ライフサイエンスコーパス: SID

1 SID can be very useful for quaternary structure studies

2 SID can capture neuronal dynamics in vivo within a volum

3 SID fragmentation patterns of peptides are, in general,

4 SID fragments with the same m/z but different charge sta

5 SID of approximately 100-fmol amounts of model peptides

6 SID provides structural information on noncovalent prote

7 SID reveals similar dissociation patterns over all trapp

8 SID showed clear differences among S. cerevisiae populat

9 SID-1 acts cell-autonomously and is required for cellula

10 SID-1 is expressed in cells sensitive to RNAi, is locali

11 SID-2, when expressed in the environmental RNAi defectiv

12 SID-2-dependent dsRNA transport requires an acidic extra

13 SID-5 is detected in cytoplasmic foci that partially col

14 SID-mSin3A interaction is necessary for the anti-prolife

15 erently than the previously described SID-1, SID-2, and SID-3 proteins, thus expanding the systemic R

16 etween many different tissues via at least 2 SID-1 independent export pathways.

17 Here, we identify systemic RNAi defective-3 (SID-3) as a conserved tyrosine kinase required for the e

18 ity [SID] = 0.984), 51 (SID = 0.95), and 42 (SID = 0.881) types, respectively, among the 85 MRSA isol

19 son's index of diversity [SID] = 0.984), 51 (SID = 0.95), and 42 (SID = 0.881) types, respectively, a

20 n of primary cells, whereas Mnt containing a SID deletion cooperates with Ras in the absence of Myc t

21 uption of Sin3 function by introduction of a SID decoy that interferes with PAH2 binding to SID-conta

22 for the first time that the repression of a SID-containing protein is regulated by signaling rather

23 gers are exported to other tissues through a SID-1-independent mechanism.

24 rity to the well-characterized 13-amino-acid SID of the Mad bHLHZip repressor.

25 Here, we demonstrate that using CDMS after SID on an Orbitrap platform offers subunit connectivity,

26 Ion mobility is utilized after SID to separate products overlapping in m/z to simplify

27 In this study, an SID device was designed and successfully installed in a

28 n the previously described SID-1, SID-2, and SID-3 proteins, thus expanding the systemic RNAi pathway

29 e number of electrodes, (2) increase CID and SID sensitivity by lengthening the collision cell, and (

30 ted in ion mobility and subjected to CID and SID.

31 that can block interactions between PAH2 and SID-containing proteins offers a targeted epigenetic app

32 hat the correlation between dimethyl-SRM and SID-SRM is within 0.3-33% variation, demonstrating the a

33 The N-terminus and SID equally enhance SR protein turnover by altering the

34 ural substrates for the low social drive and SIDs in schizophrenia.

35 s associated with both negative symptoms and SIDs.

36 ion-level microsatellite profiling approach, SID (Saccharomyces cerevisiae IDentifier), to identify t

37 ndosomal proteins similarly relocalizes both SID-5 and LMP-1::GFP.

38 e protein-ligand complex ions as assessed by SID.

39 hat can be obtained for protein complexes by SID.

40 imported from the acidic intestinal lumen by SID-2 via endocytosis and are released from internalized

41 that, when expressed in Drosophila S2 cells, SID-2 enables the uptake of dsRNAs.

42 is elegans have shown that the dsRNA channel SID-1 is required for the import of such transported sil

43 secondary step mediated by the dsRNA channel SID-1.

44 genetically conserved transmembrane channel, SID-1.

45 ey, IUPAC name, KEGG, LipidMaps, PubChem CID+SID, SMILES and chemical synonym names.

46 CRISPR-SID represents a potent approach for in vivo mapping of

47 orida and Maryland State Inpatient Database (SID), we examined the prevalence of HRSN among hospitali

48 5-2002 New Jersey State Inpatient Databases (SID) developed as part of the Healthcare Cost and Utiliz

49 zed data from the State Inpatient Databases (SID) for 29-44 US states over a 10-year period (2000-200

50 rom 2009-2012 and State Inpatient Databases (SIDs) from 2008-2014.

51 HCUP data from 43 State Inpatient Databases (SIDs) to calculate 'adjusted' donation rates.

52 ength proteins with these mutations decrease SID-1-mediated RNA transport efficiency, providing evide

53 unknown, but smell identification deficits (SIDs) exist in schizophrenia, and olfaction is related t

54 he general "substitution/insertion/deletion (SID) model".

