ライフサイエンスコーパス: S-adenosyl

1 poenzyme, PaMTH1-SAM (co-factor), and PaMTH1-S-adenosyl homocysteine (by-product) co-complexes refine

2 romatography/mass spectrometry (LC/MS)-based S-adenosyl homocysteine (SAH) detection assay for histon

3 Here, we describe a suite of S-adenosyl homocysteine (SAH) photoreactive probes and t

4 ethyltransferase mechanisms, the addition of S-adenosyl homocysteine (SAH), which is the by-product a

5 in the free form and a ternary complex with S-adenosyl homocysteine and a histone H3 peptide and bio

6 ed the expression of DNMT1, MMP9, TIMP1, and S-adenosyl homocysteine hydrolase (SAHH) and upregulated

7 We show here that the cofactor analogue S-adenosyl homocysteine promotes this promiscuous DNA cl

8 .01), and the decreased S-adenosylmethionine/S-adenosyl homocysteine ratio (P<0.01).

9 when PIMT protein binding was poisoned with S-adenosyl homocysteine.

10 ence and absence of its methyl donor product S-adenosyl-homocysteine (SAH) and its ortholog scTrm10 f

11 ibility possibly reflected in high levels of S-adenosyl-homocysteine (SAH) and low levels of S-adenos

12 (SAM), which is converted via methylation to S-adenosyl-homocysteine (SAH), which accumulates during

13 d that 1 equiv each of 5'-deoxyadenosine and S-adenosyl-homocysteine are produced for each methylatio

14 chaelis-Menten kinetics, and is inhibited by S-adenosyl-homocysteine.

15 that is generated by a reductive cleavage of S-adenosyl- l-methionine.

16 ibitors and immunoprecipitation of RyR2 from S-adenosyl-l-[methyl-(3)H]methionine ([(3)H]SAM) pretrea

17 d from yeast cells radiolabeled in vivo with S-adenosyl-l-[methyl-(3)H]methionine.

18 l analysis of Rpl3 radiolabeled in vivo with S-adenosyl-l-[methyl-(3)H]methionine.

19 and reductant and then incubated with excess S-adenosyl-l-[methyl-d3]methionine in the presence of su

20 a previously undescribed co-factor, carboxy-S-adenosyl-l-ethionine (cxSAE), thereby enabling the ste

21 Here we present synthesis of the SAM analog S-adenosyl-l-ethionine (SAE) and show SAE is a mechanist

22 ere determined for MycE bound to the product S-adenosyl-L-homocysteine (AdoHcy) and magnesium, both w

23 tetrameric complex with the cofactor product S-adenosyl-l-homocysteine (AdoHcy) at 2.4 angstrom resol

24 TbPRMT7 in complex with its cofactor product S-adenosyl-l-homocysteine (AdoHcy) at 2.8 A resolution a

25 ne hydrolase (AHCY) hydrolyzes its substrate S-adenosyl-L-homocysteine (AdoHcy) to L-homocysteine (Hc

26 ionine (d (min) = 1.6 angstrom), the product S-adenosyl-l-homocysteine (d (min) = 1.8 angstrom), or i

27 ures of human NTMT1 in complex with cofactor S-adenosyl-L-homocysteine (SAH) and six substrate peptid

28 The affinity of S-adenosyl-l-homocysteine (SAH) for SAM binding proteins

29 ive and sensitive fluorescent biosensors for S-adenosyl-l-homocysteine (SAH) that provide a direct "m

30 SAHH) catalyzes the reversible conversion of S-adenosyl-L-homocysteine (SAH) to adenosine (ADO) and L

31 e product of the methyltransferase reaction, S-adenosyl-l-homocysteine (SAH), is converted into adeni

32 equence (5'-(m7)G0pppA1G2U3U4G5U6U7-3'), and S-adenosyl-l-homocysteine (SAH), the by-product of the m

33 ne and the second SAM (SAM2) is converted to S-adenosyl-l-homocysteine (SAH).

