ライフサイエンスコーパス: S-adenosylmethionine

1 lating agents, even physiological ones (e.g. S-adenosylmethionine).

2 sms, the TgCBS activity is not stimulated by S-adenosylmethionine.

3 substrate and noncompetitive to the cofactor S-adenosylmethionine.

4 but also by the endogenous methylating agent S-adenosylmethionine.

5 e detergent Triton X-100 and the methyldonor S-adenosylmethionine.

6 he Stackebrandtia phosphonoglycan arise from S-adenosylmethionine.

7 with the donor methyl group of the cofactor, S-adenosylmethionine.

8 affected by intermolecular interactions with S-adenosylmethionine.

9 n reactions that occur via the generation of S-adenosylmethionine.

10 the transfer of 1 deuterated methyl group to S-adenosylmethionine.

11 epsilon-amino group for methyl transfer with S-adenosylmethionine.

12 sts a mechanism for allosteric activation by S-adenosylmethionine.

13 rolysis of 5'-methylthioadenosine to salvage S-adenosylmethionine.

14 sis, and 5'-methylthioadenosine recycling to S-adenosylmethionine.

15 due to a reduced conversion of methionine to S-adenosylmethionine.

16 tion of tetrahydrofolate and biosynthesis of S-adenosylmethionine.

17 persisted 1 month, whereas the methyl donor S-adenosylmethionine (500 mum) had an opposite effect on

18 Methionine, through S-adenosylmethionine, activates a multifaceted growth pr

19 S-adenosylmethionine administration at these early stage

20 S-adenosylmethionine (AdoMet or SAM)-dependent methyltra

21 Bhmt resulted in a 43% reduction in hepatic S-adenosylmethionine (AdoMet) (p < 0.01) and a 3-fold in

22 ost invariably catalyzed by enzymes that use S-adenosylmethionine (AdoMet) as the methyl group donor.

23 MoaA is a radical S-adenosylmethionine (AdoMet) enzyme that catalyzes a co

24 osphate synthase; EC 4.1.99.17) is a radical S-adenosylmethionine (AdoMet) enzyme that uses a [4Fe-4S

25 Under anaerobic conditions, S-adenosylmethionine (AdoMet) radical chemistry is used.

26 insertion, LipA uses a [4Fe-4S] cluster and S-adenosylmethionine (AdoMet) radical chemistry; the rem

27 ncoded proteins, a cobalamin (Cbl)-dependent S-adenosylmethionine (AdoMet) radical enzyme, OxsB, and

28 The S-adenosylmethionine (AdoMet) radical superfamily of enz

29 e multiple methyltransferase domains for the S-adenosylmethionine (AdoMet) reactions.

30 The S-adenosylmethionine (AdoMet) salvage enzyme 5'-methylth

31 ThiC is a member of the radical S-adenosylmethionine (AdoMet) superfamily and catalyzes

32 catalyze the transfer of a methyl group from S-adenosylmethionine (AdoMet) to a peptidylarginine on a

33 catalyzes the transfer of methyl groups from S-adenosylmethionine (AdoMet) to acceptor lysine residue

34 rase (COMT) catalyzes a methyl transfer from S-adenosylmethionine (AdoMet) to dopamine.

35 anding enzyme-catalyzed methyl transfer from S-adenosylmethionine (AdoMet) to small-molecule catechol

36 Inclusion of the PIMT co-substrate, S-adenosylmethionine (AdoMet), during panning permitted

37 cause MATbeta lowers the Ki of MATalpha2 for S-adenosylmethionine (AdoMet), this allowed steady-state

38 an CBS (hCBS) is allosterically activated by S-adenosylmethionine (AdoMet), which binds to the regula

39 r of methyl groups for methyltransferases is S-adenosylmethionine (AdoMet), which in most cells is sy

40 S-adenosylmethionine (AdoMet)-based methylation is integ

41 Small (>1) BIEs are observed for an S-adenosylmethionine (AdoMet)-binary and abortive ternar

42 domain lysine methyltransferases (KMTs) are S-adenosylmethionine (AdoMet)-dependent enzymes that cat

43 investigated METTL12, a mitochondrial human S-adenosylmethionine (AdoMet)-dependent methyltransferas

44 s elegans synthesizes phosphocholine via two S-adenosylmethionine (AdoMet)-dependent phosphoethanolam

45 on PFL by the PFL-AE in a reaction requiring S-adenosylmethionine (AdoMet).

