ライフサイエンスコーパス: SET domain

1 SET domain [Su(var)3-9, Enhancer-of-zeste, Trithorax] pr

2 SET domain containing (lysine methyltransferase) 7 (SETD

3 SET domain containing 6 (SETD6) monomethylates the RelA

4 SET domain enzymes represent a distinct family of protei

5 SET domain lysine methyltransferases (KMTs) are S-adenos

6 SET domain lysine methyltransferases (KMTs) methylate sp

7 SET domain lysine methyltransferases are known to cataly

8 SET domain protein lysine methyltransferases (PKMT) are

9 SET domain protein lysine methyltransferases (PKMTs) reg

10 SET domain proteins are histone lysine methyltransferase

11 SET domain-containing 3 (SETD3) is a protein (i.e. actin

12 SET domain-containing protein 8, an L3MBTL1-associated p

13 SET domain-containing proteins of the SU(VAR)3-9 class a

14 SET domain-containing proteins play a vital role in regu

15 SET-domain (SET: Su(var)3-9, E(z) and Trithorax)-contain

16 thylation activity is conferred by the ALL-1 SET domain.

17 subset of ccRCC (these included polybromo-1, SET domain containing 2 and BRCA1-associated protein-1,

18 ation of this enzyme, it appears that the 12 SET domain family members in yeast can now be divided in

19 y be a target for methylation by subfamily 2 SET domain methyltransferases.

20 The relationships of 22 SET domain proteins from maize (Zea mays) and 32 SET dom

21 domain proteins from maize (Zea mays) and 32 SET domain proteins from Arabidopsis were evaluated by p

22 encodes the zebrafish homolog of Blimp-1, a SET domain-containing transcription factor that promotes

23 E(Z) bears a SET domain that houses the enzyme active site.

24 fic histone methyltransferases all contain a SET domain, a conserved 130 amino acid motif originally

25 methyltransferases, Dot1 does not contain a SET domain, and it specifically methylates nucleosomal h

26 Set9 contains a SET domain, but lacks the pre- and post-SET domains.

27 2/E(Z), mes-6/ESC, or mes-4, which encodes a SET domain protein.

28 The YDR198c gene encodes a SET domain similar to that of the Rkm1 enzyme responsibl

29 pSET, a transcriptional regulator encoding a SET domain-containing protein recruited to active and in

30 Here, we show that mice expressing a SET domain mutant of MLL3 share phenotypes with isogenic

31 Enhancer of zeste 2 (Ezh2), a SET domain-containing protein, is crucial for developmen

32 tified a protein, termed Metnase, that has a SET domain and a transposase/nuclease domain.

33 yielded seven loss-of-function alleles in a SET domain protein with histone H3 Lys9 methyltransferas

34 MLL5 includes a SET domain and a single PHD finger, but lacks A-T hooks

35 arge subunit methyltransferase (PsLSMT) is a SET domain protein responsible for the trimethylation of

36 Egg is a SET domain protein that is similar to the human protein

37 SMYD3 is a SET domain-containing protein with histone methyltransfe

38 a Rubisco large subunit methyltransferase, a SET domain protein lysine methyltransferase catalyzing t

39 presents the first structural analysis of a SET domain PKMT in complex with its intact polypeptide s

40 peatedly isolated the C-terminal region of a SET domain-containing protein subsequently identified as

41 Knockdown of Setdb2, a SET domain-containing protein possessing a potential his

42 that ESET (an ERG-associated protein with a SET domain, also called SETDB1) histone methyltransferas

43 Here, we report that MES-4, a SET-domain protein, binds to the autosomes but not to th

44 essed ASH1-RELATED3 (ASHR3) gene, encoding a SET-domain protein conferring histone H3 lysine-36 methy

45 Hsmar1 transposon integrated downstream of a SET-domain methylase gene.

46 We report further that the 149-aa SET domain of ASH1 is sufficient for H3-K4 methylation i

47 ns are important for cofactor binding across SET domain enzymes.

48 o subunits to confer an unusual split active SET domain for catalysis.

49 thologs Drosophila E(Z) and human EZH2 among SET domain proteins known to function as HMTs (reviewed

50 Both L3MBTL1 and SET domain-containing protein 8 were upregulated in the

51 somatic cells, and Polycomb group (PcG) and SET domain-related proteins promote this ectopic express

52 Furthermore, F-box, U-box, and SET domains were present in >70% of all species, suggest

53 Bop encodes a protein containing MYND and SET domains, which have been shown to regulate transcrip

54 in interactions that are mediated by PHD and SET domains, and by binding to DNA via A-T hooks and met

55 he evolutionarily conserved SACI, SACII, and SET domains of Set2 are necessary for this repression.

