ライフサイエンスコーパス: SLAM

1 SLAM accomplishes these four features by using a time-re

2 SLAM binds near the stalk-head junction of the hemagglut

3 SLAM coengagement with CD3 under Th17 polarizing conditi

4 SLAM engagement amplified PKC-theta recruitment in wt bu

5 SLAM family markers enhanced the purification of fetal l

6 SLAM family members are now recognized as important immu

7 SLAM family receptor expression is conserved among HSCs

8 SLAM recruited a complex containing the intracellular cl

9 SLAM regulated activity of the NADPH oxidase NOX2 comple

10 SLAM signaling was shown to inhibit production of IL-12

11 SLAM-expressing T cells are more readily infected by all

12 ls, T(FR) cell development depends on Bcl-6, SLAM-associated protein (SAP), CD28 and B cells; however

13 orylation of NK, T, and B cell Ag (NTB-A), a SLAM family homophilic receptor, in clone 2E2 compared w

14 novel SAP adaptor-independent function for a SLAM receptor.

15 We rescued a SLAM-blind recombinant CDV with six mutations that did n

16 l selection on hematopoietic cells through a SLAM-associated protein (SAP)-dependent mechanism simila

17 To completely abolish SLAM-dependent fusion, combinations of mutations were ne

18 ther with their downstream signaling adaptor SLAM-associated protein (SAP), have emerged as key playe

19 nd the downstream recruitment of the adaptor SLAM-associated protein (SAP) and the Src kinase Fyn, wh

20 Mutations affecting SLAM-associated protein (SAP) prevent GC formation becau

21 ural data also suggest that, like NTB-A, all SLAM family homophilic dimers adopt a highly kinked orga

22 -4 and CD46 binding while minimally altering SLAM binding.

23 Although SLAM controls production of IL-12, tumor necrosis factor

24 antly higher SELENA-SLEDAI (P = 0.00002) and SLAM (P = 0.02) scores.

25 s and B cell help, including ICOS, PD-1, and SLAM family receptors.

26 located in these areas for SLAM-binding and SLAM-dependent membrane fusion, as measured by surface p

27 nd if male, Bruton tyrosine kinase (Btk) and SLAM-associated protein (SAP/SH2D1A).

28 rolla captured engaged CD28, ICOS, CD226 and SLAM-F1 co-stimulators.

29 on T-cell-derived signals through CD40L and SLAM-associated protein (SAP), but not IL-17.

30 blind, and H(AA) (Y481A and R533A)-CD46 and SLAM blind.

31 the natural measles virus receptors CD46 and SLAM.

32 through the native viral receptors CD46 and SLAM.

33 c strains demonstrated that the FcgammaR and SLAM intervals independently controlled the severity of

34 tion, and the expression of CD25, PD-L1, and SLAM.

35 y hematopoietic compartments [Lin-, LSK, and SLAM (LSK/CD48-/CD150+)] increased with the age.

36 essive overgrowth of myeloid, Lin-, LSK, and SLAM cells, but not lymphocytes, from a low number of en

37 The expressions of SAP and SLAM family members were assessed in human bone marrow-d

38 Hence, SAP and SLAM receptors regulate positive and negative signals re

39 dependent variables were the SLAM score and SLAM global (physician).

40 g lymphocyte activation molecule (SLAM), and SLAM activation further increased ERK phosphorylation.

41 Moreover, both CD84 and another SLAM member, Ly108, mediated T cell adhesion and partici

42 readily infected by all MV strains than are SLAM-expressing B cells.

43 enomes of other large DNA viruses might bear SLAM family homologs further underscores the importance

44 Because SLAM signaling plays such a critical role in the innate

45 Besides, SLAM signaling failed to phosphorylate ERK in low respon

46 We examined the overlap between SLAM family member expression with an established isolat

47 s between Ly-9-/- mice as compared with both SLAM-/- and SAP-/- mice.

48 However, compared with XLP caused by SLAM-Associated Protein deficiency (SH2D1A mutation), XI

49 fied residues necessary for efficient canine SLAM-dependent membrane fusion.

50 mophilic adhesion molecules, CD84 and CD150 (SLAM [signaling lymphocyte activation molecule]), which

51 Unlike costimulation with anti-CD28, SLAM costimulation requires the presence of the adaptor

52 We found that the CD34(+) SLAM population contributed equally or less to colony fo

53 The 2 CD84/SLAM adapter proteins, SAP (SLAM-associated protein) and

54 ys to address such shortcomings by combining SLAM with inverse methods are discussed.

