ライフサイエンスコーパス: SLRP

1 SLRPs belong to the group of extracellular leucine-rich

2 SLRPs have been localized to most skeletal regions, with

3 Mice with double-deficiency of 2 SLRPs, fibromodulin and biglycan (dKO), acquire skeletal

4 osome 9q22-9q21.3 where asporin is part of a SLRP gene cluster that includes extracellular matrix pro

5 We show that osteoglycin, a SLRP, inhibits Hh-induced differentiation toward the smo

6 ic reticulum stress that results in abnormal SLRP synthesis and secretion, which ultimately affects s

7 We cloned two additional SLRP genes highly expressed in cornea: KERA (encoding ke

8 ing was shown by the reduction in aggregated SLRP oligomers upon RAP coexpression.

9 Deficiency in fibromodulin, an SLRP, causes abnormal collagen fibril ultrastructure and

10 that could be representative of an ancestral SLRP gene.

11 ch as collagens, fibronectins, laminins, and SLRP family proteins, whereas genes involved in ECM degr

12 of MMPs to digest cross-linked collagen and SLRPs, a model reaction system using purified collagen t

13 sistance of RFUVA-cross-linked collagens and SLRPs to MMPs has been investigated.

14 esults suggest that the interactions between SLRPs and collagen caused by RFUVA protect both SLRPs an

15 Ps and collagen caused by RFUVA protect both SLRPs and collagen fibrils from cleavage by MMPs.

16 Certain SLRPs are involved in the antimyeloma effect of osteobla

17 of a given SLRP, but also between different SLRPs.

18 an in the cornea of mice deficient in either SLRP gene and in double-mutant mice.

19 herefore, increasing endogenous or exogenous SLRPs in myelomatous bone may help control myeloma.

20 Such activity implies a broader role for SLRP family members in regulating collagen cross-linking

21 e formed not only among molecules of a given SLRP, but also between different SLRPs.

22 subset of small leucine-rich glycoproteins (SLRPs) that may function downstream of Hh signaling in t

23 ed collagen I, IV, and natively glycosylated SLRPs are susceptible to degradation by MMPs.

24 On the other hand, SLRP depletion is correlated with degenerative diseases

25 on, with both having similar effects at high SLRP/collagen ratios.

26 ily which is distinct from the other class I SLRPs since it possesses a unique stretch of aspartate r

27 The study shows that mutations in SLRPs may predispose to osteoarthritis and offers a valu

28 ression of multiple ECM components including SLRPs.

29 t, with the exception of biglycan, all known SLRP genes reside in three gene clusters.

30 In addition, both cross-linked SLRPs themselves and cross-linked polymers of SLRPs and

31 s a coordinate regulation involving multiple SLRPs.

32 the identification and classification of new SLRP sequences in genome databases.

33 Together, our data indicate that the novel SLRP CHADL is expressed in cartilaginous tissues, influe

34 ing that this gene belongs to a new class of SLRP family.

35 his expanded list we describe a new class of SLRP sequences that could be representative of an ancest

36 Our search has expanded the family of SLRPs to include new predicted protein sequences, mainly

37 tural element exclusive to the main group of SLRPs.

38 These studies highlight the importance of SLRPs in maintaining periodontal homeostasis through reg

39 LRPs themselves and cross-linked polymers of SLRPs and collagen appear able to resist degradation.

40 The cellular retention of SLRPs in the absence of RAP coexpression appeared to be

41 emistry (IHC) revealed increased staining of SLRPs (asporin, lumican, and decorin) and dentin matrix

42 red: the small leucine-rich proteoglycans or SLRPs, pronounced "slurps, " and the modular proteoglyca

43 The expression levels of other SLRP members including lumican, decorin, and fibromoduli

44 and did not perturb the expression of other SLRPs in cornea.

45 rast to the tissue distribution of the other SLRPs, DSPG3 is predominantly expressed in cartilage.

46 chromosomal locations of the newly predicted SLRP genes would support the large-scale genome or gene

47 ll leucine-rich repeat proteoglycan/protein (SLRP) family members, a novel gene, nephrocan (NPN), has

48 eins, including small leucine-rich proteins (SLRPs), but the regulatory mechanisms are not well under

49 agen-associated small leucine-rich proteins (SLRPs).

50 Small leucine-rich repeat proteoglycan (SLRP) family proteins play important roles in a number o

51 ss I small leucine-rich repeat proteoglycan (SLRP) family which is distinct from the other class I SL

52 the small leucine-rich repeat proteoglycan (SLRP) family, including decorin, biglycan, fibromodulin,

53 n, the main small leucine-rich proteoglycan (SLRP) expressed and produced by osteoblasts, in the anti

54 bers of the small leucine-rich proteoglycan (SLRP) family.

55 ongs to the small leucine-rich proteoglycan (SLRP) gene family and is one of the major components of

56 Lumican, a small leucine rich proteoglycan (SLRP), is a component of extracellular matrix which also

57 Decorin, a small leucine-rich proteoglycan (SLRP), is involved in the pathophysiology of human conge

58 small leucine-rich family of proteoglycans (SLRP).

59 cine-rich repeat proteins and proteoglycans (SLRPs) form an important family of regulatory molecules

60 Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules suggested to r

61 lagens and small leucine-rich proteoglycans (SLRPs) interact to produce the transparent corneal struc

62 re class I small leucine-rich proteoglycans (SLRPs) involved in regulation of collagen fibril and mat

63 e class of small leucine-rich proteoglycans (SLRPs) is a family of homologous proteoglycans harboring

64 Small leucine-rich proteoglycans (SLRPs) regulate extracellular matrix organization, a pro

65 llagen and small leucine-rich proteoglycans (SLRPs) remains unknown.

66 While the small leucine rich proteoglycans (SLRPs), including decorin and lumican, have been studied

67 osylated, commercially available recombinant SLRPs, keratocan, lumican, mimecan, decorin, and biglyca

68 the extracellular small leucine-rich repeat (SLRP) proteoglycan and protein family attached to the ce

69 to 12q, where there is a cluster of several SLRP genes.

70 oteins in intestine development and suggests SLRPs as novel regulators of smooth muscle cell differen

71 ears that the majority of the introns in the SLRP genes were inserted after the differentiation of th

72 The expanded list of members of the SLRP family offers interesting insights into early verte

73 Taken together, NPN is a novel member of the SLRP family that may play important roles in kidney deve

74 We have examined the evolution of the SLRP gene family and found that gene products clustered

75 re inserted after the differentiation of the SLRP genes from an ancestral gene that was most likely c

76 This minireview will focus on the SLRP roles in bone physiology and pathology.

77 Here, we demonstrate that the SLRP family member Asporin (ASPN) plays a crucial role i

78 Such oligomers of the SLRPs likely resulted from formation of intermolecular d

79 with SLRP2, -3, and -4 cDNAs, each of these SLRPs was secreted.

80 When these SLRPs were overexpressed by cell transfection, only SLRP

81 A capping motif specific to SLRPs has been recently described in the crystal structu

82 chanism underlying CSCD in which a truncated SLRP protein core is retained intracellularly, its accum

83 teractions of biglycan and fibromodulin, two SLRPs highly expressed in tendons and bones, were invest

84 and function of a previously uncharacterized SLRP, chondroadherin-like (CHADL).

85 abnormal synthesis and secretion of various SLRPs in mutant mouse corneas.