ライフサイエンスコーパス: SPL

1 SPL also binds regulators of G protein signaling (RGS) p

2 SPL attributes are compared with field measurements and

3 SPL augmented the activation status of IKKepsilon and en

4 SPL expression in HEK293 cells potentiated apoptosis in

5 SPL genes are posttranscriptionally downregulated by miR

6 SPL is a majestic molecular machine composed of an entan

7 SPL is a member of the radical AdoMet superfamily of enz

8 SPL is a radical S-adenosyl-l-methionine (SAM) enzyme, w

9 SPL is a radical S-adenosylmethionine (SAM) enzyme, util

10 SPL utilizes a special [4Fe-4S] cluster to reductively c

11 SPL-KD cells accumulated intracellular and extracellular

12 SPL-KD cells successfully differentiated when treated wi

13 SPL-KD cells transfected with mimics for miR-1 or miR-20

14 SPL-mediated inhibition of virus-induced cell death was

15 SPL-overexpressing cells were partially protected agains

16 the enzyme, sphingosine-1-phosphate lyase 1 (SPL), has neuroprotective effects in Huntington's diseas

17 re was an 8kHz octave band of noise at 105dB SPL for 4h.

18 t it addresses fundamental limitations of 2D SPL by allowing one to compensate for unavoidable imperf

19 A total of 49 SPLs falling into 6 subcategories have been identified.

20 was comparable to that obtained with a 50dB SPL acoustic click.

21 sinusoidal acoustical excitation of 40-90dB SPL, in the frequency range from 100Hz to 10kHz.

22 minimal detectable sound level of 31-35dB(A) SPL for humans.

23 Accordingly, SPL-overexpressing cells were much more resistant than c

24 In addition, SPL expression and activity were down-regulated in adeno

25 apoptosis and provide an example of altered SPL expression in a human tumor.

26 Although SPL is robustly expressed in thymic epithelial cells (TE

27 Here, we evaluate data from an SPL instrument - the High Resolution Quantum Lidar Syste

28 thermore, the transcription factors BEL1 and SPL/NZZ, previously described as key regulators of ovule

29 vivo approaches (mouse insulinoma cells and SPL-deficient mice), that SPL is a potent negative regul

30 whereas parts of the left and right IPL and SPL are specialized for the processing of spatial attrib

31 Finally, memory-related HGP in left IPS and SPL was sufficiently reliable to enable brain-based deco

32 Comparisons of PAC and SPL showed a lack of spatiotemporal correlations.

33 In addition, both MIR156 and SPLs are responsive to auxin signaling suggesting that m

34 ated using a small interfering RNA approach, SPL's anti-influenza viral activity was markedly suppres

35 We postulate an antagonistic effect between SPLs and the heterogeneous MYB-bHLH factors binding to T

36 rthermore, we examined whether the bilateral SPL regions play a causal role in the rate of perceptual

37 Constitutive ablation of SPL in the brain (SPL(fl/fl/Nes)) but not postnatal neuronal forebrain-res

38 This was due to reciprocal modulation by SPL and NRB of the potency of RGS2 to inhibit Ca(2+) sig

39 ipids called sphingadienes increased colonic SPL levels and reduced S1P levels, STAT3 signaling, cyto

40 Under differentiation conditions, SPL-KD cells also demonstrated delayed induction of 3 my

41 By contract, SPL, but not NRB, binds the 3iL of the GPCRs alpha(1B)-a

42 , on the high sound pressure levels (>100 dB SPL) necessary to produce them.

43 focused on high-intensity exposures (>100 dB SPL).

44 ol and tone-exposed hamsters (10 kHz, 115 dB SPL, 4h) before and after application of carbachol to th

45 d creatine plus tempol and exposed to 120 dB SPL one-octave band noise centered at 4 kHz for 5 h.

46 exposure (narrow band noise, 12 kHz, 120 dB SPL, 1 hour) on the physiological response of the inferi

47 ea pig following noise exposure (5 h, 120 dB SPL, 1 OCB).

48 -type mice in response to loud sound (120 dB SPL, 30 minutes low-pass filtered noise).

49 l distortion generated by the 110- to 120-dB SPL produced at the open ear with fortissimo playing; (c

50 Results indicate that a precursor (>20 dB SPL) induced efferent activation, resulting in a decreas

51 meteors can generate audible sound at 25 dB SPL.

52 tinuous noise with an overall level of 33 dB SPL.

