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1 SCr at 12 months was 1.6+/-0.7 in group 1 and 1.8+/-1.0
2 SCr decreased by 1.1 mg/dL in patients receiving terlipr
3 SCr in reversible AKI returned to baseline </=48 h after
4 SCr increases > or = 0.5 mg/dL occurred in 4.4% (9 of 20
5 SCr level improved from baseline to day 14 on terlipress
6 SCr level in the early postischemic period (24-72 hr) se
7 SCr levels after contrast material administration are lo
8 SCr values probably underestimate the degree of kidney f
9 SCr values were not statistically different late posttra
10 SCr-based and CrC-based scores were similar between grou
12 dence of HRS reversal (defined as at least 1 SCr value </=1.5 mg/dL while on treatment), transplant-f
13 tions between renal function (estimated by 1/SCr and 1/CysC) and SBI, controlling for potential confo
14 rithmic GFR from the following covariates: 1/SCr, 1/SCr2, age, and sex (where SCr = serum creatinine)
15 imated by the inverse of serum creatinine (1/SCr); moderate renal impairment was defined as SCr > or
16 [CI] 1.09 to 1.32; P < 0.001) but not for 1/SCr (OR 1.08; 95% CI 0.98 to 1.19; P = 0.14), for which
21 fidence interval {CI}: 0.65, 1.86], P = .70; SCr >/= 0.3 mg/dL or 50% over baseline AKI definition od
22 rease or GFR decrease for 3 days after CT, a SCr increase (of >or=0.5 mg/dL [44.2 micromol/L, 25%] or
23 e of AR, as 32% of patients in group 4 had a SCr at 10 days after transplantation (SCr(10d)), before
26 The U-curve relationship between admission SCr and respiratory failure during hospitalization was o
29 Of these patients, 799 (1.1%) had admission SCr of <=0.4 mg/dL, and 2886 (4.3%) developed respirator
30 justment for confounders, very low admission SCr of <=0.4 mg/dL was significantly associated with inc
32 um creatinine (SCr; peak SCr minus admission SCr) and categorized as no AKI (SCr change, <0.3 mg/dL),
33 spiratory failure based on various admission SCr, using SCr of 0.7-0.8 mg/dL as the reference group i
34 of AHR, serum creatinine (SCr) level at AHR, SCr level after PP and IVIg at 3 months, days to achieve
35 s no AKI (SCr change, <0.3 mg/dL), mild AKI (SCr change, 0.3-<0.5 mg/dL), moderate AKI (SCr change, 0
36 (SCr change, 0.3-<0.5 mg/dL), moderate AKI (SCr change, 0.5-<1.0 mg/dL), and severe AKI (SCr change,
37 us admission SCr) and categorized as no AKI (SCr change, <0.3 mg/dL), mild AKI (SCr change, 0.3-<0.5
41 <45, <30, 30-44, 45-59 mL/min/1.73 m(2)) and SCr (<1.5, >/=1.5, >/=1.6, >/=1.7, >/=1.8, >/=1.9, >/=2.
42 vations occurred in 10% vs. 4% (p=0.28), and SCr elevations occurred in 20% vs. 6% (p=0.06) of patien
46 0 mg/dL, those with SCr 1.0 to 1.4 mg/dL and SCr >1.4 mg/dL had an increased hazard ratio of death (u
51 iscrepancy between kidney injury markers and SCr level can be reconciled by the recognition that many
52 ham surgery was induced in C57BL/6 mice, and SCr level and inulin clearance (Cin) were measured betwe
53 n adults) across the FAS (2 to 90 years) and SCr range (40 to 490 umol/L [0.45 to 5.54 mg/dL]) and wi
54 r); moderate renal impairment was defined as SCr > or = 1.3 mg/dl for women and > or = 1.5 mg/dl for
57 itus, use of N-acetylcysteine, mean baseline SCr, and estimated glomerular filtration rate were compa
60 ile of CysC, whereas the association between SCr and SBI was U-shaped, with greater prevalence at hig
61 , we found a significant interaction between SCr and right atrial pressures (interaction P<0.0001); i
62 there was a significant relationship between SCr 6mo in paired recipients (P < 0.0008 by Spearman).