34 (d (min) = 1.8 angstrom), or in complex with S-adenosyl-l-homocysteine and (S)-cis-N-methylstylopine

35 otein alpha-amine, resulting in formation of S-adenosyl-l-homocysteine and alpha-N-methylated protein

36 syl-l-methionine (AdoMet) to glycine to form S-adenosyl-l-homocysteine and sarcosine.

37 ormational state complexed with the products S-adenosyl-L-homocysteine and sinapaldehyde.

38 for the malonyl moiety and was inhibited by S-adenosyl-L-homocysteine and sinefungin.

39 e, with concomitant exchanges of the product S-adenosyl-l-homocysteine and the methyl donor substrate

40 (hDNMT1, residues 351-1600) in complex with S-adenosyl-l-homocysteine at 2.62A resolution.

41 r-associated inhibiting H3K27M peptide and a S-adenosyl-l-homocysteine cofactor.

42 ransition in the active site relative to the S-adenosyl-L-homocysteine complexes, suggesting a mechan

43 tures with bound S-adenosyl-L-methionine and S-adenosyl-L-homocysteine confirm that the cofactor bind

44 S-Adenosyl-L-homocysteine hydrolase (AHCY) hydrolyzes it

45 S-Adenosyl-L-homocysteine hydrolase (SAHH) catalyzes the

46 osophila homologs of the SAH hydrolase Ahcy (S-adenosyl-L-homocysteine hydrolase [SAHH[), CG9977/dAhc

47 eranyl S-thiolodiphosphate (GSPP) along with S-adenosyl-L-homocysteine in the cofactor binding site,

48 se-linked continuous assay that converts the S-adenosyl-L-homocysteine product of DNA methylation to

49 DnrK-Ser in complex with aclacinomycin T and S-adenosyl-L-homocysteine refined to 1.9-A resolution re

50 S-Adenosyl-L-homocysteine remains bound in the active si

51 ture of (s-s)MetH(CT) with cob(II)alamin and S-adenosyl-L-homocysteine represents the enzyme in the r

52 omplex with human tRNA3(Lys) and the product S-adenosyl-L-homocysteine show a dimer of heterodimers i

53 ture of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltra

54 MeT1 in complex with its exhausted cofactor, S-adenosyl-l-homocysteine, together with mutagenesis stu

55 y complex with its desmethylated cosubstrate S-adenosyl-l-homocysteine.

56 eotide small RNA duplex and cofactor product S-adenosyl-l-homocysteine.

57 A-specific m(6)A methyltransferase, bound to S-adenosyl-L-homocysteine.

58 In this assay, S-adenosyl-l-homocystine (AdoHcy/SAH), the by-product of

59 Consistent with its effect on the predicted S-adenosyl-l-Met binding site, dim1A plants lack the two

60 Here, 4-azidobut-2-enyl derivative of S-adenosyl-L-methionine (Ab-SAM) was reported as a suita

61 Recombinant TrmO employs S-adenosyl-L-methionine (AdoMet) as a methyl donor to me

62 --> m(7)GpppA-RNA --> m(7)GpppAm-RNA), using S-adenosyl-l-methionine (AdoMet) as a methyl donor.

63 Most of these MTases use the cofactor S-adenosyl-l-Methionine (AdoMet) as a methyl source.

64 TrmD enzymes are known to use S-adenosyl-l-methionine (AdoMet) as substrate; we have s

65 The biological methyl donor S-adenosyl-l-methionine (AdoMet) is spontaneously degrad

66 ch nucleophilic attack of cytosine C5 on the S-adenosyl-L-methionine (AdoMet) methyl group is concert

67 ogenase from Bacillus circulans (BtrN) is an S-adenosyl-l-methionine (AdoMet) radical enzyme.