55 We collected data from a single deme (SID) from Northern Australia and from a scattered sampli

56 We introduce seeded iterative demixing (SID), a computational source-extraction technique that e

57 ts differently than the previously described SID-1, SID-2, and SID-3 proteins, thus expanding the sys

58 ing a soft implantable drug delivery device (SID).

59 rpreted in terms of shear-induced diffusion (SID) caused by viscous interactions between particles in

60 with the concept of stable isotope dilution (SID) for metabolite quantitation.

61 metry (MRM-MS) with stable isotope dilution (SID) is increasingly becoming a widely accepted assay fo

62 ross-links based on stable isotope dilution (SID) nanoflow liquid chromatography nanospray ionization

63 lite (SN-38G) using stable isotope dilution (SID) ultrahigh-performance liquid chromatography-high re

64 but free of systemic inflammatory diseases (SIDs) (SMR = 1.04, 95% CI, 0.95-1.14) had similar mortal

65 ice capable of surface-induced dissociation (SID) and collision-induced dissociation (CID) for Fourie

66 ectrometry and surface-induced dissociation (SID) are used to investigate the TTR disassembly mechani

67 rument employs surface-induced dissociation (SID) as an activation method for obtaining structural in

68 of the typical surface-induced dissociation (SID) collision energy range, consistently cleaves the we

69 monstrate that surface-induced dissociation (SID) coupled with ion mobility mass spectrometry (IM-MS)

70 custom in-line surface-induced dissociation (SID) device has been incorporated into a commercial ion

71 novel in-line surface-induced dissociation (SID) device was designed and implemented in a commercial

72 A surface-induced dissociation (SID) device was recently commercialized, enabling broade

73 fragmented by surface-induced dissociation (SID) following trapping.

74 Surface-induced dissociation (SID) has been implemented in a matrix-assisted laser des

75 trometry (MS), surface-induced dissociation (SID) has been shown to be a powerful activation method f

76 In contrast, surface-induced dissociation (SID) has been shown to be very effective at dissociating

77 metry studies, surface-induced dissociation (SID) has been successfully applied in quadrupole time-of

78 nergy-resolved surface-induced dissociation (SID) of des-Arg(1)- and des-Arg(9)-bradykinin on a fluor

79 nergy-resolved surface-induced dissociation (SID) of ternary complexes of Co(III)(salen)+, Fe(III)(sa

80 Surface-induced dissociation (SID) of the singly protonated complex of vancomycin anti

81 try (TIMS) and surface-induced dissociation (SID) on a Bruker SolariX XR 15 T FT-ICR mass spectromete

82 sequencing by surface-induced dissociation (SID) on a MALDI-ion mobility-orthogonal TOF mass spectro

83 configured for surface-induced dissociation (SID) studies.

84 ples IM-MS and surface-induced dissociation (SID) to dissociate the source-activated precursors of th

85 tramers toward surface-induced dissociation (SID).

86 d a target for surface induced dissociation (SID).

87 d reports from surface-induced dissociation (SID); (3) avidin oligomers are best described as heterog

88 cture by cone activation produces a distinct SID spectrum, with the differences observed being conser

89 A resolved 66 (Simpson's index of diversity [SID] = 0.984), 51 (SID = 0.95), and 42 (SID = 0.881) typ

90 ies, we discovered that the repressor domain SID (SIN3-interacting domain) derived from the MXD1 prot

91 a large, nonhomologous spacer insert domain (SID) that bifurcates the kinase domain and anchors the k

92 ad2 through a novel Smad-interacting domain (SID) adjacent to its PDZ domain.

93 that the Mtb RbpA sigma-interacting domain (SID) and basic linker are sufficient for transcription a

94 A Sin3-interacting domain (SID) originally described in Mad proteins is necessary f

95 n via a Mad1-like mSin3A interacting domain (SID).

96 The SAP30 Sin3 interaction domain (SID) binds to PAH3 via a tripartite structural motif, in

97 te motif within the Sin3 interaction domain (SID) comprising a helix and an extended segment.

98 gion related to the Sin3 interaction domain (SID) of Mad proteins.