63 determined whether the relationship between SCr and dementia was particularly strong among individua
64 gnostic performance of urinary Kim-1 to BUN, SCr and urinary N-acetyl-beta-D-glucosaminidase (NAG) as
67 ntrast material-induced nephrotoxicity (CIN; SCr increase >/=0.5 mg/dL [44.20 mumol/L] or >/=25%).
69 eGFR <45 mL/min/1.73 m(2) instead of common SCr thresholds would significantly increase the number o
70 patients with prepregnancy serum creatinine (SCr) >150 micromol/L, a trend toward increased postpregn
71 ow a 6-month baseline of 1/serum creatinine (SCr) (slope of reciprocal creatinine) at or beyond 1 yea
72 ssure (BP), lipid profile, serum creatinine (SCr) and albumin-to- creatinine ratio (ACR)), types of d
73 oxicity in animal systems, serum creatinine (SCr) and blood urea nitrogen (BUN) are the primary optio
74 ed survival at seven days, serum creatinine (SCr) and blood urea nitrogen (BUN) daily for 3 days, and
78 ) is defined by changes in serum creatinine (SCr) and diuresis with risk/injury/failure/loss/end stag
80 inpatients with sufficient serum creatinine (SCr) data and stable renal function (difference between
83 n 10% vs 4% (P = .28), and serum creatinine (SCr) elevations in 27% vs 6% (P = .02) of patients with
85 RD) performance to predict serum creatinine (SCr) in severe trauma population and determined the best
86 nvestigate the validity of serum creatinine (SCr) level as an indicator of postischemic renal dysfunc
87 dose of IVIg, time of AHR, serum creatinine (SCr) level at AHR, SCr level after PP and IVIg at 3 mont
89 pe 1 or type 2 diabetes, a serum creatinine (SCr) level of 1.3-3.3 mg/dl for women and 1.5-3.5 mg/dl
90 crease in maximal observed serum creatinine (SCr) level of either (a) >/=0.5 mg/dL (44.2 mumol/L) or
94 57), elevated preoperative serum creatinine (SCr) levels (OR 1.02; 95% CI 1.01, 1.03), transition fro
97 ney function and available serum creatinine (SCr) measurement before and after imaging who underwent
98 ensitive and specific than serum creatinine (SCr) or blood urea nitrogen (BUN) in monitoring generali
101 he association between low serum creatinine (SCr) value at admission and the risk of respiratory fail
102 t function was assessed by serum creatinine (SCr) values collected at early (mean, 50 days) and late
109 dge of an optimal expected serum creatinine (SCr) would be useful to detect early renal dysfunction a
110 raft function, measured by serum creatinine (SCr), after pregnancy in KT recipients, stratified in ye
111 bilization or reduction of serum creatinine (SCr), as evidenced by a flattening or positive slope of
112 en found to associate with serum creatinine (SCr), estimated glomerular filtration rate (eGFR) and/or
113 splant monitoring included serum creatinine (SCr), peripheral T-regulatory cells (pTregs)(127/CD4+/25
114 ated with changes in eGFR, serum creatinine (SCr), systolic blood pressure (SBP), renal hypoxia, and
115 for adults are recommended serum creatinine (SCr)-based calculations for estimating glomerular filtra
120 ted by similarly increased serum creatinine (SCr; approximately 4.5 mg/dl) at 2 days, tubule necrosis
121 using absolute changes in serum creatinine (SCr; peak SCr minus admission SCr) and categorized as no
122 nction (WRF) (upward arrow serum creatinine [SCr] >or=0.3 mg/dl) during treatment of decompensated HF
124 ersal (CHRSR, defined as 2 serum creatinine [SCr] values </=1.5 mg/dL, at least 40 hours apart, on tr
125 ths after transplantation (serum creatinine [SCr]6 mo) and donor variables (P = 0.0004, analysis of v
127 ment of post-CT AKI for patients with pre-CT SCr levels of 1.6 mg/dL (141.44 mumol/L) or greater (odd
128 tion (difference between baseline and pre-CT SCr within 0.3 mg/dL and 50% of baseline) were identifie