46 ng sensitivities to the allosteric effector, S-adenosylmethionine (AdoMet); whereas T257M and T257I a

47 meI in complex with its DNA substrate and an S-adenosylmethionine analog (Sinefungin).

48 MEP50 (methylosome protein 50), bound to an S-adenosylmethionine analog and a peptide substrate deri

49 cobalamin (coenzyme B(12)), simpler, such as S-adenosylmethionine and an iron-sulfur cluster (i.e., p

50 methylarginine formation when incubated with S-adenosylmethionine and hypomethylated ribosomes prepar

51 mitochondrial fatty-acid synthesis type II, S-adenosylmethionine and iron-sulfur clusters.

52 and ALT levels, betaine treatment increased S-adenosylmethionine and up-regulated Dnmt3b levels, and

53 nt on metabolites such as acetyl-coenzyme A, S-adenosylmethionine, and NAD+, among others.

54 bacterium SAM-IV riboswitch with and without S-adenosylmethionine, and the computer-designed ATP-TTR-

55 Ursodeoxycholic acid and S-adenosylmethionine are anti-fibrotic in bile duct liga

56 y methylating phosphatidylethanolamine using S-adenosylmethionine as a methyl donor.

57 concentrations of the methionine metabolites S-adenosylmethionine, betaine, and cystathionine in MS g

58 Oscillatory production of S-adenosylmethionine, betaine, choline, phosphocholine,

59 We found that isoleucine and S-adenosylmethionine bind to the ACT domain, negatively

60 are dimeric with each monomer containing an S-adenosylmethionine binding domain with a core Rossmann

61 ltransferase fold, which besides the typical S-adenosylmethionine-binding site ((SAM)P) also contains

62 related to purine catabolism, methionine and S-adenosylmethionine biosynthesis and methionine salvage

63 ecific contributions made by thymidylate and S-adenosylmethionine biosynthesis to CRC risk.

64 ctivated one-carbons between thymidylate and S-adenosylmethionine biosynthesis.

65 dicate LaeA may perform novel chemistry with S-adenosylmethionine but also provide new insights into

66 Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose,

67 uster, catalyzes an enhancement of uncoupled S-adenosylmethionine cleavage relative to WT, together w

68 n crude invertebrate extracts spiked with an S-adenosylmethionine cofactor, revealing possible cataly

69 s affecting the production of decarboxylated S-adenosylmethionine (dcSAM) and polyamine synthesis.

70 otic genes encoding spermidine biosynthesis: S-adenosylmethionine decarboxylase (AdoMetDC) and spermi

71 S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes

72 Previously we showed that trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), a key enz

73 Instead trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), which cat

74 ne fusions of polyamine biosynthetic enzymes S-adenosylmethionine decarboxylase (AdoMetDC, speD) and

75 n of histone genes, selenoprotein genes, and S-adenosylmethionine decarboxylase (AMD1).

76 In the present study, S-adenosylmethionine decarboxylase (SAMDC), a key gene i

77 ng stems from mTORC1-dependent regulation of S-adenosylmethionine decarboxylase 1 (AMD1) stability.

78 eport X-ray structures of Trypanosoma brucei S-adenosylmethionine decarboxylase alone and in function

79 putrescine amidohydrolase in archaea, and of S-adenosylmethionine decarboxylase and ornithine decarbo

80 razone (MGBG), a polyamine analog and potent S-adenosylmethionine decarboxylase inhibitor, decreases

81 ethyltetrahydrofolate:Hcy methyltransferase, S-adenosylmethionine decarboxylase, DNA methyltransferas

82 ypanosomatid spermidine biosynthetic enzyme, S-adenosylmethionine decarboxylase, is regulated by hete

83 erimental frameshift frequencies measured in S-adenosylmethionine-decarboxylase and antizyme mutants,

84 all living organisms, mostly relies on SAM (S-adenosylmethionine)-dependent methyltransferases.

85 cofactor, revealing possible catalysis by an S-adenosylmethionine-dependent carboxylic acid methyltra

86 llular adenosine mediated by modification of S-adenosylmethionine-dependent DNA methylation.