99 bound together, the Sin3 interaction domain (SID) of Mad1 forms extensive hydrophobic contacts with t

100 The mSin3 interaction domain (SID) of the human MAD1 protein provided moderate repress

101 motif known as the Sin3 interaction domain (SID).

102 cterize the VP5 scaffold interaction domain (SID).

103 acent to the SRA-interacting protein domain (SID), which is the domain of APOL1 that interacts with S

104 alian Sin3A with the transrepression domain (SID) of human Mad1 reveals that both domains undergo mut

105 gh two independent Sin3 interaction domains (SIDs), Pf1SID1 and Pf1SID2.

106 with glycosylated SRCR-Interspersed Domains (SIDs).

107 5 ug/mL (EID5) and standard interval dosing (SID) of 4 weeks.

108 d with patients on standard interval dosing (SID; n=1093) every 4 weeks.

109 2000 eV so that changes to ion energy during SID do not cause major m/z shifts.

110 ociated with stimulation-induced dysarthria (SID) and to predict stimulation-induced worsening of int

111 This new setup allows efficient SID for a broad range of molecules.

112 Here, we show that, in C. elegans, SID-1 is required for efficient silencing of multicopy t

113 ry to the observation time frame of existing SID spectrometers, which are on the order of 10 micros f

114 nematodes engineered to endogenously express SID-3 variants analogous to TNK2 PD-associated SNPs exhi

115 We expressed SID-1, a transmembrane protein from Caenorhabditis elega

116 rometer (FT-ICR MS) specially configured for SID experiments.

117 s and are larger than a few milliseconds for SID implemented in Fourier transform ion cyclotron reson

118 ver, drastic differences can be observed for SID spectra of different conformations, implying differe

119 menting the calculation of fibr-wise ORs for SID, was employed to identify the distributional pattern

120 amino acids 8-20 of Mad1 are sufficient for SID:PAH2 interaction.

121 Furthermore, SID-5 acts differently than the previously described SID

122 ient Database for the state of Florida (HCUP-SID-FL) for calendar years 2011-2015, inclusive, with 96

123 d mSin3 is not only dependent on the helical SID but is also dependent on both putative helices of th

124 We present here SID of a large noncovalent tetradecamer protein, GroEL (

125 the "long indel" model (a space-homogeneous SID model) and the model used by Dawg, a genuine sequenc

126 Here, we show that a human SID-1 orthologue, SIDT1, facilitates rapid, contact-depe

127 The advantage of IM-SID-o-TOF-MS is that a single experiment can be used to

128 ork highlights the potential of utilizing IM-SID to study quaternary structures of protein complexes

129 ) or symptomatic secondary immunodeficiency (SID) remain uncertain.

130 s and experimental results that implementing SID in a commercial MALDI TOF spectrometer is feasible a

131 cytosolic import through the dsRNA importer SID-1 in the parental germline and/or developing progeny

132 rmline requires the dsRNA-selective importer SID-1.

133 nous (exo)-RNAi pathway: the dsRNA importer, SID-1 and the argonaute, RDE-1.

134 served in EID group compared with 4 cases in SID cohort.

135 ollision cell and yields a 3-10x increase in SID sensitivity.

136 ; 7% of patients had enhancing T1 lesions in SID compared with 9% in EID (p=0.08); annualised relapse

137 Genetic missense mutations in SID-1 ECD causal for deficient systemic RNAi resulted in

138 average charge states of monomer products in SID of each of these forms are unique.

139 as well as some domestic databases including SID, Magiran, IranDoc, IranMedex from inception to the e

140 efficient import of dsRNA requires an intact SID-3 kinase domain.

141 te that systemic RNAi in C. elegans involves SID-1-mediated intercellular transport of dsRNA.

142 ation with NGP-based stable-isotope-labeled (SID)-MRM in the individual samples of 38 HCC serum and 2

143 rom the gut lumen across gut cells that lack SID-1.