134 and with published guidelines (>/=2.0 mg/dL [SCr] and <45 mL/min/1.73 m(2) [eGFR]) using McNemar and
135 endpoints demonstrated similar results (eg, SCr >/=1.6 mg/dL [141.44 mumol/L] by using traditional C
140 oth the donor and recipient, and an elevated SCr(10d) predicts a higher risk of acquiring additional
141 6), patients without AR but with an elevated SCr(6mo) (group 2, n=117), and patients with AR but low
142 ly worse in patients with AR and an elevated SCr(6mo) (group 4, n=165) compared with patients in the
144 linically indistinguishable with established SCr-defined criteria, suggesting that intravenous iodina
148 ed a formula to predict the optimal expected SCr after transplantation derived from donor and recipie
150 While more of patients with SRI experienced SCr elevations, 3 (75%) patients had acute kidney injury
151 percentage of patients with SRI experienced SCr elevations, 3 (75%) patients were in AKI prior to RD
153 nfidence interval 1.26 to 2.17, P<0.0001 for SCr 1.0 to 1.4 mg/dL; unadjusted hazard ratio 2.54, 95%
158 en the solitary and bilateral kidney groups (SCr >/= 0.5 mg/dL AKI definition odds ratio = 1.11 [95%
159 sed thresholds: 92.6% (26 285 of 28 390) had SCr <1.5 mg/dL; 91.3% (25 922 of 28 390) had eGFR of >/=
160 .5%) than in the iopromide group (27.8%) had SCr increase 0.5 mg/dL or higher (>or=25%, P = .012).
164 rate renal impairment, reflected by a higher SCr, is associated with an excess risk of incident demen
165 Among those in good-excellent health, higher SCr was associated with vascular-type dementia but not A
166 atients, but there were significantly higher SCr increments among group III patients after the 1 year
167 ctive IgG AECAs and had statistically higher SCr values and incidences of cellular rejection early po
169 ts in the ED suggests that dynamic change in SCr among patients with AKI was associated with hs-cTnT
172 Least squares mean percentage change in SCr from baseline to end of treatment did not differ bet
173 The placebo group had a mean+/-SD change in SCr from baseline to end of treatment of 0.33+/-0.67 mg/
175 igher in the highest vs the lowest change in SCr quartile (64.7% [95% CI, 58.4%-71.5%] vs 36.3% [95%
176 cTnT >14 ng/L) in association with change in SCr, and to assess the diagnostic performance of hs-cTnT
183 eatment success was defined by a decrease in SCr level to </=1.5 mg/dL for at least 48 hours by day 1
186 idence of in-hospital respiratory failure in SCr of 0.7-0.8 mg/dL and increased in-hospital respirato
187 se to therapy was assessed by improvement in SCr, histologic improvement, and decline in DSA strength
188 ta to assess for WRF defined as: increase in SCr >=0.3 mg/dL, or >=25% decrease in estimated glomerul
190 ement in 1/SCr (equivalent to an increase in SCr from 1.0 to 2.0 mg/dl) was associated with a 26% inc
194 t, the time to reach a 0.5-mg/dl increase in SCr was virtually identical after moderate to severe AKI
197 patients), whereas more modest increases in SCr were common (e.g., >or=0.5 mg/dl in 1237 [13%] patie
198 duction in creatinine clearance, the rise in SCr was 246% with normal baseline kidney function, 174%
199 pressures (interaction P<0.0001); increased SCr best predicted death in patients with right atrial p
202 view, we describe the weaknesses of isolated SCr-based diagnoses, the clinical and molecular subtypin
206 erent among patients without AR and with low SCr(6mo) (group 1, n=376), patients without AR but with
210 le there was an improvement (P=0.02) in mean SCr (2.4 mg/dL) at the end of therapy compared with SCr
211 e of an exogenous marker (reference method), SCr level, age, sex, and height were used to develop a n
214 older fulfilling AKI criteria with 2 or more SCr measurements and 1 or more hs-cTnT measurement.