68 he substrate, catalyzes methyl transfer from S-adenosyl-l-methionine (AdoMet) to glycine to form S-ad

69 Mammalian CBS is modulated by the binding of S-adenosyl-l-methionine (AdoMet) to its regulatory domai

70 catalyze the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the 5-position of cy

71 DNA substrate and the methyl donor cofactor, S-adenosyl-l-methionine (AdoMet), displayed AdoMet non-c

72 eductive cleavage of the sulfonium center of S-adenosyl-L-methionine (AdoMet), generating methionine

73 For example, how both the methyl donor S-adenosyl-l-methionine (AdoMet), which is water-soluble

74 fX at 1.7 A and found that it belongs to the S-adenosyl-L-methionine (AdoMet)-dependent alpha/beta-kn

75 Modification of protein residues by S-adenosyl-L-methionine (AdoMet)-dependent methyltransfe

76 m reduced flavodoxin and a methyl group from S-adenosyl-L-methionine (AdoMet).

77 n and a regulatory C-terminal domain binding S-adenosyl-l-methionine (AdoMet).

78 ped an enzyme-coupled luminescence assay for S-adenosyl-l-methionine (AdoMet/SAM)-based PMTs.

79 We describe a new metabolite, carboxy-S-adenosyl-l-methionine (Cx-SAM), its biosynthetic pathw

80 GfTNMT was co-crystallized with the cofactor S-adenosyl-l-methionine (d (min) = 1.6 angstrom), the pr

81 d by adenosylcobalamin-dependent and radical S-adenosyl-l-methionine (RS) enzymes.

82 composed of enzymes that reductively cleave S-adenosyl-l-methionine (SAM or AdoMet) to generate a 5'

83 cts and is catalyzed by multiple families of S-adenosyl-L-methionine (SAM or AdoMet)-dependent methyl

84 S-adenosyl-L-methionine (SAM) acts as a signal and binds

85 ach, specific PMTs are engineered to process S-adenosyl-L-methionine (SAM) analogs as cofactor surrog

86 activity of vSET in vivo with an engineered S-adenosyl-l-methionine (SAM) analogue as methyl donor c

87 The synthesis of an azide-bearing N-mustard S-adenosyl-L-methionine (SAM) analogue, 8-azido-5'-(diam

88 chemoenzymatic platform for the synthesis of S-adenosyl-L-methionine (SAM) analogues compatible with

89 h of CliEn-seq involves in vivo synthesis of S-adenosyl-L-methionine (SAM) analogues from cell-permea

90 Radical SAM (RS) enzymes use S-adenosyl-l-methionine (SAM) and a [4Fe-4S] cluster to

91 NSD2 binds to S-adenosyl-l-methionine (SAM) and nucleosome substrates

92 ders the enzyme inaccessible to the cofactor S-adenosyl-l-methionine (SAM) and probably to the substr

93 conventional methyltransferases that utilize S-adenosyl-L-methionine (SAM) as a cofactor.

94 Molecular modeling and competitive S-adenosyl-l-methionine (SAM) binding assay suggest that

95 Mutations to the S-adenosyl-l-methionine (SAM) binding motif in the nsp14

96 spectroscopy on the resting oxidized and the S-adenosyl-l-methionine (SAM) bound forms of pyruvate fo

97 kcat value in the conversion of 5'-ClDA into S-adenosyl-l-methionine (SAM) but a reduced kcat value i

98 route to biodiesel produces FAMEs by direct S-adenosyl-L-methionine (SAM) dependent methylation of f

99 rin-2 in a chemical reaction catalysed by an S-adenosyl-L-methionine (SAM) dependent Methyltransferas

100 S-adenosyl-l-methionine (SAM) dependent O-methyltransfer

101 Lysine 2,3-aminomutase (LAM) is a radical S-adenosyl-L-methionine (SAM) enzyme and, like other mem

102 DesII, a radical S-adenosyl-l-methionine (SAM) enzyme from Streptomyces v

103 patients have mutations in MOCS1A, a radical S-adenosyl-l-methionine (SAM) enzyme involved in the con

104 Here we demonstrate that a putative radical S-adenosyl-L-methionine (SAM) enzyme superfamily member

105 d by DesII, which is a member of the radical S-adenosyl-L-methionine (SAM) enzyme superfamily.

