4x faster than HapCol in the case of Roche/454 instances and up to 20x faster when compared o
40 th high sensitivity and specificity, in both Roche/454 sequencing of individuals and deep Illumina/So
43 IV reverse transcriptase (RT) was performed (Roche/454), and the sequences were screened for nucleosi
44 oughput and relatively short read lengths of Roche/454, Illumina/Solexa, and other platforms have spu
47 y (hs) cTn assays (hs-cTnI, Abbott; hs-cTnT, Roche) among 2300 consecutive patients with suspected AM
48 .3% for the Roche Cobas assay, 94.5% for the Roche Amplicor assay, 93.0% for the Biocentric assay, an
51 -1 subtype detection, and correlation to the Roche Amplicor HIV-1 monitor test, version 1.5 (Amplicor
52 [RT-PCR]), Roche TaqMan RUO (Roche RT-PCR), Roche Amplicor Monitor HCV 2.0 (Roche Monitor), and Baye
53 ma viral loads using the Abbott test and the Roche Amplicor Monitor test showed a mean difference of
54 three FDA-approved platforms: UltraSensitive Roche Amplicor Monitor, v1.5 (Monitor), the Abbott RealT
55 s tested individually and in pools using the Roche Amplicor PCR for C. trachomatis and N. gonorrhoeae
56 obeTec SDA, Gen-Probe Aptima Combo2 TMA, and Roche Amplicor PCR) for detection of C. trachomatis and
57 nson ProbeTec, Gen-Probe Aptima Combo 2, and Roche Amplicor tests to detect Chlamydia trachomatis and
58 virus type 1 (HIV-1) plasma RNA levels using Roche AMPLICOR version 1.5 (HIV RNA) is an integral part
59 tion [PCR] results for C. trachomatis DNA by Roche Amplicor) and 25 true-negative specimens (direct o
61 ted a sensitivity of 100% (46/46), while the Roche analyte-specific reagents (ASR) and LDT showed sen
62 a laboratory-developed test (LC CMV) (using Roche analyte-specific reagents [ASR] on the LightCycler
63 e analytical performance of READ platform to Roche analyzer as a prospective clinical validation meth
64 nd ribavirin had HCV RNA <LLOQ at EOT by the Roche and Abbott assays, but only 38 achieved SVR12 (PPV
66 solid form screens conducted at Hoffmann-La Roche and Eli Lilly and Company over the course of 8+ an
68 gle-nucleotide polymorphisms (SNPs) from the Roche and Genomic Institute of the Novartis Research Fou
70 trons on real RNA-seq data sets from PacBio, Roche and Illumina runs, and on six benchmarks, and comp
71 hilst at least one in two compounds from the Roche and Lilly set display polymorphism with a higher e
74 ining data generated from 454 Life Sciences (Roche) and Illumina (formerly known as Solexa sequencing
76 was accomplished using a combination of 454 (Roche) and Illumina sequencing and community-based fundi
78 say (96.2%, 86.0%, and 73.9% for the Abbott, Roche, and BD tests, respectively) in sample types forma
83 tau measured using assays from Quanterix and Roche, and the specificity of NT1 for AD versus a nonspe
84 real-time PCR method using the LightCycler (Roche Applied Science, Indianapolis, IN) was compared to
85 ssing with the MagNA Pure LC instrument (MP; Roche Applied Science, Indianapolis, IN) were evaluated
88 SR in combination with the High Pure system (Roche ASR-HP) showed a sensitivity of 1.4 log(10) IU/ml
89 on (R(2) = 0.79) and agreement were poor for Roche ASR-HP, with bias relative to concentration and ge
92 the Abbot assay was more sensitive than the Roche assay for both C. trachomatis and N. gonorrhoeae.