55 We conclude that the coreceptor SLAM plays a central role at the interface of acquired a

56 The use of costimulating SLAM Abs was found to augment the differentiation of IL-

57 SAP mediates this function by coupling SLAM family receptors to the protein tyrosine kinase Fyn

58 ata illustrate complexities of SAP-dependent SLAM family receptor signaling, revealing a prominent ro

59 The B6.Sle1b-derived SLAM/CD2 family haplotype is found in many other laborat

60 verexpress C57BL/6 (B6) alleles of different SLAM family genes on an autoimmune-prone B6.Sle1b backgr

61 n provides an opportunity for all two-domain SLAM family receptors to colocalize within the immunolog

62 These findings prove formally that efficient SLAM recognition is necessary for MV virulence and patho

63 aused by mutations in SH2D1A/SAP that encode SLAM-associated protein (SAP), is characterized by an in

64 ) arises from mutations in the gene encoding SLAM-associated protein (SAP) and leads to abnormalities

65 erved that MV infection temporarily enhanced SLAM expression.

66 5RA(+)CD62L(+)) T lymphocytes, which express SLAM very infrequently, with much higher efficiency than

67 omyelocytic leukemia zinc finger-expressing, SLAM family receptor adapter protein-dependent thymocyte

68 tion strategies that specifically facilitate SLAM signaling may improve vaccine potency when targetin

69 Nba2 intervals where genes for the FcgammaR, SLAM, and IFN-inducible families are encoded.

70 idual amino acids located in these areas for SLAM-binding and SLAM-dependent membrane fusion, as meas

71 nstrating a functional role in platelets for SLAM family interactions.

72 eover, PKC-theta, like SAP, was required for SLAM-mediated increases in IL-4 production, and, convers

73 or signaling, revealing a prominent role for SLAM receptor ligation in IL-4 production by GC CD4 T ce

74 We further demonstrate a role for SLAM/SAP signaling in the regulation of early surface CD

75 Here we show that four SLAM family markers, CD150, CD48, CD229, and CD244, can

76 The source apportionment results from SLAM were compared against those from zeroing-out indivi

77 he H protein beta4-beta5 hydrophobic groove, SLAM merely covers it.

78 ot treated with HCQ on enrollment had higher SLAM and SDI scores than patients who were treated.

79 By connecting homotypic SLAM family receptor interactions with the FynT Src kina

80 undergone to efficiently interfere with host SLAM family activities.

81 These cells expressed human SLAM, and it was observed that MV infection temporarily

82 in lymphatic organs of mice expressing human SLAM with human-like tissue specificity.

83 C-B MV selectively unable to recognize human SLAM (SLAM-blind).

84 magglutinin (H) amino acids supporting human SLAM-dependent cell entry, we mutated canine distemper v

85 n of T cell:B cell interactions and identify SLAM family members as critical components of sustained

86 on molecule (SLAM), it replicates briskly in SLAM-expressing cells in lymphatic organs.

87 ude to the previously reported Th2 defect in SLAM-/- mice but is more subtle than that observed in SA

88 thought to contribute to HLH development in SLAM-Associated Protein deficiency were not observed in

89 oration of proteins known to be important in SLAM-mediated signaling.

90 Notably, mutations in SLAM-associated protein (SAP) lead to X-linked lymphopro

91 tion or bacterial killing as was observed in SLAM-/- macrophages.

92 plasma cell development, and Ab responses in SLAM(-/-) mice after a viral infection (lymphocytic chor

93 After infection, SLAM-associated protein (SAP)-/- mice show increased T c

94 tified a critical role for the co-inhibitory SLAM family member 2B4 (CD244) in attenuating primary an

95 were identified by diminished intracellular SLAM-associated protein (SAP), X-linked inhibitor of apo

96 We isolated SLAM (CD150(+)CD48(-)) and non-SLAM (not CD150(+)CD48(-)

97 k-SLAM is a highly efficient algorithm for the characteriz

98 k-SLAM's speed allows a full taxonomic classification and

99 nked lymphoproliferative disease, which lack SLAM-associated protein (SAP) expression.

100 sed SHIP-1, SHP-1, SHP-2, and CSK but lacked SLAM-associated protein (SAP) and Ewing's sarcoma-activa

101 mediates its effects in NK cells by linking SLAM family receptors to phospholipase Cgamma, calcium f

102 tions affecting the adaptor SAP, which links SLAM family receptors to downstream signaling.