106 DesII is a radical S-adenosyl-l-methionine (SAM) enzyme that can act as a d

107 Tryptophan lyase (NosL) is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the

108 yase activating enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a cat

109 NifB is a radical S-adenosyl-L-methionine (SAM) enzyme that is essential f

110 Spore photoproduct lyase is a radical S-adenosyl-l-methionine (SAM) enzyme with the unusual pr

111 Viperin is predicted to be a radical S-adenosyl-l-methionine (SAM) enzyme, but it is unknown

112 SPL is a radical S-adenosyl-l-methionine (SAM) enzyme, which uses a [4Fe-

113 ted by AbmJ, which is annotated as a radical S-adenosyl-l-methionine (SAM) enzyme.

114 Radical S-adenosyl-l-methionine (SAM) enzymes are widely distrib

115 Radical S-adenosyl-l-methionine (SAM) enzymes initiate biologica

116 Catalysis by canonical radical S-adenosyl-l-methionine (SAM) enzymes involves electron

117 While the number of characterized radical S-adenosyl-l-methionine (SAM) enzymes is increasing, the

118 The radical S-adenosyl-L-methionine (SAM) enzymes RlmN and Cfr methy

119 Radical S-adenosyl-L-methionine (SAM) enzymes use an iron-sulfur

120 que to a family of proteins known as radical S-adenosyl-l-methionine (SAM) enzymes.

121 nding isotope effects (BIEs) of the cofactor S-adenosyl-l-methionine (SAM) for SET8-catalyzed H4K20 m

122 ransferases (MATs) catalyze the formation of S-adenosyl-l-methionine (SAM) inside living cells.

123 S-adenosyl-l-methionine (SAM) is a necessary cosubstrate

124 S-adenosyl-L-methionine (SAM) is converted to 5'-chloro-

125 S-Adenosyl-l-methionine (SAM) is recognized as an import

126 S-Adenosyl-l-methionine (SAM) is the central cofactor in

127 S-adenosyl-L-methionine (SAM) is the sole methyl-donor c

128 The radical S-adenosyl-L-methionine (SAM) methyl synthases, RlmN and

129 Many cobalamin (Cbl)-dependent radical S-adenosyl-l-methionine (SAM) methyltransferases have be

130 These results indicate that the radical S-adenosyl-L-methionine (SAM) protein PylB mediates a ly

131 ts of bciD, which encodes a putative radical S-adenosyl-l-methionine (SAM) protein, are unable to syn

132 dent enzymes that are members of the radical S-adenosyl-l-methionine (SAM) superfamily was previously

133 QueE is a member of the radical S-adenosyl-l-methionine (SAM) superfamily, all of which

134 ranslational riboswitches were identified in S-adenosyl-l-methionine (SAM) synthetase metK genes in m

135 ) to cytosine (Cyt) C6, methyl transfer from S-adenosyl-l-methionine (SAM) to Cyt C5, and proton abst

136 erate a 3-amino-3-carboxypropyl radical from S-adenosyl-L-methionine (SAM) to form a C-C bond.

137 three cysteines in a CX(3)CX(2)C motif, and S-adenosyl-L-methionine (SAM) to generate a 5'-deoxyaden

138 hesis is the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to magnesium protoporphyri

139 er of the 3-amino-3-carboxypropyl group from S-adenosyl-l-methionine (SAM) to the histidine residue o

140 es a DNA cofactor in order to stably bind to S-adenosyl-l-methionine (SAM), suggesting that it procee

141 S-Adenosyl-l-methionine (SAM), the primary methyl group

142 The highly conserved S-adenosyl-l-methionine (SAM)-binding residues of the Dx

143 on structures of Bud23-Trm112 in the apo and S-adenosyl-L-methionine (SAM)-bound forms.