53 n increased gap detection threshold at 50 dB SPL, but not at 60 or 80 dB SPL.

54 75th percentile was associated with a 1.6-dB SPL (sound pressure level) decrease in DPOAE amplitude (

55 2 m from the sound source, at or above 60 dB SPL, and that this acoustic sensitivity is sufficient to

56 e LA making it hyperactive to sounds>/=60 dB SPL.

57 evel coding by the AN population above 60 dB SPL.

58 espond to low-frequency sounds (80 Hz; 65 dB SPL) by freezing-a common anti-predatory behavior charac

59 requency tones (80 Hz at approximately 65 dB SPL)-recordings that also represent the first record of

60 SRTs were measured for 65-dB SPL sentences presented in speech-weighted noise or four

61 Hz with a fixed probe level of either 70 dB SPL or 8 dB SL (whichever was greater) and probe duratio

62 for input sound levels between 50 and 70 dB SPL.

63 1,000 Hz and is typically spoken at 45-70 dB SPL; together, they lie in the sweet spot of mosquito he

64 SSwap had WBN sound levels from 40 to 78 dB SPL, and separations of 22.5, 45, 90, and 180 degrees :

65 rains; 10-50 Hz in increments of 5 Hz; 80 dB SPL) in carefully screened cannabis users and controls.

66 Tone bursts (80 dB SPL) were binaurally presented via insert earphones in t

67 For a high-input level (80 dB SPL), slow compression was preferred over fast compressi

68 otal OHC power output is about 2 pW at 80 dB SPL, with a maximum of about 10 fW per OHC.

69 reshold at 50 dB SPL, but not at 60 or 80 dB SPL.

70 long exposure to moderate-level noise (84 dB SPL) in mice with varying degrees of cochlear de-efferen

71 imuli at low sound pressure levels (</=84 dB SPL), revealing a previously unrecognised consequence of

72 tave density, 4-Hz rate) applied to an 85-dB SPL, 2-kHz lowpass-filtered pink-noise carrier.

73 lt mice were exposed (8-16 kHz, 100 or 91 dB SPL for 2 h) and then evaluated from 1 h to approximatel

74 ignificant (tuned to 1.5 and 4 kHz; 60-98 dB SPL), and capable of mediating behavioral responses of p

75 a 3 hour 4 kHz octave band noise at 117 dB (SPL).

76 ity blocks of 65, 72.5, 80, 87.5, and 95 dB (SPL).

77 (TECs), in this study, we show that deleting SPL in CD11c(+) dendritic cells (DCs), rather than TECs

78 neuronal forebrain-restricted SPL deletion (SPL(fl/fl/CaMK)) caused marked accumulation of S1P.

79 Dense SPL-IR areas included the periaqueductal grey, trigemina

80 sing the expression of functionally distinct SPL transcription factors.

81 type is only partially corrected by elevated SPL gene expression, and that amp1 has no significant ef

82 Endogenous SPL expression was induced by DNA damage in WT cells, wh

83 ther, these results indicate that endogenous SPL may play a physiological role in stress-induced apop

84 that of NH listeners when compared at equal SPL (sound pressure level).

85 Exogenous SPL expression inhibited influenza A virus replication,

86 his indicates that IKKepsilon is crucial for SPL-mediated inhibition of influenza virus replication.

87 ed in effects opposite to those observed for SPL overexpression.

88 In this study, we show a crucial role for SPL in mediating cellular responses to stress.

89 hat 5R-SP, but not 5S-SP, is a substrate for SPL is consistent with the expectation that 5R is the SP

90 Here, we report a cantilever-free SPL architecture that can generate 100 nanometer-scale m

91 that canopy and ground characteristics from SPL are similar to discrete return lidar despite differe

92 t canopy structure and ground elevation from SPL point clouds.

93 ty were observed in hippocampal neurons from SPL(fl/fl/Nes) mice.

94 Further, SPL expression led to constitutive activation of p38.

95 hrough activation of the SPOROCYTELESS gene (SPL, also known as NOZZLE,NZZ), a regulator of sporogene

96 d V6/V6A as functional counterparts of human SPL because they contained the most widespread shift sig

97 the functional characteristics of the human SPL shifting area.

