ライフサイエンスコーパス: SLC6A4

1 HT uptake by the serotonin transporter (SERT/SLC6A4).

2 folding of the serotonin transporter (SERT; SLC6A4).

3 ymorphism in the serotonin transporter gene (SLC6A4).

4 GS2, two in HTR2A, one in SLC6A2, and one in SLC6A4).

5 y to ASD are PTEN and Serotonin transporter (SLC6A4).

6 LO1, FANCF, HNRNPDL, CD47, OLFM1, SMAD7, and SLC6A4.

7 n the promoter region (5-HTTLPR) of the gene SLC6A4.

8 e were GAD1, NTRK3, ADRA2A, FZD10, GRK4, and SLC6A4.

9 terial artificial chromosome drivers Pet1 or Slc6a4.

10 variants of two functional polymorphisms of SLC6A4 (5-HTTLPR, intron 2 variable number tandem repeat

11 The serotonin transporter (SLC6A4), 5-HT(2A) (HTR2A) and 5-HT(2B) (HTR2B) recepter

12 variants of the serotonin transporter gene (SLC6A4), a long-standing OCD candidate, have so far been

13 anxiety typically associated with the short SLC6A4 allele.

14 er region of the serotonin transporter gene (SLC6A4; also known as 5-HTT) and its contribution to str

15 at had a CFE score as good as or better than SLC6A4, an empirical finding which we used as a de facto

16 ted with altered transcriptional activity of SLC6A4; an earlier study reported an association of the

17 Analyzing four markers in SLC6A4 and four markers in ITGB3 in 117 white family tri

18 Recent major findings from studies of SLC6A4 and its corresponding protein, the serotonin (5-H

19 F, CYP2D6, OPRD1, OPRK1, OPRM1, HTR1B, POMC, SLC6A4 and OUD-associated pathways, including opioid sig

20 Messenger RNA (mRNA) expression of SLC6A4 and p11 was measured in sigmoid and rectal mucosa

21 nteraction between two markers--rs1042173 in SLC6A4 and rs3809865 in ITGB3.

22 nges in mice and rats), it seems likely that SLC6A4 and SERT will remain areas of high interest in ou

23 llustrate significant variation worldwide at SLC6A4 and that the functionally implicated alleles at t

24 Restraint stress was applied to pregnant Slc6a4 (+/+) and Slc6a4 (+/-) mice and post-stress embry

25 nsiently express the 5-HT transporter (SERT; Slc6a4) and accumulate 5-HT, suggesting that the SERT ac

26 ions between the serotonin transporter gene (SLC6A4) and alcohol, heroin, cocaine, or methamphetamine

27 er region of the serotonin transporter gene (SLC6A4) and exposure to childhood trauma.

28 er protein (SERT or soluble carrier protein, SLC6A4) and p11 (S-100A10, or calpactin I light chain).

29 variants at the serotonin transporter gene (SLC6A4) and serotonin 2A receptor gene (HTR2A) predict c

30 fic expression of the serotonin transporter (SLC6A4) and serotonin receptor (HTR1A, HTR2A, HTR2C) gen

31 of interest--the serotonin transporter gene (SLC6A4) and the integrin beta 3 gene (ITGB3) on chromoso

32 en Nrxn1alpha, En2 and Fmr1; Nlgn3, BTBR and Slc6A4; and also between X monosomy and Mecp2.

33 Polymorphisms in SLC6A4 are associated with differences in emotional, end

34 am region of the serotonin transporter gene (SLC6A4) are associated with individual differences in st

35 llection of multiple, often rare, alleles at SLC6A4 as imposing risk of autism.

36 Again, using SLC6A4 as the cutoff, twelve top biomarkers had the stro

37 there was no consistent association between SLC6A4*C and any Tridimensional Personality Questionnair

38 analysis revealed a positive linkage between SLC6A4*C and the 2 anxiety-related subdimensions of Harm

39 We have attempted to confirm the role of SLC6A4*C in anxiety-related personality traits by sibpai

40 association, raising the question of whether SLC6A4*C locus is itself affecting anxiety or is linked

41 sent study we replicated the relationship of SLC6A4*C to anxiety by sibpair linkage analysis but foun

42 ter of the human serotonin transporter gene (SLC6A4*C) was identified and found to be linked to an an

43 Association studies at SLC6A4 cannot a priori extrapolate across populations an

44 membrane serotonin (5-HT) transporter (SERT, SLC6A4) clears 5-HT after release at nerve termini and i

45 escribed in the promoter region of the gene (SLC6A4) coding for the serotonin transporter protein (SE

46 Methylation in BDNF and SLC6A4 correlated with depression and anxiety symptoms.

47 hism, 5HTTLPR, in the serotonin transporter, SLC6A4, coupled with prenatal stress is reported to incr

48 of p38alpha MAPK in serotonergic neurons (by Slc6a4-Cre or ePet1-Cre) or astrocytes (by Gfap-CreERT2)

49 thy human volunteers (ADORA2A, SLC6A3, BDNF, SLC6A4, CSNK1E, SLC6A2, DRD2, FAAH, COMT, OPRM1).