103 Although HSPCs (Lin(-)Sca1(+)Kit(+) (LSK)/SLAM(+) and LSK) in Mll(PTD/WT) mice are reduced in abso

104 Although Ly9, SLAM, and SAP play a common role in promoting Th2 polari

105 to lipopolysaccharide (LPS) by macrophages, SLAM does not regulate phagocytosis and responses to pep

106 hen generated an EpR-blind virus maintaining SLAM-dependent cell entry and inoculated rhesus monkeys

107 e validated Systemic Lupus Activity Measure (SLAM) and the Safety of Estrogens in Lupus Erythematosus

108 The Systemic Lupus Activity Measure (SLAM) score was used as the primary outcome for clinical

109 AI) and the Systemic Lupus Activity Measure (SLAM).

110 ity (by the Systemic Lupus Activity Measure [SLAM]) and damage (by the Systemic Lupus International C

111 Stochastic Lagrangian Apportionment Method (SLAM) carries out the following: (1) account for chemica

112 Thus, our method, SLAM-ITseq (SLAMseq in tissue), enables cell-specific tr

113 synthetic-lethality analysis by microarray (SLAM) methods have been used for synthetic-lethality scr

114 synthetic lethality analyzed by microarray (SLAM).

115 ng through the signaling-activation molecule SLAM-adaptor SAP pathway.

116 SH2D1A encodes the adaptor molecule SLAM-associated protein (SAP), which is expressed in T a

117 equires the presence of the adaptor molecule SLAM-associated protein.

118 ment for the costimulation/adhesion molecule SLAM (signaling lymphocytic activation molecule) was fou

119 e signaling lymphocytic activation molecule (SLAM [CD150]) that is expressed in lymphocytes and other

120 or signaling lymphocyte activation molecule (SLAM or CD150), we asked whether and how its tropism is

121 or signaling lymphocyte activation molecule (SLAM or CD150).

122 ro/signaling lymphocyte-activation molecule (SLAM) cells in PRN assays.

123 r signaling lymphocytic activation molecule (SLAM) controls cell entry and governs tropism.

124 Signaling lymphocytic activation molecule (SLAM) family (SLAMF) receptors are involved in the regul

125 he signaling lymphocyte activation molecule (SLAM) family during host-virus coevolution.

126 he signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic recept

127 e signaling lymphocytic activation molecule (SLAM) family includes homophilic and heterophilic recept

128 signalling lymphocytic activation molecule (SLAM) family member 7 (SLAMF7), selectively kills SLAMF7

129 en signaling lymphocyte activation molecule (SLAM) family members.

130 signalling lymphocytic activation molecule (SLAM) family of homotypic haematopoietic cell-specific r

131 e signaling lymphocytic activation molecule (SLAM) family of immunomodulatory receptors, is mutated i

132 he signaling lymphocyte activation molecule (SLAM) family of receptors and their associated signaling

133 he signaling lymphocyte activation molecule (SLAM) family of receptors has been reported in the mouse

134 e signaling lymphocytic activation molecule (SLAM) family of receptors plays an important role in sev

135 he signaling lymphocyte activation molecule (SLAM) family of receptors that signals through SLAM-asso

136 r signaling lymphocytic activation molecule (SLAM) family receptor CD244 (2B4/SLAMf4) has been shown

137 he signaling lymphocyte activation molecule (SLAM) family receptor, SLAMF6.

138 Signaling lymphocytic activation molecule (SLAM) family receptors (SFRs) can mediate either activat

139 Signaling lymphocyte activation molecule (SLAM) family receptors are critically involved in modula

140 he signaling lymphocyte activation molecule (SLAM) family receptors CD319 and CD229 on pDCs and CD319

141 he signaling lymphocyte-activation molecule (SLAM) family that binds CD48.

142 e signaling lymphocytic activation molecule (SLAM) receptor-binding site and has been implicated in t

143 Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes

144 ed signaling lymphocyte activation molecule (SLAM), and SLAM activation further increased ERK phospho

145 r signaling lymphocytic activation molecule (SLAM), and the epithelial receptor nectin-4.

146 r signaling lymphocytic activation molecule (SLAM), it replicates briskly in SLAM-expressing cells in

147 e signaling lymphocytic activation molecule (SLAM), the receptor for MV on lymphatic cells.