216 -CT AKI by using Acute Kidney Injury Network SCr criteria; the secondary endpoint was post-CT AKI by
218 All severe trauma patients with a normal SCr were retrospectively included between January 2005 a
219 old difference between expected and observed SCr that should trigger investigation and potential inte
220 The difference between expected and observed SCr was significantly greater among deceased donor kidne
221 the difference between expected and observed SCr, suggesting that recipient body weight is a major pr
222 ed the expected SCr with the lowest observed SCr in a cohort of living (79) and deceased (67) donor a
223 Expected SCr correlated with the observed SCr in both living and deceased donor kidney recipients,
224 Using eGFR <45 mL/min/1.73 m(2) instead of SCr of >/=1.5 mg/dL would result in a significant but sm
226 ) after iodixanol (P=0.39), whereas rates of SCr increases > or = 25% were 9.8% and 12.4%, respective
229 g to the poor sensitivity and specificity of SCr and BUN, we used rat toxicology studies to compare t
231 iants, explaining 0.5% of the variability of SCr in Icelanders in addition to the 1% already accounte
234 These rare variants have a larger effect on SCr than previously reported common variants, explaining
239 olute changes in serum creatinine (SCr; peak SCr minus admission SCr) and categorized as no AKI (SCr
241 e subgroup threshold analysis was performed (SCr <1.5 [<132.60 mumol/L]; >/=1.5 to >/=2.0 mg/dL [>/=1
249 s, hepatic malignancy, elevated preoperative SCr levels, postoperative transition from AKI to AKD, AK
251 tions in SLC6A19 that associate with reduced SCr, three of which have been shown to cause Hartnup dis
252 ttransplant function rely on the recipient's SCr and calculations of estimated glomerular filtration
257 aneurysm, urinary Fg increased earlier than SCr in patients who developed postoperative AKI (AUC-ROC
258 UC-ROC=0.90), with a performance higher than SCr (AUC-ROC=0.73) and similar to cystatin C (AUC-ROC=0.
264 alculated that 64% of the variability in the SCr 6mo among patients was due to donor factors and 36%
267 ith a protective effect against reaching the SCr threshold of 1.6 mg/dL (RR=0.80, P<0.001) beyond 12
269 of racially dissimilar pairs showed that the SCr 6mo and graft survival 6 months after transplantatio
272 72 hr and 7 days after ischemia, even though SCr level at 7 days was not different between control an
273 ndpoint was post-CT AKI by using traditional SCr criteria for contrast material-induced nephrotoxicit
274 had a SCr at 10 days after transplantation (SCr(10d)), before they had AR, that was equal to or high
276 However, at 1 year after transplantation, SCr was 1.4 +/- 0.2 in group I, 2.0 +/- 0.9 in group II,
279 f skin color on MELD scores calculated using SCr or corrected creatinine (CrC) in female candidates f
281 ailure based on various admission SCr, using SCr of 0.7-0.8 mg/dL as the reference group in the analy
284 2 patients) with iodixanol (P=0.11), whereas SCr increases > or = 25% were 10.3% and 15.2%, respectiv
287 nces and all but one are rare (MAF <2%) with SCr effects between 0.085 and 0.129 standard deviations.
288 We tested the five variants associating with SCr for association with CKD in an Icelandic sample of 1
289 d loss-of-function variants associating with SCr in three solute carriers (SLC6A19, SLC25A45 and SLC4
291 4 mg/dL) at the end of therapy compared with SCr at the time of diagnosis (2.9 mg/dL), this improveme
294 ith patients with SCr <1.0 mg/dL, those with SCr 1.0 to 1.4 mg/dL and SCr >1.4 mg/dL had an increased
295 5% CI: 0.26-2.7 for group 2 vs. 1) or 1-year SCr (regression coefficient=0.02 for ln(SCr), P=0.3; 95%