50 Embryos of stressed Slc6a4 (+/+) dams exhibited significantly altered methyl

51 ontrast, the response of embryos of stressed Slc6a4 (+/-) dams was found to be attenuated, shown by s

52 idate genes for neuropsychiatric phenotypes: SLC6A4, encoding the serotonin transporter; and SLC18A2,

53 ults contribute to a better understanding of SLC6A4 expression genetics and provide a functional hapl

54 hydroxytryptamine, 5-HT) transporter (hSERT, SLC6A4) figures prominently in the etiology and treatmen

55 nalysis supports that the association of the SLC6A4 gene with substance use disorder varies depending

56 T) transporter SERT (which is encoded by the SLC6A4 gene) to platelet 5-HT stores suggests an importa

57 point to a more complex relationship between SLC6A4 genotype and protein availability.

58 There was no effect of SLC6A4 genotype upon serotonin transporter binding.

59 l-based correlation analysis, independent of SLC6A4 genotype, revealed that 5HT(2A) BP in the adjacen

60 potential (BP) and RNA gene expression in 16 SLC6A4 genotyped marmosets with responsivity to 5HT(2A)

61 elective labeling of type I afferent fibers, Slc6a4-GFP mice labeled type II fibers with a slight pre

62 The serotonin transporter (SERT/SLC6A4) has a rich pharmacology including inhibitors, re

63 ion of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of n

64 The serotonin transporter (SLC6A4) has been associated with several stress-related

65 The 5-HT transporter (SERT) gene (SLC6A4) has been associated with whole blood 5-HT levels

66 er region of the serotonin transporter gene (SLC6A4) has been found to moderate several categories of

67 promoter of the serotonin transporter gene (SLC6A4) has been proposed as a pharmacogenetic marker fo

68 Variation at the serotonin transporter gene, SLC6A4, has been associated with a variety of neuropsych

69 rotonin (5-HT) transporter (SERT, encoded by SLC6A4) have been identified in ASD.

70 genotyped for six candidate polymorphisms in SLC6A4, HTR2A and HTR2B genes.

71 In conclusion, these findings implicate SLC6A4* HTTLPR as a major genetic determinant associated

72 e found normal colonic mucosal expression of SLC6A4 in diarrhea (IBS-D)- or constipation-predominant

73 Colonic mucosal expression of SLC6A4 in IBS is normal.

74 ssion and activity of 5-HT Transporter (SERT/Slc6a4) in 5-HT neurons leading to an increase of 5-HT u

75 he serotonin (5-HT) transporter gene (5-HTT, SLC6A4) in modulating amygdala and prefrontal activation

76 The serotonin transporter (SERT, SLC6A4) in the platelet plasma membrane represents a wel

77 amine (5-HT)] transporters (hSERT, 5HTT, and SLC6A4) inactivate 5-HT after release and are prominent

78 lymorphism of the serotonin transporter gene SLC6A4, influences cerebral cortical structure volumes i

79 The serotonin transporter gene (SLC6A4) is a strong autism candidate gene because of its

80 The serotonin transporter (SERT/SLC6A4) is arguably the most extensively studied solute

81 variation in the serotonin transporter gene (SLC6A4) is associated with vulnerability to affective di

82 , including the human serotonin transporter (SLC6A4), is critical for efficient synaptic transmission

83 er region of the serotonin transporter gene (SLC6A4), is implicated in speech encoding in the human s

84 The serotonin transporter [(SERT)/SLC6A4] is a target for antidepressants and the best und

85 The serotonin transporter [(SERT)/SLC6A4] is an important drug target in the treatment of

86 Similarly, maternal Slc6a4 knock-out and prenatal stress in rodents results

87 Combining these HTR3A/HTR3B and SLC6A4-LL/TT genotypes increased the target cohort from

88 B in the same sample that they genotyped for SLC6A4-LL/TT in the previous randomized, double-blind, 1

89 rted that the 5'-HTTLPR-LL and rs1042173-TT (SLC6A4-LL/TT) genotypes in the serotonin transporter gen

90 nvestigate the role of additional functional SLC6A4 loci in OCD.

91 The SLC6A4 locus encodes the serotonin transporter, which in

92 pothesis that the S allele of 5HTTLPR at the SLC6A4 locus is associated with a poor outcome after tre

93 umber of genes including SLC6A3, DRD5, DRD4, SLC6A4, LPHN3, SNAP-25, HTR1B, NOS1 and GIT1.

94 ess was applied to pregnant Slc6a4 (+/+) and Slc6a4 (+/-) mice and post-stress embryonic brains were

95 this phenotype is exacerbated in Pten(+/-); Slc6a4(+/-) mice.

96 ype that is exacerbated in female Pten(+/-); Slc6a4(+/-) mice.