87 S-Adenosylmethionine-dependent DNA methyltransferases (M

88 th recent evidence supporting a role for the S-adenosylmethionine-dependent enzyme NifB in the incorp

89 methylation of lysine residues, catalyzed by S-adenosylmethionine-dependent lysine methyltransferases

90 e identify a previously undescribed class of S-adenosylmethionine-dependent methylases that convert a

91 We present a selection design that couples S-adenosylmethionine-dependent methylation to growth.

92 we provide in vivo evidence that a dedicated S-adenosylmethionine-dependent methyltransferase encoded

93 e ATP binding region-containing proteins and S-adenosylmethionine-dependent methyltransferase protein

94 3-deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase that ta

95 ethanocaldococcus jannaschii encodes a novel S-adenosylmethionine-dependent methyltransferase, now id

96 AF7, is predicted to belong to the family of S-adenosylmethionine-dependent methyltransferases charac

97 , belongs to the family of seven-beta-strand S-adenosylmethionine-dependent methyltransferases.

98 Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine

99 to one-carbon metabolism due to their common S-adenosylmethionine-dependent transmethylation and has

100 me and transposon derepression indicate that S-adenosylmethionine-dependent transmethylation is inhib

101 ss-linked peptide formed by MftC through two S-adenosylmethionine-dependent turnovers.

102 PqqE, a radical S-adenosylmethionine enzyme in pyrroloquinoline quinone

103 Here we demonstrate that BzaF is a radical S-adenosylmethionine enzyme that catalyzes the remarkabl

104 MoaA, a radical S-adenosylmethionine enzyme, catalyzes the first step in

105 It is repaired by a radical SAM (S-adenosylmethionine) enzyme, the spore photoproduct lya

106 accessory proteins, two of which are radical S-adenosylmethionine enzymes (HydE, HydG) and one of whi

107 chemical characterization of these 8 radical S-adenosylmethionine enzymes and, in the context of huma

108 In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesi

109 Iba57p, which aconitase and certain radical S-adenosylmethionine enzymes require for activity.

110 he current state of knowledge of the radical S-adenosylmethionine enzymes required for synthesis of t

111 HydE and HydG are radical S-adenosylmethionine enzymes that chemically modify a H-

112 O(2)-sensitive [4Fe-4S] clusters in radical S-adenosylmethionine enzymes.

113 ns, two of which (HydE and HydG) are radical S-adenosylmethionine enzymes.

114 ations with the AMMECR1 domain and a radical S-adenosylmethionine family domain.

115 ibose and 2,6-diaminopurine produced 2-amino-S-adenosylmethionine for hydrolytic conversion to 2AMTA.

116 ionine (SAM) enzyme that reductively cleaves S-adenosylmethionine, generating 5'-deoxyadenosyl radica

117 serine-glycine-one-carbon pathway coupled to S-adenosylmethionine generation.

118 on affecting essential pathways that utilize S-adenosylmethionine in addition to methionine.

119 ver that the enzyme converting methionine to S-adenosylmethionine in mESCs, methionine adenosyltransf

120 um produces 5-methylthioadenosine (MTA) from S-adenosylmethionine in polyamine biosynthesis; however,

121 ethyl incorporation of radioactively labeled S-adenosylmethionine into recombinant fragments of OmpB.

122 S-Adenosylmethionine is widely used in a variety of biol

123 nity (KD of 0.14-2.2 muM) than the substrate S-adenosylmethionine (KD of 22-43 muM), which indicates

124 deficiency, as demonstrated by reductions in S-adenosylmethionine levels and in global DNA methylatio

125 Huh7 cells overexpressing MAT1A had higher S-adenosylmethionine levels but lower bromodeoxyuridine

126 protein and methylation potential [ratio of S-adenosylmethionine (major methyl donor):S-adenosylhomo

127 pionate breakdown pathway and the methionine/S-adenosylmethionine (Met/SAM) cycle.

128 SAH catabolism is linked to S-adenosylmethionine metabolism, and the development of

129 ther choline, which can serve as a source of S-adenosylmethionine methyl groups, influences PC-DHA or

130 s sp. CX-1, and identified a gene encoding a S-adenosylmethionine methyltranserase termed BlArsM with

131 ation can be mediated by the enzyme arsenite S-adenosylmethionine methyltransferase (ArsM) or through

132 s catalyzed by the enzyme arsenite (As[III]) S-adenosylmethionine methyltransferase (ArsM).