98 ate whether a potential homolog of the human SPL shifting region exists in monkeys (Macaca mulatta),

99 ation of LpSpl and its comparison with human SPL reveals high structural conservation, thus supportin

100 result questions the currently hypothesized SPL mechanism which excludes the involvement of protein

101 Moreover, the identified SPL activity defines a distinct pathway in control of th

102 Substance P-like immunoreactivity (SPL-IR) was semiquantitatively mapped, and correlated ve

103 Importantly, SPL expression was significantly down-regulated in human

104 val in wild-type mice after CA/CPR (81.8% in SPL-334.1 versus 36.4% in placebo; log rank P=0.031).

105 ective movement coincided with activation in SPL.

106 nd functional assays in model systems and in SPL(-/-) and NRB(-/-) mice to show that SPL and NRB reci

107 Protein radicals are known to be involved in SPL catalysis; however, how these radicals are quenched

108 platelet function we previously observed in SPL(-/-) mice, these data show that (1) regulated seques

109 Here we review the current progress in SPL mechanistic studies.

110 des the involvement of protein residue(s) in SPL reaction, suggesting that some protein residue(s), w

111 ranscription factor (TF) families, including SPLs, MYBs, ERFs and bZIPs, might regulate corresponding

112 , we show that one consequence of inhibiting SPL is intracellular inhibition of histone deacetylases,

113 e randomized to receive the GSNOR inhibitor, SPL-334.1, or normal saline as placebo.

114 ith control animals, mice lacking intestinal SPL exhibited greater disease activity, colon shortening

115 To investigate SPL's role in myogenesis at the cellular level, we gener

116 hat a member of miR156 family and one of its SPL target genes have inverse expression levels, which i

117 aracterized a murine myoblast SPL-knockdown (SPL-KD) cell line lacking SPL.

118 ast SPL-knockdown (SPL-KD) cell line lacking SPL.

119 By contrast, HGP in left SPL increased for CRs early after stimulus onset (200-30

120 eriod between the more abstract role of left SPL in activating the appropriate S-R associations and t

121 ed as functions of the sound pressure level (SPL) and duration of 2-kHz tone bursts.

122 d levels down to 31 dB sound pressure level (SPL), translating to air particle velocity at nanometer

123 of approximately 65 dB sound pressure level (SPL).

124 c input power at 10 dB sound pressure level (SPL).

125 ver a range of masker sound pressure levels (SPLs) and frequencies.

126 By regulating S1P levels, SPL also controls SC recruitment and muscle regeneration

127 Single photon lidar (SPL) is an innovative technology for rapid forest struct

128 xpression of SQUAMOSA PROMOTER BINDING-LIKE (SPL) family members, SPL3, SPL5, and SPL9, is upregulate

129 156-targeted SQUAMOSA PROMOTER BINDING-LIKE (SPL) genes are involved in the control of flowering.

130 ssion of the SQUAMOSA promoter-binding-like (SPL) transcription factors.

131 156-targeted SQUAMOSA PROMOTER BINDING-LIKE (SPL/SBP) transcription factors by activating SINGLE FLOW

132 s of SQUAMOSA PROMOTER BINDING PROTEIN LIKE (SPL) genes showed that wall ingrowth deposition was incr

133 n of SQUAMOSA PROMOTER BINDING PROTEIN LIKE (SPL), NAC, YUCCA and AGAMOUS-LIKE genes associated with

134 the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) gene family appear universally conserved in land pl

135 the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) gene family.

136 eted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) genes, which are deeply conserved and known to have

137 gets SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) genes: SPL3, SPL9 and SPL10 are involved in the rep

138 eral SQUAMASA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors are involved in plant develop

139 n of SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE (SPL) transcription factors renders Arabidopsis plants in

140 even SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors, including SPL13, are targete

141 eted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors, suggesting that AMP1 might p

142 Scanning probe lithography (SPL) is a promising candidate approach for desktop nanof

143 tivation in the left superior parietal lobe (SPL).

144 ucture of bilateral superior parietal lobes (SPL) could account for interindividual variability in pe

145 Superior and inferior parietal lobule (SPL and IPL) possessed both types of structure.

146 eye fields (FEF), superior parietal lobule (SPL) and intraparietal sulcus (IPS).

147 es (IPL), the left superior parietal lobule (SPL) and the right precuneus-SPL, which were all more ac

148 cus (IPS) and left superior parietal lobule (SPL) differing in time and sign for recognized old items

149 l sulcus (aIPS) or superior parietal lobule (SPL) disrupts on-line adaptive adjustments of grasp when

150 itical role of the superior parietal lobule (SPL) in shifting spatial attention, a finding not predic

151 eye fields (FEF), superior parietal lobule (SPL), and right supramarginal gyri (SMG).