97 ions of the DR, there were no differences in slc6a4 mRNA expression between MS15 and AFR rats.

98 ubsequent exposure to adult social defeat on slc6a4 mRNA expression in the dorsal raphe nucleus (DR)

99 sed to social defeat as adults had increased slc6a4 mRNA expression throughout the DR compared to bot

100 to a novel cage control condition, increased slc6a4 mRNA expression was observed in the dorsal part o

101 Social defeat increased slc6a4 mRNA expression, but only in MS180 rats and only

102 ience during adulthood interact to determine slc6a4 mRNA expression.

103 ween these factors on serotonin transporter (slc6a4) mRNA expression, we investigated in rats the eff

104 human primates indicate that combinations of SLC6A4 non-coding 5', 3' UTRs and intronic regions plus

105 ne promotor polymorphism (5-HTTLPR) locus of SLC6A4 now exist.

106 R and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine.

107 In Necdin-KO pups, the genetic deletion of Slc6a4 or treatment with Fluoxetine, a 5-HT reuptake inh

108 on serotonin (5-HT) transporter (5-HTT/SERT, SLC6A4) polymorphism is believed to confer lower 5-HTT e

109 gical mechanisms underlying the link between SLC6A4 polymorphisms and the emotionally vulnerable phen

110 SLC6A4 polymorphisms STin2, 5-HTTLPR, and rs25531 were g

111 influenced ability to detect association of SLC6A4 polymorphisms with personality measures; populati

112 We first sequenced the marmoset SLC6A4 promoter and identified a double nucleotide polym

113 rry a specific stress responsiveness-related SLC6A4 promoter genotype.

114 The SLC6A4 promoter L alleles associated with decreased sync

115 The SLC6A4 promoter polymorphism 5-HTTLPR influences cerebra

116 The authors assessed genotypes at the SLC6A4 promoter polymorphism in 96 healthy European Amer

117 They assessed genotype at the SLC6A4 promoter polymorphism, and an additional polymorp

118 , serotonin], member 4) gene, as well as the SLC6A4 promoter region polymorphism, 5-HTTLPR.

119 ociation between the serotonin protein gene (SLC6A4) promoter variant (5-HTTLPR) and risk of current

120 ansmitter transporter, serotonin), member 4 (SLC6A4), promoter, affects transcription and may be invo

121 sm and serotonin transporter genotype at the SLC6A4 promotor VNTR polymorphism in 30 healthy subjects

122 equence polymorphisms in the common marmoset SLC6A4 repeat region (AC/C/G and CT/T/C) associated with

123 ndings suggest that genetic variation in the SLC6A4 repeat region may contribute to the trait anxious

124 PR) in the human serotonin transporter gene (SLC6A4), resulting in altered transcription and transpor

125 synaptosomal-associated protein, 25 kDa) and SLC6A4 (serotonin transporter).

126 nnels, the HTR1A(serotonin 5-HT1A receptor), SLC6A4(serotonin reuptake transporter), and COMT(catecho

127 found that conditional deletion of KOR from Slc6a4 (SERT)-expressing neurons blocked stress-induced

128 ter (SLC6A2, NET) and serotonin transporter (SLC6A4, SERT) genes and remission in depressed older adu

129 stnatally, coinciding with the period of PFC Slc6a4/SERT expression.

130 an early postnatal period in mice (P0-P10), Slc6a4/SERT is transiently expressed in a subset of laye

131 sants that block the serotonin transporter, (Slc6a4/SERT), selective serotonin reuptake inhibitors (S

132 sopressin receptor 1a) gene and STin2 in the SLC6A4 (solute carrier family 6 [neurotransmitter transp

133 17q11.2 region that harbors the SERT locus (SLC6A4) supports a genetic effect at or near this gene.

134 netic ablation of the serotonin transporter (Slc6a4(-/-), target site for SSRI) and depleted peripher

135 ed copy of the 5-HT transporter (i.e., SERT, slc6a4) that bears a single amino acid substitution, I17

136 cleotide polymorphisms (SNPs) for AVPR1A and SLC6A4 to determine whether other variants in these gene

137 location of the serotonin transporter (SERT, SLC6A4) to the synaptic terminals of serotonergic neuron

138 P1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally significant effe

139 Because the L(A) allele confers increased SLC6A4 transcription, increased serotonin transporter le

140 sm in the serotonin transporter gene (locus, SLC6A4; variant, serotonin 5-HTTLPR) moderates risk of p

141 In vivo, SLC6A4 variants in humans and other species lead to mark

142 32 and all other known non-coding functional SLC6A4 variants revealed a highly significant omnibus as

143 Genotype of the promoter for SLC6A4 was also assessed in all participants.

144 To determine the extent of variation at SLC6A4, we genotyped 23 markers on approximately 2500 in

145 There were also two biomarkers (RLP3 and SLC6A4) with the strongest overall evidence for mania.

146 ted with DNA methylation changes in BDNF and SLC6A4, with the association in BDNF attenuated after in