133 sults suggest that BlArsM is a novel As(III) S-adenosylmethionine methyltransferase requiring only tw

134 cally, we demonstrate that ChuW is a radical S-adenosylmethionine methyltransferase that catalyzes a

135 We found that binding by the cofactor S-adenosylmethionine mitigates this autoinhibited struct

136 E responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO.

137 he apo form and in complex with its cofactor S-adenosylmethionine or S-adenosylhomocysteine.

138 is monomeric in the absence and presence of S-adenosylmethionine or S-adenosylhomocysteine.

139 cofactocin biosynthesis is one example of an S-adenosylmethionine protein-dependent RiPP pathway.

140 subset of these pathways depends on radical S-adenosylmethionine proteins to modify the RiPP-produce

141 bus acidocaldarius Both proteins are radical S-adenosylmethionine proteins, indicating that GDGT cycl

142 uorum sensing and encode one or more radical S-adenosylmethionine (RaS) enzymes, a diverse protein su

143 ides (RiPPs) and contain one or more radical S-adenosylmethionine (RaS) enzymes, a versatile superfam

144 es (RiPPs) that contain at least one radical S-adenosylmethionine (RaS) metalloenzyme and are regulat

145 contain one or more uncharacterized radical S-adenosylmethionine (RaS) metalloenzymes.

146 idoxal 5'-phosphate (PLP) for catalysis, and S-adenosylmethionine regulates the activity of human CBS

147 ated methyl cycle (AMC), which generates the S-adenosylmethionine required by methyltransferases and

148 o three putative cobalamin-dependent radical S-adenosylmethionine (RS) enzymes, ThnK, ThnL, and ThnP,

149 Radical S-adenosylmethionine (RS) enzymology has emerged as a ma

150 PqqE is a radical S-adenosylmethionine (RS) protein with a C-terminal SPAS

151 osed to be catalyzed by two putative radical S-adenosylmethionine (rSAM) enzymes, PoyB and PoyC.

152 scovery of four different classes of radical S-adenosylmethionine (rSAM) methyltransferases that meth

153 acid were dose-dependently increased, while S-adenosylmethionine, S-adenosylhomocysteine, and cystat

154 S-Adenosylmethionine, S-adenosylhomocysteine, S-ribosylh

155 ), cystathionine (P<0.01), and the decreased S-adenosylmethionine/S-adenosyl homocysteine ratio (P<0.

156 This was associated with a higher S-adenosylmethionine/S-adenosylhomocysteine ratio and lo

157 A decreased S-adenosylmethionine: S-adenosylhomocysteine ratio and i

158 LC availability, methylation potential (the S-adenosylmethionine: S-adenosylhomocysteine ratio) in t

159 Radical S-adenosylmethionine (SAM) (RS) methylases perform methy

160 ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophe

161 he levels of which are reliant upon adequate S-adenosylmethionine (SAM) and inhibited by S-adenosylho

162 ar levels of methionine and the methyl donor S-adenosylmethionine (SAM) and resulting in loss of dime

163 carbide originates from the methyl group of S-adenosylmethionine (SAM) and that it is inserted into

164 Protein methyltransferases require S-adenosylmethionine (SAM) as a co-factor (methyl donor)

165 T methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor.

166 site (rVSV-K1651A, -D1762A, and -E1833Q) or S-adenosylmethionine (SAM) binding site (rVSV-G1670A, -G

167 recombinant hMPVs carrying mutations in the S-adenosylmethionine (SAM) binding site in CR VI of L pr

168 The nutrient-sensing metabolite S-adenosylmethionine (SAM) controls one-carbon metabolis

169 arly days, radical enzyme reactions that use S-adenosylmethionine (SAM) coordinated to an Fe-S cluste

170 development and fertility via the methionine/S-Adenosylmethionine (SAM) cycle and breaks down the sho

171 a (Mat1a) knockout (KO) mice express hepatic S-adenosylmethionine (SAM) deficiency and increased ERK

172 The studies revealed GilMT as a typical S-adenosylmethionine (SAM) dependent O-methyltransferase

173 We found that the methyl donor S-adenosylmethionine (SAM) disrupts the SAMTOR-GATOR1 co

174 ntiviral protein that belongs to the radical S-adenosylmethionine (SAM) enzyme family.