93 assay and those detected by the Siemens and Roche assays (92.0% and 88% correlation coefficient of t
96 tau, but not tau measured using Quanterix or Roche assays, is elevated in subjects who progress to AD
97 ed by the Basel S-gene and WHO-based E-gene (Roche) assays in parallel using the Basel N-gene assay f
98 Basel, Switzerland) and daclizumab (Zenapax; Roche, Basel, Switzerland) combined (relative risk, 0.54
99 h factor (VEGF) agent ranibizumab (Lucentis; Roche, Basel, Switzerland) compared with ranibizumab mon
100 ion, chlorination, and amination of the homo-Roche building blocks was performed to demonstrate that
103 al [CI], 0.95 to 1.00) for the AmpliSens and Roche CAP/CTM Qual assays and 0.96 (95% CI, 0.90 to 0.98
105 tem cytomegalovirus (CMV) DNA (version 2.0), Roche CMV UL54 analyte-specific reagent, and QIAGEN Real
107 mydia trachomatis and Neisseria gonorrhoeae (Roche cobas 4800), a fully automated system, was compare
108 logic Panther Fusion, DiaSorin Simplexa, and Roche Cobas 6800 failed to detect positive specimens onl
113 at the amplicon generated by the widely used Roche COBAS Amplicor Hepatitis C Virus Test, version 2.0
115 DNA strand displacement assay (SDA), and the Roche Cobas Amplicor PCR was defined by using a rotating
116 me PCR assay by comparison with the existing Roche COBAS AmpliPrep/AMPLICOR MONITOR conventional PCR
117 ed with the AmpliSens DNA-HIV-FRT assay, the Roche COBAS AmpliPrep/COBAS TaqMan (CAP/CTM) HIV-1 Qual
121 e assessed: the Abbott RealTime HBV IUO, the Roche Cobas AmpliPrep/Cobas TaqMan HBV test, the Roche C
122 nge, the assay is highly correlated with the Roche cobas AmpliPrep/cobas TaqMan HCV Test, version 2.0
124 anti-HIV-1 antibodies), but positive by the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 test v2.0 (targ
127 results were compared with results from the Roche COBAS AmpliPrep/COBAS TaqMan HIV-1 test, v2.0.
128 tima assay was also compared to those of the Roche COBAS AmpliPrep/COBAS TaqMan HIV-1 v.2 (CAP/CTM) a
129 mated real-time HIV-1 viral load assays, the Roche Cobas AmpliPrep/Cobas TaqMan test and the Abbott R
130 ots (DPS) with a commonly used VL assay, the Roche Cobas Ampliprep/Cobas TaqMan V.2.0 (CAP/CTM).
131 fied inefficiently with gSCA compared to the Roche Cobas Ampliprep/TaqMan 2.0, whereas all 10 samples
132 iagnostic Medical Devices Directive-approved Roche COBAS AmpliPrep/TaqMan96 real-time PCR assay by co
134 een swabs for both viral gene targets in the Roche cobas assay (p=0.05 and p=0.05) as well as the Neu
135 re 96.6% for the Abbott assay, 96.3% for the Roche Cobas assay, 94.5% for the Roche Amplicor assay, 9
136 inflammatory biomarkers were measured using Roche cobas c702 and Meso Scale Discovery V-Plex Plus: h
137 We performed a prospective evaluation of the Roche cobas Liat group A streptococcus (GAS) assay compa
138 se transcription-PCR (RT-PCR) platforms, the Roche Cobas SARS-CoV2 and the Cepheid Xpert Xpress SARS-
139 point was proportion with HBV DNA <69 IU/mL (Roche COBAS Taqman assay; Roche Molecular Systems, Inc,
140 e Cobas AmpliPrep/Cobas TaqMan HBV test, the Roche Cobas TaqMan HBV test with HighPure system, and th
141 urements of HCV RNA were performed using the Roche COBAS TaqMan HCV test and the Abbott RealTime HCV
143 We evaluated the Abbott RealTime (ART) and Roche Cobas TaqMan Hepatitis C virus (HCV) viral load as
144 st) and compared results with those of LABT (Roche COBAS TaqMan HIV-1 Qualitative test) with respect
145 V-2 (Cepheid, DiaSorin, Hologic Panther, and Roche Cobas) on a total of 169 nasopharyngeal swabs.
146 ulvovaginal-swab and urine specimens by PCR (Roche Cobas) or strand displacement amplification (SDA;
147 ercial high-throughput laboratory analyzers (Roche Cobas, Abbott m2000, and Hologic Panther Fusion) a
148 tibodies from different vendors (Vector, BD, Roche, Dako, Novocastra, and Accurate) and DNA denaturat
150 NA was quantified by using Amplicor Monitor (Roche Diagnostic Systems, Inc, Branchburg, NJ) from 275
151 -Probe Inc.), the Amplicor CT/NG Assay (PCR; Roche Diagnostics Corp.), or the BD ProbeTec ET System C
152 ghtCycler Strep B analyte-specific reagents (Roche Diagnostics Corporation, Indianapolis, Ind.), were
154 d was extracted using the MagNA Pure system (Roche Diagnostics) and subsequently tested by each PCR m
155 tion capacity was documented by LightCycler (Roche Diagnostics) measurements of virion-associated hep
156 cially available clinical laboratory method (Roche Diagnostics) to measure PTH concentrations with a
157 eared rapid (<20 min) PCR assay (Cobas Liat; Roche Diagnostics) to our routine influenza A and B real
158 the Linear Array HPV genotyping assay (LA) (Roche Diagnostics), INNO-LiPA HPV Genotyping Extra (LiPA
159 energy transfer probes and the LightCycler (Roche Diagnostics), which will detect the presence of th
161 standard troponin T and testing for hs-cTnT (Roche Diagnostics, Basel, Switzerland) at presentation.