144 Here we report a versatile S-adenosyl-l-methionine (SAM)-dependent enzyme, LepI, th

145 revealing new metalloenzymes, flavoenzymes, S-adenosyl-L-methionine (SAM)-dependent enzymes and othe

146 synthesis protein NifB catalyzes the radical S-adenosyl-L-methionine (SAM)-dependent insertion of car

147 atic analyses predicted EftM to be a Class I S-adenosyl-l-methionine (SAM)-dependent methyltransferas

148 ergent enzyme evolution has been observed in S-adenosyl-L-methionine (SAM)-dependent methyltransferas

149 S-adenosyl-l-methionine (SAM)-dependent methyltransferas

150 rmed by O-methyltransferases, members of the S-adenosyl-l-methionine (SAM)-dependent O-methyltransfer

151 proposed to comprise two distinct groups of S-adenosyl-l-methionine (SAM)-dependent RNA enzymes, nam

152 delta position of the piperazyl scaffold is S-adenosyl-l-methionine (SAM)-dependent.

153 introduced methyl group is assembled from an S-adenosyl-L-methionine (SAM)-derived methylene fragment

154 o influence accumulation of the methyl donor S-adenosyl-L-methionine (SAM).

155 ven known families of riboswitches that bind S-adenosyl-l-methionine (SAM).

156 due and the 3-amino-3-carboxypropyl group of S-adenosyl-l-methionine (SAM).

157 tilis yitJ S-box (SAM-I) riboswitch bound to S-adenosyl-L-methionine (SAM).

158 co-substrate for methyltransferase activity, S-adenosyl-l-methionine (SAM).

159 ue, the highly abundant methylation cofactor S-adenosyl-l-methionine (SAM).

160 es share a binding site for the methyl donor S-adenosyl-l-methionine and are inhibited by individual

161 acyl-homoserine lactones (AHL) signals using S-adenosyl-l-methionine and either cellular acyl carrier

162 Two structures with bound S-adenosyl-L-methionine and S-adenosyl-L-homocysteine co

163 inhibitors, by mimicking each substrate, the S-adenosyl-l-methionine and the deoxycytidine, and linki

164 ting many methyltransferase enzymes that use S-adenosyl-l-methionine as a cofactor.

165 es and shed light on the structural basis of S-adenosyl-L-methionine binding and methyltransferase ac

166 -alone adenylation domain interrupted by the S-adenosyl-l-methionine binding region of a methyltransf

167 l for a proposed intermediate in the radical S-adenosyl-L-methionine biogenesis of the M-cluster.

168 al ligands, including the first structure of S-adenosyl-l-methionine bound to a KsgA/Dim1 enzyme in a

169 structure of this enzyme in complex with the S-adenosyl-l-methionine cofactor at 1.7 A resolution con

170 we demonstrate that the pyruvoyl cofactor of S-adenosyl-L-methionine decarboxylase (AMD1) is dynamica

171 S-adenosyl-l-methionine dependent methyltransferases cat

172 iguration, which is catalyzed by the radical S-adenosyl-l-methionine enzyme AbmJ.

173 The radical S-adenosyl-L-methionine enzyme DesII from Streptomyces v

174 The radical S-adenosyl-L-methionine enzyme HydG lyses free tyrosine

175 Here we show that PhnJ is a novel radical S-adenosyl-L-methionine enzyme that catalyses C-P bond c

176 Intriguingly, radical S-adenosyl-L-methionine enzymes are vital for the assemb

177 HydG is a member of the radical S-adenosyl-L-methionine family of enzymes that transform

178 The radical S-adenosyl-l-methionine HydG, the best characterized of

179 approach designed to target specifically the S-adenosyl-l-methionine pocket of catechol O-methyl tran

180 enases to provide the substrates of LipA, an S-adenosyl-L-methionine radical enzyme that inserts two

181 Numerous cellular processes involving S-adenosyl-l-methionine result in the formation of the t

182 The response to S-adenosyl-L-methionine stimulation or thermal activatio

183 a far better acceptor of methyl groups from S-adenosyl-L-methionine than was malonyl-CoA.