152 e field (FEF), the superior parietal lobule (SPL), and the right ventrolateral prefrontal cortex (VLP

153 e spatial topography of spike-phase locking (SPL) was similar to that of PAC.

154 Spore photoproduct lyase (SPL) repairs 5-thyminyl-5,6-dihydrothymine, a thymine di

155 Spore photoproduct lyase (SPL) repairs a covalent UV-induced thymine dimer, spore

156 onine) enzyme, the spore photoproduct lyase (SPL), at the bacterial early germination phase.

157 adical SAM enzyme, spore photoproduct lyase (SPL), at the early germination phase.

158 mage by the enzyme spore photoproduct lyase (SPL).

159 S1P lyase (SPL) catalyzes the irreversible degradation of sphingosi

160 Overexpression of S1P lyase (SPL), which induces the degradation of S1P, interfered w

161 l S1P levels are kept low through S1P lyase (SPL)-mediated metabolism.

162 reversibly degraded by the enzyme S1P lyase (SPL).

163 ating the S1P-metabolizing enzyme S1P lyase (SPL).

164 Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid S1

165 Sphingosine 1-phosphate (S1P) lyase (SPL) is an intracellular enzyme that mediates the irreve

166 ic knockout mouse models in which S1P-lyase (SPL), the enzyme responsible for irreversible S1P cleava

167 Altogether, the miR156-SPL module mediates the response to recurring HS in Arab

168 at these traits are controlled by the miR156-SPL pathway.

169 lowers, and we found that miR172-AP2, miR156-SPLs were critical regulatory nodes contributing to the

170 ve to auxin signaling suggesting that miR156/SPL modules might be involved in the proper timing of th

171 Despite the important roles of the miR156/SPL network, our understanding of its downstream genes t

172 downstream of, or in parallel to, the miR156/SPL pathway, and that it is not universally required for

173 ely, these results unravel a role for miR156/SPLs modules in lateral root development in Arabidopsis.

174 In ago9, rdr6 and drm1drm2 mutants, SPL/NZZ is expressed ectopically, suggesting that the mu

175 enerated and characterized a murine myoblast SPL-knockdown (SPL-KD) cell line lacking SPL.

176 C141 can be readily alkylated in the native SPL by an iodoacetamide treatment, suggesting that it is

177 l organ-building" gene SPOROCYTELESS/NOZZLE (SPL/NZZ) plays a central role in regulating anther cell

178 fferentiation requires SPOROCYTELESS/NOZZLE (SPL/NZZ), as demonstrated by the spl/nzz mutant failing

179 In this study, we examined the ability of SPL to modulate the activity of beta-cell M(3) muscarini

180 Constitutive ablation of SPL in the brain (SPL(fl/fl/Nes)) but not postnatal neur

181 romote S1P metabolism through the actions of SPL.

182 Administration of SPL-334.1 attenuated the increase in GSNOR activity in b

183 amental advances into mechanistic aspects of SPL, providing a conceptual basis for controlling the SP

184 Coexpression of SPL or NRB with the alpha(1B)AR in Xenopus oocytes revea

185 Accordingly, deletion of SPL in mice enhanced binding of RGS2 to NRB and Ca(2+) s

186 ivates SHP-1 and causes dephosphorylation of SPL tyrosine residues, PGI2 and forskolin cause phosphor

187 , this suggests that DYT1 acts downstream of SPL/NZZ and EMS1/EXS.

188 t the concept that the inhibitory effects of SPL on M3R activity are mediated by RGS4.

189 hb2 partially reversed beneficial effects of SPL overexpression.

190 Arabidopsis, and decreased the expression of SPL genes regulated by miR156.

191 study, we report that ectopic expression of SPL/NZZ not only affects flower development in the wild-

192 ves and flowers, while ectopic expression of SPL/NZZ resulted in ectopic expression of AG and SEP3 in

193 be attributable to the ectopic expression of SPL/NZZ.

194 ver, the S1P degradation-incompetent form of SPL also enhanced IFN responses, suggesting that SPL's p

195 aled that SPL, as well as the mutant form of SPL, interacts with IKKepsilon.