148 Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP [SH2D1A]) expression in CD

149 Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) can mediate the function

150 in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impai

151 al signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) in T, invariant natural k

152 Signaling lymphocyte activation molecule (SLAM)-associated protein (SAP)) interactions with SLAM f

153 o signaling lymphocytic activation molecule (SLAM)-associated protein (SAP), the X-linked lymphoproli

154 a signaling lymphocytic activation molecule (SLAM)-associated protein (SAP)-deficient mouse model.

155 he signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first identified as t

156 yn to signal lymphocyte activation molecule (SLAM)-related receptors.

157 er signaling lymphocyte activation molecule (SLAM).

158 e signaling lymphocytic activation molecule (SLAM)/CD150 family includes a family of chromosome 1-enc

159 Signaling lymphocytic activation molecule (SLAM, CD150) is the universal morbillivirus receptor.

160 an signaling lymphocyte activation molecule (SLAM, CD150) with human-like tissue specificity.

161 e signaling lymphocytic activation molecule (SLAM; CD150) and the adherens junction protein nectin-4

162 e signaling lymphocytic activation molecule (SLAM; CD150) is the immune cell receptor for measles vir

163 The ectodomains of most SLAM family members are composed of an N-terminal IgV do

164 In contrast to most SLAM receptor functions, SLAMF7-mediated phagocytosis wa

165 d homing and maintenance of long-term murine SLAM(+) hematopoietic stem cells (HSCs), as well as huma

166 We isolated SLAM (CD150(+)CD48(-)) and non-SLAM (not CD150(+)CD48(-)) cells from human umbilical co

167 on in NSG mice compared with the CD34(+) non-SLAM population.

168 ich harbors the lupus-associated NZM2410/NZW SLAM family genes, produce antinuclear Abs (ANAs).

169 cross-linking in the presence or absence of SLAM cross-linking revealed that SLAM coengagement block

170 Finally, analysis of SLAM-deficient mice revealed an overall defect in platel

171 Characterization of SLAM family receptor expression revealed that thymic gam

172 onstraints relevant to the colocalization of SLAM-family proteins with other signaling molecules in t

173 hus be predicted based on the combination of SLAM family members they expressed.

174 purify HSCs based on a simple combination of SLAM receptors allowed us to identify HSCs in tissue sec

175 ce that PKC-theta is a critical component of SLAM/SAP-mediated pathways that influence TCR-driven IL-

176 Disruption of SLAM family receptor signaling through deletion of SAP r

177 ates cytokine production in DC downstream of SLAM engagement and that a genetic polymorphism that dis

178 With regard to signaling downstream of SLAM receptors, pDCs expressed SHIP-1, SHP-1, SHP-2, and

179 As an example of SLAM's application, we show its use in apportioning sour

180 ducing pDCs displayed a higher expression of SLAM molecules compared with IFN-alpha(-) pDCs.

181 defined molecularly by loss of expression of SLAM-associated protein (SAP).

182 type strains correlate with the frequency of SLAM expression and are highest in B cells, which are 40

183 ed protein (SAP) can mediate the function of SLAM molecules, which have been proposed to be involved

184 mportantly, we find that stringent gating of SLAM markers is essential to achieving purity in HSC iso

185 MV) immunosuppression is due to infection of SLAM-positive immune cells, whereas respiratory shedding

186 interactions that permits the intermixing of SLAM receptors with major histocompatibility complex-spe

187 plicated within neutrophils, despite lack of SLAM expression.

188 Mutations in SH2D1A resulting in lack of SLAM-associated protein (SAP) expression cause the human

189 Cytokines also changed the levels of SLAM-associated protein adaptors, which prevent the inhi

190 dendritic cells and iNKT cells had a loss of SLAM receptor expression.

191 the interaction between a phosphopeptide of SLAM (signaling lymphocytic activation molecule) and its

192 We show that a unique property of SLAM, namely that it predicts gene structures simultaneo

193 mary lymphocytes at low levels regardless of SLAM expression.

194 However, the role of SLAM receptors in the differentiation of iNKT cell effec

195 ew, we cover recent findings on the roles of SLAM family receptors and the SAP family of adaptors, wi

196 that interacts with the cytoplasmic tail of SLAM and related receptors, including 2B4, Ly108, CD84,

197 SAP binds to the cytoplasmic tail of SLAM, and we show that SLAM is expressed on resting and

198 ce and compared their phenotype with that of SLAM-/- and SAP-/- mice.

199 prints of nectin-4 and CD46 but not those of SLAM.

200 lpha-CD47 blockade was strictly dependent on SLAM family receptors in vitro and in vivo.

201 munoprecipitate with tyrosine-phosphorylated SLAM.