56 ough the domains present in plant and animal SET domain proteins often differ, the domains found in t

57 mbined analysis of the maize and Arabidopsis SET domain proteins reveals that duplication of SET doma

58 MEA and a related protein, SWINGER (SWN), as SET-domain partners of FIS2.

59 The histone methylating activity of the ATX1-SET domain argues that the molecular basis of these effe

60 small family of HMTs that contain bifurcated SET domains.

61 A single FSXXLXXL motif in the NR-binding SET domain protein NSD1 facilitates its interactions wit

62 transferases of the nuclear receptor-binding SET domain protein (NSD) family, including NSD1, NSD2 an

63 Nuclear receptor-binding SET domain protein 2 (NSD2) is a histone H3 lysine 36 (H

64 The NSD (nuclear receptor-binding SET domain protein) family encodes methyltransferases th

65 The nuclear receptor-binding SET domain-containing protein (NSD1) belongs to an emerg

66 sine methylase, the nuclear receptor-binding SET domain-containing protein 1 (NSD1), and a lysine dem

67 gh sequestration and inhibition of SAM-bound SET domain methyltransferases.

68 chromatin states and is mostly catalyzed by SET domain-containing proteins.

69 Protein lysine methylation by SET domain enzymes regulates chromatin structure, gene s

70 in modulating lysine multiple methylation by SET domain KMTs and provide the first molecular snapshot

71 le versus multiple methyl group transfers by SET domain protein lysine methyltransferases.

72 ism is less likely for lysine methylation by SET domains; and that the only invariant active site res

73 s indicate that Set8 employs its i-SET and c-SET domains to engage nucleosomal DNA 1 to 1.5 turns fro

74 strains with deletion mutations in candidate SET domain-containing genes were in vivo labeled with S-

75 20h2 active site diverges from the canonical SET domain configuration and generates a high degree of

76 containing protein 2 (SMYD2) is a catalytic SET domain containing methyltransferase reported to mono

77 ilial relatives, Set1A possesses a catalytic SET domain responsible for histone H3K4 methylation.

78 The fly complex contains a catalytic SET domain subunit, E(Z), plus three noncatalytic subuni

79 MLL4 contains a catalytic SET domain that mono-methylates histone H3K4 and seven P

80 despite the presence of an intact catalytic SET domain.

81 ation at lysine residue 266 in its catalytic SET domain.

82 7 of histone H3 (H3K27me3) via its catalytic SET domain.

83 They are characterized by a split catalytic SET domain and an intervening MYND zinc finger domain, a

84 he EZH2 CXC region adjacent to the catalytic SET domain and associates with EZH2 on the CDH1 and BRCA

85 nomethylation, and mutation of the catalytic SET domain is sufficient to cause the re-replication def

86 Y641 and A677 residues within the catalytic SET domain of EZH2 occur in diffuse large B-cell lymphom

87 ne 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two other s

88 including the p.Tyr1499Asp in the catalytic SET domain, behave as loss-of-function (LoF) alleles.

89 SET-II, the isoform containing the catalytic SET domain, inhibits CSR without affecting either IgH ge

90 Similarly, loss of the catalytic SET domains of MLL3 and MLL4 in mouse embryonic stem cel

91 hyltransferase that possesses characteristic SET domain and ANK repeats.

92 Most characterized SET domain (SETD) proteins are protein lysine methyltran

93 thyltransferase, whereas other characterized SET-domain enzymes are protein lysine methyltransferases

94 PKMTs contain a conserved SET domain in almost all of the cases and may transfer o

95 ursaria chlorella viruses encode a conserved SET domain methyltransferase, termed vSET, that function

96 is elegans gene, set-1, encoding a conserved SET-domain protein.

97 h sequence similarity to proteins containing SET domain methyltransferase, although experiments using

98 These results identify critical SET domain residues needed for PRC2 enzyme function, and

99 ctures are reported for three very different SET domain-containing proteins.

100 Proteins bearing the widely distributed SET domain have been shown to methylate lysine residues

101 H3-K27 methylation in vivo, shows that each SET domain mutation disrupts PRC2 histone methyltransfer

102 Ybr030w and SET7 genes both encode SET domain containing proteins homologous to known prote

103 ditional double knockout of MLL3/4 enzymatic SET domain.