196 Importantly, influenza virus infection of SPL-overexpressing cells induced rapid activation of ext

197 In contrast, the lack of SPL expression led to an elevated cellular susceptibilit

198 GA concentrations/responses with the loss of SPL/SPB function impaired canonical meristem maturation

199 (MD) simulations of an 800 000 atom model of SPL C complex from yeast Saccharomyces cerevisiae and co

200 Overexpression of SPL protected against cytokine toxicity.

201 re, ectopic expression and overexpression of SPL/NZZ altered expression of AG, SEP3, and AP2 in roset

202 PGI2 and forskolin cause phosphorylation of SPL Ser94 without reducing tyrosine phosphorylation.

203 ets, and (2) differential phosphorylation of SPL tyrosine and serine residues provides a key to under

204 telets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.

205 uthors show that age dependent regulation of SPL transcription factors by miR156 influence flowering

206 the poorly understood upstream regulation of SPL/NZZ in ovules, showing that the RdDM pathway is impo

207 However, little is known about the role of SPL expressed in peripheral cell types including pancrea

208 Here, we investigated the role of SPL in colitis-associated cancer (CAC).

209 e a direct relationship between structure of SPL and individuals' perceptual switch rate.

210 In contrast to that of SPL, the overexpression of S1P-producing sphingosine kin

211 The clinical relevance of SPLs in human malignancies however is still poorly under

212 However, the roles of SPLs in flowering remain elusive in grasses.

213 , and that amp1 has no significant effect on SPL transcript levels, or on the level or the activity o

214 relevant to the molecular mechanism of other SPL family members.

215 have previously reported that overexpressed SPL displays anti-influenza viral activity; however, the

216 e exposed to an impulse noise at 155 dB peak SPL.

217 arietal lobule (SPL) and the right precuneus-SPL, which were all more activated during localization c

218 factors, suggesting that AMP1 might promote SPL activity.

219 Fifteen genes in the E. pusilla SPL (EpSPL) family were identified, nine of which contai

220 acts together with other microRNA-regulated SPL transcription factors to control the timing of flowe

221 the ovule and therefore indirectly regulates SPL/NZZ expression.

222 In contrast with related SPL techniques, this approach affords a direct-write lit

223 ependent of ceramide generation but required SPL enzymatic activity and the actions of p38 MAP kinase

224 describing the network required to restrict SPL/NZZ expression to specify a single MMC.

225 at the RdDM pathway is important to restrict SPL/NZZ expression.

226 not postnatal neuronal forebrain-restricted SPL deletion (SPL(fl/fl/CaMK)) caused marked accumulatio

227 hus, we show for the first time that the S1P/SPL/S1P-receptor axis regulates the expression of a numb

228 In fibroblasts, silencing SPL promoted tumorigenic transformation through a pathwa

229 rescued the egress phenotype of DC-specific SPL knockout mice.

230 Sphingolipids (SPLs) are the largest class of bioactive lipids associat

231 Spinophilin (SPL) and neurabin (NRB) are structurally similar scaffol

232 Spinophilin (SPL), a multidomain scaffolding protein known to modulat

233 omprising the scaffold protein, spinophilin (SPL), and the tyrosine phosphatase, SHP-1, and show that

234 s formed by a scaffold protein, spinophilin (SPL), the tyrosine phosphatase, Src homology region 2 do

235 ernal forces exerted by the splanchnopleure (SPL) and the omphalomesenteric veins (OVs) drive rotatio

236 of a nascent mRNA transcript by spliceosome (SPL) is a hallmark of gene regulation in eukaryotes.

237 nzyme catalysis (employing Bacillus subtilis SPL) revealed that it is the 6-H(proR) atom of SP that i

238 One [Y99(Bs) in Bacillus subtilis SPL] is downstream of the cysteine, suggesting that SPL

239 Thus, association of each target SPL gene to a trait or set of traits is essential for de

240 miR156 targets SPL transcription factor genes that are master regulator

241 ors of this process, miR156 and its targets, SPL transcription factors.

242 hermochemical scanning probe lithography (tc-SPL) with a flow-through reactive gas cell to achieve na

243 The tc-SPL produced defects can present either p- or n-type dop

244 Furthermore, we demonstrate that SPL can induce microsporogenesis in the absence of AG fu

245 In this study, we demonstrate that SPL functions as a positive regulator of IKKepsilon to p

246 lly defined SP substrates demonstrating that SPL specifically repairs only the 5R isomer of SP.

247 We also found that SPL genes control meristem size by repressing WUSCHEL ex

248 We found that SPL is induced during myoblast differentiation.

249 Our results indicate that SPL is the first member of the radical SAM superfamily (

250 e levels, and tumorigenesis, indicating that SPL prevents transformation and carcinogenesis.