202 ated IL-4 production in response to TCR plus SLAM-mediated stimulation.

203 f B cell-intrinsic expression of polymorphic SLAM receptors that affect B cell tolerance at the GC ch

204 at the self ligand and cell surface receptor SLAM functioned not only as a costimulatory molecule but

205 ative disease gene product, SH2D1A/DSHP/SAP (SLAM-associated protein, or SAP) in NK cells.

206 ugh mice that lack the adaptor molecule SAP (SLAM-associated protein) resemble ICOS(-/-) mice (and ca

207 ylation of NTB-A and the association of SAP (SLAM-associated protein), the protein absent in X-linked

208 a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development.

209 n molecule) and its interacting protein SAP (SLAM-associated protein).

210 The 2 CD84/SLAM adapter proteins, SAP (SLAM-associated protein) and EAT-2 (EWS-activated transc

211 They also suggest that the selectively SLAM-blind wild-type MV can be developed into a vaccine

212 Several SLAM family receptors have been shown to interact with t

213 iated in part by the adaptor protein SH2D1A (SLAM-associated protein, SAP).

214 The comparisons show SLAM to produce almost identical results as BFM for NH3,

215 human cells, this function required a single SLAM family member, SLAMF7 (also known as CRACC, CS1, CD

216 selectively unable to recognize human SLAM (SLAM-blind).

217 gagement of the homophilic receptors Slamf1 (SLAM) and Slamf6 (Ly108) and the downstream recruitment

218 apped with the T>C-aware alignment software, SLAM-DUNK, which allows mapping of reads containing T>C

219 Both SAP and the specific SLAM receptor NK, T, and B cell Ag (NTB-A) are required

220 rtet of residues previously shown to sustain SLAM-dependent fusion is not involved in binding.

221 We further demonstrate that SLAM (Slamf1, CD150), a surface receptor that uses SAP s

222 These results demonstrate that SLAM-family receptor-regulated cell-cell interactions ar

223 These findings prove formally that SLAM recognition is necessary for morbillivirus virulenc

224 We found that SLAM family receptors exhibited a similar expression pat

225 absence of SLAM cross-linking revealed that SLAM coengagement blocked activation of p38 MAPK and JNK

226 e cytoplasmic tail of SLAM, and we show that SLAM is expressed on resting and activated CD4 T cells,

227 These findings suggest that SLAM and FcgammaR intervals act cooperatively to influen

228 Collectively, these results suggest that SLAM-SAP signaling drives the differentiation and functi

229 y recognizing self-antigens, suggesting that SLAM/SAP regulate B-cell receptor-mediated central toler

230 The SLAM/CD2 gene family encodes receptors that play importa

231 Although the SLAM family member Ly9 (CD229) is known to interact with

232 ormation of undesired heterodimers among the SLAM family homophilic receptors.

233 Expression of SAP and the SLAM family receptor NK, T, and B cell antigen (NTB-A) w

234 the observed genetic association between the SLAM locus and SLE, suggest a role for CD319 and CD229 i

235 signals in both cell types, mediated by the SLAM-associated protein (SAP) family of adaptors.

236 into the multiplicity of roles played by the SLAM/CD2 family and its potential importance in human au

237 promoter region of the NZB gene encoding the SLAM signaling pathway adapter molecule EWS-activated tr

238 solated from these contexts, we examined the SLAM family markers CD150 and CD48.

239 findings demonstrate a specific role for the SLAM-SH2D1A system in the regulation of T-dependent humo

240 D4 T cell differentiation, separate from the SLAM-SAP-Fyn signaling pathway regulating Th1/Th2 differ

241 ucture-based stage for understanding how the SLAM-elicited conformational changes travel through the

242 Finally, uncertainties in the SLAM approach and ways to address such shortcomings by c

243 Polymorphisms in the SLAM family receptors are implicated in human and mouse

244 ally occurring polymorphic variations in the SLAM family show a direct role in initiating the break i

245 t signaling of the adhesion molecules in the SLAM family, activated by proximity during aggregation,

246 he inclusion of canonical HSC markers in the SLAM scheme can greatly augment HSC purity.

247 king CD84-a homophilic immunoreceptor of the SLAM (signaling lymphocyte activation molecule) family-o

248 dy, we hypothesized that coexpression of the SLAM adapter EWS-FLI1-activated transcript 2 (EAT-2) alo

249 Members of the SLAM costimulatory molecule family constitute prime cand

250 , regulation, and mechanism of action of the SLAM family in NK cells by analyzing a mouse lacking the

251 he recently reported homophilic dimer of the SLAM family member NTB-A.

