ライフサイエンスコーパス: SCF ubiquitin ligase

1 e LKB1 polyubiquitination by activating Skp2-SCF ubiquitin ligase.

2 remove Nedd8 from Cullin1, a subunit of the SCF ubiquitin ligase.

3 n regulating the activity of Cul1-containing SCF ubiquitin ligases.

4 mechanism underlying E2 selection by VHL and SCF ubiquitin ligases.

5 d Skp1 proteins in reconstitution of VHL and SCF ubiquitin ligases.

6 otheses for how CSN promotes the activity of SCF ubiquitin ligases.

7 tobacco extracts was shown to interact with SCF ubiquitin ligases.

8 -like protein Nedd8 from the Cul1 subunit of SCF ubiquitin ligases.

9 (deneddylation) from the cullin component of SCF ubiquitin ligases.

10 recognition by the Skp1-Cdc53-F-box protein (SCF) ubiquitin ligase.

11 hydroxylate Pro143 of Skp1, a subunit of E3(SCF)ubiquitin-ligases.

12 te recognition subunit of SKP1-CULLIN-F-box (SCF) ubiquitin ligases.

13 sylation of DdSkp1, an adaptor subunit in E3(SCF) ubiquitin ligases.

14 other core components of Skp1-Cullin-F-box (SCF) ubiquitin ligases.

15 We conclude that CSN inhibits SCF ubiquitin ligase activity in targeting p27 proteolys

16 into the role of CAND1 in the regulation of SCF ubiquitin-ligase activity.

17 hese data indicate that Skp1 and possibly E3(SCF)ubiquitin-ligase activity modulate O(2)-dependent cu

18 , CAND1 regulated the assembly of productive SCF ubiquitin ligases, allowing a common CUL1-ROC core t

19 W7 is the substrate-recruiting subunit of an SCF ubiquitin ligase and a major tumor-suppressor protei

20 It interacts with SCF ubiquitin ligases and deconjugates Nedd8/Rub1 from c

21 dditional layer for substrate recruitment by SCF ubiquitin ligases and provide conceptual insight int

22 Skp1 is an adaptor-like protein in E3(SCF)-ubiquitin ligases and other multiprotein complexes

23 Archipelago (Ago), the F box component of an SCF-ubiquitin ligase and the Drosophila ortholog of a hu

24 ly binds Skp1 protein (a 'core' component of SCF ubiquitin ligase), and phosphorylated IkappaB(alpha)

25 SCF ubiquitin ligases are composed of a core of conserve

26 well-known adaptors of the Skp1-Cul1-F-box (SCF) ubiquitin ligase, as the key missing components of

27 (s) as the target of the SKP1-Cullin1-F Box (SCF) ubiquitin ligases assembled with AUF1/2.

28 auxin regulates gene expression by promoting SCF ubiquitin-ligase-catalysed degradation of the Aux/IA

29 The SCF ubiquitin ligases catalyze protein ubiquitination in

30 a suggest that hCUL1 functions as part of an SCF ubiquitin ligase complex in human cells.

31 es encode several components involved in the SCF ubiquitin ligase complex including a viral Skp1 homo

32 The SCF ubiquitin ligase complex of budding yeast triggers D

33 The SCF ubiquitin ligase complex regulates diverse cellular

34 I1, through which EMI1 assembles a canonical SCF ubiquitin ligase complex that constitutively targets

35 1 interacts with beta-TrCP, a subunit of the SCF ubiquitin ligase complex that mediates the degradati

36 directly with the Skp1 component of the host SCF ubiquitin ligase complex, and that the binding of M-

37 epeat-containing protein, a component of the SCF ubiquitin ligase complex, previously shown to be req

38 ning protein (beta-TrCP), a component of the SCF ubiquitin ligase complex, to p100.

39 expression of Skp2 and Cks1, subunits of the SCF ubiquitin ligase complex, which ubiquitinates p27(Ki

40 and activation of the beta-TrCP1-containing SCF ubiquitin ligase complex.

41 argets YAP1 for degradation via the betaTrCP-SCF ubiquitin ligase complex.

42 erved F box protein, suggesting a role in an SCF ubiquitin ligase complex.

43 and consequent loss of its affinity for the SCF ubiquitin ligase complex.

44 x proteins act as bridging components of the SCF ubiquitin ligase complex; the N-terminal F-box binds

45 The SCF ubiquitin-ligase complex targets the ubiquitin-media

46 Gli2 interacts directly with betaTrCP in the SCF ubiquitin-ligase complex through two binding sites,

47 g F-box proteins that degrade toxins via the SCF ubiquitin-ligase complex.