251 us replication in the cells, indicating that SPL protects cells from influenza virus via the activati

252 sulinoma cells and SPL-deficient mice), that SPL is a potent negative regulator of M3R-mediated signa

253 Our previous studies proved that SPL utilizes the 5'-dA* generated by the SAM cleavage re

254 alpha(1B)AR in Xenopus oocytes revealed that SPL reduces, whereas NRB increases, the intensity of Ca(

255 Biochemical analyses revealed that SPL, as well as the mutant form of SPL, interacts with I

256 d in SPL(-/-) and NRB(-/-) mice to show that SPL and NRB reciprocally regulate Ca(2+) signaling by GP

257 We also show that SPL/RGS/SHP1 complexes are present in resting platelets

258 These data suggest that SPL or other G-protein-coupled receptor-associated prote

259 e energy transfer technology, suggested that SPL is able to recruit regulator of G-protein signaling

260 downstream of the cysteine, suggesting that SPL uses a novel hydrogen atom transfer (HAT) pathway wi

261 also enhanced IFN responses, suggesting that SPL's pro-IFN function is independent of S1P.

262 r large areas quickly strongly suggests that SPL should be considered as an efficient and potentially

263 The SPL and right VLPFC showed heightened activity only duri

264 SP repair by the SPL C141A mutant yields TpTSO(2)(-) and TpT simultaneous

265 iding a conceptual basis for controlling the SPL via small-molecule modulators able to tackle splicin

266 Interestingly, the SPL overexpression did not suppress the cytokine-induced

267 Furthermore, the right VLPFC but not the SPL showed the greatest activation during the nogo decis

268 on among the critical distal proteins of the SPL assembly is pivotal for fast and accurate directing

269 periods but the higher point density of the SPL data provides more structural detail.

270 xpression of miR156-regulated members of the SPL family of transcription factors and provide evidence

271 dy and analyzed in part with the help of the SPL functions obtained in the present study.

272 llustrate the functional significance of the SPL-IKKepsilon-IFN axis during host innate immunity agai

273 er94 blocks cAMP-induced dissociation of the SPL/RGS/SHP-1 complex.

274 Thus, we propose that the role of the SPL/RGS/SHP1 complex in platelets is time and context de

275 riggering dephosphorylation and decay of the SPL/RGS/SHP1 complex.

276 corresponding increase in their targets-the SPL transcription factors.

277 tionally closer to motor processing than the SPL and the right VLPFC.

278 Our results indicate that the SPL/NZZ gene is engaged in controlling stamen identity v

279 ized sources, first in the aIPS and then the SPL.

280 Hence, the SPLs potentially rearrange the complex, attenuating its

281 ncreased potency of forward maskers as their SPL was increased, despite the fact that the excitatory

282 reaction of Geobacillus thermodenitrificans SPL (GtSPL) with SAM forms Omega within ~15 ms after mix

283 In support of this, SPL-deficient cells were defective in mounting an effect

284 Thus, SPL and NRB bind all members of the R4 subfamily of RGS

285 se in reaction time when rTMS was applied to SPL.

286 deletion of NRB enhanced binding of RGS2 to SPL and reduced Ca(2+) signaling by alphaAR.

287 Moreover, cytokine-treated SPL-overexpressing cells exhibited increased expression

288 es supporting the conserved function of TTG1-SPL complex.

289 hereby illuminating the significance of TTG1-SPLs interactions in trichome formation control.

290 s induced by DNA damage in WT cells, whereas SPL knockdown diminished apoptotic responses.

291 Here, we asked whether SPL and other RGS18 binding proteins such as 14-3-3gamma

292 n of GPCR-mediated Ca(2+) signaling in which SPL/NRB forms a functional pair of opposing regulators t

293 ory with a time constant that increases with SPL from approximately 200 to 370 msec.

294 HC power output increases and saturates with SPL.

295 tively mapped, and correlated very well with SPL-IR observed in other species.

296 PS and subsequent on-line adjustments within SPL.

297 rast to the >5 turnovers exhibited by the WT SPL reaction, suggesting that the enzyme catalytic cycle

298 ax) KIE of 2.8 +/- 0.3 determined for the WT SPL reaction.

299 tom transfer mechanism in the wild-type (WT) SPL reaction.

300 stage, miR156-mediated repression of zygotic SPL transcripts prevents premature accumulation of trans