252 Members of the SLAM family of receptors promote the progression of inva

253 Cell surface receptors of the SLAM family, including CD150, CD244, and CD48, were diff

254 2B4 is the only heterophilic receptor of the SLAM family, whose other members, e.g., NK-T-B-antigen (

255 his study reveals that the expression of the SLAM receptors CD319 and CD229 is regulated on pDCs and

256 To assess the importance of the SLAM-MV interactions for virus spread and pathogenesis,

257 We have now examined the role(s) of the SLAM-SAP-Fyn signaling axis in in vivo CD4 T cell functi

258 ure and expression of several members of the SLAM/CD2 family in T and B lymphocytes from B6.Sle1b mic

259 isms between two divergent haplotypes of the SLAM/CD2 family of genes.

260 In these patients, the SLAM score was significantly improved at 2 and 3 months

261 portance in human autoimmunity positions the SLAM/CD2 family as an excellent target for immunotherapy

262 with previous reports, demonstrate that the SLAM family homophilic affinities span at least three or

263 We further found that the SLAM family member CD84 was required for prolonged T cel

264 Together, these data suggest that the SLAM/SAP signaling pathway plays a larger role in gammad

265 In the absence of SAP, signaling through the SLAM family members Ly108 and 2B4 resulted in increased

266 okines IL-10 and IFNalpha were linked to the SLAM interval.

267 new isolation method was reported, using the SLAM family of cell-surface markers, including CD150 (Sl

268 purity recently has been enhanced using the SLAM family receptors CD150, CD244, and CD48.

269 We examined the possibility of using the SLAM markers to facilitate the isolation of highly enric

270 odels where the dependent variables were the SLAM score and SLAM global (physician).

271 We sought to determine whether the SLAM/SAP pathway regulates the establishment of human B-

272 udy, we investigated the extent to which the SLAM/SAP signaling pathway regulates the functional prog

273 were each significantly associated with the SLAM and SELENA-SLEDAI.

274 dies; however, E-C3d was associated with the SLAM but not with the SELENA-SLEDAI.

275 ulatta) was inoculated intranasally with the SLAM-blind virus, no clinical symptoms were documented.

276 sponsible for binding specificity within the SLAM family and imposes physical constraints relevant to

277 asis for heterophilic recognition within the SLAM family.

278 tein hemagglutinin and infects cells through SLAM about 40 times less efficiently than the isogenic w

279 ressing cells but only reduced entry through SLAM.

280 rough both nectin-4 and CD46 but not through SLAM.

281 t activation of p38 and ERK, in part through SLAM, mediates T-cell IFN-gamma production in response t

282 s both positive and negative signals through SLAM receptors to stabilize intercellular contacts.

283 AM) family of receptors that signals through SLAM-associated protein (SAP), an SH2 domain protein tha

284 Thus, SLAM acts as a coreceptor that regulates signals transdu

285 Thus, SLAM connects the gram-negative bacterial phagosome to u

286 Thus, SLAM family markers do not permit the same degree of HSC

287 creased levels of Th1 markers, such as Tim3, SLAM, T-bet, and Ly6C, had smaller amounts of cytotoxic

288 with H mutations that disrupt attachment to SLAM and/or nectin4.

289 In contrast to SLAM-/- and SAP-/- mice, T cells from Ly9-/- mice prolif

290 fecting SAP, an adaptor that recruits Fyn to SLAM family receptors.

291 In addition, SAP can recruit Fyn kinase to SLAM.

292 +) T cells produce more IL-17 in response to SLAM costimulation as compared with CD28 costimulation.

293 ude soluble forms and the absence of typical SLAM signaling motifs in their cytoplasmic domains, like

294 ly defined spike-in pool to resemble typical SLAM experiments and performed TAG microarray hybridizat

295 Thus, using SLAM family markers to isolate HSCs excludes a substanti

296 , from a low number of engrafted JAK2(V617F) SLAM cells.

297 or with syncytium-based assays in Vero, Vero-SLAM, and Vero-Nectin 4 cell lines.

298 ralization of wild-type MV infection of Vero/SLAM cells correlated with IgG avidity.

299 One important area where SLAM-mediated immune regulation may have keen importance

300 ese data emphasize the robustness with which SLAM family markers distinguish progenitors at different

301 -associated protein (SAP)) interactions with SLAM family proteins play important roles in immune func