104 Notably, deletion of the enzymatic SET domain in lineage-specific precursor cells mimics H3

105 77A/Y5523A/Y5563A mutations in the enzymatic SET domain of the MLL4 protein.

106 ion of H3.3K4M, or deletion of the enzymatic SET domain, destabilizes enhancer H3K4 methyltransferase

107 This requires the EZH1 SET domain, which augments AML1-ETO-dependent repression

108 d covalently bound to Cys668 within the EZH2-SET domain, triggering EZH2 degradation through COOH ter

109 tSWP1, and a plant-specific C2H2 zinc finger-SET domain protein, AtCZS, interact with each other in p

110 A model is proposed for SET domain protein lysine methyltransferases in which in

111 letion of the histone methyltransferase gene SET-domain containing 2 (SETD2) and the ensuing loss of

112 rs, including histone deacetylase 1 (HDAC1), SET domain, bifurcated 1 (SETDB1), DNA methyltransferase

113 As for previously characterized histone SET domain proteins, the methionine substitution substan

114 We purified and cloned a novel human SET domain-containing protein, named SET8, which specifi

115 Here we identify SET domain protein 3 (SETD3) as the physiological actin

116 g both class I (Rossmann fold) and class II (SET domain) methyltransferases and pave the way for stud

117 plex assembled with a catalytically inactive SET domain variant preferentially catalyzes H3K4 dimethy

118 protein lysine methyltransferases, including SET domain-containing protein 8 (SETD8), are highly desi

119 yses indicated that RNA interaction inhibits SET domain-containing proteins, such as PRC2, nonspecifi

120 H2-mediated cell invasion required an intact SET domain and histone deacetylase activity.

121 T activity of PRC2 is dependent on an intact SET domain in the E(z) protein.

122 aucity of E(z) mutant alleles that alter its SET domain.

123 tion, and this property was conferred by its SET domain, required for the HKMT activity.

124 SET1B, but not its SET domain, is critical for maintaining cell viability,

125 function in replication restart and that its SET domain is essential for recovery from hydroxyurea-in

126 zymatic potential of NSD1 and found that its SET domain possesses intrinsic histone methyltransferase

127 Through its SET domain, WHSC1 regulates the methylation status of th

128 to DNA in hotspots and subsequently uses its SET domain to locally trimethylate histone H3 at lysine

129 ethylation in H3, we show that Set2, via its SET domain, is responsible for methylation at this site

130 Based on known SET domain structures, the mutations likely affect eithe

131 ansferase (RLSMT) is a chloroplast-localized SET domain PKMT responsible for the formation of trimeth

132 deed, deletion of the H3K9 methyltransferase SET domain bifurcated 1 (Setdb1) results in reduced H3K9

133 entify the actin histidine methyltransferase SET domain containing 3 (SETD3) as critically important

134 n to its canonical histone methyltransferase SET domain, the MLL protein contains three plant homeodo

135 bules and that the histone methyltransferase SET-domain-containing 2 (SETD2), which is responsible fo

136 We further show that the MLL SET domain is a histone H3 lysine 4-specific methyltrans

137 kemogenic MLL fusion proteins delete the MLL SET domain Lys(4) methyltransferase activity and fuse ML

138 We demonstrate that the isolated MLL1 SET domain is a slow monomethyltransferase and that tyro

139 We introduced these mutations into the MLL1 SET domain and observed that all are defective for H3K4

140 fied a new interaction site between the MLL1 SET domain and the WD40 beta-propeller domain of RbBP5,

141 iate does not significantly bind to the MLL1 SET domain during the dimethylation reaction.

142 determined the crystal structure of the MLL1 SET domain in complex with cofactor product AdoHcy and a

143 the SET-I subdomain indicates that the MLL1 SET domain possesses significantly more conformational p

144 In contrast, a complex containing the MLL1 SET domain, WDR5, RbBP5, Ash2L, and DPY-30, displays a m

145 nknown non-active-site surface from the MLL1 SET domain.

146 th the NCP uniquely align the catalytic MLL1(SET) domain at the nucleosome dyad, thereby facilitating

147 We found that unlike MLL1, the MLL3 SET domain assembles with the RbBP5/Ash2L heterodimer in

148 n-protein interactions, indicating that most SET domain proteins operate in complexes.