175 The radical S-adenosylmethionine (SAM) enzyme HydG lyses free l-tyro

176 rikoshii Dph2 (PhDph2) is an unusual radical S-adenosylmethionine (SAM) enzyme involved in the first

177 The radical S-adenosylmethionine (SAM) enzyme NifB occupies a centra

178 estigation of the incredibly diverse radical S-adenosylmethionine (SAM) enzyme superfamily, PPP aided

179 DesII is a radical S-adenosylmethionine (SAM) enzyme that catalyzes the C4-

180 Viperin is an IFN-inducible radical S-adenosylmethionine (SAM) enzyme that inhibits viral re

181 Biotin synthase is a radical S-adenosylmethionine (SAM) enzyme that reductively cleav

182 TsrM, an annotated radical S-adenosylmethionine (SAM) enzyme, catalyzes the methyla

183 AprD4 is shown to be a radical S-adenosylmethionine (SAM) enzyme, catalyzing homolysis

184 ross-link, which is installed by the radical S-adenosylmethionine (SAM) enzyme, StrB.

185 SPL is a radical S-adenosylmethionine (SAM) enzyme, utilizing the 5'-deox

186 Radical S-adenosylmethionine (SAM) enzymes account for nearly 2%

187 Radical S-adenosylmethionine (SAM) enzymes are emerging as a maj

188 one and is a member of a subclass of radical S-adenosylmethionine (SAM) enzymes called radical SAM (R

189 Radical S-adenosylmethionine (SAM) enzymes catalyze an astonishi

190 Radical S-adenosylmethionine (SAM) enzymes exist in organisms fr

191 RimO and MiaB are radical S-adenosylmethionine (SAM) enzymes that catalyze the att

192 the sactipeptide RiPP class via the radical S-adenosylmethionine (SAM) enzymes that form the charact

193 Radical S-adenosylmethionine (SAM) enzymes use a [4Fe-4S] cluste

194 Radical S-adenosylmethionine (SAM) enzymes use a [4Fe-4S] cluste

195 Radical S-adenosylmethionine (SAM) enzymes use the oxidizing pow

196 We determined two radical S-adenosylmethionine (SAM) enzymes, one each from an SNP

197 In radical S-adenosylmethionine (SAM) enzymes, the 5'-dAdo* is form

198 ssembly scaffolds by the activity of radical S-adenosylmethionine (SAM) enzymes.

199 has been shown to be a member of the radical S-adenosylmethionine (SAM) family of enzymes, [4Fe-4S] c

200 ansferase (MAT2A) catalyzes the formation of S-adenosylmethionine (SAM) from ATP and methionine.

201 tenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variet

202 The methyl donor S-adenosylmethionine (SAM) is produced in most cells thr

203 S-adenosylmethionine (SAM) is the methyl donor for biolo

204 S-adenosylmethionine (SAM) is the methyl-donor substrate

205 sion, Hcy, S-adenosylhomocysteine (SAH), and S-adenosylmethionine (SAM) levels, and SAM/SAH ratios in

206 translational level in response to cellular S-adenosylmethionine (SAM) levels.

207 ate sulfur metabolism through binding to the S-adenosylmethionine (SAM) ligand and offer compelling t

208 family of proteins that perform both radical-S-adenosylmethionine (SAM) mediated sulfur insertion and

209 We found that threonine and S-adenosylmethionine (SAM) metabolism are coupled in plu

210 rmational changes upon Mg(2+) compaction and S-adenosylmethionine (SAM) metabolite binding.

211 NosN is annotated as a class C radical S-adenosylmethionine (SAM) methylase, but its true funct

212 show that NosN, a predicted class C radical S-adenosylmethionine (SAM) methylase, catalyzes both the

213 ession of the arsM gene encoding the As(III) S-adenosylmethionine (SAM) methyltransfase from Rhodopse

214 ed using CysS, a cobalamin-dependent radical S-adenosylmethionine (SAM) methyltransferase.