163 were sequenced with the 454GS FLX Titanium (Roche Diagnostics, Indianapolis, IN) and GAIIx (Illumina
164 ing and endoxifen measurements by Amplichip (Roche Diagnostics, Indianapolis, IN) and high-performanc
165 ydia trachomatis and N. gonorrhoeae (CT/NG) (Roche Diagnostics, Indianapolis, IN) followed by confirm
166 ed to the TaqMan HCV load ASR assay (TaqMan; Roche Diagnostics, Indianapolis, IN) that targets the 5'
167 Cobas LIAT Influenza A/B assay (LIAT assay; Roche Diagnostics, Indianapolis, IN) to other urgent car
168 al-time PCR analyte-specific reagents (ASR) (Roche Diagnostics, Indianapolis, IN) were also tested by
169 agen, Gaithersburg, MD), the cobas HPV test (Roche Diagnostics, Indianapolis, IN), and the APTIMA HPV
171 using the LINEAR ARRAY HPV Genotyping Test (Roche Diagnostics, Indianapolis, Indiana), which detects
175 hs-cTn was measured with 3 assays (hs-cTnT, Roche Diagnostics; hs-cTnI, Beckman-Coulter; hs-cTnI Sie
176 d B viruses (Alere i [Alere] and cobas Liat [Roche Diagnostics]) with the influenza A and B virus tes
177 otherapeutics, stimulated by the Hoffmann-La Roche discovery that Nutlin-3 can restore apoptosis in c
179 S-CoV-2, were analyzed in parallel using the Roche Elecsys SARS-CoV-2 total antibody and Abbott Alini
184 ic hydrogenation routes to homologues of The Roche ester tend to be restricted to hydrogenations of i
187 as those produced by the 454 Life Sciences (Roche) Genome Sequencer, and can scale to large data set
193 ncordance in HCV RNA assessments between the Roche High Pure System/Cobas TaqMan and Abbott RealTime
194 sults from samples tested prospectively with Roche High Pure TaqMan HCV 2.0 test (HPS) were compared
195 Human papillomavirus (HPV) was detected by Roche HPV Linear Array at enrollment, and at 6, 12, and
200 ncing technologies (e.g., 454 Life Sciences [Roche], Illumina sequencing [formerly Solexa sequencing]
203 he oral MDM2 antagonist idasanutlin (RG7388; Roche) in patients with high-risk PV/ET for whom at leas
206 National Institutes of Health, Genentech, Roche Laboratories, Lilly Research Laboratories, and Pre
208 erence laboratories using two platforms, the Roche LightCycler 480 system and the Applied Biosystems
209 able solely by melt curve analysis using the Roche LightCycler HSV 1/2 analyte-specific reagent real-
211 e and have recently been commercialized (eg, Roche LightCycler SeptiFast and T2 Biosystems T2Candida)
213 f HC2-positive results were confirmed by the Roche line blot assay, compared to 77.2% of those at an
215 rcumcision trial in Rakai, Uganda, using the Roche Linear Array assay, which detects 37 HPV genotypes
220 e compared the cobas HPV test (cobas) to the Roche Linear Array HPV genotyping assay (LA) and cytolog
223 ere evaluated for 37 HPV genotypes using the Roche LINEAR ARRAY HPV Genotyping Test (Roche Molecular
226 cervical samples for HPV DNA detection using Roche Linear Array were collected semiannually for two y
227 ected penile swab sample for HPV genotyping (Roche Linear Array) and completed a demographic and risk
233 rawn overview map of metabolism based on the Roche map satisfies (ii) and comes close to satisfying (
235 nc., Des Plaines, IL), the Cobas CT/NG test (Roche Molecular Systems Inc., Alameda, CA), and the BD P
236 ated hrHPV tests, the cobas HPV test (cobas, Roche Molecular Systems) and Hybrid Capture 2 (hc2, Qiag
242 MPLICOR Hepatitis C Virus Test, version 2.0; Roche Molecular Systems, Inc.), and COBAS TaqMan (COBAS
243 Cobas influenza A/B nucleic acid test (LIAT; Roche Molecular Systems, Inc.), and Xpert Xpress Flu (Xp
244 B virus (HBV) analyte-specific reagent (ASR; Roche Molecular Systems, Inc., Branchburg, NJ) is design
245 OBAS AMPLICOR HCV MONITOR Test, version 2.0; Roche Molecular Systems, Inc., Branchburg, NJ), COBAS AM
246 Corp., Gaithersburg, MD), Linear Array (LA; Roche Molecular Systems, Pleasanton, CA), and Amplicor (
248 the Roche LINEAR ARRAY HPV Genotyping Test (Roche Molecular Systems, Pleasanton, California), and fa
251 for acute HIV infection) was compared with a Roche Monitor HIV RNA polymerase chain reaction assay.
