ライフサイエンスコーパス: SLAMF1

1 SLAMF1 deficiency associated with increased expression o

2 SLAMF1 expression depends on adaptive immunity and also

3 SLAMF1 ligation with an agonistic monoclonal antibody in

4 SLAMF1 silencing in CLL-like Mec-1 cells, which constitu

5 tment, HGF (Q4v1OR: 3.74; p-trend = 0.0001), SLAMF1 (Q4v1OR: 4.07; p-trend = 0.0001), CSF1 (Q4v1OR: 3

6 lective disruption of TIRAP recruitment by a SLAMF1-derived peptide effectively attenuates IFNbeta pr

7 Accordingly, SLAMF1-silenced cells or SLAMF1(lo) primary CLL cells we

8 gamma1 and Vgamma4 T cells that exhibited an SLAMF1(+)SLAMF6(+) double positive phenotype were largel

9 CXCL9, CXCL11, and MCP-1, but not CCL11 and SLAMF1, were significantly up-regulated among the health

10 oteins found on the surface of the virus and SLAMF1, the immune cell receptor.

11 unfavorable clinical outcome experienced by SLAMF1(lo) patients.

12 Six proteins (MMP10, CXCL9, CCL11, SLAMF1, CXCL11 and MCP-1) were up-regulated (P < .05) in

13 amma4 T cell maturation at the CD24(+)CD73(-)SLAMF1(+)SLAMF6(+) double positive stage that was associ

14 f the autophagy macrocomplex, which contains SLAMF1, beclin1, and the enzyme VPS34.

15 ke Mec-1 cells, which constitutively express SLAMF1, modulated pathways related to cell migration, cy

16 Intrinsic and extrinsic SLAMF1 signaling was dispensable for the development of

17 signaling lymphocyte activation molecule F1 (SLAMF1) is both a microbial sensor and entry receptor fo

18 sociated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glu

19 ction and inflammation, revealing a role for SLAMF1 in innate host immunity.

20 Herein, we describe a new role for SLAMF1 to mediate MeV endocytosis that is in contrast wi

21 We generated SLAMF1(-/-) TCR transgenic mice and analyzed the respons

22 ibit Slamf1 reduce colitis in mice, so human SLAMF1 might be a therapeutic target for inflammatory bo

23 steps governing entry of measles virus into SLAMF1-positive cells and identified endocytic uptake of

24 s for key innate immune response genes KLF4, SLAMF1 and IL2RA.

25 In macrophages, SLAMF1 enhances the generation of reactive oxygen specie

26 AP in TLR7/8 signaling using P7-Pen, a novel SLAMF1-derived peptide that disrupts the TIRAP-MyD88 int

27 We demonstrated that MeV engagement of SLAMF1 induces dramatic but transient morphological chan

28 the half-life of DP cells and expression of SLAMF1, SLAMF6 and SAP.

29 ogether, these results indicate that loss of SLAMF1 expression in CLL modulates genetic pathways that

30 marked by distinct coexpression profiles of SLAMF1, SLAMF4, and SLAMF6.

31 the T cell-intrinsic and -extrinsic role of SLAMF1.

32 Accordingly, SLAMF1-silenced cells or SLAMF1(lo) primary CLL cells were resistant to autophagy

33 In the periphery, SLAMF1 and SLAMF6 expression distinguished IL-17- and IF

34 Mtb-infection of mice promotes SLAMF1 expression specifically on infected macrophages,

35 costimulatory molecule and microbial sensor SLAMF1 (also known as CD150) is lost in a subset of pati

36 Combined, these data demonstrate that SLAMF1 is a marker of macrophage-T cells interactions, a

37 In this article, we report that SLAMF1 is indispensable for host resistance to primary a

38 Here, we show that SLAMF1/CD150 is highly and uniquely induced in macrophag

39 Beclin1 dissociated from BCL2 in response to SLAMF1 ligation, resulting in formation of the autophagy

40 This uptake pathway is specific to SLAMF1-positive cells and occurs within 60 min of viral

41 espite intact T cell development, vaccinated SLAMF1(-/-) mice failed to control fungal infection.

42 )CD73(-) and CD24(+)CD73(+) subsets, whereas SLAMF1 single positive, SLAMF6 single positive, or SLAMF