149 one methyltransferase (HMT) multiple myeloma SET domain (MMSET) in mouse B cells and the CH12F3 cell

150 The multiple myeloma SET domain (MMSET) protein is overexpressed in multiple

151 n occurred in myelomas with multiple myeloma SET domain (MMSET) translocation.

152 ctor receptor 3 (FGFR3) and multiple myeloma SET domain (MMSET).

153 ctor receptor 3 [FGFR3] and multiple myeloma SET domain [MMSET]), 16q23 (c-maf), and 20q11 (mafB).

154 ociated antigens (including multiple myeloma SET domain containing protein) which are characterized b

155 hyltransferase MMSET/WHSC1 (Multiple Myeloma SET domain) is overexpressed in a number of metastatic t

156 domains, our studies draw attention to the n-SET domain as a predictor of an H2B ubiquitylation-sensi

157 , and such cross-talk is attributed to the n-SET domain of Set1 and its interaction with the Cps40/Sp

158 hes to demonstrate that Cps40/Spp1 and the n-SET domain of Set1 are required for the stability of Set

159 genetic analyses, we demonstrate that the n-SET domain within Set1, but not Swd2, is essential for H

160 the H3K4 methyltransferase family contain n-SET domains, our studies draw attention to the n-SET dom

161 contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and substoichi

162 Dot1 is a non-SET domain protein that methylates histone H3 at lysine

163 In this paper, we identify a class I, non-SET domain protein methyltransferase, calmodulin-lysine

164 We have also discovered that the non-SET domain components of the MLL1 core complex possess a

165 Here we report that DOT1L, the non-SET domain containing methyltransferase that modifies Ly

166 riptional silencers binds to SETDB1, a novel SET domain protein with histone H3-K9-specific methyltra

167 Recent studies suggest that SmyD1, a novo SET domain-containing protein, may play a critical role

168 Our analysis reveals five classes of SET domain proteins in plants that can be further divide

169 Comparison of SET domain methyltransferase substrates in yeast reveal

170 They are composed of SET domain methyltransferases and structurally unrelated

171 domain proteins reveals that duplication of SET domain proteins in plants is extensive and has occur

172 l repression signal, mediated by a family of SET domain containing AdoMet-dependent enzymes.

173 one of the founding members of the family of SET domain-containing proteins.

174 Ectopic overexpression of SET domain mutant (F681Y) almost completely rescued WIF1

175 olded conformation observed in structures of SET domain histone lysine methyltransferases.

176 Members of the SU(VAR)3-9 family of SET-domain proteins methylate K9 of histone H3.

177 duction in methylation through inhibition of SET-domain enzymes.

178 und that in the absence of WRAD, all but one SET domain catalyzes at least weak H3K4 monomethylation.

179 domain (CTD) distinguishes SmyD1 from other SET domain containing methyltransferases.

180 tumor suppressor (VHL), polybromo 1 (PBRM1), SET domain containing 2 (SETD2), phosphatase and tensin

181 However, a majority of plant SET domain proteins do not have an animal homolog with s

182 have determined the structures of the plant SET domain enzyme, pea ribulose-1,5 bisphosphate carboxy

183 ding the MYND domain, the cysteine-rich post-SET domain, and the C-terminal domain (CTD), were also i

184 n allele that lacks the entire pre- and post-SET domains and that expresses lacZ under the endogenous

185 ide substrate binds between the SET and post-SET domains, with the epsilon-ammonium of K9 positioned

186 ns a SET domain, but lacks the pre- and post-SET domains.

187 codes PRDM3, a protein with an N-terminal PR-SET domain, as well as a shorter isoform, EVI1, lacking

188 I1, lacking the N-terminus containing the PR-SET domain (DeltaPR).

189 t H3 lysine 9 methylation activities of a PR/SET domain have tumor suppression functions and may unde

190 y homologous, especially in the catalytic PR/SET domain, where they differ by only three amino acid r

191 co-predicted recognition motif for equine PR/SET domain 9 (PRDM9) in recombination hotspots.

192 ly conserved member of the Prdm family of PR/SET domain zinc finger proteins.

193 downstream signaling through the protein PR/SET domain 1 (PRDM1).

194 erved in cells expressing either the Riz1 PR/SET domain or PR-Set7 binding domain indicating that Riz

195 essor and demonstrate that the N-terminal PR/SET domain of Riz1 preferentially monomethylates H3K9.

196 The PR/SET domain 9 (PRDM9) protein is a major determinant of m

197 lhe22) forms a repressor complex with the PR/SET domain protein, Prdm8.