215 ny of the arsM gene that encodes the As(III) S-adenosylmethionine (SAM) methyltransferase.

216 Cobalamin (Cbl)-dependent radical S-adenosylmethionine (SAM) methyltransferases catalyze m

217 Members of every kingdom have ArsM As(III) S-adenosylmethionine (SAM) methyltransferases that methy

218 sis of a methyl group partially derived from S-adenosylmethionine (SAM) onto electrophilic sp(2)-hybr

219 se domains in apo form as well as with bound S-adenosylmethionine (SAM) or S-adenosylhomocysteine (SA

220 and biochemically characterized the radical S-adenosylmethionine (SAM) protein MaMmp10, the product

221 The radical S-adenosylmethionine (SAM) protein PqqE is predicted to

222 LipA is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes and us

223 TsrM is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes, but i

224 RimO is a member of the growing radical S-adenosylmethionine (SAM) superfamily of enzymes, which

225 expanding subgroup of enzymes of the radical S-adenosylmethionine (SAM) superfamily that harbor one o

226 reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation rea

227 n of the liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/II

228 It transfers the methyl group of S-adenosylmethionine (SAM) to catalyze the synthesis of

229 ecial [4Fe-4S] cluster to reductively cleave S-adenosylmethionine (SAM) to generate a reactive 5'-dA

230 At anaerobic end, enzymes reversibly cleave S-adenosylmethionine (SAM) to generate the 5'-deoxyadeno

231 atalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine generating S-adeno

232 m the [4Fe-4S](+) cluster to the coordinated S-adenosylmethionine (SAM) to induce homolytic S-C5' bon

233 talyze the transfer of the methyl group from S-adenosylmethionine (SAM) to lysine residues in histone

234 en fundamental bacterial metabolic pathways: S-adenosylmethionine (SAM) utilization, polyamine biosyn

235 Inspiration from Nature's methylating agent, S-adenosylmethionine (SAM), allowed for the design and d

236 l PBMC DNA methylation, plasma folate, blood S-adenosylmethionine (SAM), and concentrations of As in

237 , betaine, S-adenosylhomocysteine (SAH), and S-adenosylmethionine (SAM), and higher percentages of me

238 cellular concentrations of the methyl donor, S-adenosylmethionine (SAM), and increasing the demethyla

239 : phosphocholine cytidylyltransferase (PCT), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (

240 lly extensive interactions with the cofactor S-adenosylmethionine (SAM), conferring SAM-dependent sub

241 Here we review the roles of acetyl-CoA and S-adenosylmethionine (SAM), donor substrates for acetyla

242 ese nutrients, S-adenosylhomocysteine (SAH), S-adenosylmethionine (SAM), homocysteine, cysteine, and

243 been known to be allosterically inhibited by S-adenosylmethionine (SAM), only relatively recently has

244 iboswitch, one of several classes that binds S-adenosylmethionine (SAM), represses translation upon b

245 Met is the obligate precursor of S-adenosylmethionine (SAM), the methyl donor utilized by

246 hieno-pyrimidones that were competitive with S-adenosylmethionine (SAM), the physiological methyl don

247 nsp10 heterodimers bound to the methyl donor S-adenosylmethionine (SAM), the reaction product S-adeno

248 pi1p represses genes that maintain levels of S-adenosylmethionine (SAM), the substrate for most methy

249 of this pathway, is the direct precursor of S-adenosylmethionine (SAM), the universal methyl donor n

250 d expression of SIN3 leads to an increase in S-adenosylmethionine (SAM), which is the major cellular

251 acid methionine is a metabolic precursor for S-adenosylmethionine (SAM), which serves as a coenzyme f

252 residues in histone proteins is catalyzed by S-adenosylmethionine (SAM)-dependent histone lysine meth

253 depends on the integrity of the helicase and S-adenosylmethionine (SAM)-dependent methyltransferase-l

254 SAH is a potent feedback inhibitor of S-adenosylmethionine (SAM)-dependent methyltransferases

255 S-Adenosylmethionine (SAM)-dependent methyltransferases

256 ic programming and is most often achieved by S-adenosylmethionine (SAM)-dependent methyltransferases.