184 ofiles of PsACS [encode enzymes that convert S-adenosyl-L-methionine to 1-aminocyclopropane-1-carboxy

185 vates HA by transferring a methyl group from S-adenosyl-l-methionine to HA, and is the only well-know

186 specifically transfers the methyl group from S-adenosyl-L-methionine to O-4 of alpha-D-glucopyranosyl

187 atalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the N6 position of an adenine

188 es the transfer of the methyl group from the S-adenosyl-l-methionine to the protein alpha-amine, resu

189 transferase belongs to the diverse family of S-adenosyl-l-methionine transferases.

190 otope effects.(36)S-labeled l-methionine and S-adenosyl-l-methionine were synthesized from elemental

191 Posttranslational methylation by S-adenosyl-L-methionine(SAM)-dependent methyltransferase

192 d only compete with the enzyme cofactor SAM (S-adenosyl-L-methionine) but not the substrate nucleosom

193 om Streptomyces venezuelae is a radical SAM (S-adenosyl-l-methionine) enzyme that catalyzes the deami

194 adding excess substrate for DNA methylation (S-adenosyl-L-methionine) rescues the suppression of mEPS

195 ltransferase catalytic tetrad, interact with S-adenosyl-l-methionine, and contribute to autoguanylati

196 from a solution of MoaA incubated with GTP, S-adenosyl-L-methionine, and sodium dithionite in the ab

197 ite, resulting from in situ demethylation of S-adenosyl-L-methionine, at 2.05 or 1.82 A resolution, r

198 ing the methylation site, in the presence of S-adenosyl-L-methionine, reveals a V-like protein struct

199 (including acupuncture, omega-3 fatty acids, S-adenosyl-L-methionine, St. John's wort [Hypericum perf

200 virtue of the strong electrophilic nature of S-adenosyl-l-methionine, the transmethylation of the dem

201 requires a redox-active [4Fe-4S]-cluster and S-adenosyl-L-methionine, which is reductively cleaved to

202 NfuA, and the methylthiolase MiaB, a radical S-adenosyl-L-methionine-dependent enzyme involved in the

203 es demonstrated that genetic deletion of the S-adenosyl-L-methionine-dependent methyltransferase from

204 The S-adenosyl-L-methionine-dependent methyltransferase KsgA

205 We characterized Rv0560c as an S-adenosyl-L-methionine-dependent methyltransferase that

206 acterization of a C. roseus cDNA encoding an S-adenosyl-L-methionine-dependent N methyltransferase th

207 Data from time course experiments and S-adenosyl-l-methionine-dependent O-methyltransferase in

208 NovP is an S-adenosyl-l-methionine-dependent O-methyltransferase th

209 A conserved S-adenosyl-l-methionine-dependent RNA methyltransferase,

210 and in vitro enzyme studies identified a new S-adenosyl-l-methionine-dependent S-MT (TmtA) that is, s

211 ntification and characterization of a unique S-adenosyl-l-methionine-dependent sugar 1-O-methyltransf

212 ied in the TPsiC-loop of tRNA, from cofactor S-adenosyl-L-methionine.

213 cofactors, heme, pyridoxal-5'-phosphate, and S-adenosyl-l-methionine.

214 ely molecular mechanism of CBS activation by S-adenosyl-l-methionine.

215 ith (2.1 A) and without (2.0 A) its cofactor S-adenosyl-L-methionine.

216 t exchange with a fresh molecule of cofactor S-adenosyl-L-methionine.

217 e-5-phosphate and methane in the presence of S-adenosyl-L-methionine.

218 ethylthioguanine (S(6)mG) in the presence of S-adenosyl-l-methionine.

219 -homocysteine and the methyl donor substrate S-adenosyl-l-methionine.

220 is transfers a methyl group originating from S-adenosyl-l-methionine.

221 hylation of H3K36 using specifically labeled S-adenosyl-l-methionine.