198 Members of the PR/SET domain-containing (PRDM) family of zinc finger trans

199 Here, we have established that the PR/SET domain-containing transcription factor Prdm1a is co-

200 ariegation, enhancer of zeste, trithorax (PR/SET) domain-containing zinc finger protein family, and i

201 hetic binding proteins, targeting the Prdm14 SET domain and demonstrate their utility, respectively,

202 ession or by EZH2 mutated at the region (pre-SET domain) of TRIM28 interaction.

203 a triangular Zn3Cys9 zinc cluster in the pre-SET domain and a AdoMet binding site in the SET domain e

204 Plasmodium falciparum encodes ten predicted SET domain-containing protein methyltransferases, six of

205 Nuclear receptor SET domain containing protein 2 (NSD2) catalyzes the met

206 The NSD (nuclear receptor SET domain-containing) family of histone lysine methyltr

207 We propose that other closely related SET domain proteins may function similarly in gametogene

208 en K-to-M mutant histones and the respective SET domain methyltransferases are currently unknown.

209 or Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 and co-occupies its genomic target

210 The removal of the Set1A SET domain does not diminish bulk H3K4 methylation in ES

211 A (Set1A(DeltaSET)); surprisingly, the Set1A SET domain is dispensable for ESC proliferation and self

212 23-amino acid fragment upstream of the Set1A SET domain is necessary for interaction with CFP1, Ash2,

213 re we report the crystal structures of SETD2 SET domain in complex with an H3K36M peptide and SAM or

214 We further identified SETDB1 (SET domain, bifurcated 1), an H3K9-specific histone meth

215 ese studies suggest that the remaining seven SET domain proteins may also be lysine methyltransferase

216 Several SET-domain proteins possess intrinsic histone methyltran

217 ncoming methyl group of SAM-would allow some SET domain proteins to selectively methylate methionine

218 enerally encode three types of H3K9-specific SET domain methyltransferases that contribute to chromat

219 Especially histone-specific SET domain PKMTs have received widespread attention beca

220 the GxG motif in the S-sequence of the split SET domain, as a G18A/G20A double mutant and a sequence

221 domain structure characterized by a "split" SET domain, a conserved MYND zinc finger, and a novel C-

222 In Drosophila, the C-terminal SET domain is encoded by trithorax-related (trr), which

223 its include the methyltransferase C-terminal SET domain of Set1/MLL, Cps60/Ash2L, Cps50/RbBP5, Cps30/

224 ransferase activity of the carboxyl-terminal SET domain.

225 These results show that SET domain methyltransferases can be involved in transla

226 Here we show that SET domain-containing 5 (Setd5) is divergently transcrib

227 The SET domain is a highly conserved domain shared between p

228 The SET domain is responsible for histone lysine methyltrans

229 The SET domain of Ash1 binds all three TRE transcripts, with

230 The SET domain of Set1 is located at the juncture of Cps50,

231 The SET domain proteins PR-Set7 and Suv4-20 have been implic

232 Accordingly, the SET domain of ASH1L methylates H3K4 in vitro, and knockd

233 tients with missense mutations affecting the SET domain and its adjacent domains.

234 V39H1 utilizes both the chromodomain and the SET domain for catalysis.

235 trated that the SNAG domain of Snail and the SET domain of Suv39H1 were required for their mutual int

236 d region connecting the chromodomain and the SET domain, bind the nucleosome core.

237 characterization of the HKMT family and the SET domain.

238 e structure of a ternary complex between the SET domain histone methyltransferase DIM-5, its cofactor

239 Lysine 142 of DNMT1 is methylated by the SET domain containing lysine methyltransferase 7 (SET7),

240 f histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (

241 ly dimethylated at two distinct sites by the SET domain-containing enzyme Rkm1 in the yeast Saccharom

242 males bearing an egg allele that deletes the SET domain, oogenesis arrests at early stages.

243 horax-related gene of Drosophila encodes the SET domain protein TRR.

244 e of CH ... O hydrogen bond formation in the SET domain active site and suggest a role for these inte

245 -SET domain and a AdoMet binding site in the SET domain essential for methyl transfer.

246 methylation), has a nonsense mutation in the SET domain of an H3-specific histone methyltransferase a

247 terozygous for two separate mutations in the SET domain of Mll2 or heterozygous Mll2 knockout mice we

248 d within chromatin regulators, including the SET domain.