144 Unlike the kinase core, the large SID lacks stable, hydrogen-bonded structure and may prov

145 Finally, a 6 mm thick, 2-lens SID device replaced the collision cell entrance lens.

146 Here, we describe that the Mad1-like SID domain of the Sp1-like repressor TIEG2 is inhibited

147 ucturally and functionally related Mad1-like SID is also present in five Sp1-like repressor proteins

148 11-regulated functions require the Mad1-like SID, indicating that these target genes involved in thes

149 , these results demonstrate that the in-line SID setup is a valid substitute for CID, with potential

150 not have sequence similarity with either Mad SID or Pf1SID1 and therefore represents a novel Sin3 bin

151 hydrophobic residues in the amphipathic Mad1 SID.

152 , we have generated altered-specificity Mad1 SID mutants that bind only to a PAH2 domain with a recip

153 A fusion protein comprising the Mad1 SID linked to a Ga14 DNA binding domain mediates repress

154 sed to a full-length c-Myc protein, the Mad1 SID specifically represses both c-Myc's transcriptional

155 sive mutational analysis to examine the Mad1 SID-mSin3A PAH2 interaction in vitro and in vivo.

156 ntegrity of the PAH1 domain affects the Mad1 SID-PAH2 interaction.

157 across all platforms while also maintaining SID capabilities across a wide mass and energy range.

158 First MALDI-SID results in FT-ICR are presented, demonstrating uniqu

159 Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internal

160 In the Maryland SID, 12.5% (1,551) of the 12,396 PLWH had HRSN.

161 thogens by at least two distinct mechanisms: SID antagonists, which include SRA, that interact with t

162 Finally, the minimal SID can function as an autonomous and portable repressio

163 Worms expressing neuronal SID-1 showed RNAi phenotypes when fed with bacteria expr

164 een electrosprayed and analyzed with the new SID setup.

165 phic disease activity was observed in 62% of SID and 61% of EID patients (p=0.83).

166 commercialized, enabling broader adoption of SID measurements and surface-induced unfolding (SIU).

167 resented, demonstrating unique advantages of SID over conventional FT-ICR MS ion activation technique

168 ion time point on a potential application of SID for high-throughput studies in FTICR MS.

169 vented the RNAi resistance characteristic of SID-3 dysfunction.

170 t the identification and characterization of SID-2, an intestinal luminal transmembrane protein requi

171 t the identification and characterization of SID-5, a C. elegans endosome-associated protein that is

172 The coupling of SID, high resolution, and ion mobility is demonstrated f

173 Testing included determination of SID thresholds, intelligibility ratings, and a fast syll

174 expressed the extracellular domain (ECD) of SID-1 and purified it to near homogeneity.

175 Heterologous expression of SID-1 in Drosophila Schneider 2 cells enables passive up

176 ing our understanding of how the function of SID-containing repressors may be controlled.

177 The mammalian homolog of SID-3, activated cdc-42-associated kinase (ACK), acts in

178 nctional similarity of mammalian homologs of SID-1 (SIDT1 and SIDT2), we expressed and purified mouse

179 Implementation of SID to dissect protein topology during subunit exchange

180 udy illustrates the functional importance of SID-1 ECD as a dsRNA binding domain that contributes to

181 king could be improved with the inclusion of SID data; however, this work relied on knowledge of the

182 nce of inherited silencing is independent of SID-1 and RDE-1, but requires HRDE-1 and MUT-7.

183 Interpretation of SID spectra for cesium iodide clusters was greatly simpl

184 Upon overexpression of SID-3, cells import dsRNA more efficiently than do wild-

185 ed to identify the distributional pattern of SID in the STN's vicinity.

186 lity of LFM, coupled with the performance of SID, will open up a range of applications including clos

187 ve experience with analyzing a wide range of SID-MRM-MS data, we set forth a methodology for analysis

188 gence was independent of the relationship of SID and social drive.

189 mal evolution, but the physiological role of SID-1 and its orthologs remains unclear.

190 These results highlight the utility of SID and IM-MS in resolving conformational heterogeneity

191 the deficit syndrome, but the association of SIDs with diminished social drive explained both relatio

192 the deficit syndrome, but any specificity of SIDs for social dysfunction is unstudied.

193 17% of patients on SID had new T2 lesions compared with 14% in EID (p=0.02)

194 also used phage display to derive an optimal SID, which shows an essentially identical arrangement of

195 mobility (IM) and then dissociated by CID or SID for further structural analysis.

196 terminus of Mad (mSin interaction domain, or SID) and two within the second paired amphipathic helix

197 with Kr uppel-associated box (KRAB), ERD, or SID repressor domains.