222 xogenous application of ethylene precursors, S-adenosyl-Met and 1-aminocyclopropane-1-carboxylic acid

223 ways, such as glycolysis, and the Calvin and S-adenosyl-Met cycles.

224 in length and targets mRNAs encoding several S-adenosyl-Met-dependent carboxyl methyltransferase fami

225 sition adjacent to the tRNA anticodon, using S-adenosyl methionine (AdoMet) as the methyl donor.

226 on of genes involved in aromatic amino acid, S-adenosyl methionine (SAM) and folate biosynthetic path

227 Cysteine, S-adenosyl methionine (SAM) and the formation of an iron

228 ) Colorado strains carrying mutations in the S-adenosyl methionine (SAM) binding site in the CR VI of

229 small molecules via the in situ formation of S-adenosyl methionine (SAM) cofactor analogues is descri

230 inistration of the (endogenous) methyl donor S-adenosyl methionine (SAM) did not affect CpG methylati

231 g the assembly of the H cluster, the radical S-adenosyl methionine (SAM) enzyme HydG lyses the substr

232 Additionally, we find that the cofactor S-adenosyl methionine (SAM) is necessary for stable inte

233 ll proliferation and increases intracellular S-adenosyl methionine (SAM) levels to feed epigenetic ch

234 A-based fluorescent metabolite biosensor for S-adenosyl methionine (SAM) that is expressed at low lev

235 NifB utilizes two equivalents of S-adenosyl methionine (SAM) to insert a carbide atom and

236 coordinately modulating the availability of S-adenosyl methionine (SAM), the essential metabolite fo

237 we show that Red Broccoli can be fused to a S-adenosyl methionine (SAM)-binding aptamer to generate

238 te binding cleft and lacks a properly formed S-adenosyl methionine (SAM)-binding pocket necessary for

239 S-Adenosyl methionine (SAM)-dependent C-methyltransferas

240 biomolecules by a large and diverse class of S-adenosyl methionine (SAM)-dependent methyltransferases

241 zyme A 3-O-methyltransferase (CCoAOMT) is an S-adenosyl methionine (SAM)-dependent O-methyltransferas

242 Here, we explore the mechanism for tuning of S-adenosyl methionine (SAM)-I riboswitch folding.

243 ional switching, we constructed models of an S-adenosyl methionine (SAM)-I riboswitch RNA segment inc

244 the by-product and competitive inhibitor of S-adenosyl methionine (SAM)-mediated methyltransferase r

245 ate RNA substrate analogue and methyl donor, S-adenosyl methionine (SAM).

246 t catalyze the formation of the methyl donor S-adenosyl methionine (SAM).

247 to methionine, which is in turn converted to S-adenosyl methionine (SAM; the major methyl donor).

248 S-adenosyl methionine (SAMe) improves interferon signali

249 Hepatic S-adenosyl methionine (SAMe) levels decrease in methioni

250 The use of S-adenosyl methionine (SAMe), a naturally occurring mole

251 sugars, and other small molecules, including S-adenosyl methionine and glutathione, through top-down

252 his conversion involves methyl transfer from S-adenosyl methionine and is critical to minimize tRNA f

253 pression of NNMT in CAFs led to depletion of S-adenosyl methionine and reduction in histone methylati

254 In the absence of the methyl donor S-adenosyl methionine and under certain permissive react

255 L synthesis requires unique enzymes that use S-adenosyl methionine as an acyl acceptor and amino acid

256 ex with its histone H4 peptide substrate and S-adenosyl methionine cofactor.

257 ce assays demonstrated that l-methionine and S-adenosyl methionine concentrations decreased in the W7

258 with lysidine, those derived using modified S-adenosyl methionine derivatives and those using TET/JB

259 demonstrated by detecting the human radical S-adenosyl methionine domain containing 2 (RSAD2) gene,

260 and enhanced expression of the IRGs, radical S-adenosyl methionine domain containing 2 and myxovirus

261 nsfected cell lines showed that the internal S-adenosyl methionine domains of viperin were essential

262 MTase) that accept analogues of the cofactor S-adenosyl methionine have been widely deployed for alky

263 thase activity through changes in folate and S-adenosyl methionine metabolism.