249 onto the three-dimensional structure of the SET domain and noticed that a subset of MLL2 (KMT2D, ALR

250 hancement of the catalytic efficiency of the SET domain and thus the propagation of this repressive h

251 Conserved regions of the SET domain bind S-adenosylmethionine and substrate lysin

252 yeast YPL208w gene product, a member of the SET domain family of methyltransferases, catalyzes the r

253 three-dimensional solution structure of the SET domain histone lysine methyltransferase (vSET) from

254 ghly variable but essential component of the SET domain must be repositioned.

255 generated ESCs harboring the deletion of the SET domain of Set1A (Set1A(DeltaSET)); surprisingly, the

256 Based on structural modeling of the SET domain of Set9 with RelA, we propose that the positi

257 The crystal structure of the SET domain of the histone H3 lysine-27 (H3K27) methyltra

258 nges in the substrate binding regions of the SET domain, and the K36M residue interacts with the cata

259 g catalytic activity, due to deletion of the SET domain, fails to inhibit the Fgf21 promoter activity

260 K27M peptide bound to the active site of the SET domain, with the methionine residue located in the p

261 milar organization of domains outside of the SET domain.

262 e understanding of the molecular role of the SET domain.

263 is mediated through the HMT activity of the SET domain.

264 e MES complex appears to be dependent on the SET domain of MES-2.

265 ATX1 locus as an isoform containing only the SET domain (soloSET).

266 emphasize functional inputs from outside the SET domain.

267 somal dyad and in doing so, it positions the SET domain for catalysis with H4 Lys20.

268 in a cysteine-rich region that precedes the SET domain.

269 Gene silencing mediated by EZH2 requires the SET domain and is attenuated by inhibiting histone deace

270 ontain a conserved catalytic core termed the SET domain, which shares sequence homology with an indep

271 ind that a basic N-terminal extension to the SET domain plays an even more prominent role in nucleoso

272 on, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trith

273 ositioning of the SRA domain relative to the SET domain.

274 rough the conserved repeat 2 region with the SET domain of the homeotic regulator Trithorax (TRX), an

275 groups of AdoMet and methyllysine within the SET domain active site.

276 to a negatively charged "exosite" within the SET domain of Set9.

277 We report that the SET domains of TRX and TRX-related (TRR) have robust his

278 ated missense mutations that localize to the SET domains of several MLL family members.

279 in arginine methyltransferase family and the SET-domain-containing methyltransferase family.

280 enzymes, while H3K27me3 is catalyzed by the SET-domain Enhancer-of-zeste enzymes, which are the cata

281 H3K9me3 is catalyzed by the SET-domain SU(VAR)3-9 enzymes, while H3K27me3 is catalyz

282 Strikingly, the SET-domain protein MES-4 is concentrated on autosomes an

283 The level of homology of the SET-domains defined the distribution of the proteins int

284 gnment, compilation, and comparison of their SET-domains.

285 This SET domain protein bears no structural similarity to pre

286 Su(var)3-9, enhancer of a zeste, trithorax (SET) domain containing protein lysine methyltransferase

287 ic Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain methyltransferases.

288 f variegation, enhancer of zeste, trithorax (SET) domain.

289 f variegation, enhancer of zeste, trithorax (SET) domains from human MLL1 and Drosophila Trithorax un

290 QM/MM) molecular dynamics simulations on two SET-domain PKMTs: SET7/9 and Rubisco large subunit methy

291 shares 39% identity with an uncharacterized SET domain protein, KIAA1076, hereafter denoted Set1B.

292 emonstrate that a previously uncharacterized SET domain protein, Set9, is responsible for H4-K20 meth

293 upported the distribution pattern built upon SET-domain similarity.

294 vSET (a viral SET domain protein) is an attractive polycomb repressive

295 However, the mechanism by which SET domain methyltransferases catalyze the transfer of t

296 MBD1 then interacts with SET domain bifurcated 1 methyltransferase to promote bim

297 the induction of ERG-associated protein with SET domain (ESET) and increases trimethylation of histon

298 ERG-associated protein with SET domain (ESET), a histone H3 (K9) methyltransferase,

299 was termed ESET (ERG-associated protein with SET domain).

300 Thus, the E(Z) SET domain requires multiple partner inputs to produce a

301 Four missense alleles identify key E(Z) SET domain residues, and a fifth is located in the adjac

302 hyltransferase (HMTase) activity of the E(Z) SET domain.