198 s advantageous for deconvoluting overlapping SID fragments.

199 er (FT-ICR MS) specially equipped to perform SID experiments.

200 er (FT-ICR MS) specially equipped to perform SID experiments.

201 Here we present SID of leucine enkephalin, fibrinopeptide A, melittin, i

202 . elegans apical intestinal membrane protein SID-2 is required in C. elegans for the import of ingest

203 nstrate that an endosome-associated protein, SID-5, promotes the transport of RNAi silencing signals

204 m CID: 66449); Poly(vinyl chloride) (PubChem SID: 24864273); Tricresyl phosphate (PubChem CID: 6529);

205 m CID: 66449); Poly(vinyl chloride) (PubChem SID: 24864273); Tricresyl phosphate (PubChem CID: 6529);

206 m phosphotungstate tribasic hydrate (PubChem SID: 329753864).

207 novel small molecule thiocarbazate (PubChem SID 26681509), a potent inhibitor of human cathepsin L (

208 Recombinant purified SID-1 ECD selectively binds dsRNA but not dsDNA in a len

209 resent the crystal structure of the Mtb RbpA-SID in complex with domain 2 of the housekeeping sigma-f

210 the structure allows for a model of the RbpA-SID in the context of a transcription initiation complex

211 Reasonable SID signal was detected in single-scan spectra with tota

212 at is complementary to our recently reported SID-IM approach.

213 rited silencing within the germline requires SID-1, a primary Argonaute RDE-1, a secondary Argonaute

214 eas the import of silencing signals requires SID-1, we found that mobile silencing signals generated

215 Further, this minimal 13-residue SID peptide forms an amphipathic alpha-helix in solution

216 eling of time- and collision-energy-resolved SID data suggests that the competition between proton tr

217 er show using NMR that the mSin3A PAH3-SAP30 SID complex can bind to nucleic acids, hinting at a role

218 tios of 200-500 were obtained in single-scan SID mass spectra of model peptides with acquisition time

219 Thus, the second SID, SID2, is highly structured, and this alpha helix (h

220 cture-function analysis, we identify several SID-2 regions required for this activity, including thre

221 y goals of the redesign were to (1) simplify SID by reducing the number of electrodes, (2) increase C

222 cell-autonomous function, intestine-specific SID-5 expression restored body wall muscle (bwm) target

223 ides coupled to stable isotope dilution-SRM (SID-SRM).

224 ion, adult patients with PID and symptomatic SID display greater morbidity and mortality from COVID-1

225 ID-19 in individuals with PID or symptomatic SID and determine risk factors associated with morbidity

226 comes of individuals with PID or symptomatic SID following COVID-19 in the United Kingdom.

227 nhibitor deficiency, and 33 with symptomatic SID.

228 Tandem SID mass spectra can be acquired using either a continuo

229 0 min, comparable to or slightly longer than SID coupled with ion mobility on various instrument plat

230 mediated by the Mad protein family and that SID repression is dominant over several distinct transcr

231 It is concluded that SID may contribute to NSC, but that further experiments

232 Specifically, we demonstrate that SID on a diamond surface results in a significantly bett

233 Here, we demonstrate that SID-1 is a multispan transmembrane protein that sensitiz

234 These results demonstrate that SID-containing KLF repressor proteins can inhibit cell g

235 This study demonstrates that SID in essential tremor patients is associated with both

236 BTEB1, BTEB3 and BTEB4), demonstrating that SID-mSin3A interactions have a wider functional impact o

237 Finally, we find that SID-2-dependent transport is inhibited by drugs that int

238 To test the hypothesis that SID-1 mediates a direct biochemical recognition of RNA m

239 Further analyses revealed that SID-1 enables passive cellular uptake of dsRNA.

240 We show that SID appearance energies can be predicted from structures

241 time-of-flight instruments and suggest that SID coupled to high-resolution MS is well-suited to prov

242 Previous studies have suggested that SID-1 may serve as an RNA channel, but its precise molec

243 The SID device was designed to be installed in the Q Exactiv

244 The SID helix is wedged within a deep hydrophobic pocket def

245 The SID spectra were also compared to CID spectra.

246 The SID transcriptional repressor domain is effective as a f

247 The SID-FT-ICR platform has been tested with several protein

248 In addition, the SID represses the transcriptional activity of linked VP1

249 Also, the SID results uncovered a hidden pathway in which a specif

250 requirements for the interaction between the SID and PAH2, we have performed mutagenesis and structur

