ライフサイエンスコーパス: S-phase kinase-associated protein

1 eported to be essential for interaction with S phase kinase-associated protein 1 (SKP1) and RNA silen

2 2, signals its recruitment to the SCF(SKP2) (S-phase kinase associated protein 1 (SKP1)-cullin-SKP2)

3 lls, the cyclin A/CDK2 complex that contains S-phase kinase associated proteins 1 and 2 (SKP1 and SKP

4 They bind to S-phase kinase-associated protein 1 (SKP1) through the F

5 and TgPhyA) catalyze prolyl-hydroxylation of S-phase kinase-associated protein 1 (Skp1), a reaction e

6 clear F-box protein that interacts with host S-phase kinase-associated protein 1 (SKP1), suggesting t

7 rt a moonlighting function of two paralogous S-phase kinase-associated protein 1 (Skp1)-related prote

8 d the identified interactions of Fbxl22 with S-phase kinase-associated protein 1 and Cullin1, 2 criti

9 ding experiments indicate that neither SKP1 (S-phase kinase-associated protein 1) nor CCNB1 binding w

10 7 protein by degrading the components of the S-phase kinase-associated protein 1-CUL1-F-box ubiquitin

11 (an F-box protein) and the associated Skp1 (S-phase kinase-associated protein-1)-Cullin1 complex, le

12 S phase kinase-associated protein 2 (Skp2) is the F-box

13 essing the transcriptional activation of the S phase kinase-associated protein 2 (Skp2), an F-box pro

14 ation of Notch1 induces transcription of the S phase kinase-associated protein 2 (SKP2), the F-box su

15 we demonstrate that the F-box protein SKP2 (S phase kinase-associated protein 2), the substrate-spec

16 thway to breakdown of p27Kip1 is mediated by S phase kinase-associated protein 2; however, our eviden

17 S-phase kinase-associated protein 2 (SKP-2) is an F-box

18 ), damaged DNA-binding protein 1 (DDB1), and S-phase kinase-associated protein 2 (SKP2) as components

19 Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase

20 s in part by opposing the down-regulation of S-phase kinase-associated protein 2 (SKP2) by the more w

21 derwent K63-linked polyubiquitination by SCF S-phase kinase-associated protein 2 (SKP2) E3 ubiquitin

22 S-phase kinase-associated protein 2 (Skp2) functions as

23 he oncogenic role of the E3 ubiquitin ligase S-phase kinase-associated protein 2 (Skp2) in many types

24 The combo mutant increased expression of S-phase kinase-associated protein 2 (SKP2) in PHHs and H

25 S-phase kinase-associated protein 2 (SKP2) is a componen

26 cation pathway in which the E3 F-box protein S-phase kinase-associated protein 2 (SKP2) targets TBET

27 y, B-RAF and cyclin D1 control the levels of S-phase kinase-associated protein 2 (Skp2) that directs

28 e regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed

29 kinase inhibitor, and increased the level of S-phase kinase-associated protein 2 (Skp2), a known E3 u

30 s to down-regulated expression of cyclin E1, S-phase kinase-associated protein 2 (SKP2), minichromoso

31 namely, cyclin-dependent kinase 2 (CDK2) and S-phase kinase-associated protein 2 (SKP2).

32 attributable to an increase in expression of S-phase kinase-associated protein 2 (Skp2).

33 including hepatic induction of cyclin D1 and S-phase kinase-associated protein 2 expression and suppr

34 In the present study, we observed increased S-phase kinase-associated protein 2 mRNA expression in I

35 The E3 ligase S-phase kinase-associated protein 2(Skp2) is overexpress

36 Both SKP2 (S-phase kinase-associated protein 2) and transforming gr

37 The F-box protein Skp2 (S-phase kinase-associated protein 2) positively regulate

38 the expression of the ubiquitin ligase SKP2 (S-phase kinase-associated protein 2), which targets p27

39 KC1 Inhibition of the ubiquitin ligase SKP2 (S-phase kinase-associated protein 2), which targets the

40 eat SOCS box containing protein 2) and SKP2 (S-phase kinase-associated protein 2).

41 uced cellular senescence via inactivation of S-phase kinase-associated protein 2, an important altern

42 p45 S phase kinase-associated protein-2 (p45(skp2)), a membe

43 The S-phase kinase-associated protein-2 (SKP2) plays a key r

44 Jag-1/Notch2 signaling robustly decreased S-phase kinase-associated protein, an F-box protein that

45 Overexpression of S-phase kinase-associated protein before Notch activatio

46 n of p27 associated with decreased levels of S-phase kinase-associated protein (Skp)-2, a ubiquitin l

47 The S-phase kinase-associated protein Skp2 is required for t