264 Serine starvation increased the methionine/S-adenosyl methionine ratio, decreasing the transfer of

265 Isoflavone reductase-like protein, S-adenosyl methionine synthase, and cysteine synthase is

266 m enzymes stearoyl-CoA-desaturases (SCD) and S-adenosyl methionine synthetase (sams-1) activates the

267 We show that the MccD enzyme uses S-adenosyl methionine to transfer 3-amino-3-carboxypropy

268 that use different cofactors, primarily SAM (S-adenosyl methionine), NAD (nicotinamide adenine dinucl

269 the recruitment of the methyl donor, AdoMet (S-adenosyl methionine), to RNMT.

270 hich is required for efficient production of S-adenosyl methionine, an essential methyltransferase co

271 ) is responsible for hepatic biosynthesis of S-adenosyl methionine, the principal methyl donor.

272 are vital cofactors for the regeneration of S-adenosyl methionine, which is the methyl source for DN

273 odifying the Npl4 zinc finger domain through S-adenosyl methionine-dependent cysteine methylation.

274 methyltransferases (TMTs) might resemble the S-adenosyl methionine-dependent enzymes described for me

275 The third largest dsRNA encodes an S-adenosyl methionine-dependent methyltransferase cappin

276 that it is a leader peptide-independent and S-adenosyl methionine-dependent O-methyltransferase that

277 hich is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methy

278 dium with a mixture of labeled and unlabeled S-adenosyl methionine.

279 nine cycle (choline: lower in AD, p = 0.003; S-adenosyl methionine: higher in AD, p = 0.005); (2) tra

280 onstitution of TbtI, the responsible radical S-adenosyl-methionine (rSAM) C-methyltransferase, which

281 we describe the structures of RlmH bound to S-adenosyl-methionine (SAM) and the methyltransferase in

282 Antimorphic mutants in S-adenosyl-methionine (SAM) synthetase genes also induce

283 Methionine generates the methyl donor S-adenosyl-methionine (SAM), which is converted via meth

284 The knot loops form the S-adenosyl-methionine (SAM)-binding pocket as well as pa

285 denosyl-homocysteine (SAH) and low levels of S-adenosyl-methionine (SAM).

286 Feeding SHC enhanced hepatic S-adenosyl-methionine and arsenic methyltransferase, whe

287 Using S-adenosyl-methionine as the methyl donor, caffeic acid

288 se mutations, we determined the apo-form and S-adenosyl-methionine binary complex SbCOMT crystal stru

289 ated with increased reactive oxygen species, S-adenosyl-methionine depletion, global hypomethylation,

290 of NtMTHFR did not affect the methionine and S-adenosyl-methionine levels in the knockdown lines.

291 th the H3K9 methyltransferase Clr4 in a SAM (S-adenosyl-methionine)-dependent manner, and Clr4 is tra

292 ine, which is then used for the synthesis of S-adenosyl-methionine, a universal methyl donor for nume

293 ek and then placebo for 2 weeks, 65 received S-adenosyl-methionine, and 34 received no specific treat

294 ptive donor substrate of glycan methylation, S-adenosyl-methionine, from the cytoplasm to the Golgi w

295 treatment with the EZH2 inhibitor, selective S-adenosyl-methionine-competitive small-molecule (GSK126

296 ate that GSK126, a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibi

297 tification of two previously uncharacterized S-adenosyl-methionine-dependent O-methyltransferase gene

298 xanthine phosphoribosyltransferase, and the S-adenosyl-methionine-I riboswitch from the B. subtilis

299 ulans with various assays, including in vivo S-adenosyl-[methyl-(3)H]methionine labeling, targeted in

300 ytic subunit of the heterodimeric methionine S-adenosyl transferase-2 (MAT2A) with fluorinated N,N-di