48 ey component of the Skp1-Cul1-F-box protein (SCF) ubiquitin ligase complex and regulator of key cell-

49 city factor for the Skp1-Cul1-F-box protein (SCF) ubiquitin ligase complex and targets several protei

50 al degradation by a SKP1-CUL1-F-box protein (SCF) ubiquitin ligase complex that contains the orphan F

51 cificity for the Skp1-Cullin1-F-box protein (SCF) ubiquitin ligase complex that targets multiple onco

52 ificity subunits of the Skp1-Cullin 1-F-box (SCF) ubiquitin ligase complex that targets these CDKI pr

53 -box protein, part of the Skp1-cullin-F-box (SCF) ubiquitin ligase complex, involved in ubiquitinatio

54 he interactions between the SKP1-CUL1-FBXW7 (SCF) ubiquitin ligase complex, the kinase GSK3beta, and

55 s analogous to the cellular Skp1-Cul1-F-box (SCF) ubiquitin ligase complex.

56 group are members of the Skp, Cullin, F box (SCF) ubiquitin ligase complex.

57 component of the Skp1-Cullin-F-box protein (SCF) ubiquitin-ligase complex (SCF(skp2)).

58 hosphorylation of Ci/Gli triggers binding to SCF ubiquitin ligase complexes and consequent proteolysi

59 equired Skp2, a substrate-binding subunit of SCF ubiquitin ligase complexes, but also relied on CHIP,

60 rone system to the substrate-specific arm of SCF ubiquitin ligase complexes, suggesting a role in SCF

61 n F, the substrate receptor of 1 of 69 human SCF ubiquitin ligase complexes.

62 nt development by modulating the activity of SCF ubiquitin ligase complexes.

63 and for defining new modes of regulation of SCF ubiquitin ligase complexes.

64 -like molecule is control of the activity of SCF ubiquitin ligase complexes.

65 TRCP, all of which function as components of SCF ubiquitin-ligase complexes.

66 e combined activity of two Skp-cullin-F-box (SCF) ubiquitin ligase complexes that included as substra

67 function in Skp1-Cdc53/Cullin-F-box protein (SCF) ubiquitin ligase complexes.

68 SCF ubiquitin ligases, composed of three major subunits,

69 SCF ubiquitin ligases contain an E3 core composed of Skp

70 SCF ubiquitin ligases control various processes by marki

71 regulation of RAD51 protein stability via an SCF ubiquitin ligase dependent on EMI1.

72 Skp1-Cul1-F-box protein (SCF) ubiquitin ligases direct cell survival decisions by

73 omain-containing 7 (FBXW7), a subunit of the SCF ubiquitin ligase, down-regulates spindle assembly 6

74 F box protein Nutcracker, a component of an SCF ubiquitin ligase (E3) required for caspase activatio

75 In SCF ubiquitin ligases, F-box proteins serve as substrate

76 Release of ubiquitin-charged Cdc34 from the SCF ubiquitin ligase followed by diffusion-driven collis

77 ction of CSN is to maintain the stability of SCF ubiquitin ligases in vivo.

78 een for substrates of the Skp1-cullin-F-box (SCF) ubiquitin ligase in mammalian cells.

79 t K63-linked LKB1 polyubiquitination by Skp2-SCF ubiquitin ligase is critical for LKB1 activation by

80 rovide evidence that E2 selection by VHL and SCF ubiquitin ligases is determined not solely by the Cu

81 ion orchestrated by SKP1.CUL1.F-box protein (SCF) ubiquitin ligases is a fundamental process essentia

82 proteins in E3 Skp1/Cullin-1/F-box protein (SCF) ubiquitin ligases is well characterized.

83 3) do not efficiently interact with the core SCF ubiquitin ligase machinery or mediate the degradatio

84 te recognition component of Skp1-Cul1-F-box (SCF) ubiquitin ligase, played an essential and specific

85 rate binding subunit of a Skp1/Cullin/F Box (SCF) ubiquitin ligase, regulates the abundance of the gl

86 tes in order to allow its recognition by the SCF ubiquitin ligase subunit Cdc4.

87 ation and subsequent glycosylation of the E3(SCF) ubiquitin ligase subunit Skp1 affects its conformat

88 We applied COMET to SCF ubiquitin ligase subunits that mediate degradation o

89 ied Sic1, a prototype substrate of the Cdc34/SCF ubiquitin ligase, suggests that substrate degradatio

90 bw7 is the substrate-binding component of an SCF ubiquitin ligase that degrades critical oncoproteins

91 codes the substrate recognition subunit of a SCF ubiquitin ligase that targets proteins for degradati

92 -specific substrate recognition component of SCF ubiquitin ligases that catalyzes the ubiquitination

93 ecognition subunit of the Skp1-cullin-F-box (SCF) ubiquitin ligase that targets oncoproteins for ubiq

94 is an F-box constituent of Skp-Cullin-F-box (SCF) ubiquitin ligases that directs ubiquitylation of cy

95 is a component of Skp1-Cullin-F-box protein (SCF) ubiquitin ligases that target regulatory proteins f

96 Ams2 destruction via both the APC/C and the SCF ubiquitin ligases underlies the coordination of hist

97 yclin D1 is recognized by a Skp1-Cul1-F box (SCF) ubiquitin ligase where FBX4 and alphaB crystallin g

98 Remarkably, the Skp2-SCF ubiquitin ligase, which plays a central role in cell

99 LORAL ORGANS (UFO), an F-box component of an SCF ubiquitin ligase, yet how this regulation is effecte