257 and oxygenation through the action of eight S-adenosylmethionine (SAM)-dependent mycolic acid methyl

258 Several members of a distinct family of S-adenosylmethionine (SAM)-dependent N-methyltransferase

259 LepI is an S-adenosylmethionine (SAM)-dependent pericyclase that ca

260 The S-adenosylmethionine (SAM)-I riboswitch is a noncoding R

261 cusing almost exclusively upon Mg(2+) and/or S-adenosylmethionine (SAM)-induced folding of full-lengt

262 The S(MK) (SAM-III) box is an S-adenosylmethionine (SAM)-responsive riboswitch found i

263 he purified enzyme contains internally-bound S-adenosylmethionine (SAM).

264 ionine boosts synthesis of the methyl donor, S-adenosylmethionine (SAM).

265 methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM).

266 facilitate the unusual acyl conjugation with S-adenosylmethionine (SAM).

267 S-Adenosylmethionine (SAM, also known as AdoMet) radical

268 which have chronically low levels of hepatic S-adenosylmethionine (SAMe) and spontaneously develop st

269 T) are the primary genes involved in hepatic S-adenosylmethionine (SAMe) synthesis and degradation, r

270 The principal methyl donor of the cell, S-adenosylmethionine (SAMe), is produced by the highly c

271 ts were found for replicated studies testing S-adenosylmethionine (SAMe), methylfolate, omega-3 (prim

272 ycine N-methyltransferase (GNMT) catabolizes S-adenosylmethionine (SAMe), the main methyl donor of th

273 S-Adenosylmethionine (SAMe), the principal methyl donor

274 ole in peripheral nerve myelination and that S-adenosylmethionine (SAMe), the principal methyl donor

275 ltransferase (MAT) catalyzes biosynthesis of S-adenosylmethionine (SAMe), the principle methyl donor.

276 their liver tissues have abnormal levels of S-adenosylmethionine (SAMe).

277 arbon cycle, which produces the methyl donor S-adenosylmethionine (SAMe).

278 tant uncovered a nitrogen-, methionine-, and S-adenosylmethionine-sufficiency response, resulting in

279 s/methylsynthases that belong to the radical S-adenosylmethionine superfamily of enzymes.

280 ion of worm methionine synthase (metr-1) and S-adenosylmethionine synthase (sams-1) imply metformin-i

281 hionine synthase; inactivation of the sams-1 S-adenosylmethionine synthase also suppresses the drp-1

282 histones, is synthesized from methionine by S-adenosylmethionine synthase; inactivation of the sams-

283 teins have diverse cellular roles, including S-adenosylmethionine synthesis, respiration, and host tr

284 enzymes central to all cellular methylation, S-adenosylmethionine synthetase and S-adenosylhomocystei

285 psis (Arabidopsis thaliana), one of the four S-adenosylmethionine synthetase genes, METHIONINE ADENOS

286 Interestingly, although metK (encoding S-adenosylmethionine synthetase) was essential in vitro,

287 hich contains serine metabolic enzymes, SAM (S-adenosylmethionine) synthetases, and an acetyl-CoA syn

288 S-adenosylmethionine, the methyl donor of many methylati

289 novo synthesis of purines, thymidylate, and S-adenosylmethionine, the primary cellular methyl donor.

290 transferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the principal methyl donor, and is

291 ne (3-MeA) is formed in DNA by reaction with S-adenosylmethionine, the reactive methyl donor, and by

292 e been found to catalyze alkyl transfer from S-adenosylmethionine to halide ions.

293 The enzyme utilizes S-adenosylmethionine to methylate a variety of phosphona

294 alyzes the methyl transfer from the cofactor S-adenosylmethionine to nicotinamide and other pyridine-

295 d by a typical Sn2-type methyl transfer from S-adenosylmethionine to pEA.

296 of GSH to oxidized forms of glutathione and S-adenosylmethionine to S-adenosylhomocysteine levels, r

297 fer of donor methyl groups from the cofactor S-adenosylmethionine to specific acceptor lysine residue

298 extracellular concentration of methionine or S-adenosylmethionine was increased.

299 deuterated 5'-deoxyadenosine and deuterated S-adenosylmethionine when the reaction is carried out in

300 Addition of NTPs, Mg(2+), and S-adenosylmethionine, which allows active transcription,