251 show that a 35-residue region containing the SID represents a dominant repression domain whose activi

252 This phenomenon disrupts the SID-mSin3A interaction and thereby inhibits TIEG2's repr

253 Results from the SID of hybrid tetramers formed during subunit exchange p

254 nd electronic circuits can be moved from the SID to wearables, and thus, the mechanical softness and

255 for a nucleolar localization sequence in the SID alphaA helix in targeting the Rpd3L/Sin3L complex fo

256 08); annualised relapse rate was 0.14 in the SID group, and 0.09 in the EID group.

257 However, subtle differences in the SID spectra of the activated complex are also observed a

258 ient to cause substantial differences in the SID spectra of these complexes.

259 Interestingly, the SID decoy was effective in the triple-negative M.D. Ande

260 chanical softness and miniaturization of the SID are achieved.

261 and residues on the hydrophobic face of the SID helix are required for interaction with PAH2.

262 Mutations that alter the structure of the SID inhibit in vitro interaction between Mad and mSin3 a

263 Given the close proximity of the SID to other functional motifs in Sds3 at the sequence l

264 and SIDT2 are closely related members of the SID-1 transmembrane family.

265 The performance of the SID-Orbitrap instrument has been demonstrated with sever

266 ed mutagenesis and structural studies on the SID.

267 In particular, the SID decoy led to epigenetic reprogramming and reexpressi

268 products overlapping in m/z to simplify the SID spectra.

269 ino terminus of the Mad proteins, termed the SID, for Sin3 interaction domain, and the second of four

270 Our results indicate that the SID is necessary and sufficient for transcriptional repr

271 DI TOF spectrometer is feasible and that the SID products in this instrument fall in an observation t

272 Here, we show that the SID samples two discrete, substantially populated confor

273 ision energy and the length of time that the SID target is available for collision, two parameters th

274 Therefore, our results suggest that the SID-3/ACK tyrosine kinase acts as a regulator of RNA imp

275 four serine/threonine sites adjacent to the SID.

276 ains to be established, however, whether the SID-mSin3A interaction is constitutive or regulated.

277 s, which include SRA, that interact with the SID of various APOL proteins, and MAD antagonists that i

278 With the SID setup installed, ion transmission proved to be effic

279 The SIDs have been linked with negative symptoms and the def

280 The SIDs were related to negative symptoms and the deficit s

281 This SID nanoLC-NSI/MS/MS assay is highly sensitive and speci

282 liced transcript in human tissues lacks this SID and fails to inhibit TGFbeta responses.

283 These pathways include endocytosis through SID-3 and WASP; a uridylyltransferase that destabilizes

284 Additionally, TIMS-SID was employed on a mixture of the peptides desArg1 an

285 High-quality TIMS-SID spectra were acquired over a period of 2-10 min, com

286 Science direct, and ProQuest in addition to SID, Magiran, and Iranmedex were searched up to March 20

287 cy, providing evidence that dsRNA binding to SID-1 ECD is related to RNA transport.

288 D decoy that interferes with PAH2 binding to SID-containing partner proteins reverted the silencing o

289 tric information for peptide ions (MALDI TOF SID TOF).

290 g the Caenorhabditis elegans RNA transporter SID-1 in neurons to increase the efficacy of RNAi in pri

291 (MCM-3), and double-stranded RNA transporter SID-2.

292 sed, double-blind, placebo-controlled trial (SID-GBS), we included patients ( 12 years) with Guillain

293 pology, are released from the precursor upon SID, significantly different from the ubiquitous monomer

294 In the cell lines used, SID is superior to the KRAB repressor domain, which serv

295 Cases are presented where SID agrees with solved crystal or cryoEM structures or p

296 We examined whether SIDs in schizophrenia were related broadly to negative s

297 energy/secondary fragmentation channels with SID.

298 Individuals with SID had worse outcomes than those with PID; 75.8% (25 of

299 , and high-voltage electronics together with SID spectra of MALDI-generated peptide ions are presente

300 Without SID-3, cells perform RNA silencing well but import dsRNA