252 che RT-PCR), Roche Amplicor Monitor HCV 2.0 (Roche Monitor), and Bayer VERSANT HCV RNA 3.0 (Bayer bDN
255 a method for whole-exome sequencing coupling Roche/NimbleGen whole exome arrays to the Illumina DNA s
257 slet isolations utilizing IPC from VitaCyte, Roche, or SERVA collagenase-protease enzyme mixtures.
259 erification process between the end user and Roche Pharmaceuticals, and mandatory destruction of empt
260 oup, under the sponsorship of Genentech Inc, Roche Pharmaceuticals, and OSI Pharmaceuticals, Inc, was
262 scopy: the Hybrid Capture 2 (Qiagen), Cobas (Roche), PreTect HPV-Proofer (NorChip), Aptima HPV (Gen-P
264 meras using a nSSU data set derived from 454 Roche pyrosequencing of replicated, large control pools
265 udinal and cross-sectional samples using 454/Roche pyrosequencing, in total analyzing 174,185 sequenc
266 ethods were prospectively employed to impact Roche research projects, with the aim of highlighting th
267 Discrepant results were tested using the Roche reverse line blot (RLB) or Linear Array (LA) assay
268 ent with clinician-obtained brushes when the Roche Reverse Line Blot Assay (RLBA) was used (for swabs
271 the mean viral load value obtained with the Roche RT-PCR assay was, on average, 0.15 log10 lower tha
272 nsitivity and linear range of the Abbott and Roche RT-PCR assays enable them to be used for HCV diagn
275 anscription-PCR [RT-PCR]), Roche TaqMan RUO (Roche RT-PCR), Roche Amplicor Monitor HCV 2.0 (Roche Mon
278 s processed on the MagNA Pure LC instrument (Roche RUO-MPLC) and Abbott analyte-specific reagents (AS
279 national units (IU) of IFN-alpha (Roferon-A; Roche s.p.a., Milano, Italy) subconjunctivally inside th
280 ogies such as Illumina's Solexa platform and Roche's 454 approach provide new avenues for investigati
281 ate performance on control data sequenced on Roche's 454 platform, and compare the results to the mos
283 ercial next-generation sequencing platforms: Roche's 454, Illumina's Solexa and Applied Biosystems' S
285 We included all published and unpublished Roche-sponsored randomised placebo-controlled, double-bl
286 orm and compared the results to those of the Roche TaqMan Analyte-Specific Reagent (TaqMan) and Bayer
288 (Abbott reverse transcription-PCR [RT-PCR]), Roche TaqMan RUO (Roche RT-PCR), Roche Amplicor Monitor
290 apid virologic response (mRVR; VL <25 IU/mL [Roche TaqMan] at week 4 and undetectable at weeks 8 to 2
292 The finding by scientists at Hoffmann-La Roche that cis-imidazolines could disrupt the protein-pr
293 itative agreement between the Abbott IgG and Roche total antibody assays was 98.7% (658/667), with Co
294 pre-COVID-19 samples for the Abbott IgG and Roche total antibody assays were 99.65% (95% CI, 98.72 t
295 nucleocapsid antibody tests (Abbott IgG and Roche total antibody) and one spike protein antibody tes
297 22 (43.1%) were reactive by the Abbott IgG, Roche total antibody, and Abbott IgM assays, respectivel
299 ded sequencing using the GS20 Sequencer (454/Roche), we found that over 99